LOCUS       NM_032324               6324 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleoside-triphosphatase, cancer-related (NTPCR),
            transcript variant 1, mRNA.
ACCESSION   NM_032324
VERSION     NM_032324.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6324)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6324)
  AUTHORS   Pasdziernik,M., Kaltschmidt,B., Kaltschmidt,C., Klinger,C. and
            Kaufmann,M.
  TITLE     On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line
            SH-SY5Y
  JOURNAL   BMC Res Notes 2, 102 (2009)
   PUBMED   19519914
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6324)
  AUTHORS   Placzek,W.J., Almeida,M.S. and Wuthrich,K.
  TITLE     NMR structure and functional characterization of a human
            cancer-related nucleoside triphosphatase
  JOURNAL   J Mol Biol 367 (3), 788-801 (2007)
   PUBMED   17291528
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY133356.1, BC005102.1,
            BQ001389.1 and AL122003.17.
            
            On Nov 23, 2018 this sequence version replaced NM_032324.2.
            
            Summary: The protein encoded by this gene is a non-specific
            nucleoside triphosphatase that is slow-acting in vitro. This gene
            is overexpressed in many tumor tissues, and while it is not
            essential for the cell, overexpression is cytotoxic. However, the
            cytotoxicity is not related to its triphosphatase activity.
            [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.206319.1,
                                           SRR1660803.130785.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366628.10/ ENSP00000355587.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                HY133356.1         82-94
            14-915              BC005102.1         1-902
            916-1244            BQ001389.1         18-346              c
            1245-6324           AL122003.17        115645-120724
FEATURES             Location/Qualifiers
     source          1..6324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..6324
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /note="nucleoside-triphosphatase, cancer-related"
                     /db_xref="GeneID:84284"
                     /db_xref="HGNC:HGNC:28204"
     exon            1..134
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..673
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /EC_number="3.6.1.15"
                     /note="isoform 1 is encoded by transcript variant 1; human
                     cancer-related NTPase; nucleoside-triphosphatase C1orf57;
                     cancer-related nucleoside-triphosphatase; nucleoside
                     triphosphate phosphohydrolase"
                     /codon_start=1
                     /product="cancer-related nucleoside-triphosphatase isoform
                     1"
                     /protein_id="NP_115700.1"
                     /db_xref="CCDS:CCDS1597.1"
                     /db_xref="GeneID:84284"
                     /db_xref="HGNC:HGNC:28204"
                     /translation="MARHVFLTGPPGVGKTTLIHKASEVLKSSGVPVDGFYTEEVRQG
                     GRRIGFDVVTLSGTRGPLSRVGLEPPPGKRECRVGQYVVDLTSFEQLALPVLRNADCS
                     SGPGQRVCVIDEIGKMELFSQLFIQAVRQTLSTPGTIILGTIPVPKGKPLALVEEIRN
                     RKDVKVFNVTKENRNHLLPDIVTCVQSSRK"
     exon            135..297
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..394
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..604
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..6324
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      813..818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /note="hexamer: CATAAA"
     polyA_site      835
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /note="major polyA site"
     regulatory      1072..1077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /note="hexamer: ATTAAA"
     polyA_site      1093
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /note="major polyA site"
     regulatory      1219..1224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /note="hexamer: AATAAA"
     polyA_site      1220
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
     polyA_site      1244
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
     regulatory      6304..6309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
                     /note="hexamer: TATAAA"
     polyA_site      6324
                     /gene="NTPCR"
                     /gene_synonym="C1orf57; HCR-NTPase; THEP1"
ORIGIN      
        1 gggcgggtcc tgagtcgcga ccctggtccg gacctgacct gaattgcgac cccaacctgg
       61 actgctcccc tgaccgcaac ccctaccccc gcccaccagt atggcccggc acgtgttcct
      121 aacggggccc ccaggagttg gaaaaacaac attgatccat aaagccagtg aggttttaaa
      181 atcctctggt gtgcctgttg atggatttta taccgaagaa gtcagacagg gagggagaag
      241 aataggattc gatgtcgtca cgttgtccgg cacccggggg cctttatcga gagttgggtt
      301 agagcctcca cctggaaaac gtgaatgccg agttgggcag tatgtggtcg acctgacttc
      361 ttttgagcag ttggcactac ccgtcttgag gaatgccgac tgcagcagtg gcccagggca
      421 aagagtgtgc gtcatcgatg agattgggaa gatggagctc ttcagtcagc ttttcattca
      481 agctgttcgt cagacgctgt ctaccccagg gactataatc cttggcacaa tcccagttcc
      541 taaaggaaag ccactggctc ttgtagaaga aatcagaaac agaaaggatg tgaaggtgtt
      601 taatgtcacc aaggaaaaca gaaaccacct tctgccagat atcgtgacgt gcgtgcagag
      661 cagcaggaag tgaagacacg tgcattcctg ccttccgtga aggagtgccc agttcaagag
      721 gagcctgatg gagccctgcc tgtcgaggct gtatgcctat ggggttatgg aaccttgtgg
      781 gcttttctag agaaaactca acagctgttt cccataaaat gtttaaaaga tcaaattagc
      841 cttaatgctg gattgtctgt acaagattaa ctatccattg tggcttatct atgcttaaag
      901 atttcttgtt tatttcctct tgcagtcatg cacatgattt gggtaaactg tgagatgaga
      961 aatggttttc agagtattag atggaattca cccccgttga agtttataaa tgtgttcagg
     1021 ggaagcggga ggaaagagtt cactgcctaa tcagttttgc atgtcatgaa aattaaattc
     1081 ctctccaggt gcagcttcag cctcatgcaa cttaaagtga taacagttat ttgatttttt
     1141 aaaaaatatt attccaaaag aaaaccattt taggtcatct cccccaactc tgtttgctta
     1201 ctgcttaata aatataaaaa taaatctgat ggttacagac aggaggcatt gtgtgggagg
     1261 aatacacaac ctttggaagt gttgatagca tctgatattc agccgaccag atgacaagag
     1321 ctcaggccca cgggtttgca taagagcact gctttgcctt agtttactcg ggagcaattt
     1381 tgaatctttc tatgcctagt ttcccttcca gaaaagcagg aagtggctgt catctcagga
     1441 gtgatgtcac accacagaag gaaactgtca accactccac acaactgtgg agagtgccca
     1501 gtgccagggg ctgggcttat caggaataat ggtgtagcaa tgcggagttc agcccataac
     1561 aggggtacta taaaaatgaa gtaggaaagt agaagagacc cctgaaaccc cagaactgat
     1621 agaggataaa aacttccctc caagtggtag atggtactgg agtgataaac agttcagtgt
     1681 ttttaggtca tttttggtga agatctatga atttccagga ttttttttta acaaattagc
     1741 attggctaca aacccactgg tataagcagc agtgtgcctt ctctctaact gtggacaagt
     1801 cgggcatgtg gcgggtgagg agccctgggc tgggcactgg ggcacagtga atggggcggg
     1861 aggggctcac atcaaaacca aaatggcacg cagcccaggt ctggttcctc catcagtgtc
     1921 tctttcctca gcgcttttct tccgaggtaa ctttgtgaag cttgacttgg acttgcctag
     1981 ccttggaggg accacaacag ggaggcctaa tagattatga actaagccct caaaagggct
     2041 acctgcccag gaggaggaag tgggcatctc cttccacagt ccctgcctgg cggggctgtt
     2101 cagggagact gagttccgag ctcaggatgt ctggcaggct ggctgtgact tccagccacc
     2161 atcaccagga caccggtgtg ggctgcatgc ctcagtgggc caggagaggc acggcctctg
     2221 agttgggtag aggcttccca caaaggcctg ggaacctgat cctggccgta aatctgaaag
     2281 taccacagcc ctcaggagaa ccaagagata gggaggcagg ctggggaaat gtcatcaatg
     2341 tgcacccagg cgtggtggag ctggtcagcc ccagctggag tgggacccca tcaagatgga
     2401 gcctttcctg gcacctccgg gaggccgttt tgcgtttccg cccttcatgc atctgaaaca
     2461 ccaagggcca tgttccttct ggtgcttgtc cttttgagct tggtgtttca gccgtgtctg
     2521 ttttgtagac tttgattttg tcttaaatga gaaagaaagc tggtgaaggt tatttcaaag
     2581 ttaaatagct agtctgaggg gcttatcact gaagccagtt gtgcttatgt ggggtgggag
     2641 tgtcactgcc tacttgaaag tatgcacttg tgtggaacag attcagggtg gcccctagca
     2701 cttggggctg cgggagcttc tgcacacttt ccctttaacg gtaaagagac aagcttggag
     2761 tgtttaagtg gttcgttcag gagcacagtg atagcggtga caaaggagat ttgaacccac
     2821 gtctgcgtgg ctccaaagtt cactctttca tcactccctg ctgcgtcctt cttgaggctt
     2881 tagcattttt agtgtgtttt gtgcccccag acctcagagt tgacatttag cagtgataaa
     2941 ctgctgtaaa tccaaagaac gtttagtgtc tcttgtggtg aggtcctgaa atgattgttg
     3001 tattagtcaa acagaatgat catggagcat gtatggagat gtcagatgca atccctgtat
     3061 tgtaaggcaa tgacatttaa tgaaggataa gatgaattca cagataacta gaactcaggg
     3121 ccaaacgcac acagcctgta gcaacagtgt catgctgaga tttaaaggaa gaagaggtgc
     3181 cgtggcagaa ctccacgtga ccgtcccctc cctgcacgca gccaggatga gaggagcaga
     3241 gctgagcgcc acctccctgt cggtgccacg gctgaggtga ggagctcttg ccggatggtg
     3301 gggtgggggc agcagggcag attgaagtca gggattctct tatacctgag tttggaatgc
     3361 ctcctattca aacaaagcaa aatatctaac agatggttgg atatgagtct cagggaggaa
     3421 ttcaatttga aaagcacaga attaacatgt attgcttata tgaagaatct cagctagaat
     3481 aacaaggtcg gatgggagga atcaggactg atttgaagca cgatttacta aatcattctt
     3541 tccttttcct ccttagcaga tcataccgcc agctgcttaa cacgtaatag tttaataaat
     3601 tgtttcttct tacctctcag tgagggtaag cacatgcagg gagatgggtg agtcttttaa
     3661 atggatagtg tcatctctga tgatcagcct tgacagggag agatcctagt aaagctgcaa
     3721 attcaggcac tcagttccca gccctccagt tatcaagggg gtgggaacgc tggtgggctg
     3781 gaaaatgtgg aacagacctg ctcctcttct tttcctgcca attaccgtat tcatagaagg
     3841 ttgtgtctgt ggatcacacc tgtgtgtgtg ctgatggcgg atgcttgtgt agcatagtga
     3901 cttgggacaa aacagcatgg tagatgaggc tggagacggg tgggctaagt aaacaggcat
     3961 tgcattgcac attttgtggg caaagaagtt gaagcatcgc atgattttaa caaattactt
     4021 gccagatgat ttcaacacac tgcaaaattt agaatcaata atgccaaatt ggccacatga
     4081 tttatataaa accaagtgct atggttttaa tattatcttt agaggagaaa ccattttgat
     4141 ctgtgtccaa ataactcttt tttttttttt tttttttgag acagagtctc actctgtcgc
     4201 ttgagctgga gtgcagtggt gctatctcgg ctcactgtaa cctccgcctc ctgggttcaa
     4261 gcgattctcc tgcctcaacc tcctgagtag ctgggattac aggcacccgc caccacgccc
     4321 agctaatttt ttgtattttt agtagagacg gggtttcacc atgttggcca agctggtctc
     4381 gaactcctga cctcatgatt tgcctgcctc agcctacaaa agtgctggga ttacaggcgt
     4441 gagccaccgt gcccagcccc caaataactc ttgaactgga aaataactct ttagctatat
     4501 actggcagaa tatttgaaca actctagcaa gaaatgtcag tttagggatg cctcctctaa
     4561 atgggggctt agaatataac attttgcagg aagtcctttc tgatacatag ctgactagat
     4621 gaaggaccag attaacaagt tcatgagttg taaatataaa agttgtgtac cacgataaaa
     4681 aagaaaaaga agtatggctg cactgttgat ggctggtcaa acagccccca agaatcctgg
     4741 ggtgactcca atactgccac cttttctctg tgggtgcagt tgcctgcgga tgtgtgtgca
     4801 catctgtgcc tcggtatgca cactcgagat gcccgctctc atagacggtg cagagcgtca
     4861 ctgcattcct atctgattaa tgtgacctta gtgttgtaga tacactgtgt cactttcatc
     4921 ctccctcctc cccacaaaag atgccacgag aactcgtgaa ctgtgataag caatgaacag
     4981 aataactgtt gaagaagcac ctcatgaacc tccccagaga aacgggatgg aggagcaccc
     5041 agggtgctct tgctctcttg cctgcgctgc catttccttc cagcctgggt ttctagctct
     5101 ttggggagat tccccgtttt gtggaatgct ttctgtgttt cctacttctg gatgcctaag
     5161 gagtggccag tcatactcct ggctgaccac tgccaggcac cgtggttttc ctcactgaac
     5221 tcaaggagtc accctccgtg gggaggccac actcacagct ccaggcctgc catttagccc
     5281 ttggggcttg gctgtaaagt tgcccaagag gattacagga gctgccagcc aagtttaatt
     5341 tggccacctt agagaactgc agcaaggccc tatcagcttc ccattagaca aacaactgca
     5401 tttaaattaa ataaagtttg cacctctagg gagtgctgac ctgaaaataa gaaccttctg
     5461 tctgtgatta tagagtacac ttgcttttat taattgctga ttcttagttt acaaaaaaaa
     5521 aaattagaaa agcattacca tttactttcc aaggggcaag agattctcta caataccctt
     5581 cccccaaccc tctcctcaaa tttccaaatc ctaaatactt tgaagaaatt tgtgtgactg
     5641 tttaaaattg agtatttcct tctaactatt gtcttttgaa aagggatggt tcaccaggcc
     5701 agtgatactc tatggactgc attttgggac ctctacccca gcaaggatac aggttcctgg
     5761 ggtcttgaag atgggaaaag ttgtctcaga atttacccaa atgtcgttct caccataaaa
     5821 gatatacttg tagaaatgag aagcttcagt ataactcaaa acactggacg cagcaataac
     5881 tataaacatt ttaatttcaa aaacaaaggt gtgtgcgatg ttgtgtgcac agtaagggtt
     5941 gcggggcttg gagaacaagc acgcgtccct gtgaagcccg cagggtgctg gcggcccacc
     6001 aatcgcctgg actacagtga ggagcattgt gtgactccgc ggtggatttc catgcaccga
     6061 atggactcag tttctaaact cacatcctaa cgtatcctgg cttttcacag aatactggag
     6121 acatgactgc atgcatgatc acggttcttg ttgtgaagct gccaccatgt tacgcttaac
     6181 agctgcataa atattataaa gaaatagggt tttcttgaca cttagattta accttaatgc
     6241 atctgcccag ctgatggtat cagacgtgct gctgttcatt tctttttcat ggtaacagta
     6301 atgtataaag tgccgatgat gtaa
//
