LOCUS       NM_032536               4673 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens netrin G2 (NTNG2), mRNA.
ACCESSION   NM_032536
VERSION     NM_032536.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4673)
  AUTHORS   Heimer,G., van Woerden,G.M., Barel,O., Marek-Yagel,D., Kol,N.,
            Munting,J.B., Borghei,M., Atawneh,O.M., Nissenkorn,A., Rechavi,G.,
            Anikster,Y., Elgersma,Y., Kushner,S.A. and Ben Zeev,B.
  TITLE     Netrin-G2 dysfunction causes a Rett-like phenotype with areflexia
  JOURNAL   Hum Mutat 41 (2), 476-486 (2020)
   PUBMED   31692205
  REMARK    GeneRIF: Netrin-G2 dysfunction causes a Rett-like phenotype with
            areflexia.
REFERENCE   2  (bases 1 to 4673)
  AUTHORS   Dias,C.M., Punetha,J., Zheng,C., Mazaheri,N., Rad,A., Efthymiou,S.,
            Petersen,A., Dehghani,M., Pehlivan,D., Partlow,J.N., Posey,J.E.,
            Salpietro,V., Gezdirici,A., Malamiri,R.A., Al Menabawy,N.M.,
            Selim,L.A., Vahidi Mehrjardi,M.Y., Banu,S., Polla,D.L., Yang,E.,
            Rezazadeh Varaghchi,J., Mitani,T., van Beusekom,E., Najafi,M.,
            Sedaghat,A., Keller-Ramey,J., Durham,L., Coban-Akdemir,Z.,
            Karaca,E., Orlova,V., Schaeken,L.L.M., Sherafat,A., Jhangiani,S.N.,
            Stanley,V., Shariati,G., Galehdari,H., Gleeson,J.G., Walsh,C.A.,
            Lupski,J.R., Seiradake,E., Houlden,H., van Bokhoven,H. and
            Maroofian,R.
  TITLE     Homozygous Missense Variants in NTNG2, Encoding a Presynaptic
            Netrin-G2 Adhesion Protein, Lead to a Distinct Neurodevelopmental
            Disorder
  JOURNAL   Am J Hum Genet 105 (5), 1048-1056 (2019)
   PUBMED   31668703
  REMARK    GeneRIF: Appropriate expression of NTNG2 plays an important role in
            neurotypical development.
REFERENCE   3  (bases 1 to 4673)
  AUTHORS   Abu-Libdeh,B., Ashhab,M., Shahrour,M., Daana,M., Dudin,A.,
            Elpeleg,O., Edvardson,S. and Harel,T.
  TITLE     Homozygous frameshift variant in NTNG2, encoding a synaptic cell
            adhesion molecule, in individuals with developmental delay,
            hypotonia, and autistic features
  JOURNAL   Neurogenetics 20 (4), 209-213 (2019)
   PUBMED   31372774
  REMARK    GeneRIF: Homozygous frameshift variant in NTNG2, encoding a
            synaptic cell adhesion molecule, in individuals with developmental
            delay, hypotonia, and autistic features.
REFERENCE   4  (bases 1 to 4673)
  AUTHORS   Pirone,A., Cozzi,B., Edelstein,L., Peruffo,A., Lenzi,C.,
            Quilici,F., Antonini,R. and Castagna,M.
  TITLE     Topography of Gng2- and NetrinG2-expression suggests an insular
            origin of the human claustrum
  JOURNAL   PLoS One 7 (9), e44745 (2012)
   PUBMED   22957104
  REMARK    GeneRIF: presence of Gng2 and Netrin-G2 immunoreactive elements in
            the insular cortex, but not in the putamen, suggests a possible
            common ontogeny of the claustrum and insula
REFERENCE   5  (bases 1 to 4673)
  AUTHORS   Brasch,J., Harrison,O.J., Ahlsen,G., Liu,Q. and Shapiro,L.
  TITLE     Crystal structure of the ligand binding domain of netrin G2
  JOURNAL   J Mol Biol 414 (5), 723-734 (2011)
   PUBMED   22041449
  REMARK    GeneRIF: the crystal structure for a fragment comprising the LN
            domain and domain LE1 of netrin G2 by sulfur single-wavelength
            anomalous diffraction phasing and refined it to 1.8 A resolution
            was determined.
REFERENCE   6  (bases 1 to 4673)
  AUTHORS   Eastwood,S.L. and Harrison,P.J.
  TITLE     Decreased mRNA expression of netrin-G1 and netrin-G2 in the
            temporal lobe in schizophrenia and bipolar disorder
  JOURNAL   Neuropsychopharmacology 33 (4), 933-945 (2008)
   PUBMED   17507910
  REMARK    GeneRIF: The data of this stusty implicate NTNG2 in the
            pathophysiology of schizophrenia and bipolar disorder, but do not
            support the hypothesis that altered mRNA expression is the
            mechanism by which genetic variation of NTNG2 may confer disease
            susceptibility.
REFERENCE   7  (bases 1 to 4673)
  AUTHORS   Meerabux,J.M., Ohba,H., Fukasawa,M., Suto,Y., Aoki-Suzuki,M.,
            Nakashiba,T., Nishimura,S., Itohara,S. and Yoshikawa,T.
  TITLE     Human netrin-G1 isoforms show evidence of differential expression
  JOURNAL   Genomics 86 (1), 112-116 (2005)
   PUBMED   15901489
REFERENCE   8  (bases 1 to 4673)
  AUTHORS   Aoki-Suzuki,M., Yamada,K., Meerabux,J., Iwayama-Shigeno,Y.,
            Ohba,H., Iwamoto,K., Takao,H., Toyota,T., Suto,Y., Nakatani,N.,
            Dean,B., Nishimura,S., Seki,K., Kato,T., Itohara,S., Nishikawa,T.
            and Yoshikawa,T.
  TITLE     A family-based association study and gene expression analyses of
            netrin-G1 and -G2 genes in schizophrenia
  JOURNAL   Biol Psychiatry 57 (4), 382-393 (2005)
   PUBMED   15705354
  REMARK    GeneRIF: An association between NTNG2 and schizophrenia was
            observed with SNPs and haplotypes that clustered in the 5' region
            of the gene.
REFERENCE   9  (bases 1 to 4673)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 4673)
  AUTHORS   Nakashiba,T., Nishimura,S., Ikeda,T. and Itohara,S.
  TITLE     Complementary expression and neurite outgrowth activity of netrin-G
            subfamily members
  JOURNAL   Mech Dev 111 (1-2), 47-60 (2002)
   PUBMED   11804778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353631.17, AL159997.14 and CK301008.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032536.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB058760.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393229.4/ ENSP00000376921.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AL353631.17        45259-45440
            183-878             AL353631.17        49550-50245
            879-1522            AL353631.17        81167-81810
            1523-1695           AL159997.14        14938-15110
            1696-1719           AL159997.14        18661-18684
            1720-1887           AL159997.14        27193-27360
            1888-2022           AL159997.14        28999-29133
            2023-4234           AL159997.14        29965-32176
            4235-4673           CK301008.1         23-461              c
FEATURES             Location/Qualifiers
     source          1..4673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.13"
     gene            1..4673
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /note="netrin G2"
                     /db_xref="GeneID:84628"
                     /db_xref="HGNC:HGNC:14288"
                     /db_xref="MIM:618689"
     exon            1..182
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..878
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             666..2258
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /note="netrin G1; Netrin-G2; laminet 2"
                     /codon_start=1
                     /product="netrin-G2 precursor"
                     /protein_id="NP_115925.2"
                     /db_xref="CCDS:CCDS6946.1"
                     /db_xref="GeneID:84628"
                     /db_xref="HGNC:HGNC:14288"
                     /db_xref="MIM:618689"
                     /translation="MLHLLALFLHCLPLASGDYDICKSWVTTDEGPTWEFYACQPKVM
                     RLKDYVKVKVEPSGITCGDPPERFCSHENPYLCSNECDASNPDLAHPPRLMFDKEEEG
                     LATYWQSITWSRYPSPLEANITLSWNKTVELTDDVVMTFEYGRPTVMVLEKSLDNGRT
                     WQPYQFYAEDCMEAFGMSARRARDMSSSSAHRVLCTEEYSRWAGSKKEKHVRFEVRDR
                     FAIFAGPDLRNMDNLYTRLESAKGLKEFFTLTDLRMRLLRPALGGTYVQRENLYKYFY
                     AISNIEVIGRCKCNLHANLCSMREGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSYL
                     PLPHGSPNACATAGSFGNCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGY
                     YRNGSAELDDENVCIECNCNQIGSVHDRCNETGFCECREGAAGPKCDDCLPTHYWRQG
                     CYPNVCDDDQLLCQNGGTCLQNQRCACPRGYTGVRCEQPRCDPADDDGGLDCDRAPGA
                     APRPATLLGCLLLLGLAARLGR"
     exon            879..1522
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1695
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1719
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1887
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2022
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..4673
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2956..2961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /note="hexamer: AGTAAA"
     polyA_site      2984
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /note="major polyA site"
     regulatory      4651..4656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
                     /note="hexamer: AATAAA"
     polyA_site      4673
                     /gene="NTNG2"
                     /gene_synonym="bA479K20.1; LHLL9381; Lmnt2; NEDBASH;
                     NetrinG2; NTNG1"
ORIGIN      
        1 gatctgacgg cggcggcggc ggcggccaca gcggcgggag cggcgcgggg aaggagcagc
       61 ggctcgcagc cctcggcccg cgcccccacc cagcgccagc ccgagggggg aggcgcagcg
      121 ccggagggtg gcggtcctcg gccctcccag gtctccgcgc cgggaagccg ctccgagccg
      181 gggctggagg gttgttttgc cgttgtgttg agcacgtcac ccattaagag ccctttaaag
      241 acctggattg attggaagga caaaaattaa aagcaatctg atccagcctc atgcaggatc
      301 cctgcggatt ttctccttat cccatttcca tccactgtca caatttgaga atctgcctga
      361 tttgatcaga ttcacctcca ggggaggtgt gataccaggg ttaggaggac gtgaagttat
      421 gggcaacttt ctgatctgtc catcagcagt ctgagaaacg ctggctctga attttccgtg
      481 tcggcctttt ggaaacaaca agttcctcgc tgtttgcaaa gcttcagtgc tcgggtccct
      541 gggacacccc ggccaccctc gcctggtaga tgtggcattt ccatgctgag gccgcgagtc
      601 ccgcctgacc ccgtcgctgc ctctccaggg cttctctggg ccgcgcctct gcagactgcg
      661 cagccatgct gcatctgctg gcgctcttcc tgcactgcct ccctctggcc tctggggact
      721 atgacatctg caaatcctgg gtgaccacag atgagggccc cacctgggag ttctacgcct
      781 gccagcccaa ggtgatgcgc ctgaaggact acgtcaaggt gaaggtggag ccctcaggca
      841 tcacatgtgg agacccccct gagaggttct gctcccatga gaatccctac ctatgcagca
      901 acgagtgtga cgcctccaac ccggacctgg cccacccgcc caggctcatg ttcgacaagg
      961 aggaggaggg cctggccacc tactggcaga gcatcacctg gagccgctac cccagcccgc
     1021 tggaagccaa catcaccctt tcgtggaaca agaccgtgga gctgaccgac gacgtggtga
     1081 tgaccttcga gtacggccgg cccacggtca tggtcctgga gaagtccctg gacaacgggc
     1141 gcacctggca gccctaccag ttctacgccg aggactgcat ggaggccttc ggtatgtccg
     1201 cccgccgggc ccgcgacatg tcatcctcca gcgcgcaccg cgtgctctgc accgaggagt
     1261 actcgcgctg ggcaggctcc aagaaggaga agcacgtgcg cttcgaggtg cgggaccgct
     1321 tcgccatctt tgccggcccc gacctgcgca acatggacaa cctctacacg cggctggaga
     1381 gcgccaaggg cctcaaggag ttcttcaccc tcaccgacct gcgcatgcgg ctgctgcgcc
     1441 cggcgctggg cggcacctat gtgcagcggg agaacctcta caagtacttc tacgccatct
     1501 ccaacatcga ggtcatcggc aggtgcaagt gcaacctgca cgccaacctg tgctccatgc
     1561 gcgagggcag cctgcagtgc gagtgcgagc acaacaccac cggccccgac tgcggcaagt
     1621 gcaagaagaa tttccgcacc cggtcctggc gggccggctc ctacctgccg ctgccccatg
     1681 gctctcccaa cgcctgtgcc actgcaggtt cctttggcaa ctgcgaatgc tacggtcact
     1741 ccaaccgctg cagctacatt gacttcctga atgtggtgac ctgcgtcagc tgcaagcaca
     1801 acacgcgagg tcagcactgc cagcactgcc ggctgggcta ctaccgcaac ggctcggcag
     1861 agctggatga tgagaacgtc tgcattgagt gtaactgcaa ccagataggc tccgtgcacg
     1921 accggtgcaa cgagaccggc ttctgcgagt gccgcgaggg cgcggcgggc cccaagtgcg
     1981 acgactgcct ccccacgcac tactggcgcc agggctgcta ccccaacgtg tgcgacgacg
     2041 accagctgct gtgccagaac ggaggcacct gcctgcagaa ccagcgctgc gcctgcccgc
     2101 gcggctacac cggcgtgcgc tgcgagcagc cccgctgcga ccccgccgac gatgacggcg
     2161 gtctggactg cgaccgcgcg cccggggccg ccccgcgccc cgccaccctg ctcggctgcc
     2221 tgctgctgct ggggctggcc gcccgcctgg gccgctgagc cccgcccgga ggacgctccc
     2281 cgcacccgga ggccgggggt cccggggtcc cggggcgggg ccggcgtccg aggccgggcg
     2341 gtgagaaggg tgcggcccga ggtgctccca ggtgctactc agcagggccc cccgcccggc
     2401 ccgcgctccc gcccgcactg ccctcccccc gcagcagggg cgccttggga ctccggtccc
     2461 cgcgcctgcg atttggtttc gtttttcttt tgtattatcc gccgcccagt tccttttttg
     2521 tctttctctc tctctctttt tttttttttt tttctggcgg tgagccagag ggtcgggaga
     2581 aacgctgctc gccccacacc ccgtcctgcc tcccaccaca cttacacaca cgggactgtg
     2641 gccgacaccc cctggcctgt gccaggctca cgggcggcgg cggaccccga cctccagttg
     2701 cctacaattc cagtcgctga cttggtcctg ttttctattc tttatttttc ctgcaaccca
     2761 ccagacccca ggcctcaccg gaggcccggt gaccacggaa ctcaccgtct gggggaggag
     2821 gagagaagga aggggtgggg ggcctggaaa cttcgttctg tagagaacta tttttgtttg
     2881 tattcactgt cccctgcaag ggggacgggg cgggagcact ggtcaccgcg ggggccgatg
     2941 gtggagaatc cgaggagtaa agagtttgct cactgctgcc tccacggcct gttttctttc
     3001 tgtgttgggg acggtgggca ggtgtggggc ttacagagga atccacaaca cagccttaaa
     3061 gaaacggttt ccctactggg gccaccattt ccctgggcct ttctgtggat tccagcaggc
     3121 agtgccccct ccccgcaggc ttggctggca gagttttcca ccccgcggcc aggctgcagg
     3181 tgccccacct gttaggagcc tccccacact gaaaggctgc ctccctcctt tcccaaaaaa
     3241 gaaatccgga gtgtattggc ccttttctac agaagtccaa gggaaatgac tcagggagaa
     3301 tcctagcaga ggttgaatcc aatgctctga tttatactgt gtctcggtgg ccacctccga
     3361 tggatgtgtc atctcagacc tgttgcagcc ggagcctcaa gtccaatatc agatgaagct
     3421 gaacccacaa ttcggccacc gcctccttcc agagtttcag atggccaggt gggcagaggc
     3481 gggcagtgca gagaccccag acgtgccggc cctgtcctcc ctaccttctc aagattagga
     3541 aggggtgctg gaggggacag gggcagcttg ggagtggtga ggaagctcct agattcgggg
     3601 ctcatcccct ggggcctctg attcagagga tccagcagtt ctcccatctc cgcttggtgt
     3661 ctccagccct ggggccacac ttccccctcg gtccagcctc ctgtccacct atgtttattt
     3721 cagagcagtg ccgggggtcc ggtcctggtt gctaactgct gccactgctc cacctgcagg
     3781 tgctcccagc actggcttct gccaccacac ctgttctttc ccagctgcga ggtttagacc
     3841 tgggtccttc ccttgagtcc ccaaagctaa gctaagacca agtggaacaa acttggcctt
     3901 ggggacagca ggagattaca acacagaaaa ggagggggag gcacaacggg acactgcata
     3961 ggactcacag tgtcccgagc ccacacacca gcccctcctg gcctcctctc tctgctccca
     4021 cccccagcac cctgctgacc cggaagtgcc ttccgacagg ccctgcatcc tcctgcagct
     4081 ggcccatctc taccctcaca ttcttcctta cgcacagaac cccactgcct gggacccaaa
     4141 gtgcccagat aaaataaaac acctctctgg ggcttcttgt ggataggagt ggccagggga
     4201 cacagctctg ggcagtgaga tgtaagcagg actgatgggt gggcttccag aaagttctta
     4261 aaagtcatcc cttcctccac gccccacaaa gcctcagttg tccaagtttg tggctctggt
     4321 ttttctctct catccctccc tctgctcttc agtcagcagg atggggaagg agccttcttg
     4381 agacactgag cataacagtg tcaccctcag gatagtgaag ggtggagccg ggggtggaag
     4441 ttgcagagcc tgggacacct gccttggctg caacctctgc actgctttta tttatctact
     4501 tatttttata gagttgaggt ctcactatgt tgcccaggct ggtctcaaac tcctaggctc
     4561 aagtgagcct ccggccttgg cctcccgaag tgctgagatt acaggcatga gccaccgcac
     4621 cacctgcctg tcttactgtg tgagaaaaaa aataaacggt gatgtgatta aaa
//
