LOCUS       NM_001113226            6330 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens netrin G1 (NTNG1), transcript variant 1, mRNA.
ACCESSION   NM_001113226 XM_011541021
VERSION     NM_001113226.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6330)
  AUTHORS   Gao,X., Lin,Y., Huang,X., Lu,C., Luo,W., Zeng,D., Li,Y., Su,T.,
            Liang,R. and Ye,J.
  TITLE     Comprehensive analysis of the role of Netrin G1 (NTNG1) in
            hepatocellular carcinoma cells
  JOURNAL   Eur J Pharmacol 963, 176262 (2024)
   PUBMED   38101695
  REMARK    GeneRIF: Comprehensive analysis of the role of Netrin G1 (NTNG1) in
            hepatocellular carcinoma cells.
REFERENCE   2  (bases 1 to 6330)
  AUTHORS   Liang,Y., Cen,J., Huang,Y., Fang,Y., Wang,Y., Shu,G., Pan,Y.,
            Huang,K., Dong,J., Zhou,M., Xu,Y., Luo,J., Liu,M. and Zhang,J.
  TITLE     CircNTNG1 inhibits renal cell carcinoma progression via
            HOXA5-mediated epigenetic silencing of Slug
  JOURNAL   Mol Cancer 21 (1), 224 (2022)
   PUBMED   36536414
  REMARK    GeneRIF: CircNTNG1 inhibits renal cell carcinoma progression via
            HOXA5-mediated epigenetic silencing of Slug.
            Erratum:[Mol Cancer. 2023 Jan 20;22(1):14. doi:
            10.1186/s12943-023-01726-w.. PMID: 36670419]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6330)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6330)
  AUTHORS   Vattathil,S.M., Liu,Y., Harerimana,N.V., Lori,A., Gerasimov,E.S.,
            Beach,T.G., Reiman,E.M., De Jager,P.L., Schneider,J.A.,
            Bennett,D.A., Seyfried,N.T., Levey,A.I., Wingo,A.P. and Wingo,T.S.
  TITLE     A Genetic Study of Cerebral Atherosclerosis Reveals Novel
            Associations with NTNG1 and CNOT3
  JOURNAL   Genes (Basel) 12 (6), 815 (2021)
   PUBMED   34073619
  REMARK    GeneRIF: A Genetic Study of Cerebral Atherosclerosis Reveals Novel
            Associations with NTNG1 and CNOT3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6330)
  AUTHORS   Lehrer,S. and Rheinstein,P.H.
  TITLE     SARS-CoV-2 orf1b Gene Sequence in the NTNG1 Gene on Human
            Chromosome 1
  JOURNAL   In Vivo 34 (3 Suppl), 1629-1632 (2020)
   PUBMED   32503821
  REMARK    GeneRIF: A 117-base pair SARS-CoV-2 orf1b sequence matched a
            sequence in the human genome with 94.6% identity. The sequence was
            in chromosome 1p within an intronic region of the netrin G1 (NTNG1)
            gene, implicated in schizophrenia.
REFERENCE   6  (bases 1 to 6330)
  AUTHORS   Meerabux,J.M., Ohba,H., Fukasawa,M., Suto,Y., Aoki-Suzuki,M.,
            Nakashiba,T., Nishimura,S., Itohara,S. and Yoshikawa,T.
  TITLE     Human netrin-G1 isoforms show evidence of differential expression
  JOURNAL   Genomics 86 (1), 112-116 (2005)
   PUBMED   15901489
  REMARK    GeneRIF: NTNG1 may use alternative splicing to diversify its
            function in a developmentally and tissue-specific manner.
REFERENCE   7  (bases 1 to 6330)
  AUTHORS   Aoki-Suzuki,M., Yamada,K., Meerabux,J., Iwayama-Shigeno,Y.,
            Ohba,H., Iwamoto,K., Takao,H., Toyota,T., Suto,Y., Nakatani,N.,
            Dean,B., Nishimura,S., Seki,K., Kato,T., Itohara,S., Nishikawa,T.
            and Yoshikawa,T.
  TITLE     A family-based association study and gene expression analyses of
            netrin-G1 and -G2 genes in schizophrenia
  JOURNAL   Biol Psychiatry 57 (4), 382-393 (2005)
   PUBMED   15705354
  REMARK    GeneRIF: Specific haplotypes encompassing alternatively spliced
            exons of NTNG1 were associated with schizophrenia, and
            concordantly, messenger ribonucleic acid isoform expression was
            significantly different between schizophrenic and control brains.
REFERENCE   8  (bases 1 to 6330)
  AUTHORS   Fukasawa,M., Aoki,M., Yamada,K., Iwayama-Shigeno,Y., Takao,H.,
            Meerabux,J., Toyota,T., Nishikawa,T. and Yoshikawa,T.
  TITLE     Case-control association study of human netrin G1 gene in Japanese
            schizophrenia
  JOURNAL   J Med Dent Sci 51 (2), 121-128 (2004)
   PUBMED   15508520
  REMARK    GeneRIF: findings suggest that netrin G1 or a nearby gene may
            contribute to overall genetic risk for schizophrenia
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 6330)
  AUTHORS   Lin,J.C., Ho,W.H., Gurney,A. and Rosenthal,A.
  TITLE     The netrin-G1 ligand NGL-1 promotes the outgrowth of
            thalamocortical axons
  JOURNAL   Nat Neurosci 6 (12), 1270-1276 (2003)
   PUBMED   14595443
  REMARK    GeneRIF: Netrin-G1 is an important part of the NGL-1 receptor and
            functions to promote the outgrowth of dorsal thalamic axons.
REFERENCE   10 (bases 1 to 6330)
  AUTHORS   Nakashiba,T., Ikeda,T., Nishimura,S., Tashiro,K., Honjo,T.,
            Culotti,J.G. and Itohara,S.
  TITLE     Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian
            netrin that is functionally divergent from classical netrins
  JOURNAL   J Neurosci 20 (17), 6540-6550 (2000)
   PUBMED   10964959
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590427.15, AL513187.6 and
            AC114491.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Aug 22, 2019 this sequence version replaced
            XM_011541021.2, NM_001113226.2.
            
            Summary: This gene encodes a preproprotein that is processed into a
            secreted protein containing eukaroytic growth factor (EGF)-like
            domains. This protein acts to guide axon growth during neuronal
            development. Polymorphisms in this gene may be associated with
            schizophrenia. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Aug
            2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (G1a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.101081.1,
                                           SRR1803613.260960.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370068.6/ ENSP00000359085.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AL590427.15        8585-8686
            103-873             AL590427.15        15615-16385
            874-1514            AL513187.6         33689-34329
            1515-1687           AL513187.6         104561-104733
            1688-1714           AL513187.6         117089-117115
            1715-1882           AC114491.1         187407-187574       c
            1883-2017           AC114491.1         181525-181659       c
            2018-6330           AC114491.1         133401-137713       c
FEATURES             Location/Qualifiers
     source          1..6330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..6330
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /note="netrin G1"
                     /db_xref="GeneID:22854"
                     /db_xref="HGNC:HGNC:23319"
                     /db_xref="MIM:608818"
     exon            1..102
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /inference="alignment:Splign:2.1.0"
     exon            103..873
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             628..2247
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /note="isoform G1a preproprotein is encoded by transcript
                     variant 1; laminet 1; axon guidance molecule"
                     /codon_start=1
                     /product="netrin-G1 isoform G1a preproprotein"
                     /protein_id="NP_001106697.1"
                     /db_xref="CCDS:CCDS44180.1"
                     /db_xref="GeneID:22854"
                     /db_xref="HGNC:HGNC:23319"
                     /db_xref="MIM:608818"
                     /translation="MYLSRFLSIHALWVTVSSVMQPYPLVWGHYDLCKTQIYTEEGKV
                     WDYMACQPESTDMTKYLKVKLDPPDITCGDPPETFCAMGNPYMCNNECDASTPELAHP
                     PELMFDFEGRHPSTFWQSATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQM
                     ILEKSLDYGRTWQPYQYYATDCLDAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNS
                     KIIHFEIKDRFAFFAGPRLRNMASLYGQLDTTKKLRDFFTVTDLRIRLLRPAVGEIFV
                     DELHLARYFYAISDIKVRGRCKCNLHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQ
                     GRPWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTR
                     GQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRCNGSGFCECKTGTTGPKCD
                     ECLPGNSWHYGCQPNVCDNELLHCQNGGTCHNNVRCLCPAAYTGILCEKLRCEEAGSC
                     GSDSGQGAPPHGSPALLLLTTLLGTASPLVF"
     exon            874..1514
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1687
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1714
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1882
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2017
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..6330
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3240..3245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /note="hexamer: AATAAA"
     polyA_site      3262
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /note="major polyA site"
     regulatory      3788..3793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /note="hexamer: AATAAA"
     polyA_site      3809
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
     regulatory      4249..4254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /note="hexamer: AATAAA"
     polyA_site      4291
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
     regulatory      4845..4850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /note="hexamer: AATAAA"
     polyA_site      4875
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
     regulatory      6285..6290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
                     /note="hexamer: AATAAA"
     polyA_site      6330
                     /gene="NTNG1"
                     /gene_synonym="Lmnt1; NetG1; NetrinG1"
ORIGIN      
        1 gcatttcgga agaggacgtc aacgggaagg aattccccct ctgggtgcgg gctccgagag
       61 ggggcgactt gcaggaggct ccccccgggg gcggaggcga agggtgttgg tgccagaaga
      121 aaagaatgat tgatgggaaa cagacaccgg gctatagaca ctcatccttt tgcttcagat
      181 actgatatct cagcctgctt gagcatccct tgtgagctgt gaacattgag gatcactcag
      241 ggttatcgga tgtacaacgg gagagccatc gctttgctaa attattatct gcaattggac
      301 atcttttaca aaaaccaaac tagacctgag tctaatagat atgttctaag acaaagaaaa
      361 agctgcaagt tgttaacgcc taacacacaa gtatgttagg cttccaccaa agtcctcaat
      421 atacctgaat acgcacaata tcttaactct tcatatttgg ttttgggatc tgctttgagg
      481 tcccatcttc atttaaaaaa aaatacagag acctacctac ccgtacgcat acatacatat
      541 gtgtatatat atgtaaacta gacaaagatc gcagatcata aagcaagctc tgctttagtt
      601 tccaagaaga ttacaaagaa tttagagatg tatttgtcaa gattcctgtc gattcatgcc
      661 ctttgggtta cggtgtcctc agtgatgcag ccctaccctt tggtttgggg acattatgat
      721 ttgtgtaaga ctcagattta cacggaagaa gggaaagttt gggattacat ggcctgccag
      781 ccggaatcca cggacatgac aaaatatctg aaagtgaaac tcgatcctcc ggatattacc
      841 tgtggagacc ctcctgagac gttctgtgca atgggcaatc cctacatgtg caataatgag
      901 tgtgatgcga gtacccctga gctggcacac ccccctgagc tgatgtttga ttttgaagga
      961 agacatccct ccacattttg gcagtctgcc acttggaagg agtatcccaa gcctctccag
     1021 gttaacatca ctctgtcttg gagcaaaacc attgagctaa cagacaacat agttattacc
     1081 tttgaatctg ggcgtccaga ccaaatgatc ctggagaagt ctctcgatta tggacgaaca
     1141 tggcagccct atcagtatta tgccacagac tgcttagatg cttttcacat ggatcctaaa
     1201 tccgtgaagg atttatcaca gcatacggtc ttagaaatca tttgcacaga agagtactca
     1261 acagggtata caacaaatag caaaataatc cactttgaaa tcaaagacag gttcgcgttt
     1321 tttgctggac ctcgcctacg caatatggct tccctctacg gacagctgga tacaaccaag
     1381 aaactcagag atttctttac agtcacagac ctgaggataa ggctgttaag accagccgtt
     1441 ggggaaatat ttgtagatga gctacacttg gcacgctact tttacgcgat ctcagacata
     1501 aaggtgcgag gaaggtgcaa gtgtaatctc catgccactg tatgtgtgta tgacaacagc
     1561 aaattgacat gcgaatgtga gcacaacact acaggtccag actgtgggaa atgcaagaag
     1621 aattatcagg gccgaccttg gagtccaggc tcctatctcc ccatccccaa aggcactgca
     1681 aatacctgta tccccagtat ttccagtatt ggtaattgtg aatgcttcgg ccactccaat
     1741 cgatgcagtt atatcgatct gctaaataca gtcatttgcg tgagctgtaa acacaacact
     1801 agagggcagc actgtgagtt atgcaggctg ggctacttca gaaatgcttc tgcacaactg
     1861 gacgatgaga atgtgtgcat agagtgttat tgtaaccctt tgggctcaat ccatgatcgt
     1921 tgtaatggct caggattttg tgagtgtaag actggaacaa cagggcctaa gtgtgatgag
     1981 tgtctgccgg gaaattcctg gcactacggc tgtcaaccga atgtctgcga caacgagctc
     2041 ctgcactgcc agaacggagg gacgtgccac aacaacgtgc gctgcctgtg cccggccgca
     2101 tacacgggca tcctctgcga gaagctgcgg tgcgaggagg ctggcagctg cggctccgac
     2161 tctggccagg gcgcgccccc gcacggctcc ccagcgctgc tgctgctgac cacgctgctg
     2221 ggaaccgcca gccccctggt gttctaggtg tcacctccag ccacaccgga cgggcctgtg
     2281 ccgtggggaa gcagacacaa cccaaacatt tgctactaac ataggaaaca cacacataca
     2341 gacaccccca ctcagacagt gtacaaacta agaaggccta actgaactaa gccatattta
     2401 tcacccgtgg acagcacatc cgagtcaaga ctgttaattt ctgactccag aggagttggc
     2461 agctgttgat attatcactg caaatcacat tgccagctgc agagcatatt gtggattgga
     2521 aaggctgcga cagcccccca aacaggaaag acaaaaaaca aacaaatcaa ccgacctaaa
     2581 aacattggct actctagcgt ggtgcgccct agtacgactc cgcccagtgt gtggaccaac
     2641 caaatagcat tctttgctgt caggtgcatt gtgggcataa ggaaatctgt tacaagctgc
     2701 catattggcc tgcttccgtc cctgaatccc ttccaacctg tgctttagtg aacgttgctc
     2761 tgtaaccctt gttggttgaa agatttcttt gtctgatgtt agtgatgcac atgtgtaaca
     2821 gccccctcta aaagcgcaag ccagtcatac ccctgtatat cttagcagca ctgagtccag
     2881 tgcgagcaca cacccactat acaagagtgg ctataggaaa aaagaaagtg tatctatcct
     2941 tttgtattca aatgaagtta tttttcttga actactgtaa tatgtagatt ttttgtatta
     3001 ttgccaattt gtgttaccag acaatctgtt aatgtatcta attcgaatca gcaaagactg
     3061 acattttatt ttgtcctctt tcgttctgtt ttgtttcact gtgcagagat ttctctgtaa
     3121 gggcaacgaa cgtgctggca tcaaagaata tcagtttaca tatataacaa gtgtaataag
     3181 attccaccaa aggacattct aaatgttttc ttgttgcttt aacactggaa gatttaaaga
     3241 ataaaaactc ctgcataaac gatttcagga atttgtattg caatttctta agatgaaagg
     3301 aacagccacc aagcagtttc acactcactt tactgatttc tgtgtggact gagtacattc
     3361 agctgacgaa tttagttccc aggaagatgg attgatgttc actagcttgg acaacttctg
     3421 caaaatatga gactatttcc acttgggaaa aattacaaca gcaaaaaaaa aaaaaaaaaa
     3481 aaaaaaaaat ctaagtgatt gccaagatta tgccaaagcc tgttggcaga gtactaagag
     3541 acttttattt ttaagtcatg ctattttcac agattgatgg tgatcatgtg actctaggga
     3601 tgctgatcta tgtatctttc caaatacagt gtttacatgg agtatcacaa gacgcaacct
     3661 ggggaaccag gaagggagca gggaaattga gtgatttgca atttgacttt gaatatattc
     3721 agacttaagt atttagagga aatatcaaaa tataaagcag caagtagaca taactgctgt
     3781 tcctgagaat aaagtttgtt ttaagtgctg cccaaggtgt aataaattct tgtttctgcc
     3841 ttttattagg ccaattactg tgcaagacag caaggggagg caggtgggga agaacctttg
     3901 caaagtttca aagaggctaa gacagtgtgc atttcgttcc cagcacactg ttgtcctaca
     3961 gattacaagt gtattagcag cagcatctcc tggaatcaaa aacaattatc agcccgaacc
     4021 agagtcttaa ggacaatgaa attctacatg acttggtaga acaataacct atgatagtgt
     4081 aaggtcagaa acctagttcc agtctgaatt cttcaccctg ctgccactcc ttgctgaaac
     4141 agggaagggg ggaggaatgt ctcctgataa ataacctggg taaaaactag atgaaggaac
     4201 agcatgtctt attggttttg ttcccagaaa agccaattcg aagaaggcaa taaaaggtaa
     4261 acaggtaatg cctgtgctgc ctgccacccc acgtctaagt ctattgaatg tttgttattc
     4321 aaaccaacag tctcttttga tgtaagaaat aaggaaagat ggaaataaat tagagcttag
     4381 gcttagtgcc agagtggcca accagaaatt ggagatttac gttggaagca taaatagaaa
     4441 attatatttc aggctcacca aagaaacaca tgaaaatgct gataacatag ggagtttgag
     4501 attatttata atgaggtgga tttctgatat taaaattaga gtttaagttg tcttatagtt
     4561 tattagcaca aaccaaaggc agcccatgtt atttctggca aagatgcact ttatcgttat
     4621 ctgctcatgg ctttgtcgca acgctcagga atcagacact gcacacttca atagttggga
     4681 ttccaaaagc taattctaaa atttaatgaa ggcctgattt aaactgattc atctgcattt
     4741 tatctttatg aggccataag aatctaaatt gatgaggaat atctttcatt ccgtgtattt
     4801 agatatagtt ttctgaattt cctgaagcga tgtgatctgc ttttaataaa aattcacttt
     4861 taggtgtaca acaaatggaa atgaaatgtt ctttttaaat ctggattctc aagttcttct
     4921 aaaggagcta ctcctctgag gaaacctcaa ctcagtggac ttgattcatc tgttactttc
     4981 cagcattctt acaaagctgg tttcatctac aatgttgtgc cctaagaaca ggactggggt
     5041 gaaaagcggg tactcagttg ttcatatatt tgaggtccta attcttggta ttttttccct
     5101 ttgataaatc ccttaaagtg gcttaatgta gtcttgcata tgagttaatc tatcaacttt
     5161 cccacataga actgatataa ttccttctat caataatatt gatgggcata acatttcaaa
     5221 aaatgggaca aaggttcagc tatctagaaa gatttgctat ttataggaag ataatggaca
     5281 tgccctgctg tgatttgagg gttatttatt tctgaccctg tacacagcct aggggaagaa
     5341 tttagtccag caaagagggg accttgctta gagagaccca ttctgactct cctccagctt
     5401 tctcccagat atcaggaacc tagagtttcc tactcagata accgcccccc acacgcacac
     5461 ttttaggcca aatgtaggcc ccctctgggg gtttaaactc ctggaggcaa gcaacatcct
     5521 gagtgcatat acctgggcac agggagtggc aaagggtgca tctgtgtgga tggattaggc
     5581 cctggggcct ggagtgttca ctgtggaatt tacacacaag caaggagaag ccacttgcca
     5641 tgaaaacaag agtccagggc tgaaaaataa agggatgagg ggtaggaagg agatagacaa
     5701 gggctaccac gaggctgggg gccagtacag aacactgaac agtctaagaa ttctaaatct
     5761 atacctgggc ttccaagggt tatgaaagca tcatgtgtca aagtggcagg atggaagata
     5821 atttaacagt ttgttagctt tatgtatgac ttttaaatac ttagacatgt ggcatggggt
     5881 cctccattgg tacttttgca caagatcctg cagacatttg gggtcgatct gcctgaggtg
     5941 cccttgagtc agatccctaa gttggcacaa actgctaacc acataacaca aagaaaggtc
     6001 caggttggaa gaaggcgtct gctccacagt tcagctggcc ctgtagttaa tgctcccctc
     6061 accttctctt ggacctgtgg tctgactgga gtataagaaa ttttggatgc actgggggaa
     6121 caactgtgag gaaatcttga catcgaatat tttgttccat ctccttcacc ctctaccatc
     6181 aataatccag tatgattggg atgtaaagac ccagcattct gaaatgggat gctctgtact
     6241 atatgggaaa tgggttgttg tactttaccg gttgttaaac actaaataaa atacctgttt
     6301 aacagattct ctgctcacag gattgaccaa
//
