LOCUS       NM_145807               1846 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens netrin 5 (NTN5), mRNA.
ACCESSION   NM_145807
VERSION     NM_145807.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1846)
  AUTHORS   Garrett,A.M., Jucius,T.J., Sigaud,L.P., Tang,F.L., Xiong,W.C.,
            Ackerman,S.L. and Burgess,R.W.
  TITLE     Analysis of Expression Pattern and Genetic Deletion of Netrin5 in
            the Developing Mouse
  JOURNAL   Front Mol Neurosci 9, 3 (2016)
   PUBMED   26858598
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1846)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008888.7.
            
            On Feb 27, 2020 this sequence version replaced NM_145807.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033207.1, SRR14038195.1488080.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155371, SAMEA2155974
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270235.11/ ENSP00000270235.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC008888.7         52326-52411         c
            87-737              AC008888.7         49750-50400         c
            738-926             AC008888.7         43973-44161         c
            927-1076            AC008888.7         43537-43686         c
            1077-1130           AC008888.7         43155-43208         c
            1131-1211           AC008888.7         42857-42937         c
            1212-1846           AC008888.7         40801-41435         c
FEATURES             Location/Qualifiers
     source          1..1846
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1846
                     /gene="NTN5"
                     /note="netrin 5"
                     /db_xref="GeneID:126147"
                     /db_xref="HGNC:HGNC:25208"
     exon            1..86
                     /gene="NTN5"
                     /inference="alignment:Splign:2.1.0"
     exon            87..737
                     /gene="NTN5"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1576
                     /gene="NTN5"
                     /note="netrin-1-like protein"
                     /codon_start=1
                     /product="netrin-5 precursor"
                     /protein_id="NP_665806.1"
                     /db_xref="CCDS:CCDS33068.1"
                     /db_xref="GeneID:126147"
                     /db_xref="HGNC:HGNC:25208"
                     /translation="MPVTFALLLLLGQATADPCYDPQGRPQFCLPPVTQLAAVAASCP
                     QACALSPGNHLGARETCNGSLTLALGGPFLLTSVSLRFCTPGPPALILSAAWASGGPW
                     RLLWHRPAWPGALGGPERVTFHSTPGPKATVAASHLRVEFGGQAGLAAAGLRGRCQCH
                     GHAARCAARARPPRCHCRHHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHA
                     RRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQ
                     CHPIGATGGTCNQTSGQCTCKLGVTGLTCNRCGPGYQQSRSPRMPCQRIPEATTTLAT
                     TPGAYSSDPQCQNYCNMSDTRVHMSLRRYCQQDHVLRAQVLASEAAGPAWQRLAVRVL
                     AVYKQRAQPVRRGDQDAWVPRADLTCGCLRLQPGTDYLLLGSAVGDPDPTRLILDRHG
                     LALPWRPRWARPLKRLQQEERAGGCRGVRAPTPSPRPEH"
     exon            738..926
                     /gene="NTN5"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1076
                     /gene="NTN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1130
                     /gene="NTN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1211
                     /gene="NTN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1846
                     /gene="NTN5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1823..1828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTN5"
                     /note="hexamer: AATAAA"
     polyA_site      1846
                     /gene="NTN5"
                     /note="major polyA site"
ORIGIN      
        1 actccctcct gagagcccac cgcgccacag cttggaggaa gagcctgcgg ggaactggct
       61 gcaggacgct ctcttcttga gtgcaggtgc tggctctgct gtgaccatgc ccgtgacctt
      121 tgccctcctg ctcctcctgg gccaggccac tgcggaccca tgctacgatc cacagggccg
      181 cccccaattc tgcctcccgc cagtgacaca gctggctgcc gtggcggcct cctgccctca
      241 ggcctgtgcc ctgtccccag gaaaccacct tggcgccagg gaaacctgca atggcagcct
      301 gactttggcc ctgggtggcc ccttcctcct gacatctgtc agcttgcgct tctgtacccc
      361 aggaccccca gccctcatcc tgtctgctgc ctgggcctca gggggtccct ggaggctgct
      421 gtggcacagg cccgcctggc ctggggcctt agggggccct gaaagggtga ccttccactc
      481 cacaccaggt cctaaggcca ctgtggcggc cagccacctc cgtgtggagt ttgggggcca
      541 ggccgggcta gcggcagctg ggctgagagg ccgctgccag tgtcatggcc acgctgcccg
      601 ctgtgccgcc cgtgcccggc ccccccgctg ccactgccgc caccatacca ctggcccggg
      661 gtgcgagagc tgccgcccgt cccatcgaga ctggccctgg cggcctgcca cgccccggca
      721 cccccaccct tgcctaccct gctcctgcaa ccagcacgcc cgacgctgcc ggttcaactc
      781 tgagctgttc agactgtcgg gcggccggag tgggggtgtt tgtgagcggt gccgccacca
      841 cacagctggg cggcactgcc actactgcca acctgggttc tggagggacc ctagccagcc
      901 tatcttcagc cgcagggcct gcagagcctg ccagtgccac cctattgggg caacaggagg
      961 aacctgcaac cagaccagtg ggcagtgcac ctgcaagtta ggggtcacag gcctgacctg
     1021 caaccgctgt ggccctggct accagcagag ccgctccccc aggatgccct gccagcgaat
     1081 tccagaggca acaaccaccc ttgccactac tcctggtgct tatagctctg accctcagtg
     1141 tcaaaactac tgcaatatgt cggacaccag ggtacacatg agccttcgga ggtactgcca
     1201 gcaggaccat gttctccgcg cgcaggtgct agcgtccgag gcggcgggcc cggcatggca
     1261 gcggctggcc gtgcgcgtgc tggccgttta caagcagcgg gcgcagcccg tgcgacgcgg
     1321 cgaccaggac gcctgggtgc cccgcgccga cctgacctgc ggctgcctgc gcctgcagcc
     1381 aggcaccgac tacctgctgc tgggcagcgc cgtgggcgac cccgacccca cgcgcctcat
     1441 cctcgaccgc cacggcctcg cgctgccatg gaggccgcgc tgggcccggc ccctgaagcg
     1501 gctgcagcag gaggagcgcg ccggaggctg ccgcggcgtg cgggcaccca cacccagtcc
     1561 caggccggag cactagacgt gagatggggc tgcctcgagc accaacaaag taatttggga
     1621 gcgactagga gctgagcctt ctacctcgac ggtgcactgc agagagccaa tcagacgtcg
     1681 cagagccccg acgacactat gcttgcgccc acgccgagca ggcgtgcgga acttttagca
     1741 aaaggcggca agcgggactt ctggtcccaa catttcctcc tttggcctgt ggcttattcc
     1801 ccgccagtga tctgtttccc ccaataaagt ctcaaatctt tgggaa
//
