LOCUS       NM_001329700            3552 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens netrin 4 (NTN4), transcript variant 2, mRNA.
ACCESSION   NM_001329700
VERSION     NM_001329700.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3552)
  AUTHORS   Vennela,J., Pottakkat,B., Vairappan,B.S., Verma,S.K. and
            Mukherjee,V.
  TITLE     Hepatic Expression of NTN4 and Its Receptors in Patients with
            Hepatocellular Carcinoma
  JOURNAL   Asian Pac J Cancer Prev 24 (12), 4285-4292 (2023)
   PUBMED   38156865
  REMARK    GeneRIF: Hepatic Expression of NTN4 and Its Receptors in Patients
            with Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3552)
  AUTHORS   Wu,Z., Liu,S., Pang,G. and Jiang,H.
  TITLE     RNA-binding protein quaking 5 inhibits the progression of non-small
            cell lung cancer by upregulating netrin-4 expression
  JOURNAL   Oncol Rep 50 (5) (2023)
   PUBMED   37800632
  REMARK    GeneRIF: RNA-binding protein quaking 5 inhibits the progression of
            non-small cell lung cancer by upregulating netrin-4 expression.
REFERENCE   3  (bases 1 to 3552)
  AUTHORS   Dong,F., Liu,Y., Yan,W., Meng,Q., Song,X., Cheng,B. and Yao,R.
  TITLE     Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability,
            Angiogenesis and Tumors
  JOURNAL   Cell Mol Neurobiol 43 (5), 1663-1683 (2023)
   PUBMED   36350538
  REMARK    GeneRIF: Netrin-4: Focus on Its Role in Axon Guidance, Tissue
            Stability, Angiogenesis and Tumors.
            Review article
REFERENCE   4  (bases 1 to 3552)
  AUTHORS   Hayano,Y., Sasaki,K., Ohmura,N., Takemoto,M., Maeda,Y.,
            Yamashita,T., Hata,Y., Kitada,K. and Yamamoto,N.
  TITLE     Netrin-4 regulates thalamocortical axon branching in an
            activity-dependent fashion
  JOURNAL   Proc Natl Acad Sci U S A 111 (42), 15226-15231 (2014)
   PUBMED   25288737
  REMARK    GeneRIF: NTN4 acts as a positive regulator for TC axon branching
            through activity-dependent expression
REFERENCE   5  (bases 1 to 3552)
  AUTHORS   Lejmi,E., Leconte,L., Pedron-Mazoyer,S., Ropert,S., Raoul,W.,
            Lavalette,S., Bouras,I., Feron,J.G., Maitre-Boube,M., Assayag,F.,
            Feumi,C., Alemany,M., Jie,T.X., Merkulova,T., Poupon,M.F.,
            Ruchoux,M.M., Tobelem,G., Sennlaub,F. and Plouet,J.
  TITLE     Netrin-4 inhibits angiogenesis via binding to neogenin and
            recruitment of Unc5B
  JOURNAL   Proc Natl Acad Sci U S A 105 (34), 12491-12496 (2008)
   PUBMED   18719102
  REMARK    GeneRIF: Knockdown of Netrin-4 expression in EC increased their
            ability to form tubular structures; Netrin-4 bound only to neogenin
            but not to Unc5B or Unc5C receptors
REFERENCE   6  (bases 1 to 3552)
  AUTHORS   Esseghir,S., Kennedy,A., Seedhar,P., Nerurkar,A., Poulsom,R.,
            Reis-Filho,J.S. and Isacke,C.M.
  TITLE     Identification of NTN4, TRA1, and STC2 as prognostic markers in
            breast cancer in a screen for signal sequence encoding proteins
  JOURNAL   Clin Cancer Res 13 (11), 3164-3173 (2007)
   PUBMED   17545519
  REMARK    GeneRIF: NTN4, TRA1, and STC2 have roles in progression of breast
            cancer
REFERENCE   7  (bases 1 to 3552)
  AUTHORS   Qin,S., Yu,L., Gao,Y., Zhou,R. and Zhang,C.
  TITLE     Characterization of the receptors for axon guidance factor netrin-4
            and identification of the binding domains
  JOURNAL   Mol Cell Neurosci 34 (2), 243-250 (2007)
   PUBMED   17174565
REFERENCE   8  (bases 1 to 3552)
  AUTHORS   Zhang,C., Meng,F., Wang,C., Guo,H., Fan,M., Liu,S., Zhou,R. and
            He,F.
  TITLE     Identification of a novel alternative splicing form of human
            netrin-4 and analyzing the expression patterns in adult rat brain
  JOURNAL   Brain Res Mol Brain Res 130 (1-2), 68-80 (2004)
   PUBMED   15519678
REFERENCE   9  (bases 1 to 3552)
  AUTHORS   Koch,M., Murrell,J.R., Hunter,D.D., Olson,P.F., Jin,W., Keene,D.R.,
            Brunken,W.J. and Burgeson,R.E.
  TITLE     A novel member of the netrin family, beta-netrin, shares homology
            with the beta chain of laminin: identification, expression, and
            functional characterization
  JOURNAL   J Cell Biol 151 (2), 221-234 (2000)
   PUBMED   11038171
REFERENCE   10 (bases 1 to 3552)
  AUTHORS   Genini,M., Schwalbe,P., Scholl,F.A. and Schafer,B.W.
  TITLE     Isolation of genes differentially expressed in human primary
            myoblasts and embryonal rhabdomyosarcoma
  JOURNAL   Int J Cancer 66 (4), 571-577 (1996)
   PUBMED   8635876
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB473670.2, BI549738.1,
            AY330211.1, AK315796.1, AK290591.1 and AL137540.1.
            
            On May 31, 2019 this sequence version replaced NM_001329700.1.
            
            Summary: This gene encodes a member of the netrin family of
            proteins, which function in various biological processes including
            axon guidance, tumorogenesis, and angiogenesis. Netrins are
            laminin-related proteins that have an N-terminal laminin-type
            domain, epidermal growth factor-like repeat domain, and a
            positively charged heparin-binding domain at the C-terminus. The
            protein encoded by this gene is involved in processes including
            neurite growth and migration, angiogenesis and mural cell adhesion
            to endothelial cells. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY330211.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               DB473670.2         52-490
            440-505             BI549738.1         447-512
            506-594             AY330211.1         51-139
            595-1874            AK315796.1         448-1727
            1875-2019           AY330211.1         1420-1564
            2020-2020           AK290591.1         1620-1620
            2021-2273           AY330211.1         1566-1818
            2274-3552           AL137540.1         1205-2483
FEATURES             Location/Qualifiers
     source          1..3552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..3552
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /note="netrin 4"
                     /db_xref="GeneID:59277"
                     /db_xref="HGNC:HGNC:13658"
                     /db_xref="MIM:610401"
     exon            1..510
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..2273
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; beta-netrin; hepar-derived netrin-like protein"
                     /codon_start=1
                     /product="netrin-4 isoform 2 precursor"
                     /protein_id="NP_001316629.1"
                     /db_xref="CCDS:CCDS86325.1"
                     /db_xref="GeneID:59277"
                     /db_xref="HGNC:HGNC:13658"
                     /db_xref="MIM:610401"
                     /translation="MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALG
                     RKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFP
                     RTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYF
                     ATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQ
                     LKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHG
                     FRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKC
                     NGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDAC
                     KPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCD
                     CAGSCDPITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWEWEDAQGFSALLHSVLKIK
                     ILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEYLV
                     AGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKRECK"
     exon            511..1040
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1319
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1446
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1635
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1849
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1965
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2136
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..3552
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3533..3538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /note="hexamer: AATAAA"
     polyA_site      3552
                     /gene="NTN4"
                     /gene_synonym="PRO3091"
                     /note="major polyA site"
ORIGIN      
        1 ggagaaggac gggacggagc cggggcagcc agaagaggtg ggaaaagcgg aggaggacgc
       61 ccaggaggag gcggcggcgg cggccgggaa gtgaaaggtc tcgcaaagtt cagcggcggc
      121 tgcgggcgcc gagccccggg ctagcggcag acgagcccgc agggccgctc cgcggggcag
      181 cgcagccagg ccggctatgg tcccggggct cccgccgccc cccaggtgcc cgggacccgc
      241 caggccggtg cgcgagggtc accccacctc cccgcgcggt cccggcccct ggctcccagc
      301 tgccggcgac cgctgaccga gcccggcgcc ccaggaggag gaagaaacca gggccccgtt
      361 ccctcccgag gacggcggcg cttcatcccg cagcccagag gtctcggctc cctccggcac
      421 ccgcccggcc cggctgctcc cggctcctcc cggccatggg gagctgcgcg cggctgctgc
      481 tgctctgggg ctgcacggtg gtggccgcag gactgagtgg agtagctgga gtgagttccc
      541 gctgtgaaaa agcctgcaac cctcggatgg gaaatttggc tttggggcga aaactctggg
      601 cagacaccac ctgcggtcag aatgctaccg aactgtactg cttctacagt gagaacacgg
      661 atctgacttg tcggcagccc aaatgtgaca agtgcaatgc tgcctatcct cacctggctc
      721 acctgccatc tgccatggca gactcatcct tccggtttcc tcgcacatgg tggcagtctg
      781 cggaggatgt gcacagagaa aagatccagt tagacctgga agctgaattc tacttcactc
      841 acctaattgt gatgttcaag tcccccaggc cggctgccat ggtgctggac cgctcccagg
      901 actttgggaa aacatggaag ccttataagt actttgcgac taactgctcc gctacatttg
      961 gcctggaaga tgatgttgtc aagaagggcg ctatttgtac ttctaaatac tccagtcctt
     1021 ttccatgcac tggaggagag gttattttca aagctttgtc accaccatac gatacagaga
     1081 acccttacag tgccaaagtt caggagcagc tgaagatcac caaccttcgc gtgcagctgc
     1141 tgaaacgaca gtcttgtccc tgtcagagaa atgacctgaa cgaagagcct caacatttta
     1201 cacactatgc aatctatgat ttcattgtca agggcagctg cttctgcaat ggccacgctg
     1261 atcaatgcat acctgttcat ggcttcagac ctgtcaaggc cccaggaaca ttccacatgg
     1321 tccatgggaa gtgtatgtgt aagcacaaca cagcaggcag ccactgccag cactgtgccc
     1381 cgttatacaa tgaccggcca tgggaggcag ctgatggcaa aacgggggct cccaacgagt
     1441 gcagaacctg caagtgtaat gggcatgctg atacctgtca cttcgacgtt aatgtgtggg
     1501 aggcatcagg gaatcgtagt ggtggtgtct gtgatgactg tcagcacaac acagaaggac
     1561 agtattgcca gaggtgcaag ccaggcttct atcgtgacct gcggagaccc ttctcagctc
     1621 cagatgcttg caaaccgtgt tcctgccatc cagtaggatc agctgtcctt cctgccaact
     1681 cagtgacctt ctgcgacccc agcaatggtg actgcccttg caagcctggg gtggcagggc
     1741 gacgttgtga caggtgcatg gtgggatact ggggcttcgg agactatggc tgtcgaccat
     1801 gtgactgtgc ggggagctgt gaccctatca ccggagactg catcagcagc cacacagaca
     1861 tagactggta tcatgaagtt cctgacttcc gtcccgtgca caataagagc gaaccagcct
     1921 gggagtggga ggatgcgcag gggttttctg cacttctaca ctcagtgcta aaaataaaga
     1981 ttttatcagc tcatgataaa ggtactcatg ttgaggtcaa tgtgaagatt aaaaaggtct
     2041 taaaatctac caaactgaag attttccgag gaaagcgaac attatatcca gaatcatgga
     2101 cggacagagg atgcacttgt ccaatcctca atcctggttt ggaatacctt gtagcaggac
     2161 atgaggatat aagaacaggc aaactaattg tgaatatgaa aagctttgtc cagcactgga
     2221 aaccttctct tggaagaaaa gtcatggata ttttaaaaag agagtgcaag tagcattaag
     2281 atggatagca cataatggca cttgtctatg tacaaaacac aaactttaga gcaagaagac
     2341 ctcagacagg aaactggaat tttttaaagt gccaaaacat atagaaatgt ttgaatgcat
     2401 gggtcttatc taacttatct cttctggacc catgtttaaa tacagtttta tttcatgaag
     2461 agaaatgaaa acccctacac tgatatctgt tttctatggg actgattctg aaattcttaa
     2521 ctattaagaa tattttaata gcagcatgac atttagcagt aatccattaa gggcagtacc
     2581 tctaacaagg acgccttcca gcttcagcga tgttacttac gtttgatgct acttaaagta
     2641 atgaatgacg ttttaaggaa tccctaaccc tactatcaga aaaggtgttt gttaaagagc
     2701 cttctcttgt gtgttacgca tgaactttgg tctgtaggtg ttaaatggaa cctctccatg
     2761 tgtatatagt atttccttgt ataaagcact ttactaccta ccacttgtgt tgtgaacgtt
     2821 tggtgactgc tgttgaaaga aggaaaaggg tgtgtgagaa agcctactga agcagcagca
     2881 ctgccactac atgtggacaa aagtgaccat ataaaagaag ttgtgctatt taactctgaa
     2941 tacttggaga aactaggtga agatgcaacc agaaaggaga atatgtatgc gtgaagtctc
     3001 agctttgagc tggaggctag attccaagat gacagccatg atgaaacttt ttaaaaaact
     3061 aaaccagaag agactttaaa ataagagaaa gaaatcataa atgtagacat atgcttggct
     3121 aaaggggaaa tggactttaa attttaaaga gctcatttgc aatgcacttg tatacacttc
     3181 aaaaattatt gtagacacag aatttgttat atttttgtgc ttagtattta aacctgaaca
     3241 ttgaaacagt tttcctcctt gtctttctta acagtaatag tcattatatt tacctgtttt
     3301 ttaacacaat gtatgtgata gtcaaaaaat cacagttttt cattattatt catcttctgt
     3361 acccacgcat aaccactata catagtttct tttgtacttg aatatacaaa acatgaacac
     3421 agtgccatat gaataatttc acatacagaa cctttttttc tctgaagtcc tgtggacttg
     3481 caaatatata tatatattgc tttgttaatt tgtttttata tttcatatat gtaataaagg
     3541 aatatgatct ga
//
