LOCUS       NM_006181               2188 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens netrin 3 (NTN3), mRNA.
ACCESSION   NM_006181
VERSION     NM_006181.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2188)
  AUTHORS   Perampalam,P., MacDonald,J.I., Zakirova,K., Passos,D.T., Wasif,S.,
            Ramos-Valdes,Y., Hervieu,M., Mehlen,P., Rottapel,R., Gibert,B.,
            Correa,R.J.M., Shepherd,T.G. and Dick,F.A.
  TITLE     Netrin signaling mediates survival of dormant epithelial ovarian
            cancer cells
  JOURNAL   Elife 12, 91766 (2024)
   PUBMED   39023520
  REMARK    GeneRIF: Netrin signaling mediates survival of dormant epithelial
            ovarian cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2188)
  AUTHORS   Gao,X., Metzger,U., Panza,P., Mahalwar,P., Alsheimer,S., Geiger,H.,
            Maischein,H.M., Levesque,M.P., Templin,M. and Sollner,C.
  TITLE     A Floor-Plate Extracellular Protein-Protein Interaction Screen
            Identifies Draxin as a Secreted Netrin-1 Antagonist
  JOURNAL   Cell Rep 12 (4), 694-708 (2015)
   PUBMED   26190107
REFERENCE   3  (bases 1 to 2188)
  AUTHORS   Jarjour,A.A., Durko,M., Luk,T.L., Marcal,N., Shekarabi,M. and
            Kennedy,T.E.
  TITLE     Autocrine netrin function inhibits glioma cell motility and
            promotes focal adhesion formation
  JOURNAL   PLoS One 6 (9), e25408 (2011)
   PUBMED   21980448
  REMARK    GeneRIF: an autocrine function for netrin-1 and netrin-3 in U87 and
            U373 cells that slows migration
REFERENCE   4  (bases 1 to 2188)
  AUTHORS   Krauss,R.S., Cole,F., Gaio,U., Takaesu,G., Zhang,W. and Kang,J.S.
  TITLE     Close encounters: regulation of vertebrate skeletal myogenesis by
            cell-cell contact
  JOURNAL   J Cell Sci 118 (Pt 11), 2355-2362 (2005)
   PUBMED   15923648
  REMARK    Review article
REFERENCE   5  (bases 1 to 2188)
  AUTHORS   Latil,A., Chene,L., Cochant-Priollet,B., Mangin,P., Fournier,G.,
            Berthon,P. and Cussenot,O.
  TITLE     Quantification of expression of netrins, slits and their receptors
            in human prostate tumors
  JOURNAL   Int J Cancer 103 (3), 306-315 (2003)
   PUBMED   12471613
REFERENCE   6  (bases 1 to 2188)
  AUTHORS   Hamblin,T.J., Davis,Z., Gardiner,A., Oscier,D.G. and Stevenson,F.K.
  TITLE     Unmutated Ig V(H) genes are associated with a more aggressive form
            of chronic lymphocytic leukemia
  JOURNAL   Blood 94 (6), 1848-1854 (1999)
   PUBMED   10477713
REFERENCE   7  (bases 1 to 2188)
  AUTHORS   Wang,H., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Tessier-Lavigne,M.
  TITLE     Netrin-3, a mouse homolog of human NTN2L, is highly expressed in
            sensory ganglia and shows differential binding to netrin receptors
  JOURNAL   J Neurosci 19 (12), 4938-4947 (1999)
   PUBMED   10366627
REFERENCE   8  (bases 1 to 2188)
  AUTHORS   de Wildt,R.M., Hoet,R.M., van Venrooij,W.J., Tomlinson,I.M. and
            Winter,G.
  TITLE     Analysis of heavy and light chain pairings indicates that receptor
            editing shapes the human antibody repertoire
  JOURNAL   J Mol Biol 285 (3), 895-901 (1999)
   PUBMED   9887257
REFERENCE   9  (bases 1 to 2188)
  AUTHORS   Van Raay,T.J., Foskett,S.M., Connors,T.D., Klinger,K.W.,
            Landes,G.M. and Burn,T.C.
  TITLE     The NTN2L gene encoding a novel human netrin maps to the autosomal
            dominant polycystic kidney disease region on chromosome 16p13.3
  JOURNAL   Genomics 41 (2), 279-282 (1997)
   PUBMED   9143507
REFERENCE   10 (bases 1 to 2188)
  AUTHORS   Burn,T.C., Connors,T.D., Van Raay,T.J., Dackowski,W.R.,
            Millholland,J.M., Klinger,K.W. and Landes,G.M.
  TITLE     Generation of a transcriptional map for a 700-kb region surrounding
            the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis
            type 2 (TSC2) disease genes on human chromosome 16p3.3
  JOURNAL   Genome Res 6 (6), 525-537 (1996)
   PUBMED   8828041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106820.4 and U86759.1.
            
            On May 17, 2019 this sequence version replaced NM_006181.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U86759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293973.2/ ENSP00000293973.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AC106820.4         32469-32670         c
            203-328             U86759.1           1-126
            329-329             AC106820.4         32342-32342         c
            330-2188            U86759.1           128-1986
FEATURES             Location/Qualifiers
     source          1..2188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2188
                     /gene="NTN3"
                     /gene_synonym="NTN2L"
                     /note="netrin 3"
                     /db_xref="GeneID:4917"
                     /db_xref="HGNC:HGNC:8030"
                     /db_xref="MIM:602349"
     exon            1..1333
                     /gene="NTN3"
                     /gene_synonym="NTN2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..2148
                     /gene="NTN3"
                     /gene_synonym="NTN2L"
                     /note="Netrin-2, chicken, homolog of, like; Netrin-3;
                     netrin-2-like protein"
                     /codon_start=1
                     /product="netrin-3 precursor"
                     /protein_id="NP_006172.1"
                     /db_xref="CCDS:CCDS10469.1"
                     /db_xref="GeneID:4917"
                     /db_xref="HGNC:HGNC:8030"
                     /db_xref="MIM:602349"
                     /translation="MPGWPWGLLLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGL
                     VNAALGREVLASSTCGRPATRACDASDPRRAHSPALLTSPGGTASPLCWRSESLPRAP
                     LNVTLTVPLGKAFELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGR
                     LPAPANGPAGPGPEALCFPAPLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTAT
                     DVRVVLTRPSTAGDPRDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDC
                     RHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRS
                     GGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQ
                     CPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSHCKPARG
                     SYRISLKKFCKKDYAVQVAVGARGEARGAWTRFPVAVLAVFRSGEERARRGSSALWVP
                     AGDAACGCPRLLPGRRYLLLGGGPGAAAGGAGGRGPGLIAARGSLVLPWRDAWTRRLR
                     RLQRRERRGRCSAA"
     exon            1334..1522
                     /gene="NTN3"
                     /gene_synonym="NTN2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1672
                     /gene="NTN3"
                     /gene_synonym="NTN2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1723
                     /gene="NTN3"
                     /gene_synonym="NTN2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1798
                     /gene="NTN3"
                     /gene_synonym="NTN2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..2188
                     /gene="NTN3"
                     /gene_synonym="NTN2L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagctcgtc cgccctcgct gcagccggga ggaggcggcg gcccgtgcac cgcaggcccc
       61 gcccgcccac ggcccttccc gggaggccgg gagacctgct ccgcccggcc ctcggtgggt
      121 gagtgcgagc ggcgggtggg gcctccgcgg gcggaggcac cgggagcggg ggcgacgcct
      181 gtcatcgctc taggcccagc gggaggacgc gccaacatcc ccgctgctgt gctgggcccg
      241 gggcgtgccc gccgctgctc ccacctctgg gccgggctgg ggccgcccgg gggccctgtt
      301 cctcggcatt gcgggcctgg tgggcagagc cgcggagagg gcttcttttc cccaagggca
      361 gcgtcttggg gcccggccac tggctgaccc gcagcggctc cggccatgcc tggctggccc
      421 tgggggctgc tgctgacggc aggcacgctc ttcgccgccc tgagtcctgg gccgccggcg
      481 cccgccgacc cctgccacga tgaggggggt gcgccccgcg gctgcgtgcc aggactggtg
      541 aacgccgccc tgggccgcga ggtgctggct tccagcacgt gcgggcggcc ggccactcgg
      601 gcctgcgacg cctccgaccc gcgacgggca cactcccccg ccctccttac ttccccaggg
      661 ggcacggcca gccctctgtg ctggcgctcg gagtccctgc ctcgggcgcc cctcaacgtg
      721 actctcacgg tgcccctggg caaggctttt gagctggtct tcgtgagcct gcgcttctgc
      781 tcagctcccc cagcctccgt ggccctgctc aagtctcagg accatggccg cagctgggcc
      841 ccgctgggct tcttctcctc ccactgtgac ctggactatg gccgtctgcc tgcccctgcc
      901 aatggcccag ctggcccagg gcctgaggcc ctgtgcttcc ccgcacccct ggcccagcct
      961 gatggcagcg gccttctggc cttcagcatg caggacagca gccccccagg cctggacctg
     1021 gacagcagcc cagtgctcca agactgggtg accgccaccg acgtccgtgt agtgctcaca
     1081 aggcctagca cggcaggtga ccccagggac atggaggccg tcgtccctta ctcctacgca
     1141 gccaccgacc tccaggtggg cgggcgctgc aagtgcaatg gacatgcctc acggtgcctg
     1201 ctggacacac agggccacct gatctgcgac tgtcggcatg gcaccgaggg ccctgactgc
     1261 ggccgctgca agcccttcta ctgcgacagg ccatggcagc gggccactgc ccgggaatcc
     1321 cacgcctgcc tcgcttgctc ctgcaacggc catgcccgcc gctgccgctt caacatggag
     1381 ctgtaccgac tgtccggccg ccgcagcggg ggtgtctgtc tcaactgccg gcacaacacc
     1441 gccggccgcc actgccacta ctgccgggag ggcttctatc gagaccctgg ccgtgccctg
     1501 agtgaccgtc gggcttgcag ggcctgcgac tgtcacccgg ttggtgctgc tggcaagacc
     1561 tgcaaccaga ccacaggcca gtgtccctgc aaggatggcg tcactggcct cacctgcaac
     1621 cgctgcgcgc ctggcttcca gcaaagccgc tccccagtgg cgccctgtgt taagacccct
     1681 atccctggac ccactgagga cagcagccct gtgcagcccc aggactgtga ctcgcactgc
     1741 aaacctgccc gtggcagcta ccgcatcagc ctaaagaagt tctgcaagaa ggactatgcg
     1801 gtgcaggtgg cggtgggtgc gcgcggcgag gcgcgcggcg cgtggacacg cttcccggtg
     1861 gcggtgctcg ccgtgttccg gagcggagag gagcgcgcgc ggcgcgggag tagcgcgctg
     1921 tgggtgcccg ccggggatgc ggcctgcggc tgcccgcgcc tgctccccgg ccgccgctac
     1981 ctcctgctgg ggggcgggcc tggagccgcg gctgggggcg cggggggccg ggggcccggg
     2041 ctcatcgccg cccgcggaag cctcgtgcta ccctggaggg acgcgtggac gcggcgcctg
     2101 cggaggctgc agcgacgcga acggcggggg cgctgcagcg ccgcctgagc ccgccggctg
     2161 ggcagggcgg ccgctgctcc cacatcta
//
