LOCUS       NM_004822               5986 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens netrin 1 (NTN1), mRNA.
ACCESSION   NM_004822
VERSION     NM_004822.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5986)
  AUTHORS   Badary,D.M., Elsaied,H., Abdel-Fadeil,M.R., Ali,M.K., Abou-Taleb,H.
            and Iraqy,H.M.
  TITLE     Possible Role of Netrin-1/Deleted in Colorectal Cancer/Vascular
            Endothelial Growth Factor Signaling Pathway in the Pathogenesis of
            Placenta Accreta Spectrum: A Case-control Study
  JOURNAL   Int J Gynecol Pathol 43 (6), 565-572 (2024)
   PUBMED   38289148
  REMARK    GeneRIF: Possible Role of Netrin-1/Deleted in Colorectal
            Cancer/Vascular Endothelial Growth Factor Signaling Pathway in the
            Pathogenesis of Placenta Accreta Spectrum: A Case-control Study.
REFERENCE   2  (bases 1 to 5986)
  AUTHORS   Chen,J.M., He,J., Qiu,J.M., Yang,G.G., Wang,D. and Shen,Z.
  TITLE     Netrin-1-CD146 and netrin-1-S100A9 are associated with early stage
            of lymph node metastasis in colorectal cancer
  JOURNAL   BMC Gastroenterol 24 (1), 308 (2024)
   PUBMED   39261771
  REMARK    GeneRIF: Netrin-1-CD146 and netrin-1-S100A9 are associated with
            early stage of lymph node metastasis in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5986)
  AUTHORS   Mondal,A., Bose,C., Pramanik,S., Dash,D., Mukherjee,B., Malik,R.A.
            and Mukhopadhyay,S.
  TITLE     Circulating netrin-1 levels are reduced and related to corneal
            nerve fiber loss in patients with diabetic neuropathy
  JOURNAL   J Diabetes Investig 15 (8), 1068-1074 (2024)
   PUBMED   38725153
  REMARK    GeneRIF: Circulating netrin-1 levels are reduced and related to
            corneal nerve fiber loss in patients with diabetic neuropathy.
REFERENCE   4  (bases 1 to 5986)
  AUTHORS   Perampalam,P., MacDonald,J.I., Zakirova,K., Passos,D.T., Wasif,S.,
            Ramos-Valdes,Y., Hervieu,M., Mehlen,P., Rottapel,R., Gibert,B.,
            Correa,R.J.M., Shepherd,T.G. and Dick,F.A.
  TITLE     Netrin signaling mediates survival of dormant epithelial ovarian
            cancer cells
  JOURNAL   Elife 12, 91766 (2024)
   PUBMED   39023520
  REMARK    GeneRIF: Netrin signaling mediates survival of dormant epithelial
            ovarian cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5986)
  AUTHORS   Oveisgharan,S., Yu,L., de Paiva Lopes,K., Tasaki,S., Wang,Y.,
            Menon,V., Schneider,J.A., Seyfried,N.T. and Bennett,D.A.
  TITLE     Proteins linking APOE varepsilon4 with Alzheimer's disease
  JOURNAL   Alzheimers Dement 20 (7), 4499-4511 (2024)
   PUBMED   38856164
  REMARK    GeneRIF: Proteins linking APOE varepsilon4 with Alzheimer's
            disease.
REFERENCE   6  (bases 1 to 5986)
  AUTHORS   Meyerhardt,J.A., Caca,K., Eckstrand,B.C., Hu,G., Lengauer,C.,
            Banavali,S., Look,A.T. and Fearon,E.R.
  TITLE     Netrin-1: interaction with deleted in colorectal cancer (DCC) and
            alterations in brain tumors and neuroblastomas
  JOURNAL   Cell Growth Differ 10 (1), 35-42 (1999)
   PUBMED   9950216
REFERENCE   7  (bases 1 to 5986)
  AUTHORS   Hu,G. and Fearon,E.R.
  TITLE     Siah-1 N-terminal RING domain is required for proteolysis function,
            and C-terminal sequences regulate oligomerization and binding to
            target proteins
  JOURNAL   Mol Cell Biol 19 (1), 724-732 (1999)
   PUBMED   9858595
REFERENCE   8  (bases 1 to 5986)
  AUTHORS   Serafini,T., Colamarino,S.A., Leonardo,E.D., Wang,H.,
            Beddington,R., Skarnes,W.C. and Tessier-Lavigne,M.
  TITLE     Netrin-1 is required for commissural axon guidance in the
            developing vertebrate nervous system
  JOURNAL   Cell 87 (6), 1001-1014 (1996)
   PUBMED   8978605
REFERENCE   9  (bases 1 to 5986)
  AUTHORS   Keino-Masu,K., Masu,M., Hinck,L., Leonardo,E.D., Chan,S.S.,
            Culotti,J.G. and Tessier-Lavigne,M.
  TITLE     Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
  JOURNAL   Cell 87 (2), 175-185 (1996)
   PUBMED   8861902
REFERENCE   10 (bases 1 to 5986)
  AUTHORS   Meneret,A., Trouillard,O., Dunoyer,M., Depienne,C. and Roze,E.
  TITLE     Congenital Mirror Movements
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25763452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090610.6, U75586.1 and
            AC005695.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004822.2.
            
            Summary: Netrin is included in a family of laminin-related secreted
            proteins.  The function of this gene has not yet been defined;
            however, netrin is thought to be involved in axon guidance and cell
            migration during development.  Mutations and loss of expression of
            netrin suggest that variation in netrin may be involved in cancer
            development. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U75586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000173229.7/ ENSP00000173229.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC090610.6         63939-63970
            33-48               U75586.1           3-18
            49-49               AC090610.6         63987-63987
            50-1033             U75586.1           20-1003
            1034-1035           AC090610.6         65697-65698
            1036-1978           U75586.1           1006-1948
            1979-5986           AC005695.1         103259-107266
FEATURES             Location/Qualifiers
     source          1..5986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..5986
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /note="netrin 1"
                     /db_xref="GeneID:9423"
                     /db_xref="HGNC:HGNC:8029"
                     /db_xref="MIM:601614"
     exon            1..76
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            77..1157
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1954
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /note="netrin 1, mouse, homolog of; Netrin-1; epididymis
                     tissue protein Li 131P"
                     /codon_start=1
                     /product="netrin-1 precursor"
                     /protein_id="NP_004813.2"
                     /db_xref="CCDS:CCDS11148.1"
                     /db_xref="GeneID:9423"
                     /db_xref="HGNC:HGNC:8029"
                     /db_xref="MIM:601614"
                     /translation="MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDE
                     NGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKA
                     HPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMA
                     IYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLI
                     AFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAV
                     SDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATARE
                     ANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMG
                     KPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAP
                     CIKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKINMKKYCKKDYAVQIHILKADKAG
                     DWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPD
                     QSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA"
     exon            1158..1346
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1496
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1550
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1625
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..5986
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5968..5973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /note="hexamer: AATAAA"
     polyA_site      5986
                     /gene="NTN1"
                     /gene_synonym="MRMV4; NET1; NTN1L"
                     /note="major polyA site"
ORIGIN      
        1 actcccagcg cgagtggcgg cggcggcgga gccttcgggg gcgagcgcgc gtgtgtgtga
       61 gtgcgcgccg gccagcgcgc cttctgcggc aggcggacag atcctcggcg cggcagggcc
      121 ggggcaagct ggacgcagca tgatgcgcgc agtgtgggag gcgctggcgg cgctggcggc
      181 ggtggcgtgc ctggtgggcg cggtgcgcgg cgggcccggg ctcagcatgt tcgcgggcca
      241 ggcggcgcag cccgatccct gctcggacga gaacggccac ccgcgccgct gcatcccgga
      301 ctttgtcaat gcggccttcg gcaaggacgt gcgcgtgtcc agcacctgcg gccggccccc
      361 ggcgcgctac tgcgtggtga gcgagcgcgg cgaggagcgg ctgcgctcgt gccacctctg
      421 caacgcgtcc gaccccaaga aggcgcaccc gcccgccttc ctcaccgacc tcaacaaccc
      481 gcacaacctg acgtgctggc agtccgagaa ctacctgcag ttcccgcaca acgtcacgct
      541 cacactgtcc ctcggcaaga agttcgaagt gacctacgtg agcctgcagt tctgctcgcc
      601 gcggcccgag tccatggcca tctacaagtc catggactac gggcgcacgt gggtgccctt
      661 ccagttctac tccacgcagt gccgcaagat gtacaaccgg ccgcaccgcg cgcccatcac
      721 caagcagaac gagcaggagg ccgtgtgcac cgactcgcac accgacatgc gcccgctctc
      781 gggcggcctc atcgccttca gcacgctgga cgggcggccc tcggcgcacg acttcgacaa
      841 ctcgcccgtg ctgcaggact gggtcacggc cacagacatc cgcgtggcct tcagccgcct
      901 gcacacgttc ggcgacgaga acgaggacga ctcggagctg gcgcgcgact cgtacttcta
      961 cgcggtgtcc gacctgcagg tgggcggccg gtgcaagtgc aacggccacg cggcccgctg
     1021 cgtgcgcgac cgcgacgaca gcctggtgtg cgactgcagg cacaacacgg ccggcccgga
     1081 gtgcgaccgc tgcaagccct tccactacga ccggccctgg cagcgcgcca cagcccgcga
     1141 agccaacgag tgcgtggcct gtaactgcaa cctgcatgcc cggcgctgcc gcttcaacat
     1201 ggagctctac aagctttcgg ggcgcaagag cggaggtgtc tgcctcaact gtcgccacaa
     1261 caccgccggc cgccactgcc attactgcaa ggagggctac taccgcgaca tgggcaagcc
     1321 catcacccac cggaaggcct gcaaagcctg tgattgccac cctgtgggtg ctgctggcaa
     1381 aacctgcaac caaaccaccg gccagtgtcc ctgcaaggac ggcgtgacgg gtatcacctg
     1441 caaccgctgc gccaaaggct accagcagag ccgctctccc atcgccccct gcataaagat
     1501 ccctgtagcg ccgccgacga ctgcagccag cagcgtggag gagcctgaag actgcgattc
     1561 ctactgcaag gcctccaagg ggaagctgaa gattaacatg aaaaagtact gcaagaagga
     1621 ctatgccgtc cagatccaca tcctgaaggc ggacaaggcg ggggactggt ggaagttcac
     1681 ggtgaacatc atctccgtgt ataagcaggg cacgagccgc atccgccgcg gtgaccagag
     1741 cctgtggatc cgctcgcggg acatcgcctg caagtgtccc aaaatcaagc ccctcaagaa
     1801 gtacctgctg ctgggcaacg cggaggactc tccggaccag agcggcatcg tggccgataa
     1861 aagcagcctg gtgatccagt ggcgggacac gtgggcgcgg cggctgcgca agttccagca
     1921 gcgtgagaag aagggcaagt gcaagaaggc ctagcgccga ggcagcgggc gggcgggcgg
     1981 gcgggcgcca gggcggggcc gagcgagagc gggcgccttg gcccggccgc cgcggacttg
     2041 gcccgcgagg gctttcccag gtggggggag ggagggggcg gggccgcacg gcgcgggggg
     2101 cgggaccctc ggcggcccct ccccctaccc ccaccctgcg cgctctgggc gggagccgcg
     2161 tgcacgcggg gcggggtgcg ccgccggccg ggccctggag aaatgacgag acgtagctac
     2221 ctcacggggc tccttccaga gcagagacgc gcttccctgg gcctgggcgc ggccgccgtg
     2281 gaggggctgg gggcagcctg ccctggggcc cgggggcggg cgcagaatcg cacaactggg
     2341 gccccaggcg cggggcgtgg atggcgcgga gacgtggacg ggaggagaac tgtgaattct
     2401 caagcccgta gtgtgggcgg ggcgcggagc acccaccaaa ccaccacccg acacgcagcc
     2461 gacgggatcc ccccctttct ccccggcccc ttctagcagt tccccgcggg ccacctggct
     2521 gtcacagcct ggactcctcc atctgaaggg gcctggcagc atttggggag tggacagctc
     2581 ctgtccagcc agcatgcccc aggcggcctc tgtctccact gctacctgct gagtgggtcc
     2641 tactgggtgg gggcttgggg tcggtgagtg gttcacctgt ggagagagga gaggaagccc
     2701 ctgctgctgc ctgtctctgc ccctgcccct gcccctgccc agcgtggggc tggcccatcc
     2761 ggaaggcagt gggcccaggg acacccctga gaagcccaag ccgggtggtc accgcctcat
     2821 gctggagctg cctgttggag gaggcatcgc aaacgcaaaa cctcccagag agtttccttt
     2881 tggaaacttg gaaccagccc tttttatgac gttttccagg gggaggggga ggggcactgg
     2941 ctgggtttac ggcagtgaca ctatttatgt aaatgacatc agctcccgca aggcccctca
     3001 gcaatgtcaa cagctggaaa gggcctgaac gggcttggag tctgcaggct gcgaaggcac
     3061 ttgggcctgg cttggggccg ggggcttgtt tgagctggga tggggtttgc tggctcagtg
     3121 aagtaccaga gtgcctgagc catgggtggg caggggcaca ggaatgacca ggttcctggg
     3181 ggccaaggag gccatgctgg cttctccaag ggaaggcaca gaggctgccg gcctgccccc
     3241 tacagctgtc ttgggtctgg cctgggccac accttgaccg tgcctttcca gacggtcttt
     3301 gtggagtctg cccgtgccct ccactgtgcc ccagccctcc ttccaaaatc tcctagagac
     3361 acggtcctca agcaggcagc cccttttgtt ctgacctcct cacacagggt ccattcctgt
     3421 gccctggggc ctcctggctc cctgccttcc tgggctctct gcactgcccg ggcctctggc
     3481 ccacatcctc acacccggcg cactgaatta agaggcctgg ctcccctcac agtcaggaaa
     3541 ttggtttcac tttcccggcc agagtttggc tgctcaaaag ggtcatacca agtatgaagc
     3601 tcggcccccg gtggtctggc ttccctccgc cttccccaca tttacccgca tcacggctgc
     3661 catttattga gcacctgctg tgtgccaggc actttaccca catgctccca gtgtgtactc
     3721 atgacaaccc tgtgggacag ggactcatta tcaccagcaa ggagactgga gtacacgtgc
     3781 ccaaggtcat gctgcaaatt ggtggcagga ctggggctca aactccagag cccgactttc
     3841 tgaccagggg ccacgctggc cctcactgca ctccagctct gcagcctacc cgcccaatcc
     3901 ctgtgcaggc tgggagggtg ctcttggggg agtggccacc gagcccctgg ccctggttac
     3961 tgcctcttga ggacactggc atctgggctg gagaacagga gcccggggtg gggtagggca
     4021 tggggacaat cacatcttca gaggaggcag caaagtggtg cgggatgcag ggacggactt
     4081 gccagatggc agctccaggt tccaggaagg caggccttgg atgctccgaa gaggtggtag
     4141 aaaggtgttt ttagaaaggt gttttggctg cctcagggtg gttggagaga ctccaggaga
     4201 gactggcaga ggtgcctcag gggcagggag cagacagacc tgccctggga aggggcattt
     4261 ggcttccctg aatccagccc aaggctagaa gacagggccc ctctccaagc tgtcagcgcc
     4321 cctcggatgc ccagtgtggt gtgctgggcg ccatcagcat cacaaggcac tacgctgctg
     4381 gggcggttgt cctatttctg tctatgccag tgtggtttct tcaccctgcc cagaagggct
     4441 gtggcagccc cacgatatcc caccctgggt ctgggtctca cgggtgtcct gtgaggggct
     4501 tgcatttgtg gtggtctctg aggccacctc agcaacggag ctggcgacac gccaagcaac
     4561 aaggcatctt gcggaaaatt cagccagtgt cctgcccctc ccttcggctc agcaccccgc
     4621 agggcacagg ctgtccgccc ggtggtctgg cccttgggga atgcgtcagg gtgaccagat
     4681 ccaccatgct agcagccagg tcactgttgg gattgcacgg tcgtcacgag ctgcctttcc
     4741 tatccacaca cccagccagg acccagccca ccactcccga ctgcagcccc ggcctctgcg
     4801 gtgagcacca tccttgggaa agcacccctc ctccactccg gtgccccact ccaaggagca
     4861 gagggaaatg ggaattgagg tgtcccggtt tgtacagtta ggaagggatg taaaacggaa
     4921 ctagattttg attttgaaga gtgtattaac cagaattgtg ctatgtaggt gtttgtttga
     4981 agaaaaacat accagattag tctttgtttt tgaaacagct tccccagttg tcctttttct
     5041 taccagctgg gtggtctggt gcccctgaca gctgagtgcc tgctttacgg acacgcagta
     5101 atgccgaaga tttgcggggg aggacatagg gctgtccccg ggattcacct gctggctgtg
     5161 gtctctgccc actgcttctg tccttggaaa gcagggcagg aggcagcatc cccaggggcc
     5221 tctatgtggg agggagggac acctggggtc acaacccagg gagggagggt cacagcccag
     5281 ggaggctggg agctgctcca aggccctgga actctgcctc agtcgcggca tgctggagag
     5341 gggtacggac ttactttctt ggagttgtcc caggttggaa tgagactgaa ctcaagaaga
     5401 gaccctaagg gactggggaa tggttcctgc cttcaggaaa gtgaaagacg cttaggctgt
     5461 caacacttaa aggaagtccc cttgaagccc agagtggaca gactagaccc attgatgggg
     5521 ccactggcca tggtccgtgg acaagacatt cctgtgggcc atggcacacc gggggggatc
     5581 aaaatgtgta cttgtggggt ctcgcccctt gccaaaagcc aaaccagtcc cactcctgtc
     5641 attggacgtt tcttcccatt ccctcctccc aaatgcactt cccctcctcc ctctgccccc
     5701 tcctgtgttt tggatttctg ttcactcaga attgtaaatg tttagttgtg accatgacgt
     5761 attgtttggg tcaatgtccc tttccaatgc atactaatat attatggtta ttatatatga
     5821 atatatttaa tgacatggaa aaagttgtgg attttctttc tttccttttt tttggggggg
     5881 ggtggggggt tggttagagt tgtaatggac ccagatggaa cttgtaatgt gggccccaca
     5941 tgatagaact aaattcagat atcattaaat aaactcttgt acacta
//
