LOCUS       NM_001136107            2110 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens N-terminal Xaa-Pro-Lys N-methyltransferase 2 (NTMT2),
            mRNA.
ACCESSION   NM_001136107 XM_001718898 XM_089281 XM_939434
VERSION     NM_001136107.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2110)
  AUTHORS   Petkowski,J.J., Bonsignore,L.A., Tooley,J.G., Wilkey,D.W.,
            Merchant,M.L., Macara,I.G. and Schaner Tooley,C.E.
  TITLE     NRMT2 is an N-terminal monomethylase that primes for its homologue
            NRMT1
  JOURNAL   Biochem J 456 (3), 453-462 (2013)
   PUBMED   24090352
  REMARK    GeneRIF: Concurrent expression of NRMT1 and NRMT2 accelerates the
            production of trimethylation, and we propose that NRMT2 activates
            NRMT1 by priming its substrates for trimethylation.
REFERENCE   2  (bases 1 to 2110)
  AUTHORS   Trevino,L.R., Shimasaki,N., Yang,W., Panetta,J.C., Cheng,C.,
            Pei,D., Chan,D., Sparreboom,A., Giacomini,K.M., Pui,C.H.,
            Evans,W.E. and Relling,M.V.
  TITLE     Germline genetic variation in an organic anion transporter
            polypeptide associated with methotrexate pharmacokinetics and
            clinical effects
  JOURNAL   J Clin Oncol 27 (35), 5972-5978 (2009)
   PUBMED   19901119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL445203.23.
            
            On Nov 27, 2019 this sequence version replaced NM_001136107.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC171858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMEA2159607
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439373.3/ ENSP00000408058.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AL445203.23        31318-31620
            304-479             AL445203.23        45877-46052
            480-729             AL445203.23        51861-52110
            730-2110            AL445203.23        52845-54225
FEATURES             Location/Qualifiers
     source          1..2110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..2110
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /note="N-terminal Xaa-Pro-Lys N-methyltransferase 2"
                     /db_xref="GeneID:149281"
                     /db_xref="HGNC:HGNC:31932"
     exon            1..303
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1001
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /EC_number="2.1.1.299"
                     /note="alpha N-terminal protein methyltransferase 1B;
                     methyltransferase-like protein 11B; X-Pro-Lys N-terminal
                     protein methyltransferase 1B; methyltransferase like 11B"
                     /codon_start=1
                     /product="N-terminal Xaa-Pro-Lys N-methyltransferase 2"
                     /protein_id="NP_001129579.1"
                     /db_xref="CCDS:CCDS44275.1"
                     /db_xref="GeneID:149281"
                     /db_xref="HGNC:HGNC:31932"
                     /translation="MAHRGAHFAFRSRWQKTDDELCRHSMSFILHKAIRNDFFQSYLY
                     LLEKIPLVKLYALTSQVINGEMQFYARAKLFYQEVPATEEGMMGNFIELSSPDIQASQ
                     KFLRKFVGGPGRAGTDCALDCGSGIGRVSKHVLLPVFNSVELVDMMESFLLEAQNYLQ
                     VKGDKVESYHCYSLQEFTPPFRRYDVIWIQWVSGHLTDKDLLAFLSRCRDGLKENGII
                     ILKDNVAREGCILDLSDSSVTRDMDILRSLIRKSGLVVLGQEKQDGFPEQCIPVWMFA
                     LHSDRHS"
     exon            304..479
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /inference="alignment:Splign:2.1.0"
     exon            480..729
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /inference="alignment:Splign:2.1.0"
     exon            730..2110
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1304..1309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /note="hexamer: CATAAA"
     polyA_site      1325
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
     regulatory      1916..1921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /note="hexamer: AGTAAA"
     polyA_site      1938
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /note="major polyA site"
     regulatory      2088..2093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /note="hexamer: ATTAAA"
     polyA_site      2110
                     /gene="NTMT2"
                     /gene_synonym="C1orf184; HOMT1B; METTL11B; NTM1B"
                     /note="major polyA site"
ORIGIN      
        1 acacccatga cagcctgtcc tgatatagat ggagagggga ctggtttaaa atgacagtct
       61 caagttcatt tagaaagaga aggctaattc aaagaaacag caaggcaagc ttcctttctc
      121 tgtaggaatc attattatcc ccctttgtca tggcccaccg gggagcccat tttgccttta
      181 gatcccgctg gcagaagacc gacgatgaac tctgtagaca tagcatgtct tttatccttc
      241 acaaagccat tcgcaatgac ttctttcaga gctatctcta cctgctggaa aaaattcccc
      301 tggtgaaatt gtacgcttta acaagccaag tcatcaatgg tgagatgcag ttctatgcca
      361 gagctaaact tttctaccaa gaagtaccag ccacagaaga gggtatgatg ggaaatttca
      421 ttgaactgtc cagcccagac atccaggcct ctcagaaatt tcttaggaaa tttgttgggg
      481 ggcctgggag agctggaaca gactgcgcct tggactgcgg ctccgggata ggaagggtca
      541 gcaaacacgt cttattgcct gttttcaaca gtgtggagct ggtggatatg atggaatcct
      601 ttctccttga agcccagaac tacctgcagg tcaaaggtga caaagtagaa agctaccact
      661 gctacagcct gcaggaattc acacccccct tcaggagata tgatgtcatc tggattcagt
      721 gggtctctgg gcacctgact gataaggacc ttcttgcatt tctttcccgg tgccgagatg
      781 gcctgaaaga aaatggcatc atcatattga aggacaatgt ggcccgggag ggctgtatcc
      841 ttgatctctc tgacagcagt gtgactcggg acatggacat cctccggagc ctaataagga
      901 agagtgggct ggtggtgctg ggccaggaga agcaggatgg cttcccagag cagtgcatcc
      961 ccgtgtggat gttcgcactg cacagcgaca gacactcctg aaaaagcagt gggaatgaac
     1021 gactggactg ggcagtggtg ctttgggatg gggttgctat ccttccaggt gccccttgta
     1081 atgcagatag ggatggcaag aaaagggata caacatatgt ctgcaaatta tttgtgatat
     1141 aatatgtaca tgttttcagt gattatataa tgcacacact ctgatgagac atgcacaaat
     1201 tctgtggatt ttctgaaaaa aaaatggagt gaaatatcag gaaacgtgct ttaaatccgt
     1261 ttgtatgtat ctaaactgtg caagcgtgca tgaaaacaga aggcataaag gacagctggc
     1321 ctgcatcagt atttgtaaaa attgtctttc acaacatcct agacaaaaat ggtggttttt
     1381 tttttgtttt tccatcacaa gatgaaatca gcattctgtg catcaaggaa aacaaataat
     1441 ttagctttgg gggttgttca gataaagcat ttgtctactc aaacaaaaaa aaaaaaaaga
     1501 aaaagaaaca atgcccacat attccaaact gtcttgttcc ctgataatta gtattataga
     1561 gtattctggt gggggtgggg gtaggagaaa atctacactc ctttccccgc cttcatgtca
     1621 gctacattat acttcctctt tggtactact acttctcttg aacaaacatc tccctctaat
     1681 taagaagaca ctagtcaaaa taatcttgtg aaaacaagtc cattatttaa ttttctcttt
     1741 agcctttctc ttggcagaaa aggtatttgg tttcactttc tattttgggt cagttttact
     1801 acccaatgat gtaatatgga tgtaatttga taacagaagt ctgcattaca gtgatgggaa
     1861 gtatctcctt tcaggagaaa atgttgtgcc ctgaaatttc aacctttaac atataagtaa
     1921 atgtcattga taatctaatt ttagtctttg cttttcaaca tggcttggtt cattgcagct
     1981 gctcctgggg tcttgattga tatgaatgta tattggaaag agaagcagca aaagaaatgg
     2041 acaaggaaat gataaccctg aaaattgact agctggacat tggtttaatt aaaaataatc
     2101 taaaatcatt
//
