LOCUS       NM_014064               1530 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1),
            transcript variant 2, mRNA.
ACCESSION   NM_014064
VERSION     NM_014064.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1530)
  AUTHORS   Zhao,C., Yu,M. and Li,Y.
  TITLE     Pan-cancer analysis reveals the pro-oncogenic role of
            N6-methyladenosine (m6A)-regulated NTMT1 in head and neck squamous
            cell carcinoma
  JOURNAL   J Biochem Mol Toxicol 38 (1), e23603 (2024)
   PUBMED   38014887
  REMARK    GeneRIF: Pan-cancer analysis reveals the pro-oncogenic role of
            N6-methyladenosine (m6A)-regulated NTMT1 in head and neck squamous
            cell carcinoma.
REFERENCE   2  (bases 1 to 1530)
  AUTHORS   Catlin,J.P., Marziali,L.N., Rein,B., Yan,Z., Feltri,M.L. and
            Schaner Tooley,C.E.
  TITLE     Age-related neurodegeneration and cognitive impairments of NRMT1
            knockout mice are preceded by misregulation of RB and abnormal
            neural stem cell development
  JOURNAL   Cell Death Dis 12 (11), 1014 (2021)
   PUBMED   34711807
  REMARK    GeneRIF: Age-related neurodegeneration and cognitive impairments of
            NRMT1 knockout mice are preceded by misregulation of RB and
            abnormal neural stem cell development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1530)
  AUTHORS   Zhang,J., Song,H., Chen,C., Chen,L., Dai,Y., Sun,P.H., Zou,C. and
            Wang,X.
  TITLE     Methyltransferase-like protein 11A promotes migration of cervical
            cancer cells via up-regulating ELK3
  JOURNAL   Pharmacol Res 172, 105814 (2021)
   PUBMED   34450313
  REMARK    GeneRIF: Methyltransferase-like protein 11A promotes migration of
            cervical cancer cells via up-regulating ELK3.
REFERENCE   4  (bases 1 to 1530)
  AUTHORS   Bade,D., Cai,Q., Li,L., Yu,K., Dai,X., Miao,W. and Wang,Y.
  TITLE     Modulation of N-terminal methyltransferase 1 by an
            N6-methyladenosine-based epitranscriptomic mechanism
  JOURNAL   Biochem Biophys Res Commun 546, 54-58 (2021)
   PUBMED   33561748
  REMARK    GeneRIF: Modulation of N-terminal methyltransferase 1 by an
            N(6)-methyladenosine-based epitranscriptomic mechanism.
REFERENCE   5  (bases 1 to 1530)
  AUTHORS   Chen,D., Dong,C., Dong,G., Srinivasan,K., Min,J., Noinaj,N. and
            Huang,R.
  TITLE     Probing the Plasticity in the Active Site of Protein N-terminal
            Methyltransferase 1 Using Bisubstrate Analogues
  JOURNAL   J Med Chem 63 (15), 8419-8431 (2020)
   PUBMED   32605369
  REMARK    GeneRIF: Probing the Plasticity in the Active Site of Protein
            N-terminal Methyltransferase 1 Using Bisubstrate Analogues.
REFERENCE   6  (bases 1 to 1530)
  AUTHORS   Tooley,C.E., Petkowski,J.J., Muratore-Schroeder,T.L.,
            Balsbaugh,J.L., Shabanowitz,J., Sabat,M., Minor,W., Hunt,D.F. and
            Macara,I.G.
  TITLE     NRMT is an alpha-N-methyltransferase that methylates RCC1 and
            retinoblastoma protein
  JOURNAL   Nature 466 (7310), 1125-1128 (2010)
   PUBMED   20668449
  REMARK    GeneRIF: discovery of the first alpha-N-methyltransferase, which we
            named N-terminal RCC1 methyltransferase (NRMT).
REFERENCE   7  (bases 1 to 1530)
  AUTHORS   Webb,K.J., Lipson,R.S., Al-Hadid,Q., Whitelegge,J.P. and
            Clarke,S.G.
  TITLE     Identification of protein N-terminal methyltransferases in yeast
            and humans
  JOURNAL   Biochemistry 49 (25), 5225-5235 (2010)
   PUBMED   20481588
REFERENCE   8  (bases 1 to 1530)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   9  (bases 1 to 1530)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1530)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ636193.1, BC001396.2, AK298840.1 and AL590369.18.
            
            On Feb 27, 2020 this sequence version replaced NM_014064.3.
            
            Summary: The METTL11A gene encodes an N-terminal methyltransferase
            for the RAN (MIM 601179) guanine nucleotide exchange factor
            regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A
            enzyme alpha-N-methylates other protein targets such as SET (MIM
            600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 through 5 all encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313829.1, SRR14038195.1286264.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372483.9/ ENSP00000361561.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BQ636193.1         11-21
            12-994              BC001396.2         1-983
            995-1526            AK298840.1         910-1441
            1527-1530           AL590369.18        20547-20550
FEATURES             Location/Qualifiers
     source          1..1530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..1530
                     /gene="NTMT1"
                     /gene_synonym="AD-003; C9orf32; HOMT1A; METTL11A; NRMT;
                     NRMT1; NTM1A"
                     /note="N-terminal Xaa-Pro-Lys N-methyltransferase 1"
                     /db_xref="GeneID:28989"
                     /db_xref="HGNC:HGNC:23373"
                     /db_xref="MIM:613560"
     exon            1..133
                     /gene="NTMT1"
                     /gene_synonym="AD-003; C9orf32; HOMT1A; METTL11A; NRMT;
                     NRMT1; NTM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            134..349
                     /gene="NTMT1"
                     /gene_synonym="AD-003; C9orf32; HOMT1A; METTL11A; NRMT;
                     NRMT1; NTM1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..859
                     /gene="NTMT1"
                     /gene_synonym="AD-003; C9orf32; HOMT1A; METTL11A; NRMT;
                     NRMT1; NTM1A"
                     /EC_number="2.1.1.244"
                     /note="isoform a is encoded by transcript variant 2;
                     N-terminal RCC1 methyltransferase; alpha N-terminal
                     protein methyltransferase 1A; methyltransferase-like
                     protein 11A; X-Pro-Lys N-terminal protein
                     methyltransferase 1A"
                     /codon_start=1
                     /product="N-terminal Xaa-Pro-Lys N-methyltransferase 1
                     isoform a"
                     /protein_id="NP_054783.2"
                     /db_xref="CCDS:CCDS35160.1"
                     /db_xref="GeneID:28989"
                     /db_xref="HGNC:HGNC:23373"
                     /db_xref="MIM:613560"
                     /translation="MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINS
                     SRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKT
                     YLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPN
                     GIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVY
                     SFALR"
     exon            350..602
                     /gene="NTMT1"
                     /gene_synonym="AD-003; C9orf32; HOMT1A; METTL11A; NRMT;
                     NRMT1; NTM1A"
                     /inference="alignment:Splign:2.1.0"
     exon            603..1530
                     /gene="NTMT1"
                     /gene_synonym="AD-003; C9orf32; HOMT1A; METTL11A; NRMT;
                     NRMT1; NTM1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      970..975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTMT1"
                     /gene_synonym="AD-003; C9orf32; HOMT1A; METTL11A; NRMT;
                     NRMT1; NTM1A"
                     /note="hexamer: AATATA"
     polyA_site      995
                     /gene="NTMT1"
                     /gene_synonym="AD-003; C9orf32; HOMT1A; METTL11A; NRMT;
                     NRMT1; NTM1A"
                     /note="major polyA site"
     regulatory      1488..1493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTMT1"
                     /gene_synonym="AD-003; C9orf32; HOMT1A; METTL11A; NRMT;
                     NRMT1; NTM1A"
                     /note="hexamer: AATAAA"
     polyA_site      1530
                     /gene="NTMT1"
                     /gene_synonym="AD-003; C9orf32; HOMT1A; METTL11A; NRMT;
                     NRMT1; NTM1A"
ORIGIN      
        1 agcgcgcgcc gcgagctgtc gcgtctggtc gtggtctggc ggagctgcgg ttggcttgtg
       61 gcgtctccgc cgccgccgcc ctcccttcct cttccccatc ttcttctctc ggtcccggga
      121 gcccccgccc ggagagagtc gcggttgctg atcgtggtgc ttgagtagag ccgtggttgg
      181 tgacagcatg acgagcgagg tgatagaaga cgagaagcaa ttctattcca aggccaagac
      241 ctactggaaa caaatcccac ccacggtgga cggcatgctt ggggggtatg gccacatctc
      301 cagcatcgac atcaacagct cccggaagtt tctgcagagg tttttgaggg aaggcccgaa
      361 caagacagga acgtcctgtg ccctggactg tggagctggc attgggagga tcaccaagcg
      421 gctgctcctg ccgctgttca gagaggtgga tatggtcgac ataacggagg acttcctggt
      481 tcaagccaag acctacctgg gggaggaggg caagagggtg aggaactact tctgttgtgg
      541 gctccaggac ttcaccccgg agccggactc ttacgacgtg atctggatcc agtgggtgat
      601 aggccacctc accgatcagc acctggccga gttcctgcgg cgctgcaagg gcagcctccg
      661 ccccaacggc atcatcgtca tcaaagacaa catggcccag gagggcgtga ttctggacga
      721 cgtggacagc agcgtgtgcc gggaccttga cgtggtccgc aggatcatct gcagtgcagg
      781 cctcagcctc ctggccgagg agaggcagga gaacctcccc gatgagatct accatgtcta
      841 tagctttgcc ctgagatgag ccggggctgg caggagaaac tgaggaacca cagtcctggt
      901 ggggggagct ggcagctggg caagatccag gcgccacgct ggcggttcgt gagtgtcgag
      961 gcaccactaa atatagctgt ctgccgtcca ctcattatgc gggctcttct tcaaaaggca
     1021 aggtgggacc cggcggggag ggtgctgctg aaccagcggt gaggcaggag cccagaccct
     1081 gctctcctgc gagatgggat tgggtggaag gggctccagg gctcctggtg ctccccatgt
     1141 gggaataggg tggccacatc agtaaccgat tccctgggcc tccagcccgg ccttccagcc
     1201 atgggcctgg ctgcctgaag aggaaggaaa ccacccccaa cttggttgct ggggacttga
     1261 agacttcagt gtgatcttta cctaggggag ggacagagct gggctggtgg agcccatggg
     1321 tgctgcctga tggtgctgtg gggtgggtgc tcatgtgcca agtcctgctt ggcagtggag
     1381 acctggggcc cttaaagtgt tacaacagcc tgcagcaagg gaagttcccc gtagcctcag
     1441 tcttctctgg gcttgaggct gctccttggc aggcatttaa agtaaaaaat aaaatggggc
     1501 tgggcgcggt ggctcacgcc tgtaatccca
//
