LOCUS       NM_001352005            2936 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens neurotrimin (NTM), transcript variant 9, mRNA.
ACCESSION   NM_001352005 XM_005271582
VERSION     NM_001352005.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2936)
  AUTHORS   Venkannagari,H., Kasper,J.M., Misra,A., Rush,S.A., Fan,S., Lee,H.,
            Sun,H., Seshadrinathan,S., Machius,M., Hommel,J.D. and Rudenko,G.
  TITLE     Highly Conserved Molecular Features in IgLONs Contrast Their
            Distinct Structural and Biological Outcomes
  JOURNAL   J Mol Biol 432 (19), 5287-5303 (2020)
   PUBMED   32710982
  REMARK    GeneRIF: Highly Conserved Molecular Features in IgLONs Contrast
            Their Distinct Structural and Biological Outcomes.
REFERENCE   2  (bases 1 to 2936)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2936)
  AUTHORS   Parikh,T.P., Malik,M., Britten,J., Aly,J.M., Pilgrim,J. and
            Catherino,W.H.
  TITLE     Steroid hormones and hormone antagonists regulate the neural marker
            neurotrimin in uterine leiomyoma
  JOURNAL   Fertil Steril 113 (1), 176-186 (2020)
   PUBMED   32033718
  REMARK    GeneRIF: Neurotrimin, a neural cell adhesion molecule, is increased
            in leiomyoma compared to myometrium in patient tissue after
            estrogen and progesterone treatment.
REFERENCE   4  (bases 1 to 2936)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2936)
  AUTHORS   Maruani,A., Huguet,G., Beggiato,A., ElMaleh,M., Toro,R.,
            Leblond,C.S., Mathieu,A., Amsellem,F., Lemiere,N., Verloes,A.,
            Leboyer,M., Gillberg,C., Bourgeron,T. and Delorme,R.
  TITLE     11q24.2-25 micro-rearrangements in autism spectrum disorders:
            Relation to brain structures
  JOURNAL   Am J Med Genet A 167A (12), 3019-3030 (2015)
   PUBMED   26334118
  REMARK    GeneRIF: NTM is not a susceptibility gene for autism spectrum
            disorders.
REFERENCE   6  (bases 1 to 2936)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2936)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   8  (bases 1 to 2936)
  AUTHORS   Liu,J., Li,G., Peng,X., Liu,B., Yin,B., Tan,X., Fan,M., Fan,W.,
            Qiang,B. and Yuan,J.
  TITLE     The cloning and preliminarily functional analysis of the human
            neurotrimin gene
  JOURNAL   Sci China C Life Sci 47 (2), 158-164 (2004)
   PUBMED   15379248
  REMARK    GeneRIF: Human neurotrimin is expressed on the surface of CHO cells
            and could strengthen their aggregation.
REFERENCE   9  (bases 1 to 2936)
  AUTHORS   Sellar,G.C., Watt,K.P., Rabiasz,G.J., Stronach,E.A., Li,L.,
            Miller,E.P., Massie,C.E., Miller,J., Contreras-Moreira,B.,
            Scott,D., Brown,I., Williams,A.R., Bates,P.A., Smyth,J.F. and
            Gabra,H.
  TITLE     OPCML at 11q25 is epigenetically inactivated and has
            tumor-suppressor function in epithelial ovarian cancer
  JOURNAL   Nat Genet 34 (3), 337-343 (2003)
   PUBMED   12819783
  REMARK    GeneRIF: NTM shows close linkage to OPCML on chromosome 11q25.
REFERENCE   10 (bases 1 to 2936)
  AUTHORS   Struyk,A.F., Canoll,P.D., Wolfgang,M.J., Rosen,C.L., D'Eustachio,P.
            and Salzer,J.L.
  TITLE     Cloning of neurotrimin defines a new subfamily of differentially
            expressed neural cell adhesion molecules
  JOURNAL   J Neurosci 15 (3 Pt 2), 2141-2156 (1995)
   PUBMED   7891157
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003166.2, AP000844.4,
            AP005155.2 and AP004248.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001352005.1.
            
            Summary: This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm)
            family of immunoglobulin (Ig) domain-containing
            glycosylphosphatidylinositol (GPI)-anchored cell adhesion
            molecules. The encoded protein may promote neurite outgrowth and
            adhesion via a homophilic mechanism. This gene is closely linked to
            a related family member, opioid binding protein/cell adhesion
            molecule-like (OPCML), on chromosome 11. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.79746.1,
                                           SRR1803611.243126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683400.1/ ENSP00000507313.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AP003166.2         23462-23735
            275-359             AP000844.4         57123-57207
            360-592             AP005155.2         33634-33866
            593-718             AP004248.2         58291-58416
            719-853             AP004248.2         153958-154092
            854-974             AP004248.2         156381-156501
            975-1126            AP004248.2         160821-160972
            1127-1159           AP004248.2         176422-176454
            1160-2936           AP004248.2         181315-183091
FEATURES             Location/Qualifiers
     source          1..2936
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..2936
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /note="neurotrimin"
                     /db_xref="GeneID:50863"
                     /db_xref="HGNC:HGNC:17941"
                     /db_xref="MIM:607938"
     exon            1..274
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1260
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /note="isoform 9 precursor is encoded by transcript
                     variant 9; IgLON family member 2"
                     /codon_start=1
                     /product="neurotrimin isoform 9 precursor"
                     /protein_id="NP_001338934.1"
                     /db_xref="CCDS:CCDS91626.1"
                     /db_xref="GeneID:50863"
                     /db_xref="HGNC:HGNC:17941"
                     /db_xref="MIM:607938"
                     /translation="MKTIQPKMHNSISWAIFTGLAALCLFQGVPVRSGDATFPKAMDN
                     VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI
                     QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIAT
                     GRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT
                     VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPF
                     LSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFEVKTTALTPWKGPGAVSEVSNGT
                     SRRAGCVWLLPLLVLHLLLKF"
     exon            275..359
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /inference="alignment:Splign:2.1.0"
     exon            360..592
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /inference="alignment:Splign:2.1.0"
     exon            593..718
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /inference="alignment:Splign:2.1.0"
     exon            719..853
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /inference="alignment:Splign:2.1.0"
     exon            854..974
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1126
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1159
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..2936
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /note="hexamer: AATAAA"
     polyA_site      1774
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /note="major polyA site"
     polyA_site      2426
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /note="major polyA site"
     regulatory      2909..2914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /note="hexamer: ATTAAA"
     polyA_site      2936
                     /gene="NTM"
                     /gene_synonym="CEPU-1; HNT; IGLON2; NTRI"
                     /note="major polyA site"
ORIGIN      
        1 agagtatgag tggagataat tacggagaag tcatactctc tcacaccctc ggctttcttg
       61 ttgtgtcctt cagcaaaaca gtggatttaa atctccttgc acaagcttga gagcaacaca
      121 atctatcagg aaagaaagaa agaaaaaaac cgaacctgac aaaaaagaag aaaaagaaga
      181 agaaaaaaaa tcatgaaaac catccagcca aaaatgcaca attctatctc ttgggcaatc
      241 ttcacggggc tggctgctct gtgtctcttc caaggagtgc ccgtgcgcag cggagatgcc
      301 accttcccca aagctatgga caacgtgacg gtccggcagg gggagagcgc caccctcagg
      361 tgcactattg acaaccgggt cacccgggtg gcctggctaa accgcagcac catcctctat
      421 gctgggaatg acaagtggtg cctggatcct cgcgtggtcc ttctgagcaa cacccaaacg
      481 cagtacagca tcgagatcca gaacgtggat gtgtatgacg agggccctta cacctgctcg
      541 gtgcagacag acaaccaccc aaagacctct agggtccacc tcattgtgca agtatctccc
      601 aaaattgtag agatttcttc agatatctcc attaatgaag ggaacaatat tagcctcacc
      661 tgcatagcaa ctggtagacc agagcctacg gttacttgga gacacatctc tcccaaagcg
      721 gttggctttg tgagtgaaga cgaatacttg gaaattcagg gcatcaccag ggagcagtca
      781 ggggactacg agtgcagtgc ctccaatgac gtggccgcgc ccgtggtacg gagagtaaag
      841 gtcaccgtga actatccacc atacatttca gaagccaagg gtacaggtgt ccccgtggga
      901 caaaagggga cactgcagtg tgaagcctca gcagtcccct cagcagaatt ccagtggtac
      961 aaggatgaca aaagactgat tgaaggaaag aaaggggtga aagtggaaaa cagacctttc
     1021 ctctcaaaac tcatcttctt caatgtctct gaacatgact atgggaacta cacttgcgtg
     1081 gcctccaaca agctgggcca caccaatgcc agcatcatgc tatttgaagt gaaaactaca
     1141 gccctgaccc cttggaaagg tccaggcgcc gtcagcgagg tgagcaacgg cacgtcgagg
     1201 agggcaggct gcgtctggct gctgcctctt ctggtcttgc acctgcttct caaattttga
     1261 tgtgagtgcc acttccccac ccgggaaagg ctgccgccac caccaccacc aacacaacag
     1321 caatggcaac accgacagca accaatcaga tatatacaaa tgaaattaga agaaacacag
     1381 cctcatggga cagaaatttg agggagggga acaaagaata ctttgggggg aaaaaagttt
     1441 taaaaaagaa attgaaaatt gccttgcaga tatttaggta caatggagtt ttcttttccc
     1501 aaacgggaag aacacagcac acccggcttg gacccactgc aagctgcatc gtgcaacctc
     1561 tttggtgcca gtgtgggcaa gggctcagcc tctctgccca cagagtgccc ccacgtggaa
     1621 cattctggag ctggccatcc caaattcaat cagtccatag agacgaacag aatgagacct
     1681 tccggcccaa gcgtggcgct gcgggcactt tggtagactg tgccaccacg gcgtgtgttg
     1741 tgaaacgtga aataaaaaga gcaagaaaga aaaaggaaac aaaataagac cgtctgacag
     1801 caacaacggt cccacaaaca agtcacaaaa gataccgtta aacttttttt tttttttatc
     1861 attttactac atgaacatca tggataacaa gggattctga ttcattatta atttcattaa
     1921 ttatattttc tgatatgagt ctagaactta ctgcaaaaac aagacaaaac taaaaaaata
     1981 caactgagaa gggtgaagag aagtatgttt gttaaacagt aaaaatgaat agtatacttc
     2041 ttaactaggt ttacaactgg tggaccacac accaggcact aatcacctgg tgaggatttg
     2101 gcatatccac caaaaaatgc atccgattta accaacatct ccaccagcgc tacggactcc
     2161 tcccaattct gacatctctt gcagacaata ctatgctctc tacacactgt ttagaaatgg
     2221 aaaggtgatc tgcactgtat cttgggtttg ttggctatgc ttcctttgat gacatatatt
     2281 atacagtata tatatacata tatttttttt gttagagttc tagccatttt atttctccgc
     2341 agggtccttt ctcagacatt actgcatgct gtatatggcg ttagctgtgt gttgatcttc
     2401 taaaagatga tagagtttac tggtaattgt gtaatcagct cctgcctttt tattttcttg
     2461 ggttatttac atgtcagaga catttataaa aagtgaaagg ataaaaaaaa aaaaaaacaa
     2521 ctaataccgg gcgcagcatc tttccaggtg tggctctgcg ctaggccacc ccaggtggcc
     2581 ccgctttctc cattctgccc tgtggcgtta acagacagca agcagctgaa caagcagtac
     2641 cgtcagtacc cacttgcttt agcccattat gggaatctct gatgcctttg tgaccactgg
     2701 agagtttaat cctcttggtt tattttattt cccacctttg tgtgagtgtg tatgaaagag
     2761 aagaaaatgc aatttttagg taatcttttt tttttttccc ctcccctgaa agtctgggaa
     2821 cctgagagtc ctcggggagg ggtcctggat gtgatgaggg aaagggggat tgggggatcc
     2881 gggagggtgg ggttgtctct gacttgacat taaaaagtgt tccatgtccc tcttca
//
