LOCUS       NM_006179               1962 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens neurotrophin 4 (NTF4), transcript variant 1, mRNA.
ACCESSION   NM_006179
VERSION     NM_006179.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Guo,Y., Chen,P., Li,T., Jia,L., Zhou,Y., Huang,J., Liang,X.,
            Zhou,C. and Fang,C.
  TITLE     Single-cell transcriptome and cell-specific network analysis reveal
            the reparative effect of neurotrophin-4 in preantral follicles
            grown in vitro
  JOURNAL   Reprod Biol Endocrinol 19 (1), 133 (2021)
   PUBMED   34481496
  REMARK    GeneRIF: Single-cell transcriptome and cell-specific network
            analysis reveal the reparative effect of neurotrophin-4 in
            preantral follicles grown in vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1962)
  AUTHORS   Ribeiro,D., Petrigna,L., Pereira,F.C., Muscella,A., Bianco,A. and
            Tavares,P.
  TITLE     The Impact of Physical Exercise on the Circulating Levels of BDNF
            and NT 4/5: A Review
  JOURNAL   Int J Mol Sci 22 (16), 8814 (2021)
   PUBMED   34445512
  REMARK    GeneRIF: The Impact of Physical Exercise on the Circulating Levels
            of BDNF and NT 4/5: A Review.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1962)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1962)
  AUTHORS   Jin,J., Wang,L., Liu,X., Long,Z., Zhou,Y., Huang,H. and Wang,Y.
  TITLE     NTF4 stimulates the progression of gastric cancer via regulating
            FOXL1
  JOURNAL   J BUON 26 (2), 499-505 (2021)
   PUBMED   34076998
  REMARK    GeneRIF: NTF4 stimulates the progression of gastric cancer via
            regulating FOXL1.
REFERENCE   5  (bases 1 to 1962)
  AUTHORS   Wang,T., Zhang,J., Li,P., Ding,Y., Tang,J., Chen,G. and Zhang,J.H.
  TITLE     NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after
            germinal matrix hemorrhage in neonatal rats
  JOURNAL   J Neuroinflammation 17 (1), 158 (2020)
   PUBMED   32416727
  REMARK    GeneRIF: NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1
            pathway after germinal matrix hemorrhage in neonatal rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1962)
  AUTHORS   Curtis,R., Adryan,K.M., Stark,J.L., Park,J.S., Compton,D.L.,
            Weskamp,G., Huber,L.J., Chao,M.V., Jaenisch,R., Lee,K.F. et al.
  TITLE     Differential role of the low affinity neurotrophin receptor (p75)
            in retrograde axonal transport of the neurotrophins
  JOURNAL   Neuron 14 (6), 1201-1211 (1995)
   PUBMED   7541633
REFERENCE   7  (bases 1 to 1962)
  AUTHORS   Berkemeier,L.R., Ozcelik,T., Francke,U. and Rosenthal,A.
  TITLE     Human chromosome 19 contains the neurotrophin-5 gene locus and
            three related genes that may encode novel acidic neurotrophins
  JOURNAL   Somat Cell Mol Genet 18 (3), 233-245 (1992)
   PUBMED   1496419
REFERENCE   8  (bases 1 to 1962)
  AUTHORS   Ip,N.Y., Ibanez,C.F., Nye,S.H., McClain,J., Jones,P.F., Gies,D.R.,
            Belluscio,L., Le Beau,M.M., Espinosa,R. 3rd, Squinto,S.P. et al.
  TITLE     Mammalian neurotrophin-4: structure, chromosomal localization,
            tissue distribution, and receptor specificity
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 3060-3064 (1992)
   PUBMED   1313578
REFERENCE   9  (bases 1 to 1962)
  AUTHORS   Berkemeier,L.R., Winslow,J.W., Kaplan,D.R., Nikolics,K.,
            Goeddel,D.V. and Rosenthal,A.
  TITLE     Neurotrophin-5: a novel neurotrophic factor that activates trk and
            trkB
  JOURNAL   Neuron 7 (5), 857-866 (1991)
   PUBMED   1742028
REFERENCE   10 (bases 1 to 1962)
  AUTHORS   Bothwell,M.A. and Shooter,E.M.
  TITLE     Dissociation equilibrium constant of beta nerve growth factor
  JOURNAL   J Biol Chem 252 (23), 8532-8536 (1977)
   PUBMED   925010
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008687.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 9, 2021 this sequence version replaced NM_006179.4.
            
            Summary: This gene is a member of a family of neurotrophic factors,
            neurotrophins, that control survival and differentiation of
            mammalian neurons. The expression of this gene is ubiquitous and
            less influenced by environmental signals. While knock-outs of other
            neurotrophins including nerve growth factor, brain-derived
            neurotrophic factor, and neurotrophin 3  prove lethal during early
            postnatal development, NTF5-deficient mice only show minor cellular
            deficits and develop normally to adulthood. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012421.2, SRR18074969.3065080.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000593537.2/ ENSP00000469455.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1080              AC008687.5         75047-76126         c
            1081-1962           AC008687.5         72436-73317         c
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1962
                     /gene="NTF4"
                     /gene_synonym="GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5;
                     NTF5"
                     /note="neurotrophin 4"
                     /db_xref="GeneID:4909"
                     /db_xref="HGNC:HGNC:8024"
                     /db_xref="MIM:162662"
     exon            1..1080
                     /gene="NTF4"
                     /gene_synonym="GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5;
                     NTF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1962
                     /gene="NTF4"
                     /gene_synonym="GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5;
                     NTF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             1093..1725
                     /gene="NTF4"
                     /gene_synonym="GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5;
                     NTF5"
                     /note="neurotrophin 5 (neurotrophin 4/5); neurotrophic
                     factor 4; neurotrophic factor 5; neurotrophin-5;
                     neutrophic factor 4"
                     /codon_start=1
                     /product="neurotrophin-4 preproprotein"
                     /protein_id="NP_006170.1"
                     /db_xref="CCDS:CCDS12754.1"
                     /db_xref="GeneID:4909"
                     /db_xref="HGNC:HGNC:8024"
                     /db_xref="MIM:162662"
                     /translation="MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSP
                     RVVLSRGAPAGPPLLFLLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSG
                     WVTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRG
                     VDRRHWVSECKAKQSYVRALTADAQGRVGWRWIRIDTACVCTLLSRTGRA"
     regulatory      1929..1934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTF4"
                     /gene_synonym="GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5;
                     NTF5"
                     /note="hexamer: AATAAT"
     polyA_site      1962
                     /gene="NTF4"
                     /gene_synonym="GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5;
                     NTF5"
                     /note="major polyA site"
ORIGIN      
        1 agatatgcag ccggtttccc ctgaggggtc tcggagtccg gaacccccaa cccaaatctg
       61 gaggatgagg aacccggagt ctgcatttct tagtatccga gaaggagggg cctgaattcc
      121 agaactcctg ggtctgagag aggagggcac tgggggcctg gattcctggg tctgagggag
      181 aagggcgctg ggggcatgga ctcctgggtc tgaaggagga gggcgctggg gacctggact
      241 ccagggtctg agggagaagg gtgctggggg cctgggcctg gactcctcct gggtctgagg
      301 gagaagggtg ctgggggcct ggacttctgg gtctgagaga ggagggcgct gggggcctgg
      361 actactcctg ggtctgaggg aggagggcgc tggggatctg aactcctggg tctgaaggtg
      421 gaggccctgg ggtctgcact actcggtctg agggagaagg cggtcctggt tgggtcagcc
      481 tgggctcctt tcactctcca cccttcccct ttcctgtacc gaggagccag ggcaggcagc
      541 cactccaggt atgtgcagaa gtcttgggcg ggccctggcc tgtcctgtga ggagggaaca
      601 ttccaggaag cagcttgggg aaccagggct tcttgagtgt gggccctcag ggacccgggt
      661 gtccaggcca gttccgcccc atctgggaga tgaatgggcc gagggggatg taatctcttc
      721 cagcctcctt catccactgc ctctcccttc ccctattctc ccttcccctc cctccatctg
      781 cttcccatcc cagccaggag ccatcacctg ggtagaaaag gggcctctgg aaagggggcg
      841 gggccttgac tcttgggtac cctgcacttg aagaggaact ctgggaaggg gttgttcagg
      901 gatttggccc cttccccacc tgcctctata acctgtctat tcttttcttc ccctaggtgg
      961 ttgccccctc cctctcctga gatgtcagga aggagggggc cacctgtgtc ctccacaggg
     1021 gccccccgaa gcctggggac tcccagcccc agagctccga ggcggaggag gtgctgacag
     1081 gtgctccgag agatgctccc tctcccctca tgctccctcc ccatcctcct ccttttcctc
     1141 ctccccagtg tgccaattga gtcccaaccc ccaccctcaa cattgccccc ttttctggcc
     1201 cctgagtggg accttctctc cccccgagta gtcctgtcta ggggtgcccc tgctgggccc
     1261 cctctgctct tcctgctgga ggctggggcc tttcgggagt cagcaggtgc cccggccaac
     1321 cgcagccggc gtggggtgag cgaaactgca ccagcgagtc gtcggggtga gctggctgtg
     1381 tgcgatgcag tcagtggctg ggtgacagac cgccggaccg ctgtggactt gcgtgggcgc
     1441 gaggtggagg tgttgggcga ggtgcctgca gctggcggca gtcccctccg ccagtacttc
     1501 tttgaaaccc gctgcaaggc tgataacgct gaggaaggtg gcccgggggc aggtggaggg
     1561 ggctgccggg gagtggacag gaggcactgg gtatctgagt gcaaggccaa gcagtcctat
     1621 gtgcgggcat tgaccgctga tgcccagggc cgtgtgggct ggcgatggat tcgaattgac
     1681 actgcctgcg tctgcacact cctcagccgg actggccggg cctgagaccc atgcccagga
     1741 aaataacaga gctggatgct gagagacctc agggatggcc cagctgatct aaggacccca
     1801 gtttgggaac tcatcaaata atcacaaaat cacaattctc tgattttgag ctcaatctct
     1861 gcaggatggg tgaaaccaca tggggttttg gaggttgaat aggagttctc ctggagcaac
     1921 ttgagggtaa taatgatgat gatataataa taatagccac ta
//
