LOCUS       NM_002527               1168 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens neurotrophin 3 (NTF3), transcript variant 2, mRNA.
ACCESSION   NM_002527
VERSION     NM_002527.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1168)
  AUTHORS   Xu,X., Song,L., Li,Y., Guo,J., Huang,S., Du,S., Li,W., Cao,R. and
            Cui,S.
  TITLE     Neurotrophin-3 promotes peripheral nerve regeneration by
            maintaining a repair state of Schwann cells after chronic
            denervation via the TrkC/ERK/c-Jun pathway
  JOURNAL   J Transl Med 21 (1), 733 (2023)
   PUBMED   37848983
  REMARK    GeneRIF: Neurotrophin-3 promotes peripheral nerve regeneration by
            maintaining a repair state of Schwann cells after chronic
            denervation via the TrkC/ERK/c-Jun pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1168)
  AUTHORS   Wang,H., Zhong,C., Qi,L., Fang,X. and Yuan,Y.
  TITLE     Expression and prognostic impact of NTF3 and TrkC in hepatocellular
            carcinoma
  JOURNAL   Scand J Gastroenterol 58 (11), 1309-1316 (2023)
   PUBMED   37272057
  REMARK    GeneRIF: Expression and prognostic impact of NTF3 and TrkC in
            hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1168)
  AUTHORS   Yang,Z., Zhang,H., Yin,M., Cheng,Z., Jiang,P., Feng,M., Liao,B. and
            Liu,Z.
  TITLE     Neurotrophin3 promotes hepatocellular carcinoma apoptosis through
            the JNK and P38 MAPK pathways
  JOURNAL   Int J Biol Sci 18 (15), 5963-5977 (2022)
   PUBMED   36263167
  REMARK    GeneRIF: Neurotrophin3 promotes hepatocellular carcinoma apoptosis
            through the JNK and P38 MAPK pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1168)
  AUTHORS   Cui,X., Jing,J., Wu,R., Cao,Q., Li,F., Li,K., Wang,S., Yu,L.,
            Schwartz,G., Shi,H., Xue,B. and Shi,H.
  TITLE     Adipose tissue-derived neurotrophic factor 3 regulates sympathetic
            innervation and thermogenesis in adipose tissue
  JOURNAL   Nat Commun 12 (1), 5362 (2021)
   PUBMED   34508100
  REMARK    GeneRIF: Adipose tissue-derived neurotrophic factor 3 regulates
            sympathetic innervation and thermogenesis in adipose tissue.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1168)
  AUTHORS   Rodrigues-Amorim,D., Iglesias-Martinez-Almeida,M.,
            Rivera-Baltanas,T., Fernandez-Palleiro,P., Freiria-Martinez,L.,
            Rodriguez-Jamardo,C., Comis-Tuche,M., Vallejo-Curto,M.D.C.,
            Alvarez-Ariza,M., Lopez-Garcia,M., de Las Heras,E.,
            Garcia-Caballero,A., Olivares,J.M. and Spuch,C.
  TITLE     The Role of the Second Extracellular Loop of Norepinephrine
            Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T
            Cells: A Peripheral Biomarker in the Etiology of Schizophrenia
  JOURNAL   Int J Mol Sci 22 (16), 8499 (2021)
   PUBMED   34445205
  REMARK    GeneRIF: The Role of the Second Extracellular Loop of
            Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor
            Kinase C in T Cells: A Peripheral Biomarker in the Etiology of
            Schizophrenia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1168)
  AUTHORS   Kalcheim,C., Carmeli,C. and Rosenthal,A.
  TITLE     Neurotrophin 3 is a mitogen for cultured neural crest cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1661-1665 (1992)
   PUBMED   1542658
REFERENCE   7  (bases 1 to 1168)
  AUTHORS   Ozcelik,T., Rosenthal,A. and Francke,U.
  TITLE     Chromosomal mapping of brain-derived neurotrophic factor and
            neurotrophin-3 genes in man and mouse
  JOURNAL   Genomics 10 (3), 569-575 (1991)
   PUBMED   1889807
REFERENCE   8  (bases 1 to 1168)
  AUTHORS   Maisonpierre,P.C., Le Beau,M.M., Espinosa,R. 3rd, Ip,N.Y.,
            Belluscio,L., de la Monte,S.M., Squinto,S., Furth,M.E. and
            Yancopoulos,G.D.
  TITLE     Human and rat brain-derived neurotrophic factor and neurotrophin-3:
            gene structures, distributions, and chromosomal localizations
  JOURNAL   Genomics 10 (3), 558-568 (1991)
   PUBMED   1889806
REFERENCE   9  (bases 1 to 1168)
  AUTHORS   Hallbook,F., Ibanez,C.F. and Persson,H.
  TITLE     Evolutionary studies of the nerve growth factor family reveal a
            novel member abundantly expressed in Xenopus ovary
  JOURNAL   Neuron 6 (5), 845-858 (1991)
   PUBMED   2025430
REFERENCE   10 (bases 1 to 1168)
  AUTHORS   Jones,K.R. and Reichardt,L.F.
  TITLE     Molecular cloning of a human gene that is a member of the nerve
            growth factor family
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 8060-8064 (1990)
   PUBMED   2236018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC069773.1 and CD672441.1.
            
            On Aug 13, 2020 this sequence version replaced NM_002527.4.
            
            Summary: The protein encoded by this gene is a member of the
            neurotrophin family, that controls survival and differentiation of
            mammalian neurons. This protein is closely related to both nerve
            growth factor and brain-derived neurotrophic factor. It may be
            involved in the maintenance of the adult nervous system, and may
            affect development of neurons in the embryo when it is expressed in
            human placenta. NTF3-deficient mice generated by gene targeting
            display severe movement defects of the limbs. The mature peptide of
            this protein is identical in all mammals examined including human,
            pig, rat and mouse. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) has an alternate 5' sequence
            and uses a downstream AUG start codon, as compared to variant 1.
            The resulting isoform (2) has a shorter N-terminus, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069773.1, X53655.1 [ECO:0000345]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1028              BC069773.1         1-1028
            1029-1168           CD672441.1         16-155              c
FEATURES             Location/Qualifiers
     source          1..1168
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1168
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /note="neurotrophin 3"
                     /db_xref="GeneID:4908"
                     /db_xref="HGNC:HGNC:8023"
                     /db_xref="MIM:162660"
     exon            1..1168
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..857
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; neurotrophic factor; nerve growth factor 2"
                     /codon_start=1
                     /product="neurotrophin-3 isoform 2 preproprotein"
                     /protein_id="NP_002518.1"
                     /db_xref="CCDS:CCDS8538.1"
                     /db_xref="GeneID:4908"
                     /db_xref="HGNC:HGNC:8023"
                     /db_xref="MIM:162660"
                     /translation="MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADIL
                     KNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSP
                     RVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVT
                     DKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCK
                     TSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT"
     regulatory      1150..1155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /note="hexamer: AGTAAA"
     polyA_site      1168
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /note="major polyA site"
ORIGIN      
        1 tgccagaata acacagactc agctgccaga gcctgctctt aacacctgtg tttccttttc
       61 agatcttaca ggtgaacaag gtgatgtcca tcttgtttta tgtgatattt ctcgcttatc
      121 tccgtggcat ccaaggtaac aacatggatc aaaggagttt gccagaagac tcgctcaatt
      181 ccctcattat taagctgatc caggcagata ttttgaaaaa caagctctcc aagcagatgg
      241 tggacgttaa ggaaaattac cagagcaccc tgcccaaagc tgaggctccc cgagagccgg
      301 agcggggagg gcccgccaag tcagcattcc agccggtgat tgcaatggac accgaactgc
      361 tgcgacaaca gagacgctac aactcaccgc gggtcctgct gagcgacagc acccccttgg
      421 agcccccgcc cttgtatctc atggaggatt acgtgggcag ccccgtggtg gcgaacagaa
      481 catcacggcg gaaacggtac gcggagcata agagtcaccg aggggagtac tcggtatgtg
      541 acagtgagag tctgtgggtg accgacaagt catcggccat cgacattcgg ggacaccagg
      601 tcacggtgct gggggagatc aaaacgggca actctcccgt caaacaatat ttttatgaaa
      661 cgcgatgtaa ggaagccagg ccggtcaaaa acggttgcag gggtattgat gataaacact
      721 ggaactctca gtgcaaaaca tcccaaacct acgtccgagc actgacttca gagaacaata
      781 aactcgtggg ctggcggtgg atacggatag acacgtcctg tgtgtgtgcc ttgtcgagaa
      841 aaatcggaag aacatgaatt ggcatctctc cccatatata aattattact ttaaattata
      901 tgatatgcat gtagcatata aatgtttata ttgtttttat atattataag ttgaccttta
      961 tttattaaac ttcagcaacc ctacagtata taagcttttt tctcaataaa atcagtgtgc
     1021 ttgccttccc tcaggcctct cccatctgtt aaaacttgtt ttgtgatccg gctctcagga
     1081 gtcactctgt aaaatctgtg tacaccagta ttttgcattc agtattgtca aggccatgac
     1141 tgttgtttta gtaaacttgt taaaatca
//
