LOCUS       NM_001102654            1341 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neurotrophin 3 (NTF3), transcript variant 1, mRNA.
ACCESSION   NM_001102654
VERSION     NM_001102654.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1341)
  AUTHORS   Xu,X., Song,L., Li,Y., Guo,J., Huang,S., Du,S., Li,W., Cao,R. and
            Cui,S.
  TITLE     Neurotrophin-3 promotes peripheral nerve regeneration by
            maintaining a repair state of Schwann cells after chronic
            denervation via the TrkC/ERK/c-Jun pathway
  JOURNAL   J Transl Med 21 (1), 733 (2023)
   PUBMED   37848983
  REMARK    GeneRIF: Neurotrophin-3 promotes peripheral nerve regeneration by
            maintaining a repair state of Schwann cells after chronic
            denervation via the TrkC/ERK/c-Jun pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1341)
  AUTHORS   Wang,H., Zhong,C., Qi,L., Fang,X. and Yuan,Y.
  TITLE     Expression and prognostic impact of NTF3 and TrkC in hepatocellular
            carcinoma
  JOURNAL   Scand J Gastroenterol 58 (11), 1309-1316 (2023)
   PUBMED   37272057
  REMARK    GeneRIF: Expression and prognostic impact of NTF3 and TrkC in
            hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1341)
  AUTHORS   Yang,Z., Zhang,H., Yin,M., Cheng,Z., Jiang,P., Feng,M., Liao,B. and
            Liu,Z.
  TITLE     Neurotrophin3 promotes hepatocellular carcinoma apoptosis through
            the JNK and P38 MAPK pathways
  JOURNAL   Int J Biol Sci 18 (15), 5963-5977 (2022)
   PUBMED   36263167
  REMARK    GeneRIF: Neurotrophin3 promotes hepatocellular carcinoma apoptosis
            through the JNK and P38 MAPK pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1341)
  AUTHORS   Cui,X., Jing,J., Wu,R., Cao,Q., Li,F., Li,K., Wang,S., Yu,L.,
            Schwartz,G., Shi,H., Xue,B. and Shi,H.
  TITLE     Adipose tissue-derived neurotrophic factor 3 regulates sympathetic
            innervation and thermogenesis in adipose tissue
  JOURNAL   Nat Commun 12 (1), 5362 (2021)
   PUBMED   34508100
  REMARK    GeneRIF: Adipose tissue-derived neurotrophic factor 3 regulates
            sympathetic innervation and thermogenesis in adipose tissue.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1341)
  AUTHORS   Rodrigues-Amorim,D., Iglesias-Martinez-Almeida,M.,
            Rivera-Baltanas,T., Fernandez-Palleiro,P., Freiria-Martinez,L.,
            Rodriguez-Jamardo,C., Comis-Tuche,M., Vallejo-Curto,M.D.C.,
            Alvarez-Ariza,M., Lopez-Garcia,M., de Las Heras,E.,
            Garcia-Caballero,A., Olivares,J.M. and Spuch,C.
  TITLE     The Role of the Second Extracellular Loop of Norepinephrine
            Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T
            Cells: A Peripheral Biomarker in the Etiology of Schizophrenia
  JOURNAL   Int J Mol Sci 22 (16), 8499 (2021)
   PUBMED   34445205
  REMARK    GeneRIF: The Role of the Second Extracellular Loop of
            Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor
            Kinase C in T Cells: A Peripheral Biomarker in the Etiology of
            Schizophrenia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1341)
  AUTHORS   Kalcheim,C., Carmeli,C. and Rosenthal,A.
  TITLE     Neurotrophin 3 is a mitogen for cultured neural crest cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1661-1665 (1992)
   PUBMED   1542658
REFERENCE   7  (bases 1 to 1341)
  AUTHORS   Ozcelik,T., Rosenthal,A. and Francke,U.
  TITLE     Chromosomal mapping of brain-derived neurotrophic factor and
            neurotrophin-3 genes in man and mouse
  JOURNAL   Genomics 10 (3), 569-575 (1991)
   PUBMED   1889807
REFERENCE   8  (bases 1 to 1341)
  AUTHORS   Maisonpierre,P.C., Le Beau,M.M., Espinosa,R. 3rd, Ip,N.Y.,
            Belluscio,L., de la Monte,S.M., Squinto,S., Furth,M.E. and
            Yancopoulos,G.D.
  TITLE     Human and rat brain-derived neurotrophic factor and neurotrophin-3:
            gene structures, distributions, and chromosomal localizations
  JOURNAL   Genomics 10 (3), 558-568 (1991)
   PUBMED   1889806
REFERENCE   9  (bases 1 to 1341)
  AUTHORS   Hallbook,F., Ibanez,C.F. and Persson,H.
  TITLE     Evolutionary studies of the nerve growth factor family reveal a
            novel member abundantly expressed in Xenopus ovary
  JOURNAL   Neuron 6 (5), 845-858 (1991)
   PUBMED   2025430
REFERENCE   10 (bases 1 to 1341)
  AUTHORS   Jones,K.R. and Reichardt,L.F.
  TITLE     Molecular cloning of a human gene that is a member of the nerve
            growth factor family
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 8060-8064 (1990)
   PUBMED   2236018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007848.11, BU939830.1,
            CN267386.1, BC069773.1 and CD672441.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001102654.1.
            
            Summary: The protein encoded by this gene is a member of the
            neurotrophin family, that controls survival and differentiation of
            mammalian neurons. This protein is closely related to both nerve
            growth factor and brain-derived neurotrophic factor. It may be
            involved in the maintenance of the adult nervous system, and may
            affect development of neurons in the embryo when it is expressed in
            human placenta. NTF3-deficient mice generated by gene targeting
            display severe movement defects of the limbs. The mature peptide of
            this protein is identical in all mammals examined including human,
            pig, rat and mouse. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.232075.1,
                                           SRR3476690.165428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423158.4/ ENSP00000397297.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC007848.11        37133-37138         c
            7-12                BU939830.1         6-11
            13-507              CN267386.1         9-503
            508-1201            BC069773.1         335-1028
            1202-1341           CD672441.1         16-155              c
FEATURES             Location/Qualifiers
     source          1..1341
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1341
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /note="neurotrophin 3"
                     /db_xref="GeneID:4908"
                     /db_xref="HGNC:HGNC:8023"
                     /db_xref="MIM:162660"
     exon            1..235
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1030
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; neurotrophic factor; nerve growth factor 2"
                     /codon_start=1
                     /product="neurotrophin-3 isoform 1 preproprotein"
                     /protein_id="NP_001096124.1"
                     /db_xref="CCDS:CCDS44806.1"
                     /db_xref="GeneID:4908"
                     /db_xref="HGNC:HGNC:8023"
                     /db_xref="MIM:162660"
                     /translation="MVTFATILQVNKVMSILFYVIFLAYLRGIQGNNMDQRSLPEDSL
                     NSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMD
                     TELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRG
                     EYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGC
                     RGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT"
     exon            236..1341
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1323..1328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /note="hexamer: AGTAAA"
     polyA_site      1341
                     /gene="NTF3"
                     /gene_synonym="HDNF; NGF-2; NGF2; NT-3; NT3"
                     /note="major polyA site"
ORIGIN      
        1 actcagagtt gaagctcctc tcccttccga acagctccgc gcaccgcccc gcgacgcagc
       61 ccggcgcaac tactttcttc tctctccttt ctttcttcct ctcctttttc ccctgctggg
      121 tagtggctgc ggcggggtgg gggagacttt gaatgaccga gctcgcgtcc acctttctct
      181 tcatgtcgac gtccctggaa acggccacac ggatgccatg gttacttttg ccacgatctt
      241 acaggtgaac aaggtgatgt ccatcttgtt ttatgtgata tttctcgctt atctccgtgg
      301 catccaaggt aacaacatgg atcaaaggag tttgccagaa gactcgctca attccctcat
      361 tattaagctg atccaggcag atattttgaa aaacaagctc tccaagcaga tggtggacgt
      421 taaggaaaat taccagagca ccctgcccaa agctgaggct ccccgagagc cggagcgggg
      481 agggcccgcc aagtcagcat tccagccggt gattgcaatg gacaccgaac tgctgcgaca
      541 acagagacgc tacaactcac cgcgggtcct gctgagcgac agcaccccct tggagccccc
      601 gcccttgtat ctcatggagg attacgtggg cagccccgtg gtggcgaaca gaacatcacg
      661 gcggaaacgg tacgcggagc ataagagtca ccgaggggag tactcggtat gtgacagtga
      721 gagtctgtgg gtgaccgaca agtcatcggc catcgacatt cggggacacc aggtcacggt
      781 gctgggggag atcaaaacgg gcaactctcc cgtcaaacaa tatttttatg aaacgcgatg
      841 taaggaagcc aggccggtca aaaacggttg caggggtatt gatgataaac actggaactc
      901 tcagtgcaaa acatcccaaa cctacgtccg agcactgact tcagagaaca ataaactcgt
      961 gggctggcgg tggatacgga tagacacgtc ctgtgtgtgt gccttgtcga gaaaaatcgg
     1021 aagaacatga attggcatct ctccccatat ataaattatt actttaaatt atatgatatg
     1081 catgtagcat ataaatgttt atattgtttt tatatattat aagttgacct ttatttatta
     1141 aacttcagca accctacagt atataagctt ttttctcaat aaaatcagtg tgcttgcctt
     1201 ccctcaggcc tctcccatct gttaaaactt gttttgtgat ccggctctca ggagtcactc
     1261 tgtaaaatct gtgtacacca gtattttgca ttcagtattg tcaaggccat gactgttgtt
     1321 ttagtaaact tgttaaaatc a
//
