LOCUS       NM_018024               1519 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens N-terminal glutamine amidase 1 (NTAQ1), transcript
            variant 1, mRNA.
ACCESSION   NM_018024
VERSION     NM_018024.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1519)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 1519)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 1519)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1519)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1519)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1519)
  AUTHORS   Park,M.S., Bitto,E., Kim,K.R., Bingman,C.A., Miller,M.D., Kim,H.J.,
            Han,B.W. and Phillips,G.N. Jr.
  TITLE     Crystal structure of human protein N-terminal glutamine
            amidohydrolase, an initial component of the N-end rule pathway
  JOURNAL   PLoS One 9 (10), e111142 (2014)
   PUBMED   25356641
  REMARK    GeneRIF: the peptide backbone recognition patch of hNtaq1 forms
            nonspecific interactions with N-terminal peptides of substrate
            proteins
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1519)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 1519)
  AUTHORS   Wang,H., Piatkov,K.I., Brower,C.S. and Varshavsky,A.
  TITLE     Glutamine-specific N-terminal amidase, a component of the N-end
            rule pathway
  JOURNAL   Mol Cell 34 (6), 686-695 (2009)
   PUBMED   19560421
REFERENCE   9  (bases 1 to 1519)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   10 (bases 1 to 1519)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001066.1 and AC021305.9.
            
            On May 17, 2019 this sequence version replaced NM_018024.2.
            
            Transcript Variant: This variant (1)  encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.173339.1,
                                           SRR1803615.207364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287387.7/ ENSP00000287387.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1299              AK001066.1         50-1348
            1300-1519           AC021305.9         137381-137600
FEATURES             Location/Qualifiers
     source          1..1519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..1519
                     /gene="NTAQ1"
                     /gene_synonym="C8orf32; WDYHV1"
                     /note="N-terminal glutamine amidase 1"
                     /db_xref="GeneID:55093"
                     /db_xref="HGNC:HGNC:25490"
                     /db_xref="MIM:620846"
     exon            1..159
                     /gene="NTAQ1"
                     /gene_synonym="C8orf32; WDYHV1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..694
                     /gene="NTAQ1"
                     /gene_synonym="C8orf32; WDYHV1"
                     /EC_number="3.5.1.122"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein N-terminal glutamine amidohydrolase;
                     nt(Q)-amidase; N-terminal Gln amidase; WDYHV
                     motif-containing protein 1; protein NH2-terminal glutamine
                     deamidase; WDYHV motif containing 1"
                     /codon_start=1
                     /product="protein N-terminal glutamine amidohydrolase
                     isoform 1"
                     /protein_id="NP_060494.1"
                     /db_xref="CCDS:CCDS6344.1"
                     /db_xref="GeneID:55093"
                     /db_xref="HGNC:HGNC:25490"
                     /db_xref="MIM:620846"
                     /translation="MEGNGPAAVHYQPASPPRDACVYSSCYCEENIWKLCEYIKNHDQ
                     YPLEECYAVFISNERKMIPIWKQQARPGDGPVIWDYHVVLLHVSSGGQNFIYDLDTVL
                     PFPCLFDTYVEDAFKSDDDIHPQFRRKFRVIRADSYLKNFASDRSHMKDSSGNWREPP
                     PPYPCIETGDSKMNLNDFISMDPKVGWGAVYTLSEFTHRFGSKNC"
     exon            160..259
                     /gene="NTAQ1"
                     /gene_synonym="C8orf32; WDYHV1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..310
                     /gene="NTAQ1"
                     /gene_synonym="C8orf32; WDYHV1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..459
                     /gene="NTAQ1"
                     /gene_synonym="C8orf32; WDYHV1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..584
                     /gene="NTAQ1"
                     /gene_synonym="C8orf32; WDYHV1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..1519
                     /gene="NTAQ1"
                     /gene_synonym="C8orf32; WDYHV1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1280..1285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NTAQ1"
                     /gene_synonym="C8orf32; WDYHV1"
                     /note="hexamer: AATAAA"
     polyA_site      1300
                     /gene="NTAQ1"
                     /gene_synonym="C8orf32; WDYHV1"
                     /note="major polyA site"
ORIGIN      
        1 actacaagcc cgccctttcc tacgtctggt ccagtcggtc ttcctccggc ccgggccctg
       61 gcccagctag ccggccatgg aaggtaatgg ccccgctgct gtccactacc agccggccag
      121 ccccccgcgg gacgcctgcg tctacagcag ctgctactgt gaagaaaata tttggaagct
      181 ctgtgaatac atcaaaaacc atgaccagta tcctttagaa gaatgttatg ctgtcttcat
      241 atctaatgag aggaagatga tacctatctg gaaacaacag gcgagacctg gagatggacc
      301 tgtgatctgg gattaccatg ttgttttgct tcatgtttca agtggaggac agaacttcat
      361 ttatgatctc gatactgtct tgccatttcc ctgcctcttt gacacttatg tagaagatgc
      421 ctttaagtct gatgatgaca ttcacccaca gtttaggagg aaatttagag tgatccgtgc
      481 agattcatat ttgaagaact ttgcttctga ccgatctcac atgaaagact ccagtgggaa
      541 ttggagagag cctccgccgc catatccctg cattgagact ggagattcca aaatgaacct
      601 gaacgatttc atcagtatgg atcccaaggt aggatggggc gccgtctaca cactatccga
      661 atttacacat cggtttggca gtaaaaactg ctgaacttgg tctcaagatg tggaactgtg
      721 gagaaattct aggacatgaa caagctatcc tttcatcgag gacagcaaac attatggtac
      781 agttggcttg gaattatgtc tttctctttt aatttgattg agtggaaatc tgagtgaata
      841 caaatataaa tgaacaacat aaaaactttt gttttgacat gtcaaattga aacttgataa
      901 agtgcgtact tgctaagata ttcctgtggc tcatgcgtta caacacgagg acttaagcca
      961 gtaatcgttt ttgttcagat agaggtgtgg aggtagagcc agcccctcat gtctgttttg
     1021 gatgttttgt gtctctccag ctacattgta agttccttga gggcagggcc atggcccatt
     1081 gctctgtgaa tctcaaatgc ccataaaagg tgcccataaa atgttttctt gaacatttga
     1141 atgtgctgtt gtctggaaag gggtaatatt gtgagctgaa tcagcaataa gtattagtct
     1201 ttttggacta tggtattgtt aaaaagactg cagccctctc agacttgagc gttaattggc
     1261 ttatttattt atggctttaa ataaaatcga tttaacgtta gttttgtttt gaagattttt
     1321 gtgtcaccct tgatgatctg aaatacctaa atatgcctca attgtagatg agaaccaggg
     1381 ctttaaaaaa tatttattac atgtgccttc tggaagacat cttggttatt tggctttaat
     1441 catatcattc caaatgaaag atatttggca ttacattggc atatagtacc agctctcatg
     1501 ttttcatgat tctacttta
//
