LOCUS       NM_001031701            7244 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens 5'-nucleotidase domain containing 3 (NT5DC3), mRNA.
ACCESSION   NM_001031701
VERSION     NM_001031701.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7244)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 7244)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   3  (bases 1 to 7244)
  AUTHORS   Sampietro,M.L., Trompet,S., Verschuren,J.J., Talens,R.P.,
            Deelen,J., Heijmans,B.T., de Winter,R.J., Tio,R.A.,
            Doevendans,P.A., Ganesh,S.K., Nabel,E.G., Westra,H.J., Franke,L.,
            van den Akker,E.B., Westendorp,R.G., Zwinderman,A.H., Kastrati,A.,
            Koch,W., Slagboom,P.E., de Knijff,P. and Jukema,J.W.
  TITLE     A genome-wide association study identifies a region at chromosome
            12 as a potential susceptibility locus for restenosis after
            percutaneous coronary intervention
  JOURNAL   Hum Mol Genet 20 (23), 4748-4757 (2011)
   PUBMED   21878436
REFERENCE   4  (bases 1 to 7244)
  AUTHORS   Lesch,K.P., Timmesfeld,N., Renner,T.J., Halperin,R., Roser,C.,
            Nguyen,T.T., Craig,D.W., Romanos,J., Heine,M., Meyer,J.,
            Freitag,C., Warnke,A., Romanos,M., Schafer,H., Walitza,S., Reif,A.,
            Stephan,D.A. and Jacob,C.
  TITLE     Molecular genetics of adult ADHD: converging evidence from
            genome-wide association and extended pedigree linkage studies
  JOURNAL   J Neural Transm (Vienna) 115 (11), 1573-1585 (2008)
   PUBMED   18839057
REFERENCE   5  (bases 1 to 7244)
  AUTHORS   van den Akker,E., Vankan-Berkhoudt,Y., Valk,P.J., Lowenberg,B. and
            Delwel,R.
  TITLE     The common viral insertion site Evi12 is located in the
            5'-noncoding region of Gnn, a novel gene with enhanced expression
            in two subclasses of human acute myeloid leukemia
  JOURNAL   J Virol 79 (9), 5249-5258 (2005)
   PUBMED   15827139
REFERENCE   6  (bases 1 to 7244)
  AUTHORS   Yatsuoka,T., Furukawa,T., Sunamura,M., Matsuno,S. and Horii,A.
  TITLE     TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently
            deleted in pancreatic cancer, shows reduced expression in
            pancreatic cancer cells
  JOURNAL   Oncol Rep 12 (6), 1263-1268 (2004)
   PUBMED   15547748
  REMARK    GeneRIF: TU12B1-TY may contribute to the development and/or
            progression of human pancreatic cancer
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012555.27, BC052293.1 and AC025265.21.
            
            On Nov 23, 2018 this sequence version replaced NM_001031701.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032773.1, BC052293.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392876.8/ ENSP00000376615.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC012555.27        26090-26126
            38-1843             BC052293.1         1-1806
            1844-5823           AC012555.27        89614-93593
            5824-7244           AC025265.21        1-1421
FEATURES             Location/Qualifiers
     source          1..7244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..7244
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /note="5'-nucleotidase domain containing 3"
                     /db_xref="GeneID:51559"
                     /db_xref="HGNC:HGNC:30826"
                     /db_xref="MIM:611076"
     exon            1..286
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1725
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /codon_start=1
                     /product="5'-nucleotidase domain-containing protein 3"
                     /protein_id="NP_001026871.1"
                     /db_xref="CCDS:CCDS41824.1"
                     /db_xref="GeneID:51559"
                     /db_xref="HGNC:HGNC:30826"
                     /db_xref="MIM:611076"
                     /translation="MTMAAAAVVARGAGARAATAAALRGGCGTAARGRPCAGPARPLC
                     TAPGTAPDMKRYLWERYREAKRSTEELVPSIMSNLLNPDAIFSNNEMSLSDIEIYGFD
                     YDYTLVFYSKHLHTLIFNAARDLLINEHRYPAEIRKYEYDPNFAIRGLHYDVQRAVLM
                     KIDAFHYIQLGTVYRGLSVVPDEEVIEMYEGSHVPLEQMSDFYGKSSHGNTMKQFMDI
                     FSLPEMTLLSCVNEYFLKNNIDYEPVHLYKDVKDSIRDVHIKGIMYRAIEADIEKYIC
                     YAEQTRAVLAKLADHGKKMFLITNSPSSFVDKGMSYIVGKDWRDLFDVVIVQAEKPNF
                     FNDKRRPFRKMNEKGVLLWDKIHKLQKGQIYKQGNLYEFLKLTGWRGSRVLYFGDHIY
                     SDLADLTLKHGWRTGAIIPELRSELKIMNTEQYIQTMTWLQTLTGLLEQMQVHRDAES
                     QLVLQEWKKERKEMREMTKSFFNAQFGSLFRTDQNPTYFLRRLSRFADIYMASLSCLL
                     NYDVSHTFYPRRTPLQHELPAWSERPPTFGTPLLQEAQAK"
     exon            287..471
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            472..546
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            547..602
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            603..693
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            694..831
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            832..892
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            893..995
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1097
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1179
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1266
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1407
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1472
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..7244
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7226..7231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /note="hexamer: AATAAA"
     polyA_site      7244
                     /gene="NT5DC3"
                     /gene_synonym="TU12B1-TY; TU12B1TY"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcggg tagatcttgg gccgggcagc agcagtcgca gagcggcgcg gcggcggtgg
       61 cggcagcagg cagcaggcat gaccatggca gcggcggcgg tggtggcacg cggggccggg
      121 gcgagggcag cgacagcggc ggctttgcgg ggtggctgcg ggaccgcggc tcgggggcgg
      181 ccgtgtgcgg gccccgcccg gcccttgtgc actgcacccg ggaccgcccc ggacatgaag
      241 cgctacctgt gggagcgcta ccgggaggcg aagagaagca cagaagaatt ggttccttcc
      301 attatgagca acttgttgaa tccagatgcc attttctcaa acaatgaaat gagcctgtca
      361 gacattgaaa tctatggctt cgattatgat tacaccttgg tgttttattc aaagcacctc
      421 cacacgctga tatttaatgc tgcacgggac cttctcatca atgaacaccg gtatccagca
      481 gaaatcagga agtatgagta tgacccaaat tttgcaattc gtggacttca ttatgatgta
      541 cagcgggcag tattaatgaa gatcgatgct tttcattata tccagctggg aactgtctac
      601 agaggcctca gtgttgtccc tgatgaagaa gtcattgaaa tgtacgaggg gtcccacgtg
      661 cccttggagc agatgagtga cttttacgga aagagctctc atggaaacac gatgaagcag
      721 ttcatggaca tcttctccct gcccgagatg accctcctgt cctgcgtgaa tgaatacttc
      781 ctcaagaaca acatcgacta tgagcctgtg catctgtaca aagatgtcaa ggattcaatt
      841 cgagacgtcc acatcaaagg aataatgtac agagcaattg aagcagacat tgaaaagtac
      901 atctgctatg ctgagcagac ccgcgcagtg ttggccaaac tggctgatca tggcaagaag
      961 atgtttctca tcaccaatag ccccagtagc tttgtggaca aagggatgag ttatatcgtt
     1021 gggaaagact ggagggacct gttcgatgtg gtcattgttc aggctgagaa gccaaacttc
     1081 tttaatgata agcggaggcc tttccgaaag atgaatgaga aaggtgtctt actctgggat
     1141 aaaatccata agttgcagaa aggccagata tacaagcagg gtaatttata tgaatttttg
     1201 aagcttactg gatggagagg atccagagtg ttgtattttg gtgaccatat atacagtgac
     1261 ctggcggatt tgaccctaaa gcatggctgg aggactggtg caatcatccc agagttgaga
     1321 tctgagctca aaatcatgaa cacggagcaa tacattcaaa ccatgacctg gctgcagacc
     1381 ttgactggct tattggaaca gatgcaggtt cacagagatg ctgagtcaca gctggttttg
     1441 caggagtgga aaaaggaaag gaaggagatg cgagaaatga ccaagagttt cttcaatgcc
     1501 cagtttggaa gcctgttccg cacagaccag aacccaacct acttcctaag gcgcctgtcg
     1561 cgcttcgctg acatctacat ggcgtctctg agctgcctcc tgaactatga cgtcagccac
     1621 actttctacc cccggaggac tccactgcag cacgaactgc ccgcctggtc agaaaggccc
     1681 cccaccttcg gaacccctct cctgcaggag gcccaggcca agtagccaag ggcaaaaact
     1741 agaaactgta actgcccctg attgggcagg catgatgggg ttgacttcat gtgggtctga
     1801 gtgttgcttt tggaaaagat acagataagc cttttgatat ttattttgta ccttacggag
     1861 aataattctc ccaatggtta agacaggagc tagcagccca cccctccagc ctttcccccc
     1921 atgcagggct gaaaggcaag cttcacattg gaactctgat tttgcctttt tgtttactga
     1981 ggtcctggaa catcaggttt cctgggatag gtgagaccac ttgatgccat gtctgtattc
     2041 tagcaggtca agcttgaaac ggttcttgac tcctccatgg aacatttcct gaacatttac
     2101 gggctatgca ttgggaactg caggggcaca gtgatgggca aagattagct gcttccagaa
     2161 ggctgatttc gtgggctcca caatggtaaa acgctgctgt gagtggcaga gaggttcccc
     2221 aggtgatggc cagttcccaa atcatttggt actaaggctt tgacattctg gcacatcaca
     2281 tcaaatagaa cacagcctcc ctggaaggac ttaagtgaga aagaacaaga gaagctgcaa
     2341 ctcctggacc cttttgtcct cagtgtgtgg ttcctgcgtc cttccccagc atggaggagg
     2401 gcaggagaga ggagatgaga gctctggtca aaacctgcca gctagtggaa cagccttctg
     2461 tagagccttc tgcaagaaac gagtgggttt gaagaaccaa aacatttgtg gtaggtctcc
     2521 caggagcttg ttaaacctgg aaacaccacc tgagttggtt tcatctgctc attggaagaa
     2581 agaaaatgaa ccaggaaaaa gcatctttgt catgaaatgc tatgccatgc cacccaccca
     2641 gttgaattgg aatcctgtta aaacatgaga tttaccagaa acagtccttt gtctagatgg
     2701 aaacaaacaa gatcctggct tctctctaat gagttaccaa ctgagaggtg cttggattgg
     2761 ccaggggagg aggaagatgg ccaccacaac ttagccatgt ccagccttct cttagatttc
     2821 actcctgtga tgtttgtgcg actatttggg agtttgtgta gtttgttttt tttttttttg
     2881 ttttgttttg ttttttttta gatgtctaag atgggaaagg gcgaaggaca ttgaagctaa
     2941 ggaatagata tgacctagct aaccaagctt ttctcatttc cttctgtttt gttttgttga
     3001 gatggagttt tgctcttatt gcccaggctg gagtgcagtg gcacaatctc agctcactgc
     3061 aacctctgcc tcccgggttc aagcgattct cctgcctcag cctcccaagt agctgggatt
     3121 acaggcatgc actaccacac ccagctaatt ttgtatttct agtagagatg gggtttctcc
     3181 atgttggtca ggctggtctc gaactcccga cctcagataa tctgcccgcc ttggcctccc
     3241 aaattgctgg gattacaggt gtgagccacc gcacctggcc tgcttttttc atttctttct
     3301 aggggcaatg caagtggcat gtattccttt tgttggaggg aagaatcctt aattgcacct
     3361 gcatttgtag tatccttcaa tgtaaagtgc atatttactg cactctctga gtgctatggg
     3421 aatgtctgct gttattagtt atggggctgc taatactgtt ttaattgcat atgctatatc
     3481 aatacttctg ttcagattag cctaatctag tattgctaaa actcatttta agcttttgcg
     3541 gtaacttgta tatattctta aatctaaagg atggcaggaa catgagggga gcttgtggag
     3601 agtgcttgct tattcaacat ttttattgtg ataaatgtat gtaaccatct attgatgaaa
     3661 tccaagtctg gcattccatg ggctccttgc cagatggcag aaacttaatg agttatatag
     3721 catcctttgt aatgctgctt gttatagttg gaatgtactt gtgatatttg gctgtattta
     3781 actataatgg tgaaggtgac cctttagatc caataaggct tctccccatc ttctacattt
     3841 tgttatgaac acagtaaggc acagtagtat gttctttttt tggaacaggg taggcatttt
     3901 gtttattgtt tgcttgcttc taggtgtttt cgccatcagg gtgtattgga ggctgacact
     3961 taatgggtgt gtgttgcgcc cagaactgct cggtgtcggg gttctaaaag aatgcgctgg
     4021 tgttcttggc ttcaagtttc tgctttggag aagcagattc aggaagtagg tgttgcttaa
     4081 aaataattct tggtttttat ctaatcagat attcattgat tacctaccag gtgccagtta
     4141 tagggtgttt tgtttactca agaatgaagt agaactattt ttaaaacctg tttccatgag
     4201 tgttcacgtt aggtgaccta agctttgaag gagaaaaaca tttttgggta tgaataatga
     4261 gttttgtaat caattcccag ttagaagaat ttcagtctct gggccattga gcttggcagt
     4321 gttgagatct cccatgtgac agaagcctga catctgggcc accaaggctc actgactgtg
     4381 taccttgcag actgtagacc catgtcgtgg cggtaacggg gccgaacaca gtcattccca
     4441 tgtgaacgat ggaggcacat cccactttat tattaatcct tgtatatact cagtcaggac
     4501 agattttaac ttgtcgctgt catgactttt tttttttttt tttgaggcaa ggtctcgctc
     4561 tgttgcccat tctggagtgc agtggtgtga tctcggctca ctgcaacctc ttgcctccca
     4621 ggttcaagca attttcgtgc ctcagcctcc cgagtagctg ggactactgg tacatgccac
     4681 caggcctggc caagttttgt agttttaata gagatggggt ttcaccatgt tggccaggct
     4741 ggtctcaaac tcctagcctc aagtgttctg cccacctcag ccttccaaag tgctgggatt
     4801 ctgggtgtga gccactgtca tgcctggcct cgtcatgact cttttctctt tttttttttt
     4861 tttttttttg agatttagtt ttgctctttt tgcccaggcc ggagtgcaat ggcacgatct
     4921 tggctcactc caacctccgc ctcctgggtt caagtgattc tcctgcctca gcctcccgag
     4981 tagctgggat tacaggtgcc caccaccaca tccagctaat ttttttgtat ttttagtaga
     5041 gacggggttt caccatgttg gccaggctgg tctcgaactc ctgaccttgg gtaatccacc
     5101 tgccttggcc tcccaaggtg ctgggattac aggcatgagc caccgtgccc agcctatcat
     5161 gactcaactg ggatctggca cactgcactg ggtgttttgt tctctgatgt gcacattgat
     5221 gaatgcatat tggtacaagg gaaatgaatc tgttttcagc catttaaaaa attgtgttgt
     5281 aaagcaaaca aaaatagctt gaacatttaa aaattactgt ttaatattgt ttgactgatt
     5341 ttctaagaat tatgtgaaca atgatgagtc cagggcagca gccatcacaa atatgacagt
     5401 ccagcaaggc ccatggaggt ccctttggaa gggacttgca cagctgattt tctttttcca
     5461 gtgttgtttt tacgggtgaa acgtggcttt tgaaatactt tagttgtttg gcttagagct
     5521 cccactttcc ccctaacata gtgcctgtct gttttttaaa acattttacc cttcggcact
     5581 attttctgct attcccatta atattatgta acataaacca cttgctactg atttgggcat
     5641 attacagact acaattacta gttgctttga atgcattggc actcttaatt attgcaaagg
     5701 agaattgaaa agtagtcttg tggtcctagt taatttagct ttgggcaaac taagtggctt
     5761 ttcttctgtc ctcttctcaa aaggcctttt aagcagcaga gactgggcta aatactggaa
     5821 ctgaattcca cttttctgcc tgctcatttg ctgccaaaga ccacttgggg ctccttgtct
     5881 agaatgctct aagacgaaat ttggccagac acagggttcc ttgattgttc tgttcaacta
     5941 atagagaacc tacattttgc cttcttaata tcgactttct tttgtaccag gtttttcttt
     6001 ctttcttttt tgccttagga gcttagctca aagttcagct aacctttgac actactagtg
     6061 tcatttagta acagtaatct ttgacactac tagtgtcatt taggagctta gctcaaagtt
     6121 cagctaacct ttgacactgc tagtgcgttc aagaaagggt agggaatgaa gtacccttaa
     6181 tgcagggtca gcaaactttt cctgtaaaag gccagatagg aagtattttt ggctttttgg
     6241 gctgtttgct tttgctacta ctactgtggg aatgaccatg gtcatggctg tgttccagca
     6301 caacttgatt taccaagaca agctgtgggc tgtatttggt cctcaggctg tggcttgcta
     6361 gcccctgctc taatggattg tgttggcggc aatggcaaga ttcccttgct gagaacatgc
     6421 agatgaataa ccttatagct gggatgcaga gaggagaaag ttctgtaggt aataagtgca
     6481 ctgtattccc tctgagctac ttcctgggca tagttacatg tatggccagt gtgtgtactt
     6541 gagccatcag gctcagacac ttgttgaata tacctctcat tgcattagtt tgtaattgtg
     6601 ctagtgctgg gtgctgagct cagctgcccg gatgaccttt ccagactgaa ggacatactc
     6661 ccctaacagc tgggagtgct gctggctggc catttacttc cagcccttat gaggagtttc
     6721 ccctgctgaa gagccctgcc tgccccagat cataccccct tcctgcctgt aacccttacc
     6781 ggctccatat ggggtacaaa gggctggcct cctcacccca acttgggaaa ccctctgggg
     6841 ccatcccagc tccagagccc cttgtggggt cagtgagacc tcattgtggc cacattacag
     6901 cccagtgcct ctccctgaca agcctgtacc cagccggctc agcccacagc actgtcctat
     6961 gaaccttcct gcacgccatt ctccacctca gtatctgctt tcggggaacc caacctgcga
     7021 cagtgcttct gtgtgttttc agtcctgcag gtttgaactc tgactttgga gacttttcca
     7081 gttatctcgt ggaatgacag attgtgcctg tatgatatca ggcacaatta atgcaaatta
     7141 ggcagaccta tttattctag atgtgaattt gctatttatt ttaaatgttg attttatgtg
     7201 ttatgtgact ctgaacttat tgccaaataa aagtttgaat tgta
//
