LOCUS       NM_001134231            1877 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens 5'-nucleotidase domain containing 2 (NT5DC2),
            transcript variant 1, mRNA.
ACCESSION   NM_001134231
VERSION     NM_001134231.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1877)
  AUTHORS   Sang,R., Yu,X., Xia,H., Qian,X., Yong,J., Xu,Y., Sun,Y., Yao,Y.,
            Zhou,J. and Zhuo,S.
  TITLE     NT5DC2 knockdown suppresses progression, glycolysis, and
            neuropathic pain in triple-negative breast cancer by blocking the
            EGFR pathway
  JOURNAL   Mol Carcinog 63 (4), 785-796 (2024)
   PUBMED   38289126
  REMARK    GeneRIF: NT5DC2 knockdown suppresses progression, glycolysis, and
            neuropathic pain in triple-negative breast cancer by blocking the
            EGFR pathway.
REFERENCE   2  (bases 1 to 1877)
  AUTHORS   Sha,R., Zhang,J., Meng,F. and Zhaori,G.
  TITLE     Gastric cancer metastasis-related NT5DC2 indicates unfavorable
            prognosis of patients
  JOURNAL   Medicine (Baltimore) 102 (40), e35030 (2023)
   PUBMED   37800836
  REMARK    GeneRIF: Gastric cancer metastasis-related NT5DC2 indicates
            unfavorable prognosis of patients.
REFERENCE   3  (bases 1 to 1877)
  AUTHORS   Cui,Y., Wen,Y., Lv,C., Zhao,D., Yang,Y., Qiu,H. and Wang,C.
  TITLE     Decreased RNA-binding protein IGF2BP2 downregulates NT5DC2, which
            suppresses cell proliferation, and induces cell cycle arrest and
            apoptosis in diffuse large B-cell lymphoma cells by regulating the
            p53 signaling pathway
  JOURNAL   Mol Med Rep 26 (3) (2022)
   PUBMED   35894142
  REMARK    GeneRIF: Decreased RNAbinding protein IGF2BP2 downregulates NT5DC2,
            which suppresses cell proliferation, and induces cell cycle arrest
            and apoptosis in diffuse large Bcell lymphoma cells by regulating
            the p53 signaling pathway.
            Erratum:[Mol Med Rep. 2023 Mar;27(3):67. doi:
            10.3892/mmr.2023.12954.. PMID: 36799157]
REFERENCE   4  (bases 1 to 1877)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 1877)
  AUTHORS   Zhu,Z., Hou,Q. and Guo,H.
  TITLE     NT5DC2 knockdown inhibits colorectal carcinoma progression by
            repressing metastasis, angiogenesis and tumor-associated macrophage
            recruitment: A mechanism involving VEGF signaling
  JOURNAL   Exp Cell Res 397 (1), 112311 (2020)
   PUBMED   32991874
  REMARK    GeneRIF: NT5DC2 knockdown inhibits colorectal carcinoma progression
            by repressing metastasis, angiogenesis and tumor-associated
            macrophage recruitment: A mechanism involving VEGF signaling.
REFERENCE   6  (bases 1 to 1877)
  AUTHORS   Li,K.S., Zhu,X.D., Liu,H.D., Zhang,S.Z., Li,X.L., Xiao,N.,
            Liu,X.F., Xu,B., Lei,M., Zhang,Y.Y., Shi,W.K., Cao,M.Q., Xu,Y.F.,
            Tang,Z.Y. and Sun,H.C.
  TITLE     NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in
            hepatocellular carcinoma
  JOURNAL   Cell Death Dis 11 (5), 335 (2020)
   PUBMED   32382041
  REMARK    GeneRIF: NT5DC2 promotes tumor cell proliferation by stabilizing
            EGFR in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1877)
  AUTHORS   Guo,S., Ran,H., Xiao,D., Huang,H., Mi,L., Wang,X., Chen,L., Li,D.,
            Zhang,S., Han,Q., Zhou,T., Li,A. and Man,J.
  TITLE     NT5DC2 promotes tumorigenicity of glioma stem-like cells by
            upregulating fyn
  JOURNAL   Cancer Lett 454, 98-107 (2019)
   PUBMED   30978441
  REMARK    GeneRIF: Disruption of NT5DC2 in GSCs markedly reduces the
            expression of Fyn, a Src family proto-oncogene that has been
            implicated in the regulation of GBM progression. The expression of
            NT5DC2 strongly correlated with increased aggression of human
            gliomas, but not that of other brain tumors.
REFERENCE   8  (bases 1 to 1877)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   9  (bases 1 to 1877)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   10 (bases 1 to 1877)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112215.3, DR003312.1, AW510639.1, AK022504.1 and AK023995.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001134231.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.101990.1,
                                           SRR1163657.231428.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422318.7/ ENSP00000406933.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC112215.3         83694-83773         c
            81-256              DR003312.1         8-183
            257-591             AW510639.1         116-450
            592-1653            AK022504.1         315-1376
            1654-1877           AK023995.1         1834-2057
FEATURES             Location/Qualifiers
     source          1..1877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..1877
                     /gene="NT5DC2"
                     /note="5'-nucleotidase domain containing 2"
                     /db_xref="GeneID:64943"
                     /db_xref="HGNC:HGNC:25717"
                     /db_xref="MIM:621077"
     exon            1..352
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1794
                     /gene="NT5DC2"
                     /EC_number="3.1.3.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     5'-nucleotidase domain-containing protein 2"
                     /codon_start=1
                     /product="5'-nucleotidase domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_001127703.1"
                     /db_xref="CCDS:CCDS46843.1"
                     /db_xref="GeneID:64943"
                     /db_xref="HGNC:HGNC:25717"
                     /db_xref="MIM:621077"
                     /translation="MAGAGLRAAARRWLLCGGHGGPRAASSSPSCPGCGPPGPGAHCP
                     GVPRSAPAQAPTSGADLSAHLWARYQDMRRLVHDLLPPEVCSLLNPAAIYANNEISLR
                     DVEVYGFDYDYTLAQYADALHPEIFSTARDILIEHYKYPEGIRKYDYNPSFAIRGLHY
                     DIQKSLLMKIDAFHYVQLGTAYRGLQPVPDEEVIELYGGTQHIPLYQMSGFYGKGPSI
                     KQFMDIFSLPEMALLSCVVDYFLGHSLEFDQAHLYKDVTDAIRDVHVKGLMYQWIEQD
                     MEKYILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMRHMVGPDWRQLFDVVIVQ
                     ADKPSFFTDRRKPFRKLDEKGSLQWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLY
                     FGDHLYSDLADLMLRHGWRTGAIIPELEREIRIINTEQYMHSLTWQQALTGLLERMQT
                     YQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMA
                     SLSCLLNYRVDFTFYPRRTPLQHEAPLWMDQLCTGCMKTPFLGDMAHIR"
     exon            353..537
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..612
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..668
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            669..762
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..891
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..952
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1055
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1157
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1239
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1326
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1467
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1532
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1877
                     /gene="NT5DC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NT5DC2"
                     /note="hexamer: AATAAA"
     polyA_site      1877
                     /gene="NT5DC2"
                     /note="major polyA site"
ORIGIN      
        1 attggccggc cgccgtgagg agcacgaggc caccgtggcg ggcgcgcagt cggagggcgg
       61 cgggcggcgg gcggcgggct ggccgagggc agcgcgggcg gcgggcggcg cgcggtgggc
      121 atggcgggtg cggggctgcg ggcggccgct cggcgctggc tgctgtgcgg aggccacggc
      181 gggccgcgag ccgcctcgtc ctcgccctcc tgccctgggt gcggcccccc gggtcccggc
      241 gcccactgcc ccggcgtccc gcgctccgcg cccgcccagg cacccaccag cggcgccgac
      301 ctcagcgcgc acctatgggc tcgctaccag gacatgcgga gactggtgca cgacctcctg
      361 ccccccgagg tctgcagtct cctgaaccca gcagccatct acgccaacaa cgagatcagc
      421 ctgcgtgacg ttgaggtcta cggctttgac tacgactaca ccctggccca gtatgcagac
      481 gcactgcacc ccgagatctt cagtaccgcc cgtgacatcc tgatcgagca ctacaagtac
      541 ccagaaggga ttcggaagta tgactacaac cccagctttg ccatccgtgg cctccactat
      601 gacattcaga agagccttct gatgaagatt gacgccttcc actacgtgca gctggggaca
      661 gcctacaggg gcctccagcc tgtgccagac gaggaggtga ttgagctgta tgggggtacc
      721 cagcacatcc cactatacca gatgagtggc ttctatggca agggtccctc cattaagcag
      781 ttcatggaca tcttctcgct accggagatg gctctgctgt cctgtgtggt ggactacttt
      841 ctgggccaca gcctggagtt tgaccaagca catctctaca aggacgtgac ggacgccatc
      901 cgagacgtgc atgtgaaggg cctcatgtac cagtggatcg agcaggacat ggagaagtac
      961 atcctgagag gggatgagac gtttgctgtc ctgagccgcc tggtggccca tgggaaacag
     1021 ctgttcctca tcaccaacag tcctttcagc ttcgtagaca aggggatgcg gcacatggtg
     1081 ggtcccgatt ggcgccagct cttcgatgtg gtcattgtcc aggcagacaa gcccagcttc
     1141 ttcactgacc ggcgcaagcc tttcagaaaa ctcgatgaga agggctcact tcagtgggac
     1201 cggatcaccc gcttggaaaa gggcaagatc tatcggcagg gaaacctgtt tgacttctta
     1261 cgcttgacgg aatggcgtgg cccccgcgtg ctctacttcg gggaccacct ctatagtgat
     1321 ctggcggatc tcatgctgcg gcacggctgg cgcacaggcg ccatcatccc cgagctggag
     1381 cgtgagatcc gcatcatcaa cacggagcag tacatgcact cgctgacgtg gcagcaggcg
     1441 ctcacggggc tgctggagcg catgcagacc tatcaggacg cggagtcgag gcaggtgctg
     1501 gctgcctgga tgaaagagcg gcaggagctg aggtgcatca ccaaggccct gttcaatgcg
     1561 cagttcggca gcatcttccg caccttccac aaccccacct acttctcaag gcgcctcgtg
     1621 cgcttctctg acctctacat ggcctccctc agctgcctgc tcaactaccg cgtggacttc
     1681 accttctacc cacgccgtac gccgctgcag cacgaggcac ccctctggat ggaccagctc
     1741 tgcaccggct gcatgaagac ccccttcctt ggtgacatgg cccacatccg ctgagggcac
     1801 ctttattgtc tgggacaggc cctcagcccc tcctgcccca tccacccaga caagcaataa
     1861 aagtggtctc ctccctg
//
