LOCUS       NM_152729               6919 bp    mRNA    linear   PRI 24-JAN-2025
DEFINITION  Homo sapiens 5'-nucleotidase domain containing 1 (NT5DC1), mRNA.
ACCESSION   NM_152729 NM_032519
VERSION     NM_152729.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6919)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6919)
  AUTHORS   Geng,R., Li,Z., Yu,S., Yuan,C., Hong,W., Wang,Z., Wang,Q., Yi,Z.
            and Fang,Y.
  TITLE     Weighted gene co-expression network analysis identifies specific
            modules and hub genes related to subsyndromal symptomatic
            depression
  JOURNAL   World J Biol Psychiatry 21 (2), 102-110 (2020)
   PUBMED   30489189
  REMARK    GeneRIF: Weighted gene co-expression network analysis identifies
            specific modules and hub genes related to subsyndromal symptomatic
            depression.
REFERENCE   3  (bases 1 to 6919)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 6919)
  AUTHORS   Fritsche,L.G., Chen,W., Schu,M., Yaspan,B.L., Yu,Y.,
            Thorleifsson,G., Zack,D.J., Arakawa,S., Cipriani,V., Ripke,S.,
            Igo,R.P. Jr., Buitendijk,G.H., Sim,X., Weeks,D.E., Guymer,R.H.,
            Merriam,J.E., Francis,P.J., Hannum,G., Agarwal,A., Armbrecht,A.M.,
            Audo,I., Aung,T., Barile,G.R., Benchaboune,M., Bird,A.C.,
            Bishop,P.N., Branham,K.E., Brooks,M., Brucker,A.J., Cade,W.H.,
            Cain,M.S., Campochiaro,P.A., Chan,C.C., Cheng,C.Y., Chew,E.Y.,
            Chin,K.A., Chowers,I., Clayton,D.G., Cojocaru,R., Conley,Y.P.,
            Cornes,B.K., Daly,M.J., Dhillon,B., Edwards,A.O., Evangelou,E.,
            Fagerness,J., Ferreyra,H.A., Friedman,J.S., Geirsdottir,A.,
            George,R.J., Gieger,C., Gupta,N., Hagstrom,S.A., Harding,S.P.,
            Haritoglou,C., Heckenlively,J.R., Holz,F.G., Hughes,G.,
            Ioannidis,J.P., Ishibashi,T., Joseph,P., Jun,G., Kamatani,Y.,
            Katsanis,N., N Keilhauer,C., Khan,J.C., Kim,I.K., Kiyohara,Y.,
            Klein,B.E., Klein,R., Kovach,J.L., Kozak,I., Lee,C.J., Lee,K.E.,
            Lichtner,P., Lotery,A.J., Meitinger,T., Mitchell,P.,
            Mohand-Said,S., Moore,A.T., Morgan,D.J., Morrison,M.A., Myers,C.E.,
            Naj,A.C., Nakamura,Y., Okada,Y., Orlin,A., Ortube,M.C.,
            Othman,M.I., Pappas,C., Park,K.H., Pauer,G.J., Peachey,N.S.,
            Poch,O., Priya,R.R., Reynolds,R., Richardson,A.J., Ripp,R.,
            Rudolph,G., Ryu,E., Sahel,J.A., Schaumberg,D.A., Scholl,H.P.,
            Schwartz,S.G., Scott,W.K., Shahid,H., Sigurdsson,H., Silvestri,G.,
            Sivakumaran,T.A., Smith,R.T., Sobrin,L., Souied,E.H.,
            Stambolian,D.E., Stefansson,H., Sturgill-Short,G.M., Takahashi,A.,
            Tosakulwong,N., Truitt,B.J., Tsironi,E.E., Uitterlinden,A.G., van
            Duijn,C.M., Vijaya,L., Vingerling,J.R., Vithana,E.N., Webster,A.R.,
            Wichmann,H.E., Winkler,T.W., Wong,T.Y., Wright,A.F., Zelenika,D.,
            Zhang,M., Zhao,L., Zhang,K., Klein,M.L., Hageman,G.S.,
            Lathrop,G.M., Stefansson,K., Allikmets,R., Baird,P.N., Gorin,M.B.,
            Wang,J.J., Klaver,C.C., Seddon,J.M., Pericak-Vance,M.A.,
            Iyengar,S.K., Yates,J.R., Swaroop,A., Weber,B.H., Kubo,M.,
            Deangelis,M.M., Leveillard,T., Thorsteinsdottir,U., Haines,J.L.,
            Farrer,L.A., Heid,I.M. and Abecasis,G.R.
  CONSRTM   AMD Gene Consortium
  TITLE     Seven new loci associated with age-related macular degeneration
  JOURNAL   Nat Genet 45 (4), 433-439 (2013)
   PUBMED   23455636
REFERENCE   5  (bases 1 to 6919)
  AUTHORS   Shaffer,J.R., Feingold,E., Wang,X., Lee,M., Tcuenco,K., Weeks,D.E.,
            Weyant,R.J., Crout,R., McNeil,D.W. and Marazita,M.L.
  TITLE     GWAS of dental caries patterns in the permanent dentition
  JOURNAL   J Dent Res 92 (1), 38-44 (2013)
   PUBMED   23064961
REFERENCE   6  (bases 1 to 6919)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6919)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6919)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   9  (bases 1 to 6919)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 6919)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121963.10, AL050331.11 and
            KF458258.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_152729.2.
            
            Summary: While the exact function of the protein encoded by this
            gene is not known, it belongs to the 5'(3')-deoxyribonucleotidase
            family. [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.143591.1,
                                           SRR1660803.226075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319550.9/ ENSP00000326858.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AL121963.10        65392-65562         c
            172-263             AL121963.10        60080-60171         c
            264-335             AL121963.10        57980-58051         c
            336-442             AL121963.10        55459-55565         c
            443-522             AL121963.10        50645-50724         c
            523-607             AL121963.10        48470-48554         c
            608-782             AL050331.11        48497-48671
            783-880             AL050331.11        50477-50574
            881-999             AL050331.11        64409-64527
            1000-1161           AL050331.11        65630-65791
            1162-1330           AL050331.11        66398-66566
            1331-2261           AL050331.11        71352-72282
            2262-2534           KF458258.1         1-273
            2535-6919           AL050331.11        72556-76940
FEATURES             Location/Qualifiers
     source          1..6919
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.1"
     gene            1..6919
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /note="5'-nucleotidase domain containing 1"
                     /db_xref="GeneID:221294"
                     /db_xref="HGNC:HGNC:21556"
                     /db_xref="MIM:621076"
     exon            1..171
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1446
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /note="5'-nucleotidase, cytosolic II-like 1 protein"
                     /codon_start=1
                     /product="5'-nucleotidase domain-containing protein 1"
                     /protein_id="NP_689942.2"
                     /db_xref="CCDS:CCDS5104.1"
                     /db_xref="GeneID:221294"
                     /db_xref="HGNC:HGNC:21556"
                     /db_xref="MIM:621076"
                     /translation="MAQHFSLAACDVVGFDLDHTLCRYNLPESAPLIYNSFAQFLVKE
                     KGYDKELLNVTPEDWDFCCKGLALDLEDGNFLKLANNGTVLRASHGTKMMTPEVLAEA
                     YGKKEWKHFLSDTGMACRSGKYYFYDNYFDLPGALLCARVVDYLTKLNNGQKTFDFWK
                     DIVAAIQHNYKMSAFKENCGIYFPEIKRDPGRYLHSCPESVKKWLRQLKNAGKILLLI
                     TSSHSDYCRLLCEYILGNDFTDLFDIVITNALKPGFFSHLPSQRPFRTLENDEEQEAL
                     PSLDKPGWYSQGNAVHLYELLKKMTGKPEPKVVYFGDSMHSDIFPARHYSNWETVLIL
                     EELRGDEGTRSQRPEESEPLEKKGKYEGPKAKPLNTSSKKWGSFFIDSVLGLENTEDS
                     LVYTWSCKRISTYSTIAIPSIEAIAELPLDYKFTRFSSSNSKTAGYYPNPPLVLSSDE
                     TLISK"
     exon            172..263
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..335
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..442
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..522
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..607
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..782
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..880
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..999
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1161
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1330
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..6919
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1620..1625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /note="hexamer: ATTAAA"
     polyA_site      1646
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /note="major polyA site"
     regulatory      3093..3098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /note="hexamer: AATAAA"
     polyA_site      3112
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
     regulatory      5231..5236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /note="hexamer: AATAAA"
     polyA_site      5253
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
     regulatory      6900..6905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
                     /note="hexamer: ATTAAA"
     polyA_site      6919
                     /gene="NT5DC1"
                     /gene_synonym="C6orf200; LP2642; NT5C2L1"
ORIGIN      
        1 cctgtcccgc agcgtcccgc cagccagctc cttgcaccct tcgcggccga ggcgctccct
       61 ggtgctcccc gcgcagccat ggctcagcac ttctccctgg ccgcctgcga cgtggtcgga
      121 ttcgacctgg accacactct gtgtcgctac aacctgcccg agagcgcccc gctcatttat
      181 aatagctttg cccagttcct agttaaggag aaagggtacg ataaggaatt gctcaatgtg
      241 accccagagg attgggattt ctgttgcaaa ggtttggcat tggatctaga agatgggaac
      301 ttccttaaac ttgcaaataa tggcactgtt ctcagggcaa gccatggcac caagatgatg
      361 actccagagg tgctggcaga ggcatatggc aagaaagagt ggaagcactt cttgtcggac
      421 actggaatgg cttgccgctc aggaaagtat tacttttacg acaactactt tgacctgcca
      481 ggagctcttc tgtgtgccag ggtggtggac tatttaacaa aactgaacaa tggtcaaaaa
      541 acatttgatt tttggaagga tatagttgct gctatacaac acaattataa aatgtcagct
      601 tttaaggaaa actgtggaat atattttcca gaaataaaaa gagatccagg cagatattta
      661 catagttgtc ctgaatctgt gaaaaaatgg cttcgacagc taaagaatgc tgggaaaatt
      721 cttctgttaa ttaccagttc tcacagtgat tactgtagac ttctctgcga atatattctt
      781 gggaatgatt ttacagacct ttttgacatt gtgattacaa atgcattgaa gcctggtttc
      841 ttctcccact taccaagtca gagacctttc cggacactcg agaatgatga ggagcaggag
      901 gcactgccat ctctggataa acctggctgg tactcccaag ggaacgctgt ccacctctat
      961 gaacttctga agaaaatgac tggcaaacct gaacccaagg ttgtttattt tggtgacagc
     1021 atgcattcag atattttccc agctcgtcac tatagtaatt gggagacagt cctcatcctg
     1081 gaagaactca gaggggatga aggcacgagg agtcagaggc ctgaggagtc agagcctcta
     1141 gagaagaaag gaaaatatga gggaccaaaa gcaaaacctt taaatacttc atctaaaaaa
     1201 tggggctctt tttttattga ttcagttttg ggactggaaa atacagaaga ctccttggtt
     1261 tatacatggt cttgtaagag aatcagtact tacagcacta ttgcaattcc aagtattgaa
     1321 gcaatcgcag aattacctct ggactacaaa tttacaagat tctcttcaag caattcaaaa
     1381 acagctggct actatccaaa tcctccactg gtcttatcaa gtgatgagac actgatatcc
     1441 aaataagttg tctttactga aaaatgaagt gaagacccat atatgcagtt aaaaaaaagt
     1501 taattttcaa aaaatactgt aaaagacttt aaggaacaag ttttattgac caataagttg
     1561 atatttgtcc ataggtctcc tttctataaa tcatcttgat gtttaacaac tcttattata
     1621 ttaaaatctc agtatcctaa aacttagaac cttattgata ttttctatac agtagttttg
     1681 tgattagaat tcacctgggg acacacactc acacgcacag tcactcttac acatatgcct
     1741 agtccagtgg ttctcaaagt gtgatccata gactaatagc atagcattac ctgagaactt
     1801 gataatgcat atttgcaggc cccacgcaaa acctgctgaa tcagaagctc tgagagtaag
     1861 gcctaccaat ctggtttaac aagcccgtca ggtgattctg atttacagta cagtttgaga
     1921 cccactggct agaacatatc ctccagagac ttggcttaat tggtctgggt aaatatggct
     1981 gagcgttgtt atcttttgtt atcttttata tgccctagga aagtacaacc agaattgaaa
     2041 accaactgat ctataccagt tctttcaatt aatagtcaag aacattgagt ccagtgagat
     2101 taagtgattt ttgcaggcta tgaggtttta tgctattcct gtgttctcca aaacaagaaa
     2161 ataaaaagac atgacttatt ctctgttcat acagcaagta tggaaaaaag atgatctaga
     2221 agtcaactat ctcaacctcc attgttaccc actaggtttt tttctaataa tgttaaaggc
     2281 tatttaattt atttaatcaa ctttaagcat tacattctca attggggaca aaaattggtt
     2341 cttggggtga aaaaatatta gatatggctt gtggacttcc aatatcatcc tatccaacaa
     2401 aatcttattc cttagtatta atttatctca ttgggaagaa atttgtagtt aaaactattt
     2461 aatgtaattt gaatttaatt tctgtaattg ggaaggaggg taataatgaa caaaaagttt
     2521 gagaaaaaaa tgctttaatg ggttttacag gcatgctaca atccaggact gtggtgttct
     2581 atgtgccgtg tatggtcata ttagtagcta tttgttgcaa gatacttgaa gccaaatgtt
     2641 tgcagtatag gttcctggct actgtttatg ctgtgatttc actctgtcta tcatgggcag
     2701 tattagaaaa cacactggtt ttcactatct ggtttacaaa cactatcatt attttacctg
     2761 gattgaagtg cagaatttgg catatcgatg catgcaatgg aaagaaaaaa aatttgttaa
     2821 aatttgtaaa tgttcagcta aatctcagat atactgtggg atgagtatct cagggtaagt
     2881 aacaaaaaaa caaacaaaaa aaatcactga aatttttccc tcacagtcag tagctttgtt
     2941 tgatatttaa caataagtat atggtgatat acttgaaatt tatgtccaga atgtcactgg
     3001 aatattacaa tgagcataaa taatcaagct taggactaaa tgaaagatac tatctcatgt
     3061 atgctttaaa tagagaattt atttctttta aaaataaagc tatctttcct tatccatgtt
     3121 tactctgtaa atggcaaata atacatcttt aaatgcttat gaactactgt taatatgaaa
     3181 aatgagaagt ccaaaataag aaataactgc actttttggg ccacttgagt agtggcgggg
     3241 gttcaggagg cagaattcag ttgtcagaag ttctagtatt ccctttatca ttccacctaa
     3301 agaccctgaa caagttacca ccaaatttgg cttcagtttt ttccatctta tgaaaggaaa
     3361 agtttagttt atttctaaat ttccttcctt tctagcagtc agtatttctt ctaatgaatg
     3421 ttttttttct gtaattagaa agactataat taggcttttt aaatttgtat tttcattctt
     3481 tgtaaagagt gccaatggat atgaagatta aaaataatcc aaatccataa aaattaaaaa
     3541 gaaaatatta aagaagttat atgaagcaaa aaaattgtat aaatggacag aagacatgta
     3601 atattcgcat acaggcaaac attcataatc taaaggacac ctaaaaatag atgtaagcga
     3661 gcggaggttt tctttgctgg ccactgttta tcgcatcagc agaggaaaga tctgaatgac
     3721 tcagtgacca aatgttttgt cagaatctgg tatttggaat actgaggtag taaaaacttt
     3781 atctgaacca tgaattacaa tctaaaatca acttctgagt ttgttaaact ctaaactgaa
     3841 atcaagtatt atttccccac caatattcat atccaaaaat aactttaaat acacacacac
     3901 acacacacac acacactttt agtgaactgg tttgaatgaa aataaattta tataattatt
     3961 ttatataaca aatcagcata aaatggaaaa tcaaactgcc tctctagata taataacctt
     4021 cactgactgt tggaaataca tggatagctt tttaaaatct tcagtgttgg agtaacagtc
     4081 ccttacatct tttcagcctc ttgagtacaa gaagactatc ataagagtta gttccagatt
     4141 ggtgcaagac tggaatacac ttgactgctt ttattaaagc catgagggca taccaagtaa
     4201 ttcacccagt atggtcttat tgccaccctt gaaaatccct gggcatggtc cagtccacat
     4261 agaatgaatt cagaaaggtg tctcttgttg gtctctagaa ctatcctcag aaataatagt
     4321 aaaacagtgg tcatgagtag cctcactagg ctacttcatg tacattatct tgtttactct
     4381 ctatagcaac catatgagat gtatataatt attaaattgt acagatggga aaattgaaat
     4441 tcagagagat taaatacaat gcttgctctg tgttacactg ttagtaagag agcaatacat
     4501 gaacccaagt ttgatcctca aaatcacact tttaattact tgatacataa tgtcttccaa
     4561 tattgaatct agactagggc aaattctcag cccaaaacca cacttcaatt tagcaataat
     4621 gtcgtgctag gacatgagag ggattaacat tgaagacaca gcctctatct ttaagtaatt
     4681 cataatttag ccaaatatat taaatatctg taatataaaa cttacctagg aaagtaaaat
     4741 agagatccaa gaatcaggag tcctaaagca tataatgagt ctgttcctct tggaagccac
     4801 acatgtcaag gtcatcagta agcaggccta ctctttcttc atattctggg ttaatgttca
     4861 ccttgactgc ttggtaaatt tccctcactg gtgctgaagt aaccaaaatg gggaaggagt
     4921 gatgaaaact catctttgag taagcttagt gggaaatagt atatctgggc ctatagagaa
     4981 gttgggtcat tacttagaat gacaactgga aaagtacata gactgcttgc caatcagttt
     5041 gttgtaccat gtacctgttc acagactctt ttcaaaaaac aagtttattt tacttttttt
     5101 ggtactttgg tcatgttgtt tccttggtaa agatcaaagt tgaataaagc ttaacaaagt
     5161 ttaataaaga aaaggaataa attactatct aaatgtgtta aaagcaatca ccaagtttaa
     5221 tcacttaaaa aataaatatt ctcttaacag aaatgtcagc ggttacttac aatgcttagc
     5281 agctaaattc catgagtata acgtttaatg tctttttggt acattaaata ttcagtgcct
     5341 ttgatgaagg gaacaaactg ataatttcat tcatgtgcag caaacatcaa ggttacataa
     5401 gtaaattcaa atgtgtcaat ctgtaactgt atggagtcct gtattaaatc aagtgataaa
     5461 atgtaccctt ctcaaaggct attcatgaat aagcataacc ttcaactgag gcctgaatag
     5521 tcatgtgtca gtagggtttt tgttaacatt tgtatgccaa atttattacg atagctgtga
     5581 tagagtagaa gttatgctag cttgaaatca gaaaactcaa cagtgagact tgcatcttag
     5641 gcagttctac tttctggacc tctgttttct caactattta aatggaaata ataaaacttg
     5701 tgttacaagg attatcaaag taatatgtgc acttcgaagt gcctgacata tctcagatct
     5761 tttgaggaga ttgtgaagcc agggaataag taactgaaac aagatcaaat atccatgtct
     5821 taaattgtga ttctctagga cagggactca gtaattaaaa atataggcaa gggtttgttt
     5881 tggtttttgt ttgttaatga tgaaaacatt taaggacgtt gagttaactg gagataaagc
     5941 agcagcacga ggagtaatgg ggagaagggc ctgatgagaa ggtcagagaa gccttttata
     6001 agtgtctggc ttgcactgaa tgcccagaaa tggaagcgca aggaaagtgt tgtgtgagga
     6061 ccagggtaat tatgcagtgt caccactact cacagggatt atggcctgag aaactaaaat
     6121 gatacttctt aggtgaccag aggatgggag aacttcttaa ctggtttgga ggtccacata
     6181 aagaataatt ggggtctaga attaaggaag gaaaagcaat acaaagaaat ggagcagggc
     6241 tatagcagtg aaccaattgg ttggtaagtg aaacctgtaa gatgcctaat tgagtaattt
     6301 aatgactaat tttattaggc taaacagaac agaaaccatg ctaatctgta acaaataagt
     6361 ggcgccagcc tattacagtg aatgctattg gttagactaa agcagataat aaaccaagtg
     6421 taggaaaaat gacattttct gattacatcc agaacaggca tagaaaaggt ataataaagc
     6481 ttgaaacagg tggctgacaa tgcagaaatc aatcactgaa ctgaaaaggt aaaatgaaca
     6541 ttgttagagg aatttaggat taagatggat gtagagcttg caaaagaaaa cctagctctc
     6601 taatacttaa agttctctag ccctagaaaa aaatacctca gcaagaaatt gcaagtaata
     6661 attgcaccaa gagtcagcat ctattttaac tgtatgttta attaagtttc taactcaaat
     6721 gagaaatttt gggccatttt tgtcaaattt ttgcttagat ggctacaaat acttagcaat
     6781 tcattttcat agattttgta gcatccacaa agccctcctt actgcagaga atgcagaggt
     6841 atttatccaa taaactttca tgtaattgct gctatacagc aaaactatca ttaccggtaa
     6901 ttaaagttgt gatacctga
//
