LOCUS       NM_001199103            2522 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens NT5C1B-RDH14 readthrough (NT5C1B-RDH14), transcript
            variant 1, mRNA.
ACCESSION   NM_001199103
VERSION     NM_001199103.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2522)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079148.9 and AK307653.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001199103.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring NT5C1B (5'-nucleotidase,
            cytosolic IB) and RDH14 (retinol dehydrogenase 14) genes on
            chromosome 2. Alternative splicing results in multiple transcript
            variants, one of which encodes a fusion protein that shares
            sequence identity with the products of each individual gene.
            [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1), which is a fusion
            protein sharing sequence identity with each individual gene
            product.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK307653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 57665, 93034
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC079148.9         144228-144232       c
            6-984               AK307653.1         1-979
            985-985             AC079148.9         138764-138764       c
            986-1150            AK307653.1         981-1145
            1151-1151           AC079148.9         131536-131536       c
            1152-1493           AK307653.1         1147-1488
            1494-2522           AC079148.9         109386-110414       c
FEATURES             Location/Qualifiers
     source          1..2522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.2"
     gene            1..2522
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /note="NT5C1B-RDH14 readthrough"
                     /db_xref="GeneID:100526794"
                     /db_xref="HGNC:HGNC:38831"
     exon            1..131
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2054
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /EC_number="3.1.3.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NT5C1B-RDH14 read-through transcript; Cytosolic
                     5'-nucleotidase 1B; Cytosolic 5'-nucleotidase IB"
                     /codon_start=1
                     /product="NT5C1B-RDH14 protein isoform 1"
                     /protein_id="NP_001186032.1"
                     /db_xref="GeneID:100526794"
                     /db_xref="HGNC:HGNC:38831"
                     /translation="MSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQGSQE
                     SSLRKTDSRGYLVRSQWSRISRSPSTKAPSIDEPRSRNTSAKVELPSSSTSSRTPSTS
                     PSLHDSSPPPLSGQPSLQPPASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQ
                     GIVREIRQTRDSQPLEYSRTSPTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDED
                     DYEAAYWASMRSFYEKNPSCSRPWPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEK
                     YMEYQLTNENVILTPGPAFRFVKALQYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVR
                     LINSVNHYGLLIDRFCLTGGKDPIGYLKAYLTNLYIAADSEKVQEAIQEGIASATMFD
                     GAKDMAYCDTQLRVAFDGDAVLFSDESEHFTKEHGLDKFFQYDTLCESKPLAQEEPRL
                     DVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKL
                     YKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRT
                     NLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEE
                     LLPKAMDESVARKLWDISEVMVGLLK"
     exon            132..221
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /inference="alignment:Splign:2.1.0"
     exon            222..365
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /inference="alignment:Splign:2.1.0"
     exon            366..830
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /inference="alignment:Splign:2.1.0"
     exon            831..998
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1128
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1251
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1436
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..2522
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2496..2501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /note="hexamer: AATAAA"
     polyA_site      2522
                     /gene="NT5C1B-RDH14"
                     /gene_synonym="AIRP; cN-IB; cN1B; NT5C1B"
                     /note="major polyA site"
ORIGIN      
        1 attctaaatg caaagctaga ctgagcaagg gaagtgacag gaaatggagc tggggagaca
       61 aaaatgtgga taacaacaaa agaatttcaa caggtaaaaa aatgagtcaa acatctctca
      121 aacagaaaaa gaatgagcct ggaatgaggt cctcaaaaga gagtctagaa gcagaaaaaa
      181 gaaaggaatc tgacaaaaca ggagttcgtc tgagcaatca gggatcacaa gaatcatcac
      241 tgcggaagac agactctcga gggtaccttg tgcgcagtca atggtctaga atatcccgga
      301 gcccatccac caaggctcca tccatagatg agcctagaag caggaacacc agtgctaagg
      361 tagagctccc cagcagctcc acgagctccc ggactccatc cacctcccca agcctgcatg
      421 actcctcacc gccgccgctg tccgggcagc cctcgctcca gccacccgcg tcgccccagc
      481 tgccccggtc gctggactcg cggcctccca cgcccccaga gcccgatcct ggctcccggc
      541 gcagcaccaa aatgcaagag aatccggagg cctgggccca aggcatcgtg cgggaaatcc
      601 gccagacccg ggactcgcag ccgctggaat attcgcgcac gtcccccacc gagtggaagt
      661 cctccagcca gcgcaggggg atctaccccg cctccaccca gctggaccgc aactctctgt
      721 ccgagcagca gcagcagcag cgggaggacg aggacgacta cgaggctgcc tactgggcat
      781 ccatgaggtc gttctacgag aagaacccga gctgctcgcg cccctggccg cccaaaccca
      841 agaacgccat caccattgct ctctcatcct gcgcgctctt caacatggtg gacggcagga
      901 aaatctacga gcaagagggt ctggaaaagt acatggagta tcagctcacc aatgagaacg
      961 tcatcctgac cccgggcccg gcgttccgct tcgtcaaggc actacagtat gtcaatgcta
     1021 gactccgtga tctatatcct gatgaacagg acttatttga tattgtactg atgactaata
     1081 accatgccca agtgggagtg cggcttataa acagcgtcaa tcactacggc ttactgattg
     1141 accgcttctg tctgaccggg ggaaaagacc ccattggcta tttgaaggca tatcttacca
     1201 acttgtatat tgctgcagat tctgaaaaag tgcaagaggc aatacaagaa ggtattgcct
     1261 ctgcgacaat gtttgatgga gccaaagaca tggcttactg tgacactcag ctccgtgtag
     1321 cctttgatgg ggatgctgtc ctcttctctg atgagtctga acattttacc aaggagcatg
     1381 ggctcgacaa attcttccag tatgatacat tatgtgaaag taagcctctt gctcaggaag
     1441 agcctaggct ggatgtcttg atcaataacg cagggatctt ccagtgccct tacatgaaga
     1501 ctgaagatgg gtttgagatg cagttcggag tgaaccatct ggggcacttt ctactcacca
     1561 atcttctcct tggactcctc aaaagttcag ctcccagcag gattgtggta gtttcttcca
     1621 aactttataa atacggagac atcaattttg atgacttgaa cagtgaacaa agctataata
     1681 aaagcttttg ttatagccgg agcaaactgg ctaacattct ttttaccagg gaactagccc
     1741 gccgcttaga aggcacaaat gtcaccgtca atgtgttgca tcctggtatt gtacggacaa
     1801 atctggggag gcacatacac attccactgt tggtcaaacc actcttcaat ttggtgtcat
     1861 gggctttttt caaaactcca gtagaaggtg cccagacttc catttatttg gcctcttcac
     1921 ctgaggtaga aggagtgtca ggaagatact ttggggattg taaagaggaa gaactgttgc
     1981 ccaaagctat ggatgaatct gttgcaagaa aactctggga tatcagtgaa gtgatggttg
     2041 gcctgctaaa ataggaacaa ggagtaaaag agctgtttat aaaactgcat atcagttata
     2101 tctgtgatca ggaatggtgt ggattgagaa cttgttactt gaagaaaaag aattttgata
     2161 ttggaatagc ctgctaagag gtacatgtgg gtattttgga gttactgaaa aattattttt
     2221 gggataagag aatttcagca aagatgtttt aaatatatat agtaagtata atgaataata
     2281 agtacaatga aaaatacaat tatattgtaa aattataact gggcaagcat ggatgacata
     2341 ttaatatttg tcagaattaa gtgactcaaa gtgctatcga gaggtttttc aagtatcttt
     2401 gagtttcatg gccaaagtgt taactagttt tactacaatg tttggtgttt gtgtggaaat
     2461 tatctgcctg gtgtgtgcac acaagtctta cttggaataa atttactggt acaaattctt
     2521 aa
//
