LOCUS       NM_032526               9068 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens 5'-nucleotidase, cytosolic IA (NT5C1A), mRNA.
ACCESSION   NM_032526
VERSION     NM_032526.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9068)
  AUTHORS   Jedrzejewska,A., Kutryb-Zajac,B., Krol,O., Harasim,G., Franczak,M.,
            Jablonska,P., Slominska,E. and Smolenski,R.T.
  TITLE     The decreased serum activity of cytosolic 5'-nucleotidase IA as a
            potential marker of breast cancer-associated muscle inflammation
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 41 (3), 273-284 (2022)
   PUBMED   34814800
REFERENCE   2  (bases 1 to 9068)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 9068)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9068)
  AUTHORS   Amlani,A., Choi,M.Y., Tarnopolsky,M., Brady,L., Clarke,A.E.,
            Garcia-De La Torre,I., Mahler,M., Schmeling,H., Barber,C.E.,
            Jung,M. and Fritzler,M.J.
  TITLE     Anti-NT5c1A Autoantibodies as Biomarkers in Inclusion Body Myositis
  JOURNAL   Front Immunol 10, 745 (2019)
   PUBMED   31024569
  REMARK    GeneRIF: Anti-NT5c1A Autoantibodies as Biomarkers in Inclusion Body
            Myositis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9068)
  AUTHORS   Patzak,M.S., Kari,V., Patil,S., Hamdan,F.H., Goetze,R.G.,
            Brunner,M., Gaedcke,J., Kitz,J., Jodrell,D.I., Richards,F.M.,
            Pilarsky,C., Gruetzmann,R., Rummele,P., Knosel,T., Hessmann,E.,
            Ellenrieder,V., Johnsen,S.A. and Neesse,A.
  TITLE     Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer
            and mediates gemcitabine resistance by reducing intracellular
            gemcitabine metabolites
  JOURNAL   EBioMedicine 40, 394-405 (2019)
   PUBMED   30709769
  REMARK    GeneRIF: NT5C1A is robustly expressed in tumor cells of resected
            PDAC patients. Moreover, NT5C1A mediates gemcitabine resistance by
            decreasing the amount of intracellular dFdCTP, leading to reduced
            tumor cell apoptosis and larger pancreatic tumors in mice.
REFERENCE   6  (bases 1 to 9068)
  AUTHORS   Osborne,F.N., Kalsi,K.K., Lawson,C., Lavitrano,M., Yacoub,M.H.,
            Rose,M.L. and Smolenski,R.T.
  TITLE     Expression of human ecto-5'-nucleotidase in pig endothelium
            increases adenosine production and protects from NK cell-mediated
            lysis
  JOURNAL   Am J Transplant 5 (6), 1248-1255 (2005)
   PUBMED   15888028
  REMARK    GeneRIF: overexpression of 5'-nucleotidase inhibits Natural Killer
            cell cytotoxicity to ameliorate rejection after xenotransplantation
REFERENCE   7  (bases 1 to 9068)
  AUTHORS   Sala-Newby,G.B. and Newby,A.C.
  TITLE     Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new
            gene related to human autoimmune infertility-related protein
  JOURNAL   Biochim Biophys Acta 1521 (1-3), 12-18 (2001)
   PUBMED   11690631
REFERENCE   8  (bases 1 to 9068)
  AUTHORS   Hunsucker,S.A., Spychala,J. and Mitchell,B.S.
  TITLE     Human cytosolic 5'-nucleotidase I: characterization and role in
            nucleoside analog resistance
  JOURNAL   J Biol Chem 276 (13), 10498-10504 (2001)
   PUBMED   11133996
REFERENCE   9  (bases 1 to 9068)
  AUTHORS   Skladanowski,A.C., Smolenski,R.T., Tavenier,M., de Jong,J.W.,
            Yacoub,M.H. and Seymour,A.M.
  TITLE     Soluble forms of 5'-nucleotidase in rat and human heart
  JOURNAL   Am J Physiol 270 (4 Pt 2), H1493-H1500 (1996)
   PUBMED   8967393
REFERENCE   10 (bases 1 to 9068)
  AUTHORS   Waku,K. and Nakazawa,Y.
  TITLE     Regulation of the fatty acid composition of alkyl ether
            phospholipid in Ehrlich ascites tumor cells. The substrate
            specificities of 1-O-alkylglycerol 3-phosphate and
            1-O-alkylglycero-3-phosphocholine acyltransferases
  JOURNAL   J Biochem 82 (6), 1779-1784 (1977)
   PUBMED   599155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035404.20.
            
            On Sep 16, 2020 this sequence version replaced NM_032526.2.
            
            Summary: Cytosolic nucleotidases, such as NT5C1A, dephosphorylate
            nucleoside monophosphates (Hunsucker et al., 2001 [PubMed
            11133996]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.208618.1,
                                           DRR138518.397861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000235628.2/ ENSP00000235628.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AL035404.20        86429-86632         c
            205-372             AL035404.20        80594-80761         c
            373-502             AL035404.20        80046-80175         c
            503-625             AL035404.20        77837-77959         c
            626-810             AL035404.20        75604-75788         c
            811-9068            AL035404.20        65754-74011         c
FEATURES             Location/Qualifiers
     source          1..9068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..9068
                     /gene="NT5C1A"
                     /gene_synonym="CN-I; CN-IA; CN1; CN1A; CNI"
                     /note="5'-nucleotidase, cytosolic IA"
                     /db_xref="GeneID:84618"
                     /db_xref="HGNC:HGNC:17819"
                     /db_xref="MIM:610525"
     exon            1..204
                     /gene="NT5C1A"
                     /gene_synonym="CN-I; CN-IA; CN1; CN1A; CNI"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1176
                     /gene="NT5C1A"
                     /gene_synonym="CN-I; CN-IA; CN1; CN1A; CNI"
                     /EC_number="3.1.3.5"
                     /EC_number="3.1.3.89"
                     /EC_number="3.1.3.99"
                     /note="cytosolic 5' nucleotidase, type 1A; AMP-specific
                     5'-NT; cytosolic 5'-nucleotidase IA; 5'-deoxynucleotidase"
                     /codon_start=1
                     /product="cytosolic 5'-nucleotidase 1A"
                     /protein_id="NP_115915.1"
                     /db_xref="CCDS:CCDS440.1"
                     /db_xref="GeneID:84618"
                     /db_xref="HGNC:HGNC:17819"
                     /db_xref="MIM:610525"
                     /translation="MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPK
                     SPKPQNAVTIAVSSRALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKA
                     LEAVNRRLRELYPDSEDVFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPI
                     CYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFS
                     DESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIR
                     TYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHV
                     AGAQEMGTVAAHVPYGVAQTPRRTAPAKQAPSAQ"
     exon            205..372
                     /gene="NT5C1A"
                     /gene_synonym="CN-I; CN-IA; CN1; CN1A; CNI"
                     /inference="alignment:Splign:2.1.0"
     exon            373..502
                     /gene="NT5C1A"
                     /gene_synonym="CN-I; CN-IA; CN1; CN1A; CNI"
                     /inference="alignment:Splign:2.1.0"
     exon            503..625
                     /gene="NT5C1A"
                     /gene_synonym="CN-I; CN-IA; CN1; CN1A; CNI"
                     /inference="alignment:Splign:2.1.0"
     exon            626..810
                     /gene="NT5C1A"
                     /gene_synonym="CN-I; CN-IA; CN1; CN1A; CNI"
                     /inference="alignment:Splign:2.1.0"
     exon            811..9068
                     /gene="NT5C1A"
                     /gene_synonym="CN-I; CN-IA; CN1; CN1A; CNI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9044..9049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NT5C1A"
                     /gene_synonym="CN-I; CN-IA; CN1; CN1A; CNI"
                     /note="hexamer: AATAAA"
     polyA_site      9068
                     /gene="NT5C1A"
                     /gene_synonym="CN-I; CN-IA; CN1; CN1A; CNI"
                     /note="major polyA site"
ORIGIN      
        1 agcccagccc cagccacctc cgcgtctacg ccgccgcctg ctctggccgg gccgggtcag
       61 agccggagca tggaacctgg gcagccccgg gagccccagg agccccgcga gcccgggcca
      121 ggagcggaga ccgctgcggc cccggtctgg gaggaagcca agattttcta cgacaacctc
      181 gcgcccaaga agaaacccaa atcgcccaag cctcagaatg cagtcaccat cgctgtgtcc
      241 tcccgagcct tgtttcgcat ggacgaggag cagcagatct acacggagca gggcgtggag
      301 gagtacgtgc gctaccagct ggaacatgag aacgaaccct tcagtcccgg gccagccttc
      361 ccttttgtga aggctctgga ggccgtgaac aggcggctgc gggagctgta ccctgatagt
      421 gaggacgtct tcgacatcgt cctcatgact aacaaccatg ctcaagtggg tgtccgcctc
      481 atcaacagta tcaaccacta tgacctgttc atcgagaggt tctgcatgac aggtgggaac
      541 agcccgatct gctacctcaa ggcctatcac accaacctct acttgtcagc cgatgcggaa
      601 aaagtgcgag aagccattga tgaggggatc gcagctgcca ccatcttcag ccccagcagg
      661 gatgtggttg tgtcccagag tcagctgcgc gtggccttcg atggggacgc cgtgctcttc
      721 tcggacgagt cggagcgcat cgtcaaggcc cacgggctgg accgattctt cgagcatgag
      781 aaggcccacg agaacaaacc tctggctcag ggccccttaa agggctttct ggaggcactg
      841 ggtaggttgc agaagaagtt ctactccaaa ggcctgcggc tggagtgccc aattcgtacc
      901 tacttggtga cagcacgcag tgcagccagt tccggggccc gggctctcaa gaccctgcgc
      961 agctggggcc tggagacaga tgaagccttg ttccttgctg gagcgcccaa gggccctctc
     1021 cttgagaaga tccgcccaca catcttcttt gatgaccaga tgttccatgt ggctggggct
     1081 caggagatgg gcactgtggc cgcccatgtg ccttatggtg tggcacagac accccggcgg
     1141 actgcacctg caaagcaggc cccatctgca cagtagctga accaccggct ttactgatcc
     1201 acattgctcc aggctccctg acatacttcg acacctcctc tggtagatcc ctctagtttc
     1261 tcactgttct gtccttctgc ctgtctgccc tcatccctat gagtgatgta cttgtaggaa
     1321 attatgcaga cgggtctggc attctcaaca tccctccttt ggggcaaatt ctgtgccatg
     1381 atcctgagta ggagagtagg actgtgcaga gtagctggat ttcagggggg aagttaatgg
     1441 gtctgagagg gggagggtca gagaagccag gatttctcaa tagtgactta ggatgaaaac
     1501 tagctcaatg tggtgtaaac aacactgcta tgggagagag tggatctggc ttctaagctc
     1561 tgtcctggta ttaactgcat gactttgagt aatccctccc cttcatggcc cccagtttcc
     1621 ccatcttttg ggcagttttc aagctccctt ttagccaaag aagcttggtt ctttaagatc
     1681 gccctcttag aaggaagcat tctgtgtcag tgctgctgct ggtatgtatg gcacctttgt
     1741 gcaaattaca aaaggacact gtctaggtga atgaagaaca aaaagacatc ccttcctctg
     1801 gcctgaccca gtcccatagt ggggtacaca gcttagttag caggatagag gctggatttc
     1861 agcccccatg tgtcccctca gctcagaggc ctttctcaaa tggacaaaat gcaaaatcgc
     1921 ccccagcaac tctatctata attttacaca ttttgaaacc actggacaag atgacctatc
     1981 tgctcatgtg attctctaac ctgaatggtc atcagggctc agcccaggaa gcaaggggag
     2041 tgaattggac acgcatacaa actctcctcc agccagcagg gggcactgca ggctcttccc
     2101 gggagaagca ttagtagctg cctgctcagt gtttcctttg ctcttgcttt gagccgaagt
     2161 tcagttgctc ttgcctgcca agaccctcac ttccaccacc ctcattcctc cagttattgc
     2221 atcctgttga gcagctctgc tggtggggaa cgggacagag catgggtgtc tactgttgtg
     2281 gcctcaattc taggggaaga aagtgcagtg gctgaggtag gcggttgtcc aggctgagcc
     2341 ccagggtgag gtgctgcctg gggtgaagtg ggaagtgtca ggaggtctgg tgtgagacag
     2401 aaggtactga gacagtgatg cttggagagg aaggagctga aatgtgcact agcaaaattc
     2461 tccagctatg ggattgttag tggaaagcca gtcagagctg cctttggagg taatgagctc
     2521 tccatcagtg gatgctgagc aagggcttcc aggatgagat aacctcccca tgaaatgcat
     2581 cagcggatcc tccacatttg caagagcccc tgcggcccct tcttcaccac tttcagagga
     2641 gaactctcac cgcttgatga gtcagcctcc tcctttgctg agcatccctg gctctctcca
     2701 gagggagggt ggaagcacca atggctggtc cccagggaga cagaaggggt gagcagacat
     2761 ctgtgtgtgg actgattgcc aggcttctag gaggaatcct agtcatgagc aagcactttg
     2821 taaagaaaac caaaagtatc atgagagggg cagaagcctg gagatgtggt ggtaggaaat
     2881 aggggaagag aacaccctgg ggtttttgat ctttgtcctt ctggggactc agctcagggt
     2941 ctgaaagggc acaggttctg tgcagtgtgg ggcagggtaa gagatgcaga aagatattcc
     3001 aggaaggaga acaaagtgag aaggcagaga cggttctcaa atgagcaacg atttgggcca
     3061 gaagagaaag gctgggctga gtttttactg tcattgtcag aggtctccat gaggctggtc
     3121 ccagggagga agggtatggc tgtgtggagt gactgggaca gatacccaca gtgactgctt
     3181 tatcagggga cactggcatt attgcccctg gaagggcata tgataatgtc tttgcacgag
     3241 gtcatttcca ctgcacagcc aggatccttc tggctaacag aggaggcctt ggggcagaag
     3301 acccgggttg tgtctacttc cagagctcca agcctagaca gaggtactgt gagggccaag
     3361 aacaacctca aggaaacaaa aaagaagtga aggagggagc tcagccctga gtctccttta
     3421 ttcttggctg aactgcagaa aggccctctc cttctcactc ccaggggtca gaatcacccc
     3481 cgtggaagag cctccaaggc tcacagaacc agtgactgca agaagcctac aaggccgggc
     3541 acagcccagg ctcacagcat ggcaacaggc tgactgacca gggtggacct gtgcactggg
     3601 gacggcacca gatgtcacct aattaagaaa aactgcaggg attctgggac ctgtgtggtc
     3661 ttgcccccag ggcctggtga tgaacaccac tgatgattcc atgtctctca ggaagcagga
     3721 aaatatgatg ctggaagcag aaagataagg tgcagtaaaa gccatggatt tcactggagc
     3781 catcattaat agacacagac agccctgggc aatggagaaa cactaagagt ctaaattcta
     3841 ttattgaaat cacaaatgag catctcaggc ctggaaaaaa gctttcagtc actggaataa
     3901 aaagccagaa atctgagggg cagtcttagg cagcagttac acgggccttc tgattgtctt
     3961 agaggtgagg aggtgcccag ggatgaggaa cattgagtgt tgttcaccag taaattaaaa
     4021 agccaggtga acaccaaagt cccaggccta accagggaat gcagcactga ggtggagcag
     4081 ccacggcttc tgaaacactg gaccccttta gctgagagca ccacttcccc aacaagccct
     4141 gcagaacact ggttccagga gatgcctgcc agcaaaatcc cagagccaat gggactgctg
     4201 cttagcagaa aaatggaagc cctgttacta agcactgaga ctgctcagcc agttgcaaaa
     4261 catccccctc tcctatctga gagcccaatc agagtagtgg ggatatatca gaatgtgcca
     4321 gaaaaaaata gaaactagca agaagttcaa agccaagatg gatttggcat tataatgaca
     4381 ctcaattggt gtgcaccagt acagccaaac tgatgactaa aacttgaaat acctccatag
     4441 cagttggtag ataatgctgc gctgagtccc ctgaatgtct cctcgtggcc tcagctgacc
     4501 tttccactgt gagcgctcca ttttcccaca atgcagcctc taggaggctg cagcggcact
     4561 atggccagtg tctactctgt tttgtggtgt cctggccatg ctggtttagg gaggcaaagt
     4621 aacttgtcca aagccataga gctagtaagt ggcagtgctg ggactcaaac tcatgtccat
     4681 ctgattctag gacccaggtt ttcaaccatt ttgtcatact gctcatacat atgcatggag
     4741 atagccagag aagctccatt ctgaggtctt cactaaagga gtttacttac ctgacagtta
     4801 atatgttgat ttcctgcatg gtgaaatgct ggaatacatt tgagtgcatg cttttattat
     4861 agcttcctaa acacctacaa ataatttaaa ttagagccaa acgtttgtga acccccagaa
     4921 gcacttccaa acaatcccaa gttttgagaa acccagtgtg aaggcccctg ttttgggcta
     4981 atgcagagtt tggcaaactc tgggcccacg ggccaaatct gacccatcac ctgtttttgt
     5041 aaagaaactt tgactggggc caggcacagt ggctcatgcc tgtaatccca gcactttggg
     5101 aggccaaggc gggtggatca caaggtcagg agatcgagac catcctgccc aacatgatga
     5161 aaccccgtct ctactaaaaa tacaaaaatt agctgggcgt ggtggtgcac gcctgtagtc
     5221 ccagctactc gggaggctga ggcaggagga tcacttgaac ccggaaggcg gaggttgcag
     5281 tgaaccgaga tcacgccact gcactccagc ctggcatcag ggtgagactc cgtctcaaag
     5341 aaaaaaaaaa agataaaaga aactttgatt agaacatagc catgcccatt tgtttacata
     5401 tgtttatggc tgatttcaca ctgcaacagc agagttgaat tgttgcaaca gaggctgcaa
     5461 gccaaaaata tttattatct ggccctttac agaaaaatgt gcggacccct gggccaaggc
     5521 agacagcctg gctgatgcct cagtgggatg agccaggtca catccaccta tgcatctgtg
     5581 ggcggaggct ggctccactg ccaaagggaa gggacatggg gctccatgcc catctgaaga
     5641 ttccaagttt tgactatttt caagcgaccc atggctcatg gtaatttgca gttttgttga
     5701 tgcactgatt tgacttgaat gtgctctccc aagctgatga gtgagagggc aggagcaggg
     5761 cccttggctg gggatgagcc cagctggctg tccagcatgg ctttgtattc ccgactcatt
     5821 tcctcatggg gcctcttagg caatgatcag cctagtaggt ggatgcgcat tagctaaaca
     5881 tgagttttgg atagattgaa gtgcccagtg ttgatttcag cagctccgag ccaacaaggt
     5941 catccatgta ctttctgtga aagcaagaac aagtccgtcg tgaagagggt cccgtgagga
     6001 ctttagccgg ttcagaagtt actgatcaag tgagagagaa aactcctgta acagctggaa
     6061 tggcagtttc ttgtggcatg aaggcacgtg agcaataaac acaaataccc ctcataatgg
     6121 aattgtggat caggagaatt ctaggactct gcaaatttag agatttacca ggcttccagg
     6181 atccactgca agaacagaca gtatggaaga cgccccatct acagccatca ttgctgtcgc
     6241 tatgccatca tgatactctt ctccactaag cccagactgg gtctcagaat ctttctctat
     6301 ccagcattcc aggcagccac taccagcggg ctggagctgg tgtgaaagat gaaacctatt
     6361 ttgccatccc tattggtgtt gggttttgct atccaagagg catgcaaggc ccagaatgtt
     6421 catcctctga ggatatgatg caactctgag gatgtcagag cctcacctga cttgggtaga
     6481 acacaaggag gtggatgaat agcatcgtgt ggctggcggc ttcccagatc acgggtttta
     6541 tctagtctta aagcaaaaca caaaaccacc tcctttctgc cagtaggtgg cactgcaggc
     6601 cggcacgcag ctgctggcag tagtcaagtg attctaccca ctgatttact tttctctccc
     6661 actgacttag tgctgcgctg gactctcccc acggttagct ctagccagcc aaaaaggact
     6721 tcaggtgctc tggaaatgtt tgctaaatat gcccgagtga cgagccgatt gctcttgccg
     6781 gcaattactg tgattgtgtg tatggatgca cacatattaa gtttgtgcaa caggataaaa
     6841 atcgtacacg tacgtgtatt tatgtgggtg tgtgtaatgg gccagatatc tcagccaatg
     6901 actctgtgtg tgtgtgtgta ctcactatgt gtacagatgg ttatctctgt taactgagtg
     6961 tcctgggacc cacatactga tggccagccc taggatagtt gtacccattt ccatcataac
     7021 atgggcattt gcgtatgtgc agcttggggg ccaccgagac cagcccccaa cctctggcca
     7081 agaaagtctt ggctcctaac cctctgcctc ctacccctac tcctgagcct tgggaaggaa
     7141 gtggtagaat ctgtgtaagg gcaatccttt tgactatacc tgcctcatca tctccatttg
     7201 tttcttccct ccccctaaca gtgccaaggc caacgtgtcc agttgggcag attgtgcact
     7261 gcaaaaatct agagggcgcc attggtattg tgacatgggt agtacctatt agacacctgc
     7321 acaacctgcc aactgtatac agatgccctg gtcatctcat ggccatggct acgaaagttg
     7381 ccttccctcc ccactaccag ccctgcccaa cctaggcaaa gattcctgcc tctgcttgag
     7441 tgttctaatg tggcccagaa gtgacttacc attgacctta attgggaagt atctccctga
     7501 tgggccatcc cctagaggcc tttggaattc catttataaa agtgaaatgt ggctgggaac
     7561 ttttcagtta ctcatctttg caaagtgaaa gcctctgtaa ggcaaaccaa agctgtgaag
     7621 actggggtca ctgactccca cactcctggc ctgtgggtga atatatgcct tcatggccat
     7681 ctgccacgga attagggtaa aggcctcaag gctagtcttg tagctaactg ccaccaagaa
     7741 gccaccaaga aaatcactga ggtcacccta gactggatgc ctgggccagg gtcacaaacc
     7801 ccaatgccta caggggcgag gcaggaaaca taaatgagtg gagaggatta agccagttct
     7861 tcactgagaa tggagaacac tgtggtctgc catggttgct gccacatggg aatgtggcct
     7921 gaggttgccg gatagtccgc cccatttttg aagagaagct gggaatctgg acttttaaat
     7981 gttggcaact attttgaatt tagaaaacac catctgggcc aaataaaaca tattctgtag
     8041 gcgagatccg gcccttgaat ctccagtttg catccgctgg cccaggccca gagacttggg
     8101 tttttaagac ccaagtcact gagagtctga ggatattaca ctcagattct cagtgatgga
     8161 tatttaagag acctcagaga tgacctagct cagcctttgt gtgttcaaaa ctgcgtatgt
     8221 acaaacttct tttttttttt tttttttttt tttttttttt ttttttgaga cggagtcttg
     8281 ctctgtcact caggctggag tgcagtggca caatcttggc tcactgcaac ctccgcctcc
     8341 tggggtcaag caattctcct gcctcagctt cctgagtagc tgggattaca ggtgcccgcc
     8401 accatgccca gctaattttt tgtattttta gtagagatgg ggtttcacca tattggccag
     8461 gctggtctcg aactcctgac ctcaggtgat ccaccagcct ctgcctccca aagtgctggg
     8521 attacaggcg tgagccacca cactcggcct acgaacttct ttattaatgt aatagcgcac
     8581 atatacttaa cttctggttt ctacttaaga gcatctcaat aacctccgat atagaatacg
     8641 atgaaaaatg aaacctgtgt gcataatgtg cttgtatcta cctgtcagaa gccctttgct
     8701 ttgatagcat ttgctgcctc agtcttcctc atcacccaac ctctctgggt tgcttgttat
     8761 gataaaccta agtgcctccg taaatggtta gagcatgtgt ttcttcgtct ttgtgacttc
     8821 ccttgtctgg gaataagact gcttgtactt ctcccagctt tgccctcttt ggcctactag
     8881 tagcacaccc catcgatcca gacctgtctg gctctttgta acatttacct ggtcacatga
     8941 taaagggtgc tgagtgcttg ccagtgtggg tccctgtcac ttctcatgca tgtcctatac
     9001 cttaatttta ccacatgtgc ttctgcttct taaaagccat tcaaataaat ggagagggtt
     9061 ttaattaa
//
