LOCUS       NM_148956               2336 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens NOP2/Sun RNA methyltransferase 5 (NSUN5), transcript
            variant 1, mRNA.
ACCESSION   NM_148956
VERSION     NM_148956.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2336)
  AUTHORS   Liu,S., Liu,Y., Zhou,Y., Xia,G., Liu,H., Zeng,Y., Pei,Z., Cao,J.,
            Jing,G., Zou,H. and Liao,C.
  TITLE     NSUN5 promotes tumorigenic phenotypes through the WNT signaling
            pathway and immunosuppression of CD8+ T cells in gastric cancer
  JOURNAL   Cell Signal 124, 111475 (2024)
   PUBMED   39428025
  REMARK    GeneRIF: NSUN5 promotes tumorigenic phenotypes through the WNT
            signaling pathway and immunosuppression of CD8+ T cells in gastric
            cancer.
REFERENCE   2  (bases 1 to 2336)
  AUTHORS   Zhang,T., Li,H., Jiang,E., Liu,L. and Zhang,C.
  TITLE     The downregulation of NSUN5 may contribute to preeclampsiadagger
  JOURNAL   Biol Reprod 111 (4), 856-865 (2024)
   PUBMED   38924712
  REMARK    GeneRIF: The downregulation of NSUN5 may contribute to
            preeclampsiadagger.
REFERENCE   3  (bases 1 to 2336)
  AUTHORS   Gu,X., Li,P., Gao,X., Ru,Y., Xue,C., Zhang,S., Liu,Y. and Hu,X.
  TITLE     RNA 5-methylcytosine writer NSUN5 promotes hepatocellular carcinoma
            cell proliferation via a ZBED3-dependent mechanism
  JOURNAL   Oncogene 43 (9), 624-635 (2024)
   PUBMED   38182896
  REMARK    GeneRIF: RNA 5-methylcytosine writer NSUN5 promotes hepatocellular
            carcinoma cell proliferation via a ZBED3-dependent mechanism.
REFERENCE   4  (bases 1 to 2336)
  AUTHORS   Zhang,Y., Chen,X.N., Zhang,H., Wen,J.K., Gao,H.T., Shi,B.,
            Wang,D.D., Han,Z.W., Gu,J.F., Zhao,C.M., Xue,W.Y., Zhang,Y.P.,
            Qu,C.B. and Yang,Z.
  TITLE     CDK13 promotes lipid deposition and prostate cancer progression by
            stimulating NSUN5-mediated m5C modification of ACC1 mRNA
  JOURNAL   Cell Death Differ 30 (12), 2462-2476 (2023)
   PUBMED   37845385
  REMARK    GeneRIF: CDK13 promotes lipid deposition and prostate cancer
            progression by stimulating NSUN5-mediated m5C modification of ACC1
            mRNA.
REFERENCE   5  (bases 1 to 2336)
  AUTHORS   Su,Y., Liu,J., Zheng,Z., Shi,L., Huang,W., Huang,X., Ye,C., Qi,J.,
            Wang,W. and Zhuang,H.
  TITLE     NSUN5-FTH1 Axis Inhibits Ferroptosis to Promote the Growth of
            Gastric Cancer Cells
  JOURNAL   Cell Biochem Biophys 81 (3), 553-560 (2023)
   PUBMED   37528314
  REMARK    GeneRIF: NSUN5-FTH1 Axis Inhibits Ferroptosis to Promote the Growth
            of Gastric Cancer Cells.
REFERENCE   6  (bases 1 to 2336)
  AUTHORS   Schosserer,M., Minois,N., Angerer,T.B., Amring,M., Dellago,H.,
            Harreither,E., Calle-Perez,A., Pircher,A., Gerstl,M.P.,
            Pfeifenberger,S., Brandl,C., Sonntagbauer,M., Kriegner,A.,
            Linder,A., Weinhausel,A., Mohr,T., Steiger,M., Mattanovich,D.,
            Rinnerthaler,M., Karl,T., Sharma,S., Entian,K.D., Kos,M.,
            Breitenbach,M., Wilson,I.B., Polacek,N., Grillari-Voglauer,R.,
            Breitenbach-Koller,L. and Grillari,J.
  TITLE     Methylation of ribosomal RNA by NSUN5 is a conserved mechanism
            modulating organismal lifespan
  JOURNAL   Nat Commun 6, 6158 (2015)
   PUBMED   25635753
  REMARK    Erratum:[Nat Commun. 2016 May 11;7:11530. doi:
            10.1038/ncomms11530.. PMID: 27167997]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2336)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 2336)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 2336)
  AUTHORS   Merla,G., Ucla,C., Guipponi,M. and Reymond,A.
  TITLE     Identification of additional transcripts in the Williams-Beuren
            syndrome critical region
  JOURNAL   Hum Genet 110 (5), 429-438 (2002)
   PUBMED   12073013
REFERENCE   10 (bases 1 to 2336)
  AUTHORS   Doll,A. and Grzeschik,K.H.
  TITLE     Characterization of two novel genes, WBSCR20 and WBSCR22, deleted
            in Williams-Beuren syndrome
  JOURNAL   Cytogenet Cell Genet 95 (1-2), 20-27 (2001)
   PUBMED   11978965
  REMARK    GeneRIF: Characterization of two novel genes, WBSCR20 and WBSCR22,
            deleted in Williams-Beuren syndrome
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB154882.1, BC008084.2,
            AK126375.1, EC442348.1, BM144254.1 and CX866878.1.
            
            On May 17, 2019 this sequence version replaced NM_148956.3.
            
            Summary: This gene encodes a member of an evolutionarily conserved
            family of proteins that may function as methyltransferases. This
            gene is located in a larger region of chromosome 7 that is deleted
            in Williams-Beuren syndrome, a multisystem developmental disorder.
            There are two pseudogenes for this gene located in the same region
            of chromosome 7. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098619.1, SRR1660807.214717.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438747.7/ ENSP00000388464.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                CB154882.1         42-60
            20-1623             BC008084.2         1-1604
            1624-1939           AK126375.1         1558-1873
            1940-1940           EC442348.1         31-31               c
            1941-2207           AK126375.1         1875-2141
            2208-2333           BM144254.1         19-144              c
            2334-2336           CX866878.1         29-31               c
FEATURES             Location/Qualifiers
     source          1..2336
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..2336
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /note="NOP2/Sun RNA methyltransferase 5"
                     /db_xref="GeneID:55695"
                     /db_xref="HGNC:HGNC:16385"
                     /db_xref="MIM:615732"
     exon            1..129
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1437
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Williams Beuren syndrome chromosome region 20A;
                     Williams-Beuren syndrome critical region protein 20 copy
                     A; NOP2/Sun domain family, member 5A; putative
                     methyltransferase NSUN5; NOL1-related protein;
                     NOL1/NOP2/Sun domain family member 5; Williams-Beuren
                     syndrome chromosomal region 20A protein; probable 28S rRNA
                     (cytosine-C(5))-methyltransferase; NOP2/Sun RNA
                     methyltransferase family member 5"
                     /codon_start=1
                     /product="28S rRNA (cytosine-C(5))-methyltransferase
                     isoform 1"
                     /protein_id="NP_683759.1"
                     /db_xref="CCDS:CCDS5546.1"
                     /db_xref="GeneID:55695"
                     /db_xref="HGNC:HGNC:16385"
                     /db_xref="MIM:615732"
                     /translation="MGLYAAAAGVLAGVESRQGSIKGLVYSSNFQNVKQLYALVCETQ
                     RYSAVLDAVIASAGLLRAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARL
                     KAELARLKVHRGVSRNEDLLEVGSRPGPASQLPRFVRVNTLKTCSDDVVDYFKRQGFS
                     YQGRASSLDDLRALKGKHFLLDPLMPELLVFPAQTDLHEHPLYRAGHLILQDRASCLP
                     AMLLDPPPGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGV
                     SCCELAEEDFLAVSPSDPRYHEVHYILLDPSCSGSGMPSRQLEEPGAGTPSPVRLHAL
                     AGFQQRALCHALTFPSLQRLVYSTCSLCQEENEDVVRDALQQNPGAFRLAPALPAWPH
                     RGLSTFPGAEHCLRASPETTLSSGFFVAVIERVEVPSSASQAKASAPERTPSPAPKRK
                     KRQQRAAAGACTPPCT"
     exon            130..252
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /inference="alignment:Splign:2.1.0"
     exon            253..427
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /inference="alignment:Splign:2.1.0"
     exon            428..536
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /inference="alignment:Splign:2.1.0"
     exon            537..675
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /inference="alignment:Splign:2.1.0"
     exon            676..791
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /inference="alignment:Splign:2.1.0"
     exon            792..970
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1181
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1322
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..2336
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1601..1606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /note="hexamer: AATAAA"
     polyA_site      1623
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /note="major polyA site"
     regulatory      1683..1688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
                     /note="hexamer: ACTAAA"
     polyA_site      1706
                     /gene="NSUN5"
                     /gene_synonym="NOL1; NOL1R; NSUN5A; p120; p120(NOL1);
                     WBSCR20; WBSCR20A"
ORIGIN      
        1 gcgttttgcc acagagccgt aaaggcgcgc gggaacatgg ggctgtatgc tgcagctgca
       61 ggcgtgttgg ccggcgtgga gagccgccag ggctctatca aggggttggt gtactccagc
      121 aacttccaga acgtgaagca gctgtacgcg ctggtgtgcg aaacgcagcg ctactccgcc
      181 gtgctggatg ctgtgatcgc cagcgccggc ctcctccgtg cggagaagaa gctgcggccg
      241 cacctggcca aggtgctagt gtatgagttg ttgttgggaa agggctttcg agggggtggg
      301 ggccgatgga aggctctgtt gggccggcac caggcgaggc tcaaggctga gttggctcgg
      361 ctcaaggttc atcggggtgt gagccggaat gaggacctgt tggaagtggg atccaggcct
      421 ggtccagcct cccagctgcc tcgatttgtg cgtgtgaaca ctctcaagac ctgctccgat
      481 gatgtagttg attatttcaa gagacaaggt ttctcctatc agggtcgggc ttccagcctc
      541 gatgacttac gagccctcaa ggggaagcat tttctcctgg accccttgat gccggagctg
      601 ctggtgtttc ccgcccagac agatctgcat gaacacccac tgtaccgggc cggacacctc
      661 attctgcagg acagggccag ctgtctccca gccatgctgc tggacccccc gccaggctcc
      721 catgtcatcg atgcctgtgc cgccccaggc aataagacca gtcacttggc tgctcttctg
      781 aagaaccaag ggaagatctt tgcctttgac ctggatgcca agcggctggc atccatggcc
      841 acgctgctgg cccgggctgg cgtctcttgc tgtgaactgg ctgaggagga cttcctggcg
      901 gtctccccct cggatccacg ctaccatgag gtccactaca tcctgctgga tccttcctgc
      961 agtggctcgg gtatgccgag cagacagctg gaggagcccg gggcaggcac acctagcccg
     1021 gtgcgtctgc atgccctggc agggttccag cagcgagccc tgtgccacgc actcactttc
     1081 ccttccctgc agcggctcgt ctactccacg tgctccctct gccaggagga gaatgaagac
     1141 gtggtgcgag atgcgctgca gcagaacccg ggcgccttca ggctagctcc cgccctgcct
     1201 gcctggcccc accgaggcct gagcacgttc ccgggtgccg agcactgcct ccgggcctcc
     1261 cctgagacca cactcagcag tggcttcttc gttgctgtaa ttgaacgggt cgaggtgcca
     1321 agctcagcct cacaggccaa agcatcagca ccagaacgca cacccagccc agccccaaag
     1381 agaaagaaga gacagcaaag agccgcagcc ggtgcttgca caccgccttg cacatagcag
     1441 aggctccggg ctgactcctt cctggtggga aaggaagatg cctgtcctct ccgtggagga
     1501 ccctgggccc tcaccgcagg aagcagtttg ggttttgaaa ggttattggg tcccttcctt
     1561 gggctgtgtt cttgctggtg agcaaagtgt tgcctgcaaa aataaaatgc agaacgtact
     1621 ctacgataga tcacagtttt ttattcttaa tgtcacaagc aggagaaaaa tctcacattc
     1681 atactaaaag ttccaactag actcaacagg aatgaagtct ctatttgtaa tggaaagtcc
     1741 cagcctcccg ctgccgtcca gtgcgtgtac tgtacacatc cacactcaca ctcactcagg
     1801 gttcccggac cggctgtcct gcctgcggaa ctgaggtaaa ctagctcagg tgctgacact
     1861 aggagggtct accttacata aggtacaggt agaagcttga ttgctaggcc caggcccacc
     1921 cagaccctcc aatcctaaca ggtatttagg cttgaggttc actccctcct cagctgcaca
     1981 cgcagccagg tattaacgag gatcagagct gttctgaggg gtgggaagga gcagccccac
     2041 caccactcac tcaccctcag tcacatcggg gagggggcac cagttacatt tacatcacat
     2101 tatttataaa ataagaatta catttcatat aacatggcca gaaggagctc tagtccccca
     2161 ggaaagctgc cggggacagc atttgagcct cttctttgca caggcataac ttaactatac
     2221 agctaattcc tagttaatag catttatact taaccacctc aatgaaccaa gcttgaagga
     2281 atttaaaagg caatttagct taaatacaaa aataaatttt tgttaaaaaa cgttta
//
