LOCUS       NM_015537               3643 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens NMDA receptor synaptonuclear signaling and neuronal
            migration factor (NSMF), transcript variant 2, mRNA.
ACCESSION   NM_015537 NM_182780
VERSION     NM_015537.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3643)
  AUTHORS   Aoki,K., Nitta,A. and Igarashi,A.
  TITLE     NELF and PAF1C complexes are core transcriptional machineries
            controlling colon cancer stemness
  JOURNAL   Oncogene 43 (8), 566-577 (2024)
   PUBMED   38182897
  REMARK    GeneRIF: NELF and PAF1C complexes are core transcriptional
            machineries controlling colon cancer stemness.
REFERENCE   2  (bases 1 to 3643)
  AUTHORS   Ju,M.K., Shin,K.J., Lee,J.R., Khim,K.W., A Lee,E., Ra,J.S.,
            Kim,B.G., Jo,H.S., Yoon,J.H., Kim,T.M., Myung,K., Choi,J.H., Kim,H.
            and Chae,Y.C.
  TITLE     NSMF promotes the replication stress-induced DNA damage response
            for genome maintenance
  JOURNAL   Nucleic Acids Res 49 (10), 5605-5622 (2021)
   PUBMED   33963872
  REMARK    GeneRIF: NSMF promotes the replication stress-induced DNA damage
            response for genome maintenance.
REFERENCE   3  (bases 1 to 3643)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3643)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3643)
  AUTHORS   Ko,E.K., Chorich,L.P., Sullivan,M.E., Cameron,R.S. and Layman,L.C.
  TITLE     JAK/STAT signaling pathway gene expression is reduced following
            Nelf knockdown in GnRH neurons
  JOURNAL   Mol Cell Endocrinol 470, 151-159 (2018)
   PUBMED   29050862
  REMARK    GeneRIF: These findings suggest a role for NELF in the regulation
            of the JAK/STAT signaling pathway, which have important functions
            in GnRH neurons.
REFERENCE   6  (bases 1 to 3643)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 3643)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 3643)
  AUTHORS   Miura,K., Acierno,J.S. Jr. and Seminara,S.B.
  TITLE     Characterization of the human nasal embryonic LHRH factor gene,
            NELF, and a mutation screening among 65 patients with idiopathic
            hypogonadotropic hypogonadism (IHH)
  JOURNAL   J Hum Genet 49 (5), 265-268 (2004)
   PUBMED   15362570
REFERENCE   9  (bases 1 to 3643)
  AUTHORS   Kramer,P.R. and Wray,S.
  TITLE     Novel gene expressed in nasal region influences outgrowth of
            olfactory axons and migration of luteinizing hormone-releasing
            hormone (LHRH) neurons
  JOURNAL   Genes Dev 14 (14), 1824-1834 (2000)
   PUBMED   10898796
REFERENCE   10 (bases 1 to 3643)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY255128.1, BC072412.1,
            CN306732.1, BM023184.1 and AW072125.1.
            
            On Aug 13, 2020 this sequence version replaced NM_015537.4.
            
            Summary: The protein encoded by this gene is involved in guidance
            of olfactory axon projections and migration of luteinizing
            hormone-releasing hormone neurons. Defects in this gene are a cause
            of idiopathic hypogonadotropic hypogonadism (IHH). Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (b) has the same
            N- and C-termini but is shorter compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY255129.1, BC072412.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AY255128.1         1-15
            16-2988             BC072412.1         1-2973
            2989-3218           CN306732.1         115-344
            3219-3599           BM023184.1         222-602
            3600-3643           AW072125.1         4-47                c
FEATURES             Location/Qualifiers
     source          1..3643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..3643
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="NMDA receptor synaptonuclear signaling and neuronal
                     migration factor"
                     /db_xref="GeneID:26012"
                     /db_xref="HGNC:HGNC:29843"
                     /db_xref="MIM:608137"
     exon            1..303
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1819
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="isoform b is encoded by transcript variant 2; nasal
                     embryonic luteinizing hormone-releasing hormone factor;
                     nasal embryonic LHRH factor"
                     /codon_start=1
                     /product="NMDA receptor synaptonuclear signaling and
                     neuronal migration factor isoform b"
                     /protein_id="NP_056352.3"
                     /db_xref="CCDS:CCDS7044.1"
                     /db_xref="GeneID:26012"
                     /db_xref="HGNC:HGNC:29843"
                     /db_xref="MIM:608137"
                     /translation="MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGA
                     DHLLADAYSGHDGSPEMQPAPQNKRRLSLVSNGCYEGSLSEEPSIRKPAGEGPQPRVY
                     TISGEPALLPSPEAEAIELAVVKGRRQRHPHHHSQPLRASPGGSREDVSRPCQSWAGS
                     RQGSKECPGCAQLAPGPTPRAFGLDQPPLPETSGRRKKLERMYSVDRVSDDIPIRTWF
                     PKENLFSFQTATTTMQAVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQT
                     FAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEAFEDLDWDTEKGLEAV
                     ACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIERK
                     LNVYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVN
                     PEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYRVTFESPLELSAQGKQMIETYFDFR
                     LYRLWKSRQHSKLLDFDDVL"
     exon            304..365
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            366..860
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            861..936
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1005
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1058
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1148
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1273
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1357
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1391
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1462
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1542
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1645
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1721
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..3643
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2966..2971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="hexamer: ATTAAA"
     polyA_site      2988
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="major polyA site"
     regulatory      3619..3624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="hexamer: TATAAA"
     polyA_site      3643
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
ORIGIN      
        1 ggttcgggca gcgctctccc gggagcggcg gcacgcgcgg agcgccgggt gcggccatgc
       61 ggggaccggg cccgaccccg agcccgaccc cgagcccaag cccgagccgg agcccgagcg
      121 agaccccgag cccgagcccg agcgcgaccc ccggtgcggc gcggctaccc cggcggaggc
      181 ggcgggcgcg gggcgcgctc tgaggcccgg gggatgcgcc gccgcctcga ccatgggcgc
      241 cgccgcctcc aggaggaggg cgctgaggag cgaggccatg tcctcggtgg cggccaaagt
      301 gcgagcagcc cgagcgtttg gagagtacct gtcccagagt caccctgaga accgcaacgg
      361 cgcagatcac ctgctggctg atgcctactc tggccacgac gggtcccccg agatgcagcc
      421 ggccccccag aacaagcgcc gcctgtccct cgtctccaac ggctgctacg agggcagcct
      481 ctcagaggag cccagcatta ggaagcccgc aggcgagggc cctcagcctc gagtgtacac
      541 catctctggg gagcctgccc tgctgcccag ccctgaggcg gaggccattg agctggcggt
      601 ggtgaagggg cggcggcagc ggcaccctca ccatcacagc cagcccctgc gcgccagccc
      661 tggtggcagc cgggaggacg tcagcaggcc ctgccagagc tgggcgggca gccgccaggg
      721 ctccaaggag tgccccggat gtgcccagct ggctcctggc cccacccctc gggcctttgg
      781 gctggaccag ccacctctgc ctgagacctc cggtcgccgc aagaagctgg agaggatgta
      841 cagcgttgac cgtgtgtctg acgacatccc tattcgtacc tggttcccca aggaaaatct
      901 tttcagcttc cagacagcaa ccacaactat gcaagcggtg ttcaggggct acgcggagag
      961 gaagcgccgg aaacgggaga atgattccgc gtctgtaatc cagaggaact tccgcaaaca
     1021 cctgcgcatg gtcggcagcc ggagggtgaa ggcccagacg ttcgctgagc ggcgcgagcg
     1081 gagcttcagc cggtcctgga gcgaccccac ccccatgaaa gccgacactt cccacgactc
     1141 ccgagacagc agtgacctgc agagctccca ctgcacgctg gacgaggcct tcgaggacct
     1201 ggactgggac actgagaagg gcctggaggc tgtggcctgc gacaccgaag gcttcgtgcc
     1261 accaaaggtc atgctcattt cctccaaggt gcccaaggct gagtacatcc ccactatcat
     1321 ccgccgggat gacccctcca tcatccccat cctctacgac catgagcacg caaccttcga
     1381 ggacatcctt gaggagatag agaggaagct gaacgtctac cacaagggag ccaagatctg
     1441 gaaaatgctg attttctgcc agggaggtcc tggacacctc tatctcctca agaacaaggt
     1501 ggccaccttt gccaaagtgg agaaggaaga ggacatgatt cacttctgga agcggctgag
     1561 ccgcctgatg agcaaagtga acccagagcc gaacgtcatc cacatcatgg gctgctacat
     1621 tctggggaac cccaatggag agaagctgtt ccagaacctc aggaccctca tgactcctta
     1681 tagggtcacc ttcgagtcac ccctggagct ctcagcccaa gggaagcaga tgatcgagac
     1741 gtactttgac ttccggttgt atcgcctgtg gaagagccgc cagcactcga agctgctgga
     1801 ctttgacgac gtcctgtgag gggcagaggc ctccgcccag tcaccatcag gccactccct
     1861 ctgcaccggg acctggggct gggccgcctc gtgctccccg ggactgtgtg gctccggtct
     1921 cgcctggagc cacttcaggg cacctcagac gttgctcagg ttccccctgt gggttccggt
     1981 cctcgctgca cccgtggccg cagaggctgc agtccctggg ggccgggagg atcccgccct
     2041 gtggcccgtg gatgctcagc ggccaggcac tgacctgcca tgcctcgcct ggaggctcag
     2101 ctgtgggcat ccctccatgg ggttcataga aataagtgca atttctacac ccccgaaaca
     2161 attcaaaggg aagcagcatt tcttgttaac tagttaagca ctatgctgct agttacagtg
     2221 taggcacccc ggcccagcag cccagcagcc cacatgtgtt caggaccctc cctgcccacc
     2281 ccctccctgc cgtatcgatc accagcacca gggtggcccg tgtgcgtggg gccagcgtcg
     2341 ccgggctgcc cagcctggct ctgtctacac tggccgagtc tctgggtctg tctacactgg
     2401 ccgagtctcc gactgtctgt gctttcactt acactcctct tgccaccccc catccctgct
     2461 tacttagacc tcagccggcg ccggacccgg taggggcagt ctgggcagca ggaaggaagg
     2521 gcgcagcgtc ccctccttca gaggaggctc tgggtggggc ctgctcccca tccccccaag
     2581 cccacccagc actctcattg ctgctgttga gttcagcttt taccagcctc agtgtggagg
     2641 ctccatccca gcacacaggc ctggggcttg gcaggggccc agctggggct gggccctggg
     2701 ttttgagaaa ctcgctggca ccacagtggg cccctggacc cggccgcgca gctggtggac
     2761 tgtaggggct cctgactggg cacaggagct cccagctttt gtccacggcc agcaggatgg
     2821 gctgtcgtgt atatagctgg ggcgaggggg caggcccccc ttgtgcagag ccaggggtct
     2881 gagggcacct ggctgtgttc ccagctgagg gagggctggg gcgggggccg ggcttggaac
     2941 gatgtacgat accctcatag tgaccattaa acctgatcct ccaccgcggc cgccgcgtgg
     3001 gtctgtcctc tcagtgcttt ccaggggcct tcctgtgccc agcttctggg cccactcctg
     3061 tgaggtcact gctgcagggc cttcctgcct ggacagagtt ggagctaggc cactagacca
     3121 ccccacaggg catagccagg gggaccagca caggagggga cggagaggag ctgcaggagg
     3181 gctgggggga ggctgcagtc tcggaggggg gcctcgccgg gtctggaggg gacagcagag
     3241 acagcccgtt ccccctgccg cctgagggca ccagggagag ggctgtatgt ccctcacgcc
     3301 acactgtgtg tgcagtcagc agtgtggcca cagatggggg ccactctctc aacctcaggt
     3361 gtcctcaggg cccagaccgc tgctgggcac agccaggctg gctgccagct ggttccctgc
     3421 cccgtggctg ggggacagag cagcacgtat cagctgggct agggtcaggg ggccactggt
     3481 gcgcagcctg gcacagcctg gcaggcttga ggcccagtgt gctgggggtg gtcacacagc
     3541 cgtcagccac ctccagctct tccagggcat tctagatggg gtcccgggag ggggcaggtt
     3601 ttggtgccaa tttgagtgta taaagtttta ggtaaatacc aaa
//
