LOCUS       NM_001130971            3574 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens NMDA receptor synaptonuclear signaling and neuronal
            migration factor (NSMF), transcript variant 4, mRNA.
ACCESSION   NM_001130971
VERSION     NM_001130971.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3574)
  AUTHORS   Aoki,K., Nitta,A. and Igarashi,A.
  TITLE     NELF and PAF1C complexes are core transcriptional machineries
            controlling colon cancer stemness
  JOURNAL   Oncogene 43 (8), 566-577 (2024)
   PUBMED   38182897
  REMARK    GeneRIF: NELF and PAF1C complexes are core transcriptional
            machineries controlling colon cancer stemness.
REFERENCE   2  (bases 1 to 3574)
  AUTHORS   Ju,M.K., Shin,K.J., Lee,J.R., Khim,K.W., A Lee,E., Ra,J.S.,
            Kim,B.G., Jo,H.S., Yoon,J.H., Kim,T.M., Myung,K., Choi,J.H., Kim,H.
            and Chae,Y.C.
  TITLE     NSMF promotes the replication stress-induced DNA damage response
            for genome maintenance
  JOURNAL   Nucleic Acids Res 49 (10), 5605-5622 (2021)
   PUBMED   33963872
  REMARK    GeneRIF: NSMF promotes the replication stress-induced DNA damage
            response for genome maintenance.
REFERENCE   3  (bases 1 to 3574)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3574)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3574)
  AUTHORS   Ko,E.K., Chorich,L.P., Sullivan,M.E., Cameron,R.S. and Layman,L.C.
  TITLE     JAK/STAT signaling pathway gene expression is reduced following
            Nelf knockdown in GnRH neurons
  JOURNAL   Mol Cell Endocrinol 470, 151-159 (2018)
   PUBMED   29050862
  REMARK    GeneRIF: These findings suggest a role for NELF in the regulation
            of the JAK/STAT signaling pathway, which have important functions
            in GnRH neurons.
REFERENCE   6  (bases 1 to 3574)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 3574)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 3574)
  AUTHORS   Miura,K., Acierno,J.S. Jr. and Seminara,S.B.
  TITLE     Characterization of the human nasal embryonic LHRH factor gene,
            NELF, and a mutation screening among 65 patients with idiopathic
            hypogonadotropic hypogonadism (IHH)
  JOURNAL   J Hum Genet 49 (5), 265-268 (2004)
   PUBMED   15362570
REFERENCE   9  (bases 1 to 3574)
  AUTHORS   Kramer,P.R. and Wray,S.
  TITLE     Novel gene expressed in nasal region influences outgrowth of
            olfactory axons and migration of luteinizing hormone-releasing
            hormone (LHRH) neurons
  JOURNAL   Genes Dev 14 (14), 1824-1834 (2000)
   PUBMED   10898796
REFERENCE   10 (bases 1 to 3574)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY255128.1, BC110498.2,
            CN306732.1, BM023184.1 and AW072125.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001130971.1.
            
            Summary: The protein encoded by this gene is involved in guidance
            of olfactory axon projections and migration of luteinizing
            hormone-releasing hormone neurons. Defects in this gene are a cause
            of idiopathic hypogonadotropic hypogonadism (IHH). Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (4) lacks two alternate in-frame
            exons compared to variant 1. The resulting isoform (d) has the same
            N- and C-termini but is shorter compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110498.2, SRR11853565.29676.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AY255128.1         1-145
            146-2449            BC110498.2         13-2316
            2450-2912           AY255128.1         2525-2987
            2913-3149           CN306732.1         108-344
            3150-3530           BM023184.1         222-602
            3531-3574           AW072125.1         4-47                c
FEATURES             Location/Qualifiers
     source          1..3574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..3574
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="NMDA receptor synaptonuclear signaling and neuronal
                     migration factor"
                     /db_xref="GeneID:26012"
                     /db_xref="HGNC:HGNC:29843"
                     /db_xref="MIM:608137"
     exon            1..303
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1750
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="isoform d is encoded by transcript variant 4; nasal
                     embryonic luteinizing hormone-releasing hormone factor;
                     nasal embryonic LHRH factor"
                     /codon_start=1
                     /product="NMDA receptor synaptonuclear signaling and
                     neuronal migration factor isoform d"
                     /protein_id="NP_001124443.1"
                     /db_xref="CCDS:CCDS48067.1"
                     /db_xref="GeneID:26012"
                     /db_xref="HGNC:HGNC:29843"
                     /db_xref="MIM:608137"
                     /translation="MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGA
                     DHLLADAYSGHDGSPEMQPAPQNKRRLSLVSNGCYEGSLSEEPSIRKPAGEGPQPRVY
                     TISGEPALLPSPEAEAIELAVVKGRRQRHPHHHSQPLRASPGGSREDVSRPCQSWAGS
                     RQGSKECPGCAQLAPGPTPRAFGLDQPPLPETSGRRKKLERMYSVDRVSDDIPIRTWF
                     PKENLFSFQTATTTMQANFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADT
                     SHDSRDSSDLQSSHCTLDEAFEDLDWDTEKGLEAVACDTEGFVPPKVMLISSKVPKAE
                     YIPTIIRRDDPSIIPILYDHEHATFEDILEEIERKLNVYHKGAKIWKMLIFCQGGPGH
                     LYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLF
                     QNLRTLMTPYRVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL"
     exon            304..365
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            366..860
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            861..936
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            937..989
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1079
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1204
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1288
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1322
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1393
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1473
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1576
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1652
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..3574
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2897..2902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="hexamer: ATTAAA"
     polyA_site      2919
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="major polyA site"
     regulatory      3550..3555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="hexamer: TATAAA"
     polyA_site      3574
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
ORIGIN      
        1 ggttcgggca gcgctctccc gggagcggcg gcacgcgcgg agcgccgggt gcggccatgc
       61 ggggaccggg cccgaccccg agcccgaccc cgagcccaag cccgagccgg agcccgagcg
      121 agaccccgag cccgagcccg agcgcgaccc ccggtgcggc gcggctaccc cggcggaggc
      181 ggcgggcgcg gggcgcgctc tgaggcccgg gggatgcgcc gccgcctcga ccatgggcgc
      241 cgccgcctcc aggaggaggg cgctgaggag cgaggccatg tcctcggtgg cggccaaagt
      301 gcgagcagcc cgagcgtttg gagagtacct gtcccagagt caccctgaga accgcaacgg
      361 cgcagatcac ctgctggctg atgcctactc tggccacgac gggtcccccg agatgcagcc
      421 ggccccccag aacaagcgcc gcctgtccct cgtctccaac ggctgctacg agggcagcct
      481 ctcagaggag cccagcatta ggaagcccgc aggcgagggc cctcagcctc gagtgtacac
      541 catctctggg gagcctgccc tgctgcccag ccctgaggcg gaggccattg agctggcggt
      601 ggtgaagggg cggcggcagc ggcaccctca ccatcacagc cagcccctgc gcgccagccc
      661 tggtggcagc cgggaggacg tcagcaggcc ctgccagagc tgggcgggca gccgccaggg
      721 ctccaaggag tgccccggat gtgcccagct ggctcctggc cccacccctc gggcctttgg
      781 gctggaccag ccacctctgc ctgagacctc cggtcgccgc aagaagctgg agaggatgta
      841 cagcgttgac cgtgtgtctg acgacatccc tattcgtacc tggttcccca aggaaaatct
      901 tttcagcttc cagacagcaa ccacaactat gcaagcgaac ttccgcaaac acctgcgcat
      961 ggtcggcagc cggagggtga aggcccagac gttcgctgag cggcgcgagc ggagcttcag
     1021 ccggtcctgg agcgacccca cccccatgaa agccgacact tcccacgact cccgagacag
     1081 cagtgacctg cagagctccc actgcacgct ggacgaggcc ttcgaggacc tggactggga
     1141 cactgagaag ggcctggagg ctgtggcctg cgacaccgaa ggcttcgtgc caccaaaggt
     1201 catgctcatt tcctccaagg tgcccaaggc tgagtacatc cccactatca tccgccggga
     1261 tgacccctcc atcatcccca tcctctacga ccatgagcac gcaaccttcg aggacatcct
     1321 tgaggagata gagaggaagc tgaacgtcta ccacaaggga gccaagatct ggaaaatgct
     1381 gattttctgc cagggaggtc ctggacacct ctatctcctc aagaacaagg tggccacctt
     1441 tgccaaagtg gagaaggaag aggacatgat tcacttctgg aagcggctga gccgcctgat
     1501 gagcaaagtg aacccagagc cgaacgtcat ccacatcatg ggctgctaca ttctggggaa
     1561 ccccaatgga gagaagctgt tccagaacct caggaccctc atgactcctt atagggtcac
     1621 cttcgagtca cccctggagc tctcagccca agggaagcag atgatcgaga cgtactttga
     1681 cttccggttg tatcgcctgt ggaagagccg ccagcactcg aagctgctgg actttgacga
     1741 cgtcctgtga ggggcagagg cctccgccca gtcaccatca ggccactccc tctgcaccgg
     1801 gacctggggc tgggccgcct cgtgctcccc gggactgtgt ggctccggtc tcgcctggag
     1861 ccacttcagg gcacctcaga cgttgctcag gttccccctg tgggttccgg tcctcgctgc
     1921 acccgtggcc gcagaggctg cagtccctgg gggccgggag gatcccgccc tgtggcccgt
     1981 ggatgctcag cggccaggca ctgacctgcc atgcctcgcc tggaggctca gctgtgggca
     2041 tccctccatg gggttcatag aaataagtgc aatttctaca cccccgaaac aattcaaagg
     2101 gaagcagcat ttcttgttaa ctagttaagc actatgctgc tagttacagt gtaggcaccc
     2161 cggcccagca gcccagcagc ccacatgtgt tcaggaccct ccctgcccac cccctccctg
     2221 ccgtatcgat caccagcacc agggtggccc gtgtgcgtgg ggccagcgtc gccgggctgc
     2281 ccagcctggc tctgtctaca ctggccgagt ctctgggtct gtctacactg gccgagtctc
     2341 cgactgtctg tgctttcact tacactcctc ttgccacccc ccatccctgc ttacttagac
     2401 ctcagccggc gccggacccg gtaggggcag tctgggcagc aggaaggaag ggcgcagcgt
     2461 cccctccttc agaggaggct ctgggtgggg cctgctcccc atccccccaa gcccacccag
     2521 cactctcatt gctgctgttg agttcagctt ttaccagcct cagtgtggag gctccatccc
     2581 agcacacagg cctggggctt ggcaggggcc cagctggggc tgggccctgg gttttgagaa
     2641 actcgctggc accacagtgg gcccctggac ccggccgcgc agctggtgga ctgtaggggc
     2701 tcctgactgg gcacaggagc tcccagcttt tgtccacggc cagcaggatg ggctgtcgtg
     2761 tatatagctg gggcgagggg gcaggccccc cttgtgcaga gccaggggtc tgagggcacc
     2821 tggctgtgtt cccagctgag ggagggctgg ggcgggggcc gggcttggaa cgatgtacga
     2881 taccctcata gtgaccatta aacctgatcc tccaccgcgg ccgccgcgtg ggtctgtcct
     2941 ctcagtgctt tccaggggcc ttcctgtgcc cagcttctgg gcccactcct gtgaggtcac
     3001 tgctgcaggg ccttcctgcc tggacagagt tggagctagg ccactagacc accccacagg
     3061 gcatagccag ggggaccagc acaggagggg acggagagga gctgcaggag ggctgggggg
     3121 aggctgcagt ctcggagggg ggcctcgccg ggtctggagg ggacagcaga gacagcccgt
     3181 tccccctgcc gcctgagggc accagggaga gggctgtatg tccctcacgc cacactgtgt
     3241 gtgcagtcag cagtgtggcc acagatgggg gccactctct caacctcagg tgtcctcagg
     3301 gcccagaccg ctgctgggca cagccaggct ggctgccagc tggttccctg ccccgtggct
     3361 gggggacaga gcagcacgta tcagctgggc tagggtcagg gggccactgg tgcgcagcct
     3421 ggcacagcct ggcaggcttg aggcccagtg tgctgggggt ggtcacacag ccgtcagcca
     3481 cctccagctc ttccagggca ttctagatgg ggtcccggga gggggcaggt tttggtgcca
     3541 atttgagtgt ataaagtttt aggtaaatac caaa
//
