LOCUS       NM_001130969            3649 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens NMDA receptor synaptonuclear signaling and neuronal
            migration factor (NSMF), transcript variant 1, mRNA.
ACCESSION   NM_001130969
VERSION     NM_001130969.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3649)
  AUTHORS   Aoki,K., Nitta,A. and Igarashi,A.
  TITLE     NELF and PAF1C complexes are core transcriptional machineries
            controlling colon cancer stemness
  JOURNAL   Oncogene 43 (8), 566-577 (2024)
   PUBMED   38182897
  REMARK    GeneRIF: NELF and PAF1C complexes are core transcriptional
            machineries controlling colon cancer stemness.
REFERENCE   2  (bases 1 to 3649)
  AUTHORS   Ju,M.K., Shin,K.J., Lee,J.R., Khim,K.W., A Lee,E., Ra,J.S.,
            Kim,B.G., Jo,H.S., Yoon,J.H., Kim,T.M., Myung,K., Choi,J.H., Kim,H.
            and Chae,Y.C.
  TITLE     NSMF promotes the replication stress-induced DNA damage response
            for genome maintenance
  JOURNAL   Nucleic Acids Res 49 (10), 5605-5622 (2021)
   PUBMED   33963872
  REMARK    GeneRIF: NSMF promotes the replication stress-induced DNA damage
            response for genome maintenance.
REFERENCE   3  (bases 1 to 3649)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3649)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3649)
  AUTHORS   Ko,E.K., Chorich,L.P., Sullivan,M.E., Cameron,R.S. and Layman,L.C.
  TITLE     JAK/STAT signaling pathway gene expression is reduced following
            Nelf knockdown in GnRH neurons
  JOURNAL   Mol Cell Endocrinol 470, 151-159 (2018)
   PUBMED   29050862
  REMARK    GeneRIF: These findings suggest a role for NELF in the regulation
            of the JAK/STAT signaling pathway, which have important functions
            in GnRH neurons.
REFERENCE   6  (bases 1 to 3649)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 3649)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 3649)
  AUTHORS   Miura,K., Acierno,J.S. Jr. and Seminara,S.B.
  TITLE     Characterization of the human nasal embryonic LHRH factor gene,
            NELF, and a mutation screening among 65 patients with idiopathic
            hypogonadotropic hypogonadism (IHH)
  JOURNAL   J Hum Genet 49 (5), 265-268 (2004)
   PUBMED   15362570
REFERENCE   9  (bases 1 to 3649)
  AUTHORS   Kramer,P.R. and Wray,S.
  TITLE     Novel gene expressed in nasal region influences outgrowth of
            olfactory axons and migration of luteinizing hormone-releasing
            hormone (LHRH) neurons
  JOURNAL   Genes Dev 14 (14), 1824-1834 (2000)
   PUBMED   10898796
REFERENCE   10 (bases 1 to 3649)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365502.57.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 3, 2019 this sequence version replaced NM_001130969.2.
            
            Summary: The protein encoded by this gene is involved in guidance
            of olfactory axon projections and migration of luteinizing
            hormone-releasing hormone neurons. Defects in this gene are a cause
            of idiopathic hypogonadotropic hypogonadism (IHH). Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY255128.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371475.9/ ENSP00000360530.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AL365502.57        13733-14035         c
            304-365             AL365502.57        13189-13250         c
            366-860             AL365502.57        12108-12602         c
            861-936             AL365502.57        11112-11187         c
            937-942             AL365502.57        10330-10335         c
            943-1011            AL365502.57        9940-10008          c
            1012-1064           AL365502.57        9092-9144           c
            1065-1154           AL365502.57        8432-8521           c
            1155-1279           AL365502.57        7757-7881           c
            1280-1363           AL365502.57        7437-7520           c
            1364-1397           AL365502.57        7254-7287           c
            1398-1468           AL365502.57        7066-7136           c
            1469-1548           AL365502.57        4877-4956           c
            1549-1651           AL365502.57        4624-4726           c
            1652-1727           AL365502.57        4300-4375           c
            1728-3649           AL365502.57        2271-4192           c
FEATURES             Location/Qualifiers
     source          1..3649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..3649
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="NMDA receptor synaptonuclear signaling and neuronal
                     migration factor"
                     /db_xref="GeneID:26012"
                     /db_xref="HGNC:HGNC:29843"
                     /db_xref="MIM:608137"
     exon            1..303
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1825
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="isoform a is encoded by transcript variant 1; nasal
                     embryonic luteinizing hormone-releasing hormone factor;
                     nasal embryonic LHRH factor"
                     /codon_start=1
                     /product="NMDA receptor synaptonuclear signaling and
                     neuronal migration factor isoform a"
                     /protein_id="NP_001124441.1"
                     /db_xref="CCDS:CCDS48069.1"
                     /db_xref="GeneID:26012"
                     /db_xref="HGNC:HGNC:29843"
                     /db_xref="MIM:608137"
                     /translation="MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGA
                     DHLLADAYSGHDGSPEMQPAPQNKRRLSLVSNGCYEGSLSEEPSIRKPAGEGPQPRVY
                     TISGEPALLPSPEAEAIELAVVKGRRQRHPHHHSQPLRASPGGSREDVSRPCQSWAGS
                     RQGSKECPGCAQLAPGPTPRAFGLDQPPLPETSGRRKKLERMYSVDRVSDDIPIRTWF
                     PKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKA
                     QTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEAFEDLDWDTEKGLE
                     AVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIE
                     RKLNVYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSK
                     VNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYRVTFESPLELSAQGKQMIETYFD
                     FRLYRLWKSRQHSKLLDFDDVL"
     exon            304..365
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            366..860
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            861..936
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            937..942
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1011
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1064
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1154
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1279
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1363
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1397
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1468
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1548
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1651
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1727
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..3649
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2972..2977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="hexamer: ATTAAA"
     polyA_site      2994
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="major polyA site"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
                     /note="hexamer: TATAAA"
     polyA_site      3649
                     /gene="NSMF"
                     /gene_synonym="HH9; NELF"
ORIGIN      
        1 ggttcgggca gcgctctccc gggagcggcg gcacgcgcgg agcgccgggt gcggccatgc
       61 ggggaccggg cccgaccccg agcccgaccc cgagcccaag cccgagccgg agcccgagcg
      121 agaccccgag cccgagcccg agcgcgaccc ccggtgcggc gcggctaccc cggcggaggc
      181 ggcgggcgcg gggcgcgctc tgaggcccgg gggatgcgcc gccgcctcga ccatgggcgc
      241 cgccgcctcc aggaggaggg cgctgaggag cgaggccatg tcctcggtgg cggccaaagt
      301 gcgagcagcc cgagcgtttg gagagtacct gtcccagagt caccctgaga accgcaacgg
      361 cgcagatcac ctgctggctg atgcctactc tggccacgac gggtcccccg agatgcagcc
      421 ggccccccag aacaagcgcc gcctgtccct cgtctccaac ggctgctacg agggcagcct
      481 ctcagaggag cccagcatta ggaagcccgc aggcgagggc cctcagcctc gagtgtacac
      541 catctctggg gagcctgccc tgctgcccag ccctgaggcg gaggccattg agctggcggt
      601 ggtgaagggg cggcggcagc ggcaccctca ccatcacagc cagcccctgc gcgccagccc
      661 tggtggcagc cgggaggacg tcagcaggcc ctgccagagc tgggcgggca gccgccaggg
      721 ctccaaggag tgccccggat gtgcccagct ggctcctggc cccacccctc gggcctttgg
      781 gctggaccag ccacctctgc ctgagacctc cggtcgccgc aagaagctgg agaggatgta
      841 cagcgttgac cgtgtgtctg acgacatccc tattcgtacc tggttcccca aggaaaatct
      901 tttcagcttc cagacagcaa ccacaactat gcaagccatc tcggtgttca ggggctacgc
      961 ggagaggaag cgccggaaac gggagaatga ttccgcgtct gtaatccaga ggaacttccg
     1021 caaacacctg cgcatggtcg gcagccggag ggtgaaggcc cagacgttcg ctgagcggcg
     1081 cgagcggagc ttcagccggt cctggagcga ccccaccccc atgaaagccg acacttccca
     1141 cgactcccga gacagcagtg acctgcagag ctcccactgc acgctggacg aggccttcga
     1201 ggacctggac tgggacactg agaagggcct ggaggctgtg gcctgcgaca ccgaaggctt
     1261 cgtgccacca aaggtcatgc tcatttcctc caaggtgccc aaggctgagt acatccccac
     1321 tatcatccgc cgggatgacc cctccatcat ccccatcctc tacgaccatg agcacgcaac
     1381 cttcgaggac atccttgagg agatagagag gaagctgaac gtctaccaca agggagccaa
     1441 gatctggaaa atgctgattt tctgccaggg aggtcctgga cacctctatc tcctcaagaa
     1501 caaggtggcc acctttgcca aagtggagaa ggaagaggac atgattcact tctggaagcg
     1561 gctgagccgc ctgatgagca aagtgaaccc agagccgaac gtcatccaca tcatgggctg
     1621 ctacattctg gggaacccca atggagagaa gctgttccag aacctcagga ccctcatgac
     1681 tccttatagg gtcaccttcg agtcacccct ggagctctca gcccaaggga agcagatgat
     1741 cgagacgtac tttgacttcc ggttgtatcg cctgtggaag agccgccagc actcgaagct
     1801 gctggacttt gacgacgtcc tgtgaggggc agaggcctcc gcccagtcac catcaggcca
     1861 ctccctctgc accgggacct ggggctgggc cgcctcgtgc tccccgggac tgtgtggctc
     1921 cggtctcgcc tggagccact tcagggcacc tcagacgttg ctcaggttcc ccctgtgggt
     1981 tccggtcctc gctgcacccg tggccgcaga ggctgcagtc cctgggggcc gggaggatcc
     2041 cgccctgtgg cccgtggatg ctcagcggcc aggcactgac ctgccatgcc tcgcctggag
     2101 gctcagctgt gggcatccct ccatggggtt catagaaata agtgcaattt ctacaccccc
     2161 gaaacaattc aaagggaagc agcatttctt gttaactagt taagcactat gctgctagtt
     2221 acagtgtagg caccccggcc cagcagccca gcagcccaca tgtgttcagg accctccctg
     2281 cccaccccct ccctgccgta tcgatcacca gcaccagggt ggcccgtgtg cgtggggcca
     2341 gcgtcgccgg gctgcccagc ctggctctgt ctacactggc cgagtctctg ggtctgtcta
     2401 cactggccga gtctccgact gtctgtgctt tcacttacac tcctcttgcc accccccatc
     2461 cctgcttact tagacctcag ccggcgccgg acccggtagg ggcagtctgg gcagcaggaa
     2521 ggaagggcgc agcgtcccct ccttcagagg aggctctggg tggggcctgc tccccatccc
     2581 cccaagccca cccagcactc tcattgctgc tgttgagttc agcttttacc agcctcagtg
     2641 tggaggctcc atcccagcac acaggcctgg ggcttggcag gggcccagct ggggctgggc
     2701 cctgggtttt gagaaactcg ctggcaccac agtgggcccc tggacccggc cgcgcagctg
     2761 gtggactgta ggggctcctg actgggcaca ggagctccca gcttttgtcc acggccagca
     2821 ggatgggctg tcgtgtatat agctggggcg agggggcagg ccccccttgt gcagagccag
     2881 gggtctgagg gcacctggct gtgttcccag ctgagggagg gctggggcgg gggccgggct
     2941 tggaacgatg tacgataccc tcatagtgac cattaaacct gatcctccac cgcggccgcc
     3001 gcgtgggtct gtcctctcag tgctttccag gggccttcct gtgcccagct tctgggccca
     3061 ctcctgtgag gtcactgctg cagggccttc ctgcctggac agagttggag ctaggccact
     3121 agaccacccc acagggcata gccaggggga ccagcacagg aggggacgga gaggagctgc
     3181 aggagggctg gggggaggct gcagtctcgg aggggggcct cgccgggtct ggaggggaca
     3241 gcagagacag cccgttcccc ctgccgcctg agggcaccag ggagagggct gtatgtccct
     3301 cacgccacac tgtgtgtgca gtcagcagtg tggccacaga tgggggccac tctctcaacc
     3361 tcaggtgtcc tcagggccca gaccgctgct gggcacagcc aggctggctg ccagctggtt
     3421 ccctgccccg tggctggggg acagagcagc acgtatcagc tgggctaggg tcagggggcc
     3481 actggtgcgc agcctggcac agcctggcag gcttgaggcc cagtgtgctg ggggtggtca
     3541 cacagccgtc agccacctcc agctcttcca gggcattcta gatggggtcc cgggaggggg
     3601 caggttttgg tgccaatttg agtgtataaa gttttaggta aataccaaa
//
