LOCUS       NM_138704               4834 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens NSE3 homolog, SMC5-SMC6 complex component (NSMCE3),
            mRNA.
ACCESSION   NM_138704
VERSION     NM_138704.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4834)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4834)
  AUTHORS   Adamus,M., Lelkes,E., Potesil,D., Ganji,S.R., Kolesar,P.,
            Zabrady,K., Zdrahal,Z. and Palecek,J.J.
  TITLE     Molecular Insights into the Architecture of the Human SMC5/6
            Complex
  JOURNAL   J Mol Biol 432 (13), 3820-3837 (2020)
   PUBMED   32389690
REFERENCE   3  (bases 1 to 4834)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4834)
  AUTHORS   van der Crabben,S.N., Hennus,M.P., McGregor,G.A., Ritter,D.I.,
            Nagamani,S.C., Wells,O.S., Harakalova,M., Chinn,I.K., Alt,A.,
            Vondrova,L., Hochstenbach,R., van Montfrans,J.M.,
            Terheggen-Lagro,S.W., van Lieshout,S., van Roosmalen,M.J.,
            Renkens,I., Duran,K., Nijman,I.J., Kloosterman,W.P., Hennekam,E.,
            Orange,J.S., van Hasselt,P.M., Wheeler,D.A., Palecek,J.J.,
            Lehmann,A.R., Oliver,A.W., Pearl,L.H., Plon,S.E., Murray,J.M. and
            van Haaften,G.
  TITLE     Destabilized SMC5/6 complex leads to chromosome breakage syndrome
            with severe lung disease
  JOURNAL   J Clin Invest 126 (8), 2881-2892 (2016)
   PUBMED   27427983
  REMARK    GeneRIF: NSMCE3 (also known as NDNL2) gene encodes a subunit of the
            SMC5/6 complex that is essential for DNA damage response and
            chromosome segregation
REFERENCE   5  (bases 1 to 4834)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (bases 1 to 4834)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   7  (bases 1 to 4834)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
REFERENCE   8  (bases 1 to 4834)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   9  (bases 1 to 4834)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 4834)
  AUTHORS   Chibuk,T.K., Bischof,J.M. and Wevrick,R.
  TITLE     A necdin/MAGE-like gene in the chromosome 15 autism susceptibility
            region: expression, imprinting, and mapping of the human and mouse
            orthologues
  JOURNAL   BMC Genet 2, 22 (2001)
   PUBMED   11782285
  REMARK    GeneRIF: gene expression, imprinting, and chromosome mapping of
            NDNL2
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC061965.16, AU310582.1 and
            BC053999.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_138704.3.
            
            Summary: The protein encoded by this gene is part of the SMC5-6
            chromatin reorganizing complex and is a member of the MAGE
            superfamily. This is an intronless gene. [provided by RefSeq, May
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660805.354412.1, DRR138512.517665.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332303.6/ ENSP00000330694.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC061965.16        145358-145363       c
            7-34                AU310582.1         1-28
            35-1674             BC053999.1         1-1640
            1675-4834           AC061965.16        140530-143689       c
FEATURES             Location/Qualifiers
     source          1..4834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.1"
     gene            1..4834
                     /gene="NSMCE3"
                     /gene_synonym="HCA4; LICS; MAGEG1; MAGEL3; NDNL2; NSE3"
                     /note="NSE3 homolog, SMC5-SMC6 complex component"
                     /db_xref="GeneID:56160"
                     /db_xref="HGNC:HGNC:7677"
                     /db_xref="MIM:608243"
     exon            1..4834
                     /gene="NSMCE3"
                     /gene_synonym="HCA4; LICS; MAGEG1; MAGEL3; NDNL2; NSE3"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1032
                     /gene="NSMCE3"
                     /gene_synonym="HCA4; LICS; MAGEG1; MAGEL3; NDNL2; NSE3"
                     /note="necdin-like gene 2; hepatocellular
                     carcinoma-associated protein HCA4; melanoma antigen,
                     family G, 1; necdin-like 2, SMC5-SMC6 complex component;
                     melanoma-associated antigen G1; MAGE-G1 antigen;
                     necdin-like protein 2; hepatocellular carcinoma-associated
                     protein 4; non-SMC element 3 homolog"
                     /codon_start=1
                     /product="non-structural maintenance of chromosomes
                     element 3 homolog"
                     /protein_id="NP_619649.1"
                     /db_xref="CCDS:CCDS10023.1"
                     /db_xref="GeneID:56160"
                     /db_xref="HGNC:HGNC:7677"
                     /db_xref="MIM:608243"
                     /translation="MLQKPRNRGRSGGQAERDRDWSHSGNPGASRAGEDARVLRDGFA
                     EEAPSTSRGPGGSQGSQGPSPQGARRAQAAPAVGPRSQKQLELKVSELVQFLLIKDQK
                     KIPIKRADILKHVIGDYKDIFPDLFKRAAERLQYVFGYKLVELEPKSNTYILINTLEP
                     VEEDAEMRGDQGTPTTGLLMIVLGLIFMKGNTIKETEAWDFLRRLGVYPTKKHLIFGD
                     PKKLITEDFVRQRYLEYRRIPHTDPVDYEFQWGPRTNLETSKMKVLKFVAKVHNQDPK
                     DWPAQYCEALADEENRARPQPSGPAPSS"
     regulatory      1646..1651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSMCE3"
                     /gene_synonym="HCA4; LICS; MAGEG1; MAGEL3; NDNL2; NSE3"
                     /note="hexamer: AATAAA"
     polyA_site      1669
                     /gene="NSMCE3"
                     /gene_synonym="HCA4; LICS; MAGEG1; MAGEL3; NDNL2; NSE3"
                     /note="major polyA site"
     regulatory      4808..4813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSMCE3"
                     /gene_synonym="HCA4; LICS; MAGEG1; MAGEL3; NDNL2; NSE3"
                     /note="hexamer: ATTAAA"
     polyA_site      4834
                     /gene="NSMCE3"
                     /gene_synonym="HCA4; LICS; MAGEG1; MAGEL3; NDNL2; NSE3"
ORIGIN      
        1 agtctcagcc gacactgcgc gcgcctccag gcaccggcgt tagcgggtcg ccgacccgca
       61 atccccgccg cggctgcttg cctaccggag tgtgcgccgg cacctgccgc cggagacatg
      121 ttgcaaaaac cgaggaaccg gggccgctct ggcggccagg ccgagaggga cagagactgg
      181 agccatagcg gaaaccccgg ggcttcgcgg gccggggaag acgcccgggt tctcagagac
      241 ggctttgccg aggaggcccc gagcacgtcc cgcgggccgg gcggctcgca ggggtcgcag
      301 ggcccctcgc ctcagggcgc ccgccgggcc caggccgccc ccgccgtggg gcccaggagc
      361 cagaagcagc tggagctgaa agtgtccgag ctggtgcagt tcttgctgat taaagaccag
      421 aagaagattc cgatcaagcg ggccgacata ctgaagcacg tcatcgggga ctacaaggac
      481 atcttccccg acctcttcaa acgggccgcc gagcgcctcc agtacgtctt cgggtataag
      541 ctggtggaac ttgaacccaa gagcaacact tacatcctca tcaacaccct ggagcctgtg
      601 gaggaggatg ccgagatgag gggtgaccaa ggcacgccca ctacgggcct cctgatgatc
      661 gtcttagggc tcatctttat gaagggcaac accatcaagg aaactgaagc ctgggacttt
      721 ctgcggcgct taggggtcta ccccaccaag aagcatttaa ttttcggaga tccaaagaaa
      781 ctcattactg aggactttgt gcgacagcgt tacctggaat accggcggat accccacacc
      841 gaccccgtcg actacgaatt ccagtggggc ccgcgaacca acctggaaac cagcaagatg
      901 aaagttctta agtttgtggc caaggtccat aatcaagacc ccaaggactg gccagcgcag
      961 tactgtgagg ctttggcaga tgaggagaac agggccagac ctcagcctag tggcccagct
     1021 ccatcctctt gaaaggtgga ttcagaggga cccccgggac aagggtctga gacccaaagg
     1081 cacagtttag aggattgggg gaagggagaa cgaacccagg gagcatattg ctgtaaacgc
     1141 ttcaatgtgt gtagctttag gatgtgtttg caaagttttg tttttttaat gttgtgttat
     1201 tttgctccag attttcatct ataaacaaag gagcatttgt tttgatttta ctctttttgg
     1261 tataaaaaat tttgctagct tagtaaaacg aattggaaaa cttgactatg atctggaaca
     1321 gataatgcaa gaaggaacac ataagtaagt tgctttggtg ccaagaaaat aaaaaagcta
     1381 ttatcaggtc tcctaactac cccagtttgt aaggaaaaat aaaagttttt ataaaattaa
     1441 aaaaaataat tgcctatatc cttattatgt taacctattt tatttttcta tatttcgtac
     1501 atatataagt attattcatg gttccaagca atgagtgtaa tgtattttct cccaatagta
     1561 attgtttata ttcataatta ttcagctctg ctgctaaaca cgtagttcca cttcgttttt
     1621 ttcttcttgc tactgtagtt attacaataa atactgtatt tttgaagcac ttaagcattg
     1681 tgtgtttttt aaatcgtggg tcatgagaga atttcatgac tggaaatcaa catcttaaag
     1741 tttttgctac atattaaggt caatgctgtt ttgtagaagt tgtttcactt ttgtgtgaaa
     1801 caaaatcagg atcatgaggt gaaatatatt tctcactgtg gatctcaaaa aggcttataa
     1861 aacaatagcg taaccattaa ccatgcctgt ttgggaatcg gactgtctgg gttgagatcc
     1921 tggccccacc ataactagta tatgaattta cataggttcc ttagtttgta tgcagatgtt
     1981 tcttgacctg taaaatggtt ttagtccgtg atgtggagaa ttttatttgt tattctttaa
     2041 tgtttttatt ttttattctc cttggtctgg agctgccact ttttaaatat aacttttctt
     2101 tatctttttt tccaaatcat tcctaggaga gcaattcctg gttcaaaaga tagtcctcta
     2161 gtctcactct attgtatggg gaaatataac gtgtatggtg agtgtgcccc acatagaaca
     2221 taagagcagg acataagatc tacctcctag ggagttaggt atagggaaaa gggtatgggt
     2281 cttggggctg tctggcaaac tgaatttgaa ttacggctca tgctaacttg tcagcatggt
     2341 ggttgtgggg gtaggtttta agctctctga atctcaattt atctgtaaaa tgagaaaaat
     2401 aatagctata taatagtttt atgcactaaa tgaactagaa gagttcatag tcccattgtg
     2461 ttcctccatt acgtgtagca gatgctgttt ttaatgcaga gattcaacac gttttattca
     2521 gtgggcaaat aagttaattg ttttaggggg aggtgctgca aattaacctt gaaataaggc
     2581 aaatattttt aactcgggga aaaaagtgaa cttcatcaac actggacgga atgtcattta
     2641 aaagagtcta tagtgagtat ggaggaatgt gataggttac tgggttttat ttcattctgt
     2701 tgaattggga tttgcatttg tttcatcagt ggaatatgtt tggcccttac aggcatttct
     2761 tcttgatctg cattttattt cagtgtataa actccttcct gcctcctggt ccccttacct
     2821 ccctgactca gctttctcct cctcatgccc tctgatactc gcattctcac ctgtataata
     2881 aaaattatta cccagcagtc accaccagtt atatctgagg caaaattccc cccgcttttc
     2941 tcagaggtgt tagcaattta ccatcgataa tcttgtttca aattttaaaa tatgaaacat
     3001 cagaggccac atcaaggcct tatatctttt ccttctcacc ctccccagag gtaacaaaag
     3061 tctgtggcta tcgggctgtt gtatgacttt ataattttac tatacatgta tatatacata
     3121 accaatatag agttttattt tgtgggcttt catgatttat ataagcggtg ttacgtgtgt
     3181 ccttatgcaa cttgctgtac tcactcacca ttatgtattt gagattcagc catgtggata
     3241 tatgtagacc tgattcactc attttaattg ttcttttatg ggggaaaaat aactatccat
     3301 tccttaatgt ctggacattt aaggtctttc cagttctttg agatttgcag gcattgtaca
     3361 gtacttcttt aggcacatgt gtgagtttct ccagccagaa acaaatggag caatcaagga
     3421 ctattgccaa gctgctcttg agcttgtgtc aagttacact cccatcaaca ttttatacag
     3481 ttttgttttg tttttgttta ccaatccctc caccttcacc ccctgtgaac acttggcctt
     3541 ttcagtatct tttcagccat tctggtacag tgtgaaatga taatttatta cggtattaac
     3601 ttatacctgt tgcttactag taatgttaag tatctgccta tcttttgctc tcactccttt
     3661 ttgagtgtca gatttcatgt cttagaccta tttctattga tttgtaagac atctttatat
     3721 gttctacatg ttaatccatg gtctgctcta tctatctagt gcaaatacct tctcccacat
     3781 tttcacttct tttggtcata cagatcattt gacctaaatg tgttacgatc attagtgttt
     3841 ataagagcta catttgtgta tagtgcttta aaaaattccc ctaatcctaa aattgtaaat
     3901 atgttttctg ccttttttcc ctaagtgttc aaagttttga tcttcacatt ttatgctttt
     3961 aatctgcttt tgtgtatgat gtgaggtatg gaaatagttt ttgtattttt cctatatgga
     4021 tagcctagca ccagtttttc atcatttata ctttccacac tgatttatga cactcagtat
     4081 tttgtagcaa tgtcccatgt atagataaat ttatggctag gactgaattg gtttatttgc
     4141 tatccatttg caaataccat actgtaattc tttttttctt tttgagacgg agtcttgctc
     4201 ttgtcgccca ggctggagtg cattggcaca atcttggctc agtgcaatct ctgcctcctg
     4261 gattcaagcg attctcctgc ctcagcctcc tgagtagctg ggattacagg tgcccgccac
     4321 cacgtccggc taatttttgt acttttagta gagacggggt tttgccatgt tggccagggt
     4381 ggtctcaaac tcctgacttt aggtaatctg cccgcctcgg cctcctaaag tgctaggatt
     4441 acaggcatga gccacctcgc ccagcctata attctttagc atcatatgcc tgtcttcttt
     4501 ttcaattctt aaagcctttt attttagtct tttttgcatt ggctgaaaat gcaatatatt
     4561 attgaaaaga agcagttaca gcaggctcta aggatgtttc tgattcctta ttcttgattt
     4621 taaaggaaat aattttaagt tttgccatag agtgtgatgt ttgctgttaa gagttttttt
     4681 cccctataaa taccttttat tgggctattt agttacccct tcagtcctag cttgcttaga
     4741 gatgttcaga aaaaaaacta tgaatgactt tggatgtata tatgctcttt atttacctgc
     4801 taatatgatt aaaatgtctt atttactctg taaa
//
