LOCUS       NP_619649                304 aa            linear   PRI 27-APR-2025
DEFINITION  non-structural maintenance of chromosomes element 3 homolog [Homo
            sapiens].
ACCESSION   NP_619649
VERSION     NP_619649.1
DBSOURCE    REFSEQ: accession NM_138704.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 304)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 304)
  AUTHORS   Adamus,M., Lelkes,E., Potesil,D., Ganji,S.R., Kolesar,P.,
            Zabrady,K., Zdrahal,Z. and Palecek,J.J.
  TITLE     Molecular Insights into the Architecture of the Human SMC5/6
            Complex
  JOURNAL   J Mol Biol 432 (13), 3820-3837 (2020)
   PUBMED   32389690
REFERENCE   3  (residues 1 to 304)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (residues 1 to 304)
  AUTHORS   van der Crabben,S.N., Hennus,M.P., McGregor,G.A., Ritter,D.I.,
            Nagamani,S.C., Wells,O.S., Harakalova,M., Chinn,I.K., Alt,A.,
            Vondrova,L., Hochstenbach,R., van Montfrans,J.M.,
            Terheggen-Lagro,S.W., van Lieshout,S., van Roosmalen,M.J.,
            Renkens,I., Duran,K., Nijman,I.J., Kloosterman,W.P., Hennekam,E.,
            Orange,J.S., van Hasselt,P.M., Wheeler,D.A., Palecek,J.J.,
            Lehmann,A.R., Oliver,A.W., Pearl,L.H., Plon,S.E., Murray,J.M. and
            van Haaften,G.
  TITLE     Destabilized SMC5/6 complex leads to chromosome breakage syndrome
            with severe lung disease
  JOURNAL   J Clin Invest 126 (8), 2881-2892 (2016)
   PUBMED   27427983
  REMARK    GeneRIF: NSMCE3 (also known as NDNL2) gene encodes a subunit of the
            SMC5/6 complex that is essential for DNA damage response and
            chromosome segregation
REFERENCE   5  (residues 1 to 304)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (residues 1 to 304)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   7  (residues 1 to 304)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
REFERENCE   8  (residues 1 to 304)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   9  (residues 1 to 304)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (residues 1 to 304)
  AUTHORS   Chibuk,T.K., Bischof,J.M. and Wevrick,R.
  TITLE     A necdin/MAGE-like gene in the chromosome 15 autism susceptibility
            region: expression, imprinting, and mapping of the human and mouse
            orthologues
  JOURNAL   BMC Genet 2, 22 (2001)
   PUBMED   11782285
  REMARK    GeneRIF: gene expression, imprinting, and chromosome mapping of
            NDNL2
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC061965.16, AU310582.1 and
            BC053999.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is part of the SMC5-6
            chromatin reorganizing complex and is a member of the MAGE
            superfamily. This is an intronless gene. [provided by RefSeq, May
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660805.354412.1, DRR138512.517665.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332303.6/ ENSP00000330694.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.1"
     Protein         1..304
                     /product="non-structural maintenance of chromosomes
                     element 3 homolog"
                     /note="necdin-like gene 2; hepatocellular
                     carcinoma-associated protein HCA4; melanoma antigen,
                     family G, 1; necdin-like 2, SMC5-SMC6 complex component;
                     melanoma-associated antigen G1; MAGE-G1 antigen;
                     necdin-like protein 2; hepatocellular carcinoma-associated
                     protein 4; non-SMC element 3 homolog"
                     /calculated_mol_wt=34177
     Region          1..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96MG7.1)"
     Site            57
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q96MG7.1)"
     Site            60
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q96MG7.1)"
     Site            64
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
                     propagated from UniProtKB/Swiss-Prot (Q96MG7.1)"
     Region          78..304
                     /region_name="Interaction with NSMCE1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96MG7.1)"
     Region          92..261
                     /region_name="MAGE"
                     /note="MAGE homology domain; pfam01454"
                     /db_xref="CDD:426270"
     Region          285..304
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96MG7.1)"
     CDS             1..304
                     /gene="NSMCE3"
                     /gene_synonym="HCA4; LICS; MAGEG1; MAGEL3; NDNL2; NSE3"
                     /coded_by="NM_138704.4:118..1032"
                     /db_xref="CCDS:CCDS10023.1"
                     /db_xref="GeneID:56160"
                     /db_xref="HGNC:HGNC:7677"
                     /db_xref="MIM:608243"
ORIGIN      
        1 mlqkprnrgr sggqaerdrd wshsgnpgas ragedarvlr dgfaeeapst srgpggsqgs
       61 qgpspqgarr aqaapavgpr sqkqlelkvs elvqfllikd qkkipikrad ilkhvigdyk
      121 difpdlfkra aerlqyvfgy klvelepksn tyilintlep veedaemrgd qgtpttgllm
      181 ivlglifmkg ntiketeawd flrrlgvypt kkhlifgdpk klitedfvrq ryleyrriph
      241 tdpvdyefqw gprtnletsk mkvlkfvakv hnqdpkdwpa qycealadee nrarpqpsgp
      301 apss
//
