LOCUS       XM_047421704            2333 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens NSE2 (MMS21) homolog, SMC5-SMC6 complex
            SUMO ligase (NSMCE2), transcript variant X9, mRNA.
ACCESSION   XM_047421704
VERSION     XM_047421704.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2333
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..2333
                     /gene="NSMCE2"
                     /gene_synonym="C8orf36; MMS21; NSE2; ZMIZ7"
                     /note="NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO
                     ligase; Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 7 ESTs, 271 long SRA
                     reads, 1 Protein, and 89% coverage of the annotated
                     genomic feature by RNAseq alignments, including 39 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:286053"
                     /db_xref="HGNC:HGNC:26513"
                     /db_xref="MIM:617246"
     CDS             210..896
                     /gene="NSMCE2"
                     /gene_synonym="C8orf36; MMS21; NSE2; ZMIZ7"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase NSE2 isoform X4"
                     /protein_id="XP_047277660.1"
                     /db_xref="GeneID:286053"
                     /db_xref="HGNC:HGNC:26513"
                     /db_xref="MIM:617246"
                     /translation="MPGRSSSNSGSTGFISFSGVESALSSLKNFQACINSGMDTASSV
                     ALDLVESQTEVSSEYSMDKAMVEFATLDRQLNHYVKAVQSTINHVKEERPEKIPDLKL
                     LVEKKFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDEDIIV
                     TQSQTNFTCPITKEEMKKPVKNKVCGHTYEEDAIVRMIESRQKRKKKAYEMLCPGSAW
                     RWGPSRSCEA"
ORIGIN      
        1 ctcacttttc agcggcaggc gaagggggct gaggaaagga ggtgggtcta ggcaggggaa
       61 attggggtgc caccagacgg agacagcttg gactaccaga atcaagcact cttttggaag
      121 agggtaatct ctctccaaaa actgaggaca cttaccttcc ccatatattg agtccagctg
      181 tgtttggtgg cccaggtact aatttcaaga tgccaggacg ttccagttca aattcaggtt
      241 caactggttt catctccttc agtggtgtag agtctgctct ctcctccttg aaaaacttcc
      301 aagcctgtat caactctggt atggacacag cttctagtgt tgctttggat cttgtggaaa
      361 gtcagactga agtgagtagt gaatatagta tggacaaggc aatggttgaa tttgctacat
      421 tggatcggca actaaaccat tatgtaaagg ctgttcaatc tacaataaat catgtgaaag
      481 aagaacgtcc agaaaaaata ccagatttaa aattattggt agagaagaaa tttttggctt
      541 tacagagcaa gaattctgat gcagactttc aaaataatga aaaatttgta cagtttaaac
      601 aacagctgaa agaactaaag aagcaatgtg gtcttcaagc tgacagagaa gctgacggaa
      661 cagaaggagt ggatgaagat ataattgtga cccaaagtca gaccaacttc acctgcccca
      721 ttacaaagga ggaaatgaag aagccagtga aaaataaagt gtgtggccac acctatgaag
      781 aggacgccat tgttcgcatg attgagtcca ggcaaaagcg gaagaaaaag gcctacgaaa
      841 tgctctgccc gggtagtgcc tggaggtggg gacccagccg ctcctgcgag gcctgaaggg
      901 ctgactcctg cacagcgatg atgcggcagc tgaagatcgg gtattgccac actgaactcg
      961 ctcaccaaga tgtcgtggga ttaatgccga atgcttacgg agacagttgt ttctccagag
     1021 gaggcatgcc ttgattcagc actgtggcat gatggccttc tcttatcctt tctgctttaa
     1081 aaacttgtgt ttattggaga cgaaggagaa acaaggtcct tcccagttcc agcatcaacc
     1141 tcgcctccag gaagtcttcc ctgagccctt attcatgctg gacaaaatgt cgttagcacc
     1201 ccatgtcatg ccaacattgt cagtgcagct ggctcctctc cacgagcttc ttgagagcgg
     1261 aagctgtgga ctagggcagg gactggtgca cggcaggacc tgaagtgaac tccccagtcc
     1321 ttgacacaca tcagcctgct tatttctcag ccttattgga caggcttgtc ctctgccttc
     1381 atgttcttaa agggaaaaac tgaggcacag agaatttagt cacttaccca gagtgacaca
     1441 gccagggggt ttaagcccag gtctttctca ttcttgagcc tgcaattctg tcagtaggcc
     1501 atccagctcc ccttgggagg gctatttggt tcatgcctct accatcagag tctatctcct
     1561 cagtgaactc agaccttgtt tgacatggct cactctggga tccatcccac tgaagtgaag
     1621 gtgggcgcct gctctgcagc tgagtgtgtg gttaagtcca tcagacattc tcagcatgct
     1681 ctcatgcact gactaaaacc atgatgtcat caggaagtcc tccccacctc actctccact
     1741 tccctctcca ctgcttattc actgtctggc tatgaaagtt aaggcctttg ctgggtagaa
     1801 tggaagagac caaggccagg cagtccaaag cagatattca gggttatgtt ttaagggagg
     1861 gtcatcccag caacctactt ggagttgcat ttcaatgtca tggaagccaa agttatgata
     1921 cttggctttt ctagtcacaa aagtgtctgt atcctcttca tgatcttagc tgcttttttt
     1981 catacttaca gacataattc accaggcacg gtggctcatg cctgtaatcc cagcactttg
     2041 ggaggccaag gcaggtggat cacttgagct caggagttca ggaccagcct gggaaacatg
     2101 gtgaaactct gtctctacca aaaatttttt aaaaattagc caggcgtgat attgtgcacc
     2161 tgtgggccca gctactcagg aggctgaggt gggaggattg cttgagcctc agaggcagag
     2221 gtcacagtaa gcagagatag tgccactcca gtctgggtga cagaatgaga ccctgtcaaa
     2281 aaaagaaaga ggaaagagga gagaaagaaa gaaagaaaga aagagagaga gag
//
