LOCUS       XM_011516975            1130 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens NSE2 (MMS21) homolog, SMC5-SMC6 complex
            SUMO ligase (NSMCE2), transcript variant X4, mRNA.
ACCESSION   XM_011516975
VERSION     XM_011516975.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011516975.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1130
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..1130
                     /gene="NSMCE2"
                     /gene_synonym="C8orf36; MMS21; NSE2; ZMIZ7"
                     /note="NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO
                     ligase; Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 31 ESTs, 155 long SRA reads, 5
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 71 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:286053"
                     /db_xref="HGNC:HGNC:26513"
                     /db_xref="MIM:617246"
     CDS             152..895
                     /gene="NSMCE2"
                     /gene_synonym="C8orf36; MMS21; NSE2; ZMIZ7"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase NSE2 isoform X2"
                     /protein_id="XP_011515277.1"
                     /db_xref="GeneID:286053"
                     /db_xref="HGNC:HGNC:26513"
                     /db_xref="MIM:617246"
                     /translation="MPGRSSSNSGSTGFISFSGVESALSSLKNFQACINSGMDTASSV
                     ALDLVESQTEVSSEYSMDKAMVEFATLDRQLNHYVKAVQSTINHVKEERPEKIPDLKL
                     LVEKKFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDEDIIV
                     TQSQTNFTCPITKEEMKKPVKNKVCGHTYEEDAIVRMIESRQKRKKKAYCPQIGCSHT
                     DIRKSDLIQDEALRRAIENHNKKRHRHSE"
     polyA_site      1130
                     /gene="NSMCE2"
                     /gene_synonym="C8orf36; MMS21; NSE2; ZMIZ7"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 ctcacttttc agcggcaggc gaagggggct gaggaaagga gaatcaagca ctcttttgga
       61 agagggtaat ctctctccaa aaactgagga cacttacctt ccccatatat tgagtccagc
      121 tgtgtttggt ggcccaggta ctaatttcaa gatgccagga cgttccagtt caaattcagg
      181 ttcaactggt ttcatctcct tcagtggtgt agagtctgct ctctcctcct tgaaaaactt
      241 ccaagcctgt atcaactctg gtatggacac agcttctagt gttgctttgg atcttgtgga
      301 aagtcagact gaagtgagta gtgaatatag tatggacaag gcaatggttg aatttgctac
      361 attggatcgg caactaaacc attatgtaaa ggctgttcaa tctacaataa atcatgtgaa
      421 agaagaacgt ccagaaaaaa taccagattt aaaattattg gtagagaaga aatttttggc
      481 tttacagagc aagaattctg atgcagactt tcaaaataat gaaaaatttg tacagtttaa
      541 acaacagctg aaagaactaa agaagcaatg tggtcttcaa gctgacagag aagctgacgg
      601 aacagaagga gtggatgaag atataattgt gacccaaagt cagaccaact tcacctgccc
      661 cattacaaag gaggaaatga agaagccagt gaaaaataaa gtgtgtggcc acacctatga
      721 agaggacgcc attgttcgca tgattgagtc caggcaaaag cggaagaaaa aggcctattg
      781 ccctcaaatt ggctgtagcc acacggatat aagaaagtca gatcttatcc aggatgaagc
      841 acttagaagg gcaattgaga accataacaa gaaaagacat cgtcattccg agtaggaaaa
      901 gccacctgcc tgcagggaca ccagcagcct acctcctacc ccagctgtct gttgagagca
      961 gtgctgaccc cagcagttag ggactggctg catagcatac ttgttggggg taaaacttgt
     1021 tgcttttatg tgtgcttgaa aacatttttc aaagttacac aacagaaatg caatcatatt
     1081 gtttattttt aagtgttcta taatgttaaa taaaactttg atcatctgca
//
