LOCUS       NM_015980               2350 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens neuronal vesicle trafficking associated 2 (NSG2),
            mRNA.
ACCESSION   NM_015980
VERSION     NM_015980.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2350)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2350)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2350)
  AUTHORS   Chander,P., Kennedy,M.J., Winckler,B. and Weick,J.P.
  TITLE     Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting
            Protein That Modulates Excitatory Neurotransmission
  JOURNAL   eNeuro 6 (1) (2019)
   PUBMED   30680309
  REMARK    GeneRIF: found in discrete punctae restricted to the
            somatodendritic arbors of developing mouse and human neurons, and a
            significant proportion of NSG2 punctae colocalize with postsynaptic
            HOMER1 and surface-expressed AMPA-type glutamate receptors (AMPARs)
            at excitatory synapses.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2350)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2350)
  AUTHORS   Muthusamy,N., Chen,Y.J., Yin,D.M., Mei,L. and Bergson,C.
  TITLE     Complementary roles of the neuron-enriched endosomal proteins
            NEEP21 and calcyon in neuronal vesicle trafficking
  JOURNAL   J Neurochem 132 (1), 20-31 (2015)
   PUBMED   25376768
  REMARK    Review article
REFERENCE   6  (bases 1 to 2350)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   7  (bases 1 to 2350)
  AUTHORS   Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M.,
            Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,
            Herbst,M., Suopanki,J., Scherzinger,E., Abraham,C., Bauer,B.,
            Hasenbank,R., Fritzsche,A., Ludewig,A.H., Bussow,K., Coleman,S.H.,
            Gutekunst,C.A., Landwehrmeyer,B.G., Lehrach,H. and Wanker,E.E.
  TITLE     A protein interaction network links GIT1, an enhancer of huntingtin
            aggregation, to Huntington's disease
  JOURNAL   Mol Cell 15 (6), 853-865 (2004)
   PUBMED   15383276
  REMARK    Erratum:[Mol Cell. 2005 Jul 22;19(2):287. Buessow, Konrad
            [corrected to Bussow, Konrad]]
REFERENCE   8  (bases 1 to 2350)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   9  (bases 1 to 2350)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 2350)
  AUTHORS   Saberan-Djoneidi,D., Marey-Semper,I., Picart,R., Studler,J.M.,
            Tougard,C., Glowinski,J. and Levi-Strauss,M.
  TITLE     A 19-kDa protein belonging to a new family is expressed in the
            Golgi apparatus of neural cells
  JOURNAL   J Biol Chem 270 (4), 1888-1893 (1995)
   PUBMED   7829526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC366641.1, BC002619.2, CD627354.1 and EL950772.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015980.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.717650.1,
                                           SRR3476690.104183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303177.8/ ENSP00000307722.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               DC366641.1         103-214
            113-1044            BC002619.2         98-1029
            1045-1515           CD627354.1         200-670
            1516-2011           EL950772.1         98-593
            2012-2350           BC002619.2         1997-2335
FEATURES             Location/Qualifiers
     source          1..2350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..2350
                     /gene="NSG2"
                     /gene_synonym="CALY3; HMP19"
                     /note="neuronal vesicle trafficking associated 2"
                     /db_xref="GeneID:51617"
                     /db_xref="HGNC:HGNC:24955"
                     /db_xref="MIM:616752"
     exon            1..138
                     /gene="NSG2"
                     /gene_synonym="CALY3; HMP19"
                     /inference="alignment:Splign:2.1.0"
     exon            139..289
                     /gene="NSG2"
                     /gene_synonym="CALY3; HMP19"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..676
                     /gene="NSG2"
                     /gene_synonym="CALY3; HMP19"
                     /note="hypothalamus golgi apparatus expressed 19 kDa
                     protein; calcyon family member 3; neuron-specific protein
                     family member 2; p19 protein; protein p19"
                     /codon_start=1
                     /product="neuronal vesicle trafficking-associated protein
                     2"
                     /protein_id="NP_057064.1"
                     /db_xref="CCDS:CCDS4391.1"
                     /db_xref="GeneID:51617"
                     /db_xref="HGNC:HGNC:24955"
                     /db_xref="MIM:616752"
                     /translation="MVKLNSNPSEKGTKPPSVEDGFQTVPLITPLEVNHLQLPAPEKV
                     IVKTRTEYQPEQKNKGKFRVPKIAEFTVTILVSLALAFLACIVFLVVYKAFTYDHSCP
                     EGFVYKHKRCIPASLDAYYSSQDPNSRSRFYTVISHYSVAKQSTARAIGPWLSAAAVI
                     HEPKPPKTQGH"
     exon            290..373
                     /gene="NSG2"
                     /gene_synonym="CALY3; HMP19"
                     /inference="alignment:Splign:2.1.0"
     exon            374..484
                     /gene="NSG2"
                     /gene_synonym="CALY3; HMP19"
                     /inference="alignment:Splign:2.1.0"
     exon            485..2350
                     /gene="NSG2"
                     /gene_synonym="CALY3; HMP19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2328..2333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSG2"
                     /gene_synonym="CALY3; HMP19"
                     /note="hexamer: AATAAA"
     polyA_site      2350
                     /gene="NSG2"
                     /gene_synonym="CALY3; HMP19"
                     /note="major polyA site"
ORIGIN      
        1 agaagctccg atccagacac acgcgaggcg ctgtcctttc agcaccacaa gctcgggctg
       61 aggagggagg actcctggcc gtcctcctcc tcttcaaatt ggcttgaatc tgctctgacc
      121 ccccacgagt gcagcacagt ctgggaagaa aggcgtaagg atggtgaagc tgaacagtaa
      181 ccccagcgag aagggaacca agccgccttc agttgaggat ggcttccaga ccgtccctct
      241 catcactccc ttggaggtta atcacttaca gctgcctgct ccagaaaagg tgattgtgaa
      301 gacaagaacg gaatatcagc cggaacagaa gaacaaaggg aagttccggg tgccgaaaat
      361 cgctgaattt acggtcacca tccttgtcag cctggcccta gctttccttg cgtgcatcgt
      421 gttcctggtg gtttacaaag ccttcaccta tgatcacagc tgcccagagg gattcgtcta
      481 taagcacaaa cgctgtatcc cagcctccct ggatgcttac tactcctccc aggaccccaa
      541 ttccagaagc cgcttctaca cagtcatcag ccactacagc gtggccaagc agagcactgc
      601 ccgggccatc gggccgtggc tgtcagcagc cgctgtcatc catgagccca agccgcccaa
      661 gacccagggc cactagaggc ctgccccagc cagaatgggg ggcggggtgg agaggaggac
      721 ccccattggc taagccaagc tccagttaca agacaacact gtactcctgg gatatggggg
      781 cgggggcggg gcagggcagg gtggggggaa gaacgcacca aaaacgtggt gtgtgctgga
      841 gttgtctgaa ccgatatttc tttttgttcc ttggtattgt tgattcgtcg ccgagtcagg
      901 ctcatgtaca aaggcatgtt tcgtgttgat tgttcccatg taagatattt ttaaagccac
      961 tgcttattct ttgttaggaa aatgtaacag cagaaaagga aagaaacaaa gaacatgaac
     1021 aaaaagcatt aaactggctc catcagaaga cgttgaaggg cagtgaagag cacagactct
     1081 gtgggcttct tagataagaa aacgtagctt cagtgggggc tccagggttg cagagtatga
     1141 gtgacacaga ccgggactat tccattagcc tgtggtctgc agggtaggcc cgcaggaaat
     1201 gaggaatggc cgagctggag agaagagctg attttggcat tactaagccc agaacgcaca
     1261 taacccatag tgaaatgtgc tggcctctgg tgcattttgc aagatgagca caaactttct
     1321 gggcctccat cctaggacct gggcagaccc acatggcctg ggctctgaat gcccaccctg
     1381 cgacggtggg ttctgcatca gcaaacgctg aggagtgggc agattttctt tgtcttttgc
     1441 ttgcattttc tagatccaca cctggatact gcccatgttg acgagacagc agcaggggga
     1501 gagggaggga aggaaggtgc ggctgcaaga aggaaggcac gggacaggca tgtgacacta
     1561 ggccacaagc gataagcaca ggcacctgac ttttaagttt ttgtttgttt gttgtttccc
     1621 aaagtgctga taacaataac aacaacaata ggattccaac caggagcctc aagtgacagc
     1681 caggaagaga cctgaaggtt ggggccacca caatgccaaa tcgtttctaa aggaagctga
     1741 aaaatgggac tgtcttttgc ccacttcgtt gtgttaaaag gggacatttg tccaaactcc
     1801 ccaaccgagt tctagaagct cctgacaagg aggcagcatc cagccttgac caggcctccc
     1861 agttccctgg aaccgtatca ggcattcgcc tgcctctcac aaatgtttca gggaggccag
     1921 ttctgcaggg tgtcagctcc aggacccaca gggccagaac cagctgggag aattggttat
     1981 ttgagatgtg gtactgcttc ctcacaagtc tcccacaggc catgtaaagg gtattttttt
     2041 gtggcttgct gtgttgctga gatcatcgta tgcaacagct gggtaataag actagcatag
     2101 ctcaaactat cctgccaaac gctctcatct gatttttcct cccttctccc ccaacctcca
     2161 atcaccctga gtcacctgta aattcatttg tcattcaaag cggaataaca agttgtccct
     2221 agcaaaaccg ctgagcgctt tataattttg tggtgtattt ttgtcagtag gtagcagagg
     2281 cggaagtatt ttttggtgta attcttgaaa ttttctgaca ggaaacaaat aaagatagat
     2341 gtgtctgaga
//
