LOCUS       NM_014392               2279 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens neuronal vesicle trafficking associated 1 (NSG1),
            transcript variant 1, mRNA.
ACCESSION   NM_014392
VERSION     NM_014392.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2279)
  AUTHORS   Hu,Y., He,Z., Han,B., Lin,Z., Zhou,P., Li,S., Huang,S. and Chen,X.
  TITLE     miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous Cell
            Carcinoma Progression through ERK Pathway
  JOURNAL   Int J Mol Sci 25 (11), 5961 (2024)
   PUBMED   38892156
  REMARK    GeneRIF: miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous
            Cell Carcinoma Progression through ERK Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2279)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2279)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2279)
  AUTHORS   Rasila,T., Saavalainen,O., Attalla,H., Lankila,P., Haglund,C.,
            Holtta,E. and Andersson,L.C.
  TITLE     Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape
            and Invasive Growth
  JOURNAL   Am J Pathol 189 (1), 177-189 (2019)
   PUBMED   30312582
REFERENCE   5  (bases 1 to 2279)
  AUTHORS   Muthusamy,N., Chen,Y.J., Yin,D.M., Mei,L. and Bergson,C.
  TITLE     Complementary roles of the neuron-enriched endosomal proteins
            NEEP21 and calcyon in neuronal vesicle trafficking
  JOURNAL   J Neurochem 132 (1), 20-31 (2015)
   PUBMED   25376768
  REMARK    GeneRIF: This review focuses on two closely related,
            neuron-enriched endosomal proteins: NEEP21 and Calcyon which
            perform distinct roles in regulating receptor endocytosis,
            recycling, and degradation--{REVIEW}
            Review article
REFERENCE   6  (bases 1 to 2279)
  AUTHORS   Kudoh,T., Kimura,J., Lu,Z.G., Miki,Y. and Yoshida,K.
  TITLE     D4S234E, a novel p53-responsive gene, induces apoptosis in response
            to DNA damage
  JOURNAL   Exp Cell Res 316 (17), 2849-2858 (2010)
   PUBMED   20599942
  REMARK    GeneRIF: a novel p53-responsive gene D4S234E is accumulated in the
            ER and induces apoptosis in response to DNA damage.
REFERENCE   7  (bases 1 to 2279)
  AUTHORS   Yap,C.C., Wisco,D., Kujala,P., Lasiecka,Z.M., Cannon,J.T.,
            Chang,M.C., Hirling,H., Klumperman,J. and Winckler,B.
  TITLE     The somatodendritic endosomal regulator NEEP21 facilitates axonal
            targeting of L1/NgCAM
  JOURNAL   J Cell Biol 180 (4), 827-842 (2008)
   PUBMED   18299352
REFERENCE   8  (bases 1 to 2279)
  AUTHORS   Steiner,P., Alberi,S., Kulangara,K., Yersin,A., Sarria,J.C.,
            Regulier,E., Kasas,S., Dietler,G., Muller,D., Catsicas,S. and
            Hirling,H.
  TITLE     Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and
            recycling of the glutamate receptor subunit GluR2
  JOURNAL   EMBO J 24 (16), 2873-2884 (2005)
   PUBMED   16037816
REFERENCE   9  (bases 1 to 2279)
  AUTHORS   Steiner,P., Sarria,J.C., Glauser,L., Magnin,S., Catsicas,S. and
            Hirling,H.
  TITLE     Modulation of receptor cycling by neuron-enriched endosomal protein
            of 21 kD
  JOURNAL   J Cell Biol 157 (7), 1197-1209 (2002)
   PUBMED   12070131
REFERENCE   10 (bases 1 to 2279)
  AUTHORS   Carlock,L., Vo,T., Lorincz,M., Walker,P.D., Bessert,D.,
            Wisniewski,D. and Dunbar,J.C.
  TITLE     Variable subcellular localization of a neuron-specific protein
            during NTera 2 differentiation into post-mitotic human neurons
  JOURNAL   Brain Res Mol Brain Res 42 (2), 202-212 (1996)
   PUBMED   9013775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110814.5.
            
            On Apr 23, 2020 this sequence version replaced NM_014392.4.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant (3). Variants 1, 2, and 3 all encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.4021266.1,
                                           SRR14038192.690779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621129.5/ ENSP00000480081.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC110814.5         39843-39914
            73-227              AC110814.5         40345-40499
            228-344             AC110814.5         44216-44332
            345-455             AC110814.5         62314-62424
            456-2279            AC110814.5         69976-71799
FEATURES             Location/Qualifiers
     source          1..2279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..2279
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /note="neuronal vesicle trafficking associated 1"
                     /db_xref="GeneID:27065"
                     /db_xref="HGNC:HGNC:18790"
                     /db_xref="MIM:607645"
     exon            1..72
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /inference="alignment:Splign:2.1.0"
     exon            73..227
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..656
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /note="isoform a is encoded by transcript variant 1;
                     carboxyterminally EE-tagged neuron-enriched endosomal 21
                     kDa protein; neuron-specific protein family member 1;
                     brain neuron cytoplasmic protein 1; neuron specific gene
                     family member 1; neuron-enriched endosomal protein of 21
                     kDa; neuronal vesicle trafficking-associated protein 1"
                     /codon_start=1
                     /product="neuronal vesicle trafficking-associated protein
                     1 isoform a"
                     /protein_id="NP_055207.1"
                     /db_xref="CCDS:CCDS3376.1"
                     /db_xref="GeneID:27065"
                     /db_xref="HGNC:HGNC:18790"
                     /db_xref="MIM:607645"
                     /translation="MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKV
                     VVKTKTEYEPDRKKGKARPPQIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVV
                     YKVYKYDRACPDGFVLKNTQCIPEGLESYYAEQDSSAREKFYTVINHYNLAKQSITRS
                     VSPWMSVLSEEKLSEQETEAAEKSA"
     exon            228..344
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /inference="alignment:Splign:2.1.0"
     exon            345..455
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /inference="alignment:Splign:2.1.0"
     exon            456..2279
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      935..940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /note="hexamer: AATAAA"
     polyA_site      959
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /note="major polyA site"
     regulatory      2261..2266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /note="hexamer: AATAAA"
     polyA_site      2279
                     /gene="NSG1"
                     /gene_synonym="D4S234; D4S234E; NEEP21; P21"
                     /note="major polyA site"
ORIGIN      
        1 gccattgctg cgagcaggag caggagacgc ggagctcgga gcgctcagct gacctgccgg
       61 agccgggcgt gggctgcagc ctcggagctc ccggaacgat ggtgaagttg gggaacaatt
      121 tcgcagagaa gggcaccaag cagccgctgc tggaggatgg cttcgacacc attcccctga
      181 tgacgcccct cgatgtcaat cagctgcagt tcccgccccc ggataaggtg gtcgtgaaaa
      241 ctaagaccga gtatgaacct gaccgcaaga aagggaaagc acgtcctccc caaattgctg
      301 agttcaccgt cagcatcacg gagggtgtca ccgagaggtt taaggtctcc gtgttggtcc
      361 tcttcgccct ggccttcctc acctgcgtcg tcttcctggt tgtctacaag gtgtacaagt
      421 atgaccgcgc ctgccccgat gggttcgtcc tcaagaacac ccagtgcatc ccagaaggct
      481 tggagagcta ctacgcggag caagactcca gtgcccggga gaaattttac acagtcataa
      541 accactacaa cctggccaag cagagcatca cgcgctccgt atcgccctgg atgtcagttc
      601 tgtcagaaga gaagctgtcc gagcaggaga ctgaagcggc tgagaagtca gcttagcggg
      661 atgggcaagt tccttacaat gtgtcacttg caaataacaa agggactttg agggacattt
      721 cattaaatat aattactgat actttagagg ttactcattt acggtgcaat tgcttctgtt
      781 tgctaatgct gctttgcaaa taaaacttgc tgccgaccac ccacgggcat aaaatcaagt
      841 gcatttcagc attgcctaaa gagctctgac accacttttc atgttaagat cttcatttag
      901 ctcctttact gggatttatt ggatgctgta aaaaaataaa tttacactgg atatgcgaag
      961 ggtttggatc tcagataaat gcattttgtg gaattgattt tctgaaccga ccctgctgtc
     1021 tgcaaacctt cctccatagc catatctaga gtgatctctc gctgtgctaa gagcaagcct
     1081 acttcgcatt tcttcctcgg ccatcagcgg gtaacagtgc tgactgctgc caaggtgcac
     1141 tgtagtaagt aagtggcata gagaacgagg aaaaagaccc ccccacccct ccctgtgctg
     1201 actcctgagt cggggtggga cggccctgca atgtggcagg ctcggtgtgg attgactact
     1261 ccctcccctc tgactctggc atcttggtaa ggagggaggg gcaccaccca tctgggtgga
     1321 gacagctggg gtttgctcca gtgtgtgtag actggcagag catgtgaggg agagggctgg
     1381 gaagagacgg ccctgggccc gtgaggtgca gaactctccc tgcaggtagt ctgtctgctc
     1441 tgtgatgtgc tgataggaaa gagcccccac tggccctctg gttcacttct attatgaata
     1501 aatttgcacc aatagcccca ttagttttta aagaaatgag ctgggtggga aaagtggaaa
     1561 tgtaatttct ggtaagcttg agctacttta atttttattc tatgaaactg atatcccttg
     1621 atgtgggaaa caggcaggaa aggctgtggg gtgggggtgg gggactggtg tggcaccgtg
     1681 caaacaaaat gacaaatttc aactcacaat ctttgtaaga aaattgttcc agtttgaatc
     1741 ttgatattaa agtttatgtt tacaaaactg ccagttagat gaactaagtg tgtaaaacaa
     1801 atagaaaaga cattcgcaga catttcttct atgttattga atgtgttgtt tctggtgtac
     1861 gtgtcaaaag tttcagtttt ttagatcaga aataaacgac aaatagtgtg agatgtgttg
     1921 tgaacaggca tggtgaccgt ggtcagcgcc actcttgttt cctgaaatgt gcttctaaga
     1981 cagaaaatgt attttctcat caagggtgtc tggagacaca gaccgtgacc ttggcgcagc
     2041 ggtgtgcatc agaggcgtgt gctgagaagg gtggtgttaa gctgtggaaa atgactcaag
     2101 agcaataaat cagtgccaaa gcttccctgc gcatctgaat agacacaagt gaagcccgtg
     2161 tgcgcacagt gcagaggccg agcctgtatt tccaggtaga cgtggacttt attgactgtg
     2221 aattcattta catgtaactt ctgacatttc actctgtgca aataaagaac atgaggata
//
