LOCUS       XM_005248002            7353 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens nuclear receptor binding SET domain protein
            2 (NSD2), transcript variant X5, mRNA.
ACCESSION   XM_005248002
VERSION     XM_005248002.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000004.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005248002.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..7353
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /note="nuclear receptor binding SET domain protein 2;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 56 ESTs, 3111 long SRA reads, 4
                     Proteins, and 99% coverage of the annotated genomic
                     feature by RNAseq alignments, including 92 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:7468"
                     /db_xref="HGNC:HGNC:12766"
                     /db_xref="MIM:602952"
     CDS             180..4070
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase NSD2 isoform
                     X2"
                     /protein_id="XP_005248059.1"
                     /db_xref="GeneID:7468"
                     /db_xref="HGNC:HGNC:12766"
                     /db_xref="MIM:602952"
                     /translation="MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNREC
                     SVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFES
                     QEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQK
                     PENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLL
                     KYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWI
                     FEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAAS
                     MSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVRE
                     ECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSMPR
                     SRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFAL
                     VAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKVSDSPGDE
                     PSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLA
                     CLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTV
                     FESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASN
                     SIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSW
                     FCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGS
                     KDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQE
                     SERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFEC
                     HPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDE
                     EECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNG
                     DTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSE
                     EKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKR
                     PFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAA
                     SVRSTKTEKPPPEPGKPKGKRRRRRGWRRVTEGK"
     polyA_site      7353
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 ggcgccgcgc gcgagagcct cggcctggcc gcgctgcgcc cgccgccgcc gccgccccct
       61 ccccgcctgg gccctaccgc cgcacggccc cggccccctc ccagcctgcc gctccggaga
      121 gccgcccgcc gaggatgcga cgcaccgcag tgttctaaga acggaagcat ctgggctgga
      181 tggaatttag catcaagcag agtccccttt ctgttcagag tgttgtaaag tgcataaaga
      241 tgaagcaggc accagaaatc ctcggcagtg ccaacgggaa gactccgagc tgcgaggtga
      301 accgcgagtg ttctgtgttc ctcagcaaag cccagctctc cagtagcctg caggaggggg
      361 tcatgcagaa gtttaacggc cacgacgccc tgccctttat tccagccgac aagctgaaag
      421 atcttacttc ccgggtgttt aatggagaac ccggcgcaca cgatgccaaa ctgcgttttg
      481 agtcccagga aatgaaaggg attgggacac cccctaacac tacccctatc aaaaatggct
      541 ctccagaaat taagctgaaa atcaccaaaa catacatgaa tgggaagcct ctctttgaat
      601 cttccatttg tggtgacagt gctgctgatg tgtctcagtc agaagaaaat ggacaaaaac
      661 cagaaaacaa ggcgagaagg aacaggaaga ggagcataaa atatgactcc ttgctggagc
      721 agggccttgt cgaagcagct cttgtgtcta agatctcaag tccttcagat aaaaagattc
      781 cagctaagaa agagtcttgt ccaaacactg gaagagacaa agaccacctg ttgaaataca
      841 acgttggtga tttggtgtgg tccaaagtgt cgggttaccc ttggtggcct tgcatggttt
      901 ctgcagatcc actccttcac agctatacca aacttaaagg tcagaaaaag agtgcacgcc
      961 agtatcacgt acagttcttt ggtgacgccc cagaaagagc ttggatattt gagaagagcc
     1021 tcgtagcttt tgaaggagaa ggacagtttg aaaaattatg ccaggaaagt gccaagcagg
     1081 cacccacgaa agctgagaaa attaagctat tgaaaccaat ttcagggaaa ttgagggccc
     1141 agtgggaaat gggcattgtt caagcagaag aagctgcaag catgtcagtg gaggagcgga
     1201 aagccaagtt cacctttctc tatgtggggg accagcttca tctcaaccct caagtagcca
     1261 aggaggctgg cattgctgca gagtctttgg gagaaatggc agaatcctca ggagtcagtg
     1321 aagaagctgc tgaaaacccc aagtctgtga gagaagagtg cattcccatg aagagaaggc
     1381 ggagggccaa actgtgtagc tctgcagaga ccctggagag tcaccccgac atagggaaga
     1441 gtactcctca aaagacggca gaggctgacc ccagaagagg agtagggtct cctcctggga
     1501 ggaagaagac cacagtctcc atgccacgaa gcaggaaggg agatgcagca tcccagtttt
     1561 tggtcttctg tcaaaaacac agggatgagg tggtagctga gcacccagat gcttcaggtg
     1621 aggagattga agagctgctc aggtcacagt ggagtctgct gagtgagaag cagagagcac
     1681 gctacaacac caagtttgcc ctggtggccc ctgtccaggc tgaagaagac tctggtaatg
     1741 taaatgggaa aaaaagaaac cacacaaaga ggatacagga ccctacagaa gatgctgaag
     1801 ctgaggacac acccaggaaa agactcagga cggacaagca cagtcttcgg aaggtctcgg
     1861 acagcccggg agacgagccc tcggagtccc catacgaaag tgcagacgaa acacaaactg
     1921 aagtatctgt ctcatccaaa aagtctgagc gaggagtgac tgccaaaaag gagtatgtgt
     1981 gccagctgtg tgagaagccg ggcagcctcc tgctctgtga aggaccctgc tgcggagctt
     2041 tccacctcgc ctgccttggg ctttcccgga ggccagaagg gaggttcacc tgcagcgagt
     2101 gtgcctcagg gattcactca tgtttcgtgt gtaaagagag caagacagat gttaagcgct
     2161 gtgtggtaac tcagtgtgga aaattttacc atgaggcttg tgtgaaaaaa taccctctga
     2221 ctgtatttga gagccgaggt ttccgctgcc ccctccacag ctgtgtgagc tgccatgctt
     2281 ccaacccttc aaacccaagg ccgtcaaaag gtaaaatgat gcggtgtgtc cgctgccccg
     2341 ttgcctatca cagcggggat gcttgtctgg cagcaggatg ctcagtgatc gcctccaaca
     2401 gcatcatctg cactgcccac ttcactgctc ggaaggggaa gcgacaccac gcccacgtca
     2461 acgtgagctg gtgcttcgtg tgctccaaag gggggagcct tctgtgctgt gagtcctgcc
     2521 cagcggcctt ccaccctgac tgcctgaaca tcgagatgcc tgacggcagc tggttctgca
     2581 atgactgcag ggctgggaag aagctgcact tccaggatat catttgggtg aaacttggga
     2641 actacagatg gtggccggca gaagtttgcc atcccaaaaa tgttccccca aatattcaga
     2701 aaatgaagca cgagattgga gaattccctg tgtttttctt tgggtctaaa gattattact
     2761 ggacgcatca ggcgcgagtg ttcccgtaca tggaggggga ccggggcagc cgctaccagg
     2821 gggtcagagg gatcggaaga gtcttcaaaa acgcactgca agaagctgaa gctcgttttc
     2881 gtgaaattaa gcttcagagg gaagcccgag aaacacagga gagcgagcgc aagcccccac
     2941 catacaagca catcaaggtg aataagcctt acgggaaagt ccagatctac acagcggata
     3001 tttcagaaat ccctaagtgc aactgcaagc ccacagatga gaatccttgt ggctttgatt
     3061 cggagtgtct gaacaggatg ctgatgtttg agtgccaccc gcaggtgtgt cccgcgggcg
     3121 agttctgcca gaaccagtgc ttcaccaagc gccagtaccc agagaccaag atcatcaaga
     3181 cagatggcaa agggtggggc ctggtcgcca agagggacat cagaaaggga gaatttgtta
     3241 acgagtacgt tggggagctg atcgacgagg aggagtgcat ggcgagaatc aagcacgcac
     3301 acgagaacga catcacccac ttctacatgc tcactataga caaggaccgt ataatagacg
     3361 ctggccccaa aggaaactac tctcgattta tgaatcacag ctgccagccc aactgtgaga
     3421 ccctcaagtg gacagtgaat ggggacactc gtgtgggcct gtttgccgtc tgtgacattc
     3481 ctgcagggac ggagctgact tttaactaca acctcgattg tctgggcaat gaaaaaacgg
     3541 tctgccggtg tggagcctcc aattgcagtg gattcctcgg ggatagacca aagacctcga
     3601 cgaccctttc atcagaggaa aagggcaaaa agaccaagaa gaaaacgagg cggcgcagag
     3661 caaaagggga agggaagagg cagtcagagg acgagtgctt ccgctgcggt gatggcgggc
     3721 agctggtgct gtgtgaccgc aagttctgca ccaaggccta ccacctgtcc tgcctgggcc
     3781 ttggcaagcg gcccttcggg aagtgggaat gtccttggca tcattgtgac gtgtgtggca
     3841 aaccttcgac ttcattttgc cacctctgcc ccaattcgtt ctgtaaggag caccaggacg
     3901 ggacagcctt cagctgcacc ccggacgggc ggtcctactg ctgtgagcat gacttagggg
     3961 cggcatcggt cagaagcacc aagactgaga agcccccccc agagccaggg aagccgaagg
     4021 ggaagaggcg gcggcggagg ggctggcgga gagtcacaga gggcaaatag cgccaggcgg
     4081 ccgcttggcc ggatccaggg gcggtgcagg gcggccggcc ctgcctgcgg gagagggcga
     4141 gcatgaactg gcccggagga cccagctcga gccgccagga cacagacgta caggcctcct
     4201 cgggagggag cgcctcccca ccactgagcc atcctcagca gcgtccgctg cgtctgcact
     4261 gatgaccgtc tgagcccagc tcagcgttcc tggacaaaca gcctcactcc tcagcgttac
     4321 cgccacactt gaatttctcc gaatgtcaag gttccctccc actctatttt tttaggttaa
     4381 agttaattgg catatggaat gttttaatct cctctgaaat gtgtagcgta ggcttttccc
     4441 aagggtcgct agaaactcgt cttcgcgttg ccccctttct ggctctcagc gccgtcgcca
     4501 ctcgggagag gctgggtgag gcccgtgtga ggactgaccc tggattcctc gaaactgcca
     4561 ttgtgatcat tactctgctc tttggaaatg gctgtatcat ttttttgtac taatgtgaat
     4621 tgttcctcag aaacgcttct tttccatcct agtgagaagc tggccctgca ggtggtggca
     4681 gcaatggtgt tgtaagattt cctcccgtag ttttttctcc tcatggattt gaatgaaatg
     4741 ccaataacac gtccactttc aacgtgtagt ttacgcggag cactttcgag gcctggccgg
     4801 gttgggccta cttctcacct gggcctatct tctgaactcg ctaggttctt atcaacattt
     4861 gggggataac tttgtatatt tttttcattt ggcttttctt taccagtttc tgatttttat
     4921 tctcaatata tttttgctaa acctatttca caaatcacca ccgactgaag tgtgtgttta
     4981 ctgatgcggc cctgagctcc atggcgaaag gagtgacttt gcagggcgtg agaccgcagt
     5041 ctgcttagag cacaggaagt gacaacttag ggagccccgt agggcgctgc aggccccggg
     5101 gaccccagca cgtgggtcta aagagagacg gagtctagct ctcctgccac ccagagtggc
     5161 ttccatctca gcactctgtg ggtctggtga tggaagatgc agtctctgct gatcacatgt
     5221 gccctctgcc agggcaccta ctgagaggtg cggtcctggg ggtggaggcc tgcctggcag
     5281 gtgtgcgtgc ctcgtacgtg tgttatgggc actggtctag gccaggtatg acacccactc
     5341 tcctgtgaga tttcacttta gtttttaaaa ggtccagttc tacagagtga gacctatcta
     5401 tctgagtact acatatgttt taagacttgg ttcttttttt gagggatcct tgaccctggg
     5461 aagtctggag caccctgaga agggggcacc atgtgtgcct ttgcccacgt gtcctgaggg
     5521 gctgcttgtc tgggagggag ggagagaaca ttcagcagca ggtgcttttt tatggccttt
     5581 tcttaaaata acctaagggg gacacatcca tcttgcagag aagtttacag aactcccctt
     5641 gaaaactgct gctgaggctc ctgttaaatt ttctgtggca tcttttatgc cttggtaaaa
     5701 actgcagtgt ctttggacct gagagtggct actccgtggt tttgtgacct gtaagcgtgg
     5761 ggttcagggg tgtgtggccc tgcagggtcc cacgcctccc tgagcactga ctggaagttt
     5821 cactggctgg tggctgtccc ttctcccatc agggtcccca gcaaagttaa ctacacagag
     5881 gacccagggg aaacgagctg tgtagccact gacttgctcg cgcggccgtg gcctctgagg
     5941 ggcactcgcc ggttaagaca gggtgggagt agtgctttcc agttcagact ctaacttctc
     6001 ccaaagtgtc ctaagaaaat actggatcgg ctcatagatt tatgctcctt atgatgccct
     6061 aacttggaag gttgttctag ggacaggccg ggcagtgtcc ccacacacac cttagagtcg
     6121 aaggccccag ggccccgctg tcacttgccc aaaagatccc ttccggcagg taagggacta
     6181 ccaatgctta cgtcaaaaca gcagaatcgg ctttgcagtg cactttgggg agcagatatt
     6241 aacttatttt tgtgttggac agtagtgaaa tcttgtgatt tttaatcgct ttgataatac
     6301 ttccaaattt tatgattttt ctgaaggaaa taatgcaaac attttaaata tgtttctccc
     6361 cctttccaaa aactgttaaa ctaatgagca agtaacacta actttgaatg tctctacaat
     6421 acccgttgat aactcagtgg agccaggctt tggggtagcg gccctgagct tgcagggttt
     6481 ctcgccactg gggctgacca cgcccccagc tgtgaccgtg ggtgtggctg gctctcggcc
     6541 ctgcccagct ttgttctgag gacgtggtga cttcctgaac atcagcttca atcctccatc
     6601 attaatgtga agcaaaacac aaaaaccgcc ccaatccctc aggattcctt ggcatccgaa
     6661 accagcatct gcacctaaac ccatacccac ccgtgtgcgc ccacaggggg atgtgtccga
     6721 atgggcagct taaaatgtgg tcacctgtgg gggaaactct tcaggcacct gaagtgagaa
     6781 cccagctgtc cgtcctcagg ccggcctttc ttccggcgac acccgtccat ggctggctgg
     6841 gtccccttcg cagtgtttgt ctgtcttgac atctaaaccc cggcgtgtgc agtgcccatc
     6901 ttccaggact accttatttt ccagaattaa acctgtttta taattcaagt taatgcaaat
     6961 gactgtcagt tgccaaatat cttgatccta tgagtgtagt tgatgactgt ttgttagtca
     7021 gtagagtaaa atgctgtgtc cacggggtgt cacagcctca ccataccctg ttgaggtgtg
     7081 aaatgccccg tcagaaatta aatacaaact taaatgtgcc tattggtgtc taaacttcat
     7141 acaatgtaag gtcagattcc ttttaggaat actgggtgct gtcaccaggt ttgatagtta
     7201 gacttaaaaa cttgaaattc actttttggg gggagggata tactgaaata gagagttgag
     7261 acttgccagt tgggggaaaa tagcatttaa aatggaaagc tgtgtttgga aaattgtgta
     7321 tgagtatttt tgtattaaaa acattttaaa ggc
//
