LOCUS       NM_001042424            7560 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens nuclear receptor binding SET domain protein 2 (NSD2),
            transcript variant 10, mRNA.
ACCESSION   NM_001042424
VERSION     NM_001042424.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7560)
  AUTHORS   Parolia,A., Eyunni,S., Verma,B.K., Young,E., Liu,Y., Liu,L.,
            George,J., Aras,S., Das,C.K., Mannan,R., Ur Rasool,R.,
            Mitchell-Velasquez,E., Mahapatra,S., Luo,J., Carson,S.E., Xiao,L.,
            Gajjala,P.R., Venkatesh,S., Jaber,M., Wang,X., He,T., Qiao,Y.,
            Pang,M., Zhang,Y., Tien,J.C., Louw,M., Alhusayan,M., Cao,X., Su,F.,
            Tavana,O., Hou,C., Wang,Z., Ding,K., Chinnaiyan,A.M. and
            Asangani,I.A.
  TITLE     NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in
            promoting prostate tumorigenesis
  JOURNAL   Nat Genet 56 (10), 2132-2143 (2024)
   PUBMED   39251788
  REMARK    GeneRIF: NSD2 is a requisite subunit of the AR/FOXA1
            neo-enhanceosome in promoting prostate tumorigenesis.
REFERENCE   2  (bases 1 to 7560)
  AUTHORS   Goto,N., Suke,K., Yonezawa,N., Nishihara,H., Handa,T., Sato,Y.,
            Kujirai,T., Kurumizaka,H., Yamagata,K. and Kimura,H.
  TITLE     ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in
            pericentromeric heterochromatin
  JOURNAL   J Cell Biol 223 (8) (2024)
   PUBMED   38709169
  REMARK    GeneRIF: ISWI chromatin remodeling complexes recruit NSD2 and
            H3K36me2 in pericentromeric heterochromatin.
REFERENCE   3  (bases 1 to 7560)
  AUTHORS   Feng,W., Niu,N., Lu,P., Chen,Z., Rao,H., Zhang,W., Ma,C., Liu,C.,
            Xu,Y., Gao,W.Q., Xue,J. and Li,L.
  TITLE     Multilevel Regulation of NF-kappaB Signaling by NSD2 Suppresses
            Kras-Driven Pancreatic Tumorigenesis
  JOURNAL   Adv Sci (Weinh) 11 (30), e2309387 (2024)
   PUBMED   38889281
  REMARK    GeneRIF: Multilevel Regulation of NF-kappaB Signaling by NSD2
            Suppresses Kras-Driven Pancreatic Tumorigenesis.
REFERENCE   4  (bases 1 to 7560)
  AUTHORS   Sobh,A., Encinas,E., Patel,A., Surapaneni,G., Bonilla,E.,
            Kaestner,C., Poullard,J., Clerio,M., Vasan,K., Freeman,T., Lv,D.,
            Dupere-Richer,D., Riva,A., Barwick,B.G., Zhou,D., Boise,L.H.,
            Mitsiades,C.S., Kim,B., Bennett,R.L., Chandel,N.S. and Licht,J.D.
  TITLE     NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2
            by diverting one-carbon metabolism to the epigenome
  JOURNAL   Blood 144 (3), 283-295 (2024)
   PUBMED   38598835
  REMARK    GeneRIF: NSD2 drives t(4;14) myeloma cell dependence on adenylate
            kinase 2 by diverting one-carbon metabolism to the epigenome.
REFERENCE   5  (bases 1 to 7560)
  AUTHORS   Nishi,E., Yanagi,K., Kaname,T. and Okamoto,N.
  TITLE     Clinical details of individuals with Rauch-Steindl syndrome due to
            NSD2 truncating variants
  JOURNAL   Mol Genet Genomic Med 12 (2), e2396 (2024)
   PUBMED   38353053
  REMARK    GeneRIF: Clinical details of individuals with Rauch-Steindl
            syndrome due to NSD2 truncating variants.
REFERENCE   6  (bases 1 to 7560)
  AUTHORS   Stec,I., Wright,T.J., van Ommen,G.J., de Boer,P.A., van
            Haeringen,A., Moorman,A.F., Altherr,M.R. and den Dunnen,J.T.
  TITLE     WHSC1, a 90 kb SET domain-containing gene, expressed in early
            development and homologous to a Drosophila dysmorphy gene maps in
            the Wolf-Hirschhorn syndrome critical region and is fused to IgH in
            t(4;14) multiple myeloma
  JOURNAL   Hum Mol Genet 7 (7), 1071-1082 (1998)
   PUBMED   9618163
  REMARK    Erratum:[Hum Mol Genet 1998 Sep;7(9):1527]
REFERENCE   7  (bases 1 to 7560)
  AUTHORS   Richelda,R., Ronchetti,D., Baldini,L., Cro,L., Viggiano,L.,
            Marzella,R., Rocchi,M., Otsuki,T., Lombardi,L., Maiolo,A.T. and
            Neri,A.
  TITLE     A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple
            myeloma involves the fibroblast growth-factor receptor 3 gene
  JOURNAL   Blood 90 (10), 4062-4070 (1997)
   PUBMED   9354676
REFERENCE   8  (bases 1 to 7560)
  AUTHORS   Chesi,M., Nardini,E., Brents,L.A., Schrock,E., Ried,T., Kuehl,W.M.
            and Bergsagel,P.L.
  TITLE     Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is
            associated with increased expression and activating mutations of
            fibroblast growth factor receptor 3
  JOURNAL   Nat Genet 16 (3), 260-264 (1997)
   PUBMED   9207791
REFERENCE   9  (bases 1 to 7560)
  AUTHORS   Wright,T.J., Ricke,D.O., Denison,K., Abmayr,S., Cotter,P.D.,
            Hirschhorn,K., Keinanen,M., McDonald-McGinn,D., Somer,M.,
            Spinner,N., Yang-Feng,T., Zackai,E. and Altherr,M.R.
  TITLE     A transcript map of the newly defined 165 kb Wolf-Hirschhorn
            syndrome critical region
  JOURNAL   Hum Mol Genet 6 (2), 317-324 (1997)
   PUBMED   9063753
REFERENCE   10 (bases 1 to 7560)
  AUTHORS   Battaglia,A., Carey,J.C. and South,S.T.
  TITLE     Wolf-Hirschhorn Syndrome - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301362
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105448.5, CX866583.1,
            BC032731.3, BC094825.1, AF071593.1 and BM982021.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001042424.2.
            
            Summary: This gene encodes a protein that contains four domains
            present in other developmental proteins: a PWWP domain, an HMG box,
            a SET domain, and a PHD-type zinc finger. It is expressed
            ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS)
            is a malformation syndrome associated with a hemizygous deletion of
            the distal short arm of chromosome 4. This gene maps to the 165 kb
            WHS critical region and has also been involved in the chromosomal
            translocation t(4;14)(p16.3;q32.3) in multiple myelomas.
            Alternative splicing of this gene results in multiple transcript
            variants encoding different isoforms. Some transcript variants are
            nonsense-mediated mRNA (NMD) decay candidates, hence not
            represented as reference sequences. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (10) contains a novel 5'
            non-coding exon compared to transcript variant 1, hence has a
            different 5' UTR. However, it encodes the same isoform (1) as
            transcript variants 1, 2 and 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3427661.1,
                                           SRR11853563.24873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000508803.6/ ENSP00000423972.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC105448.5         60345-60347
            4-78                CX866583.1         30-104
            79-3062             BC032731.3         1-2984
            3063-5164           BC094825.1         551-2652
            5165-7196           AF071593.1         5015-7046
            7197-7560           BM982021.1         33-396              c
FEATURES             Location/Qualifiers
     source          1..7560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..7560
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /note="nuclear receptor binding SET domain protein 2"
                     /db_xref="GeneID:7468"
                     /db_xref="HGNC:HGNC:12766"
                     /db_xref="MIM:602952"
     exon            1..150
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..776
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..4277
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /EC_number="2.1.1.357"
                     /note="isoform 1 is encoded by transcript variant 10;
                     trithorax/ash1-related protein 5; probable histone-lysine
                     N-methyltransferase NSD2; IL5 promoter REII region-binding
                     protein; multiple myeloma SET domain containing protein
                     type III; nuclear SET domain-containing protein 2;
                     Wolf-Hirschhorn syndrome candidate 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase NSD2 isoform
                     1"
                     /protein_id="NP_001035889.1"
                     /db_xref="CCDS:CCDS33940.1"
                     /db_xref="GeneID:7468"
                     /db_xref="HGNC:HGNC:12766"
                     /db_xref="MIM:602952"
                     /translation="MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNREC
                     SVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFES
                     QEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQK
                     PENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLL
                     KYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWI
                     FEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAAS
                     MSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVRE
                     ECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSMPR
                     SRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFAL
                     VAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKT
                     ARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLT
                     ENEVSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLC
                     EGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYH
                     EACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDAC
                     LAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPD
                     CLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHE
                     IGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREI
                     KLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDS
                     ECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEF
                     VNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQP
                     NCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGD
                     RPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKA
                     YHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGR
                     SYCCEHDLGAASVRSTKTEKPPPEPGKPKGKRRRRRGWRRVTEGK"
     exon            777..939
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1106
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1589
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1734
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1853
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1935
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2060
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2192
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2316
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2517
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2697
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2854
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3060
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3164
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3434
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3551
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3693
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..3800
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..4005
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4006..7560
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5132..5137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /note="hexamer: AATATA"
     polyA_site      5164
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /note="major polyA site"
     regulatory      7541..7546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /note="hexamer: ATTAAA"
     polyA_site      7560
                     /gene="NSD2"
                     /gene_synonym="KMT3F; KMT3G; MMSET; RAUST; REIIBP; TRX5;
                     WHS; WHSC1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgccgcgc gcgagagcct cggcctggcc gcgctgcgcc cgccgccgcc gccgccccct
       61 ccccgcctgg gccctaccgc cgcacggccc cggccccctc ccagcctgcc gctccggaga
      121 gccgcccgcc gaggatgcga cgcaccgcag tgttctaaga acggaagcat ctgggctgga
      181 tggaatttag catcaagcag agtccccttt ctgttcagag tgttgtaaag tgcataaaga
      241 tgaagcaggc accagaaatc ctcggcagtg ccaacgggaa gactccgagc tgcgaggtga
      301 accgcgagtg ttctgtgttc ctcagcaaag cccagctctc cagtagcctg caggaggggg
      361 tcatgcagaa gtttaacggc cacgacgccc tgccctttat tccagccgac aagctgaaag
      421 atcttacttc ccgggtgttt aatggagaac ccggcgcaca cgatgccaaa ctgcgttttg
      481 agtcccagga aatgaaaggg attgggacac cccctaacac tacccctatc aaaaatggct
      541 ctccagaaat taagctgaaa atcaccaaaa catacatgaa tgggaagcct ctctttgaat
      601 cttccatttg tggtgacagt gctgctgatg tgtctcagtc agaagaaaat ggacaaaaac
      661 cagaaaacaa ggcgagaagg aacaggaaga ggagcataaa atatgactcc ttgctggagc
      721 agggccttgt cgaagcagct cttgtgtcta agatctcaag tccttcagat aaaaagattc
      781 cagctaagaa agagtcttgt ccaaacactg gaagagacaa agaccacctg ttgaaataca
      841 acgttggtga tttggtgtgg tccaaagtgt cgggttaccc ttggtggcct tgcatggttt
      901 ctgcagatcc actccttcac agctatacca aacttaaagg tcagaaaaag agtgcacgcc
      961 agtatcacgt acagttcttt ggtgacgccc cagaaagagc ttggatattt gagaagagcc
     1021 tcgtagcttt tgaaggagaa ggacagtttg aaaaattatg ccaggaaagt gccaagcagg
     1081 cacccacgaa agctgagaaa attaagctat tgaaaccaat ttcagggaaa ttgagggccc
     1141 agtgggaaat gggcattgtt caagcagaag aagctgcaag catgtcagtg gaggagcgga
     1201 aagccaagtt cacctttctc tatgtggggg accagcttca tctcaaccct caagtagcca
     1261 aggaggctgg cattgctgca gagtctttgg gagaaatggc agaatcctca ggagtcagtg
     1321 aagaagctgc tgaaaacccc aagtctgtga gagaagagtg cattcccatg aagagaaggc
     1381 ggagggccaa actgtgtagc tctgcagaga ccctggagag tcaccccgac atagggaaga
     1441 gtactcctca aaagacggca gaggctgacc ccagaagagg agtagggtct cctcctggga
     1501 ggaagaagac cacagtctcc atgccacgaa gcaggaaggg agatgcagca tcccagtttt
     1561 tggtcttctg tcaaaaacac agggatgagg tggtagctga gcacccagat gcttcaggtg
     1621 aggagattga agagctgctc aggtcacagt ggagtctgct gagtgagaag cagagagcac
     1681 gctacaacac caagtttgcc ctggtggccc ctgtccaggc tgaagaagac tctggtaatg
     1741 taaatgggaa aaaaagaaac cacacaaaga ggatacagga ccctacagaa gatgctgaag
     1801 ctgaggacac acccaggaaa agactcagga cggacaagca cagtcttcgg aagagagaca
     1861 caatcactga caaaacggcc agaacaagct cttacaaggc catggaggca gcctcctcgc
     1921 tcaagagcca ggcagcaacg aaaaatctgt ctgatgcatg taaaccactg aagaagcgaa
     1981 atcgggcttc cacggcagca tcttcagctc ttgggtttag caaaagttca tctccttctg
     2041 catccttaac tgagaatgag gtctcggaca gcccgggaga cgagccctcg gagtccccat
     2101 acgaaagtgc agacgaaaca caaactgaag tatctgtctc atccaaaaag tctgagcgag
     2161 gagtgactgc caaaaaggag tatgtgtgcc agctgtgtga gaagccgggc agcctcctgc
     2221 tctgtgaagg accctgctgc ggagctttcc acctcgcctg ccttgggctt tcccggaggc
     2281 cagaagggag gttcacctgc agcgagtgtg cctcagggat tcactcatgt ttcgtgtgta
     2341 aagagagcaa gacagatgtt aagcgctgtg tggtaactca gtgtggaaaa ttttaccatg
     2401 aggcttgtgt gaaaaaatac cctctgactg tatttgagag ccgaggtttc cgctgccccc
     2461 tccacagctg tgtgagctgc catgcttcca acccttcaaa cccaaggccg tcaaaaggta
     2521 aaatgatgcg gtgtgtccgc tgccccgttg cctatcacag cggggatgct tgtctggcag
     2581 caggatgctc agtgatcgcc tccaacagca tcatctgcac tgcccacttc actgctcgga
     2641 aggggaagcg acaccacgcc cacgtcaacg tgagctggtg cttcgtgtgc tccaaagggg
     2701 ggagccttct gtgctgtgag tcctgcccag cggccttcca ccctgactgc ctgaacatcg
     2761 agatgcctga cggcagctgg ttctgcaatg actgcagggc tgggaagaag ctgcacttcc
     2821 aggatatcat ttgggtgaaa cttgggaact acagatggtg gccggcagaa gtttgccatc
     2881 ccaaaaatgt tcccccaaat attcagaaaa tgaagcacga gattggagaa ttccctgtgt
     2941 ttttctttgg gtctaaagat tattactgga cgcatcaggc gcgagtgttc ccgtacatgg
     3001 agggggaccg gggcagccgc taccaggggg tcagagggat cggaagagtc ttcaaaaacg
     3061 cactgcaaga agctgaagct cgttttcgtg aaattaagct tcagagggaa gcccgagaaa
     3121 cacaggagag cgagcgcaag cccccaccat acaagcacat caaggtgaat aagccttacg
     3181 ggaaagtcca gatctacaca gcggatattt cagaaatccc taagtgcaac tgcaagccca
     3241 cagatgagaa tccttgtggc tttgattcgg agtgtctgaa caggatgctg atgtttgagt
     3301 gccacccgca ggtgtgtccc gcgggcgagt tctgccagaa ccagtgcttc accaagcgcc
     3361 agtacccaga gaccaagatc atcaagacag atggcaaagg gtggggcctg gtcgccaaga
     3421 gggacatcag aaagggagaa tttgttaacg agtacgttgg ggagctgatc gacgaggagg
     3481 agtgcatggc gagaatcaag cacgcacacg agaacgacat cacccacttc tacatgctca
     3541 ctatagacaa ggaccgtata atagacgctg gccccaaagg aaactactct cgatttatga
     3601 atcacagctg ccagcccaac tgtgagaccc tcaagtggac agtgaatggg gacactcgtg
     3661 tgggcctgtt tgccgtctgt gacattcctg cagggacgga gctgactttt aactacaacc
     3721 tcgattgtct gggcaatgaa aaaacggtct gccggtgtgg agcctccaat tgcagtggat
     3781 tcctcgggga tagaccaaag acctcgacga ccctttcatc agaggaaaag ggcaaaaaga
     3841 ccaagaagaa aacgaggcgg cgcagagcaa aaggggaagg gaagaggcag tcagaggacg
     3901 agtgcttccg ctgcggtgat ggcgggcagc tggtgctgtg tgaccgcaag ttctgcacca
     3961 aggcctacca cctgtcctgc ctgggccttg gcaagcggcc cttcgggaag tgggaatgtc
     4021 cttggcatca ttgtgacgtg tgtggcaaac cttcgacttc attttgccac ctctgcccca
     4081 attcgttctg taaggagcac caggacggga cagccttcag ctgcaccccg gacgggcggt
     4141 cctactgctg tgagcatgac ttaggggcgg catcggtcag aagcaccaag actgagaagc
     4201 cccccccaga gccagggaag ccgaagggga agaggcggcg gcggaggggc tggcggagag
     4261 tcacagaggg caaatagcgc caggcggccg cttggccgga tccaggggcg gtgcagggcg
     4321 gccggccctg cctgcgggag agggcgagca tgaactggcc cggaggaccc agctcgagcc
     4381 gccaggacac agacgtacag gcctcctcgg gagggagcgc ctccccacca ctgagccatc
     4441 ctcagcagcg tccgctgcgt ctgcactgat gaccgtctga gcccagctca gcgttcctgg
     4501 acaaacagcc tcactcctca gcgttaccgc cacacttgaa tttctccgaa tgtcaaggtt
     4561 ccctcccact ctattttttt aggttaaagt taattggcat atggaatgtt ttaatctcct
     4621 ctgaaatgtg tagcgtaggc ttttcccaag ggtcgctaga aactcgtctt cgcgttgccc
     4681 cctttctggc tctcagcgcc gtcgccactc gggagaggct gggtgaggcc cgtgtgagga
     4741 ctgaccctgg attcctcgaa actgccattg tgatcattac tctgctcttt ggaaatggct
     4801 gtatcatttt tttgtactaa tgtgaattgt tcctcagaaa cgcttctttt ccatcctagt
     4861 gagaagctgg ccctgcaggt ggtggcagca atggtgttgt aagatttcct cccgtagttt
     4921 tttctcctca tggatttgaa tgaaatgcca ataacacgtc cactttcaac gtgtagttta
     4981 cgcggagcac tttcgaggcc tggccgggtt gggcctactt ctcacctggg cctatcttct
     5041 gaactcgcta ggttcttatc aacatttggg ggataacttt gtatattttt ttcatttggc
     5101 ttttctttac cagtttctga tttttattct caatatattt ttgctaaacc tatttcacaa
     5161 atcaccaccg actgaagtgt gtgtttactg atgcggccct gagctccatg gcgaaaggag
     5221 tgactttgca gggcgtgaga ccgcagtctg cttagagcac aggaagtgac aacttaggga
     5281 gccccgtagg gcgctgcagg ccccggggac cccagcacgt gggtctaaag agagacggag
     5341 tctagctctc ctgccaccca gagtggcttc catctcagca ctctgtgggt ctggtgatgg
     5401 aagatgcagt ctctgctgat cacatgtgcc ctctgccagg gcacctactg agaggtgcgg
     5461 tcctgggggt ggaggcctgc ctggcaggtg tgcgtgcctc gtacgtgtgt tatgggcact
     5521 ggtctaggcc aggtatgaca cccactctcc tgtgagattt cactttagtt tttaaaaggt
     5581 ccagttctac agagtgagac ctatctatct gagtactaca tatgttttaa gacttggttc
     5641 tttttttgag ggatccttga ccctgggaag tctggagcac cctgagaagg gggcaccatg
     5701 tgtgcctttg cccacgtgtc ctgaggggct gcttgtctgg gagggaggga gagaacattc
     5761 agcagcaggt gcttttttat ggccttttct taaaataacc taagggggac acatccatct
     5821 tgcagagaag tttacagaac tccccttgaa aactgctgct gaggctcctg ttaaattttc
     5881 tgtggcatct tttatgcctt ggtaaaaact gcagtgtctt tggacctgag agtggctact
     5941 ccgtggtttt gtgacctgta agcgtggggt tcaggggtgt gtggccctgc agggtcccac
     6001 gcctccctga gcactgactg gaagtttcac tggctggtgg ctgtcccttc tcccatcagg
     6061 gtccccagca aagttaacta cacagaggac ccaggggaaa cgagctgtgt agccactgac
     6121 ttgctcgcgc ggccgtggcc tctgaggggc actcgccggt taagacaggg tgggagtagt
     6181 gctttccagt tcagactcta acttctccca aagtgtccta agaaaatact ggatcggctc
     6241 atagatttat gctccttatg atgccctaac ttggaaggtt gttctaggga caggccgggc
     6301 agtgtcccca cacacacctt agagtcgaag gccccagggc cccgctgtca cttgcccaaa
     6361 agatcccttc cggcaggtaa gggactacca atgcttacgt caaaacagca gaatcggctt
     6421 tgcagtgcac tttggggagc agatattaac ttatttttgt gttggacagt agtgaaatct
     6481 tgtgattttt aatcgctttg ataatacttc caaattttat gatttttctg aaggaaataa
     6541 tgcaaacatt ttaaatatgt ttctccccct ttccaaaaac tgttaaacta atgagcaagt
     6601 aacactaact ttgaatgtct ctacaatacc cgttgataac tcagtggagc caggctttgg
     6661 ggtagcggcc ctgagcttgc agggtttctc gccactgggg ctgaccacgc ccccagctgt
     6721 gaccgtgggt gtggctggct ctcggccctg cccagctttg ttctgaggac gtggtgactt
     6781 cctgaacatc agcttcaatc ctccatcatt aatgtgaagc aaaacacaaa aaccgcccca
     6841 atccctcagg attccttggc atccgaaacc agcatctgca cctaaaccca tacccacccg
     6901 tgtgcgccca cagggggatg tgtccgaatg ggcagcttaa aatgtggtca cctgtggggg
     6961 aaactcttca ggcacctgaa gtgagaaccc agctgtccgt cctcaggccg gcctttcttc
     7021 cggcgacacc cgtccatggc tggctgggtc cccttcgcag tgtttgtctg tcttgacatc
     7081 taaaccccgg cgtgtgcagt gcccatcttc caggactacc ttattttcca gaattaaacc
     7141 tgttttataa ttcaagttaa tgcaaatgac tgtcagttgc caaatatctt gatcctatga
     7201 gtgtagttga tgactgtttg ttagtcagta gagtaaaatg ctgtgtccac ggggtgtcac
     7261 agcctcacca taccctgttg aggtgtgaaa tgccccgtca gaaattaaat acaaacttaa
     7321 atgtgcctat tggtgtctaa acttcataca atgtaaggtc agattccttt taggaatact
     7381 gggtgctgtc accaggtttg atagttagac ttaaaaactt gaaattcact ttttgggggg
     7441 agggatatac tgaaatagag agttgagact tgccagttgg gggaaaatag catttaaaat
     7501 ggaaagctgt gtttggaaaa ttgtgtatga gtatttttgt attaaaaaca ttttaaaggc
//
