LOCUS       NM_014886               4337 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens NSA2 ribosome biogenesis factor (NSA2), transcript
            variant 1, mRNA.
ACCESSION   NM_014886
VERSION     NM_014886.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4337)
  AUTHORS   Xing,J., Nan,X., Cui,Q., Ma,W. and Zhao,H.
  TITLE     Nop-7-associated 2 (NSA2) is required for ribosome biogenesis and
            protein synthesis
  JOURNAL   Biochem Biophys Res Commun 505 (1), 249-254 (2018)
   PUBMED   30243719
  REMARK    GeneRIF: Findings indicate a function of Nop-7-associated 2 (NSA2)
            in the regulation of ribosome biogenesis.
REFERENCE   2  (bases 1 to 4337)
  AUTHORS   Li,W., Song,A.P., Zhao,F., Hu,Y.M. and Hua,M.
  TITLE     A novel human TINP1 gene promotes cell proliferation through
            inhibition of p53 and p21 expression
  JOURNAL   Oncol Rep 30 (4), 1848-1852 (2013)
   PUBMED   23912275
  REMARK    GeneRIF: TINP1 promotes cell proliferation and significantly
            reduces p53 and p21 expression.
REFERENCE   3  (bases 1 to 4337)
  AUTHORS   Shahni,R., Czajka,A., Mankoo,B.S., Guvenel,A.K., King,A.J. and
            Malik,A.N.
  TITLE     Nop-7-associated 2 (NSA2), a candidate gene for diabetic
            nephropathy, is involved in the TGFbeta1 pathway
  JOURNAL   Int J Biochem Cell Biol 45 (3), 626-635 (2013)
   PUBMED   23220173
  REMARK    GeneRIF: NSA2, which increases in diabetic nephropathy, may be
            involved in the actions of TGFbeta1 and contribute to the
            development of diabetic nephropathy.
REFERENCE   4  (bases 1 to 4337)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4337)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4337)
  AUTHORS   Shahni,R., Gnudi,L., King,A., Jones,P. and Malik,A.N.
  TITLE     Elevated levels of renal and circulating Nop-7-associated 2 (NSA2)
            in rat and mouse models of diabetes, in mesangial cells in vitro
            and in patients with diabetic nephropathy
  JOURNAL   Diabetologia 55 (3), 825-834 (2012)
   PUBMED   22095236
  REMARK    GeneRIF: Data suggest that circulating NSA2 is elevated in diabetic
            nephropathy patients with albuminuria, and that renal and
            circulating NSA2 levels are increased in hyperglycemia in
            experimental models of diabetes.
REFERENCE   7  (bases 1 to 4337)
  AUTHORS   Zhang,H., Ma,X., Shi,T., Song,Q., Zhao,H. and Ma,D.
  TITLE     NSA2, a novel nucleolus protein regulates cell proliferation and
            cell cycle
  JOURNAL   Biochem Biophys Res Commun 391 (1), 651-658 (2010)
   PUBMED   19932687
  REMARK    GeneRIF: these results demonstrated that NSA2 is a nucleolar
            protein involved in cell proliferation and cell cycle regulation.
REFERENCE   8  (bases 1 to 4337)
  AUTHORS   Lebreton,A., Saveanu,C., Decourty,L., Jacquier,A. and
            Fromont-Racine,M.
  TITLE     Nsa2 is an unstable, conserved factor required for the maturation
            of 27 SB pre-rRNAs
  JOURNAL   J Biol Chem 281 (37), 27099-27108 (2006)
   PUBMED   16861225
  REMARK    GeneRIF: The yeast ortholog, Nsa2, is a pre-ribosomal factor that
            is essential for biogenesis of the large ribosomal subunit.
REFERENCE   9  (bases 1 to 4337)
  AUTHORS   Stanchi,F., Bertocco,E., Toppo,S., Dioguardi,R., Simionati,B.,
            Cannata,N., Zimbello,R., Lanfranchi,G. and Valle,G.
  TITLE     Characterization of 16 novel human genes showing high similarity to
            yeast sequences
  JOURNAL   Yeast 18 (1), 69-80 (2001)
   PUBMED   11124703
REFERENCE   10 (bases 1 to 4337)
  AUTHORS   Wu,X., Ivanova,G., Merup,M., Jansson,M., Stellan,B., Grander,D.,
            Zabarovsky,E., Gahrton,G. and Einhorn,S.
  TITLE     Molecular analysis of the human chromosome 5q13.3 region in
            patients with hairy cell leukemia and identification of tumor
            suppressor gene candidates
  JOURNAL   Genomics 60 (2), 161-171 (1999)
   PUBMED   10486207
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093214.2.
            
            On May 17, 2019 this sequence version replaced NM_014886.5.
            
            Summary: This gene encodes a nucleolar protein involved in cell
            cycle regulation and proliferation. This gene was identified based
            on sequence similarity to a highly conserved Saccharomyces
            cerevisiae gene encoding a pre-ribosomal protein, which is involved
            in large ribosomal subunit biogenesis. The encoded protein is found
            at elevated levels in diabetic nephropathy. Alternative splicing
            results in multiple transcript variants. Several related
            pseudogenes have been identified. [provided by RefSeq, Nov 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.10178.1,
                                           SRR1660805.238300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610426.5/ ENSP00000483484.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC093214.2         82672-82786
            116-303             AC093214.2         84354-84541
            304-454             AC093214.2         84637-84787
            455-634             AC093214.2         86054-86233
            635-827             AC093214.2         89291-89483
            828-4337            AC093214.2         92027-95536
FEATURES             Location/Qualifiers
     source          1..4337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..4337
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /note="NSA2 ribosome biogenesis factor"
                     /db_xref="GeneID:10412"
                     /db_xref="HGNC:HGNC:30728"
                     /db_xref="MIM:612497"
     exon            1..115
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..895
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /note="isoform 1 is encoded by transcript variant 1; TGF
                     beta-inducible nuclear protein 1; hairy cell leukemia
                     protein 1; TGF-beta inducible nuclear protein; NSA2,
                     ribosome biogenesis homolog"
                     /codon_start=1
                     /product="ribosome biogenesis protein NSA2 homolog isoform
                     1"
                     /protein_id="NP_055701.1"
                     /db_xref="CCDS:CCDS4025.1"
                     /db_xref="GeneID:10412"
                     /db_xref="HGNC:HGNC:30728"
                     /db_xref="MIM:612497"
                     /translation="MPQNEYIELHRKRYGYRLDYHEKKRKKESREAHERSKKAKKMIG
                     LKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVL
                     SNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGF
                     TRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGT
                     VIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV"
     exon            116..303
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..454
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..634
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..827
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..4337
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /note="hexamer: ATTAAA"
     regulatory      1023..1028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /note="hexamer: ATTAAA"
     polyA_site      1032
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /note="major polyA site"
     polyA_site      1046
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
     regulatory      1773..1778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /note="hexamer: ATTACA"
     polyA_site      1795
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
     regulatory      2286..2291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /note="hexamer: AATAAA"
     polyA_site      2328
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
     regulatory      2874..2879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /note="hexamer: AATAAA"
     polyA_site      2895
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
     regulatory      3433..3438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /note="hexamer: AATAAA"
     polyA_site      3456
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
     regulatory      4317..4322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
                     /note="hexamer: AATAAA"
     polyA_site      4337
                     /gene="NSA2"
                     /gene_synonym="CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29;
                     TINP1"
ORIGIN      
        1 actctttcct gtcccggcct gcgtggtgtg ggcttgtggg tctttgagac ccgaaaattg
       61 agagcgtttt cgcactccag cggctgctcc tggcggctct gcggccgtca ccatgccaca
      121 gaatgaatat attgaattac accgtaaacg ctatggatac cgtttggatt accatgagaa
      181 aaagagaaag aaggaaagtc gagaggctca tgaacgttca aagaaggcaa agaaaatgat
      241 tggtctgaag gctaagcttt accataaaca gcgtcatgct gagaaaatac aaatgaaaaa
      301 gactatcaag atgcatgaaa agagaaacac caaacaaaag aatgatgaaa agacaccaca
      361 gggagcagta cctgcctatc tgctggacag agagggacaa tctcgagcta aagtactttc
      421 caatatgatt aaacagaaaa gaaaagagaa ggcgggaaaa tgggaagtcc ctctgcctaa
      481 agtacgtgcc cagggagaaa cagaagtatt aaaagttatt cgaacaggaa agagaaagaa
      541 gaaggcatgg aagagaatgg ttactaaagt gtgctttgtt ggagatggct ttacaagaaa
      601 accacctaaa tatgaaagat tcatcaggcc aatgggcttg cgtttcaaga aagcccatgt
      661 aacacatcct gaactgaaag ccaccttttg cctaccaata cttggtgtaa agaagaatcc
      721 ctcatcccca ctgtatacaa ctttgggtgt tattaccaaa ggtactgtca ttgaagtaaa
      781 tgtgagcgaa ttgggccttg tgacacaagg aggcaaagtt atttggggaa aatatgccca
      841 ggttaccaac aatcctgaaa atgatggatg tataaatgca gtcttactgg tttgacagca
      901 atttcatata taattattga ggactacaca ccaattgaag aaactgccat tactgtgatg
      961 tttctgaata ctaccaaaca gccatacatg tctgcaatga agagatttat taaattgtaa
     1021 acattaaagt ggtccagttt tataaatggt ctttattttg aaatacgctt tgaccccatg
     1081 ttcataaaac tgaatgattg aaaaaaagca aatatacaaa tatcctactt catcaatatc
     1141 tgcatttgtg agtgggtatt cagcaatttc ctgaaaaaac caccagtgtt cattgaaaat
     1201 gcctttcaaa aaggttaata cacaattatg tgtctgagaa tttaactgaa gtatcttcaa
     1261 aatctcgtta atcattaatc ctaaaaaagg taggtagcat taatacagat gttaagttta
     1321 tagtgtttgt ttacactaga agtatgtgag aagacactaa aagttcagaa atcttagaga
     1381 aatcttttca cctgtgaaat ccagtacagc aaaggtctag tgaattcaca ttctaaacat
     1441 ttttttcatc tcatttacca tgtataataa tacctacttg gcactatttt ctacttgaat
     1501 catgaaaatg aaaaaaatat actaaagtct ttgtactctc ttagcatttt ctgtattcta
     1561 aacaatatat ttatactttc agaatagtat taagaattag tttaagtaac tccagctaag
     1621 ttttaaaagg aaaaagaaga ctgcactgat tccctgagga gaaatttatt tgcagttact
     1681 tagatgatgt aaaaaggtaa ggatttacgg ttgtaacttg gtgaaagcac ttttgtgatc
     1741 tgttatatgt tgtggtttta aggatggcgt atattacatt aatctataat caccacattg
     1801 ttttaaattg tttatttttt ttttaaagaa gtctgtcttc agagtacaac caatgtgatt
     1861 aattgtgcct ttaacaaagt cattcaatgt ctaaacaaat tcagtatctg aaacatcttc
     1921 atgaggaaaa ctgaaggaaa ggaatttaaa aacacagacc aggaaacaat cacaaaatat
     1981 aggtttaatt actactttta aacttaaaaa aaaataaaaa ccaagaaaac aaacataggt
     2041 actccagtaa gacttgctac tctgaataat gtaacatttt ttctaagttc tataaatata
     2101 tactggaagt tttagaacac atacagacgc ttaggaaaag aaaggctagt tccttggaaa
     2161 tgacgatcca ggatgataca atcacttgat gacagaaggt aagcctttct tacaattaga
     2221 ttttagcaga taattttacc actaatataa atgggtgatg tgtggatcac aagttctaga
     2281 aggcgaataa aaatactgac tccaggtaat ttctggatac tacaaaaatg aagtttgctt
     2341 gtttttttta gaaccaaaaa tactatcttg taaggtacaa agaaagcttg atattaagta
     2401 tgaaaacata agcataacat ttgtaactaa tcacacccat gaaagacgac tagatgacac
     2461 ctgaaacatt tttcaaaata ctgtaacaca gatgagtaat attagtataa attttttatg
     2521 tacattaaga tctgtttcag tttgctggtg tgaccaaacc ttagaaggta atcccaaggg
     2581 ataaagcaga acataagagc agatatttag atattagtac aggctcaatt tgatgcaatc
     2641 ataaaccttc aagatttcta gtcactgaaa ccccattgta ggtagtgttc tggagtctgc
     2701 tataagtaaa tctttaatga ctagatgttt tccttaccat ctacactgaa tggaaatacc
     2761 atgaatatag acacatttta agtagaagac tgacgttcta aatcatgctg tttgatttta
     2821 taaaaaaatc ataatagacc ctctcacctt taaaagttgt agaggagctt tataataaat
     2881 tcttaaatat actaatttct gtgatgtcta gcaattgaat aatttaaact tgaaagaact
     2941 aaaatactaa taaccatctg ctttatatta cacaaggaaa tatacacgta tgtacataaa
     3001 aagtgaactc ccttcacaaa taagttcaca aaggactatg tgtaatgtga ctggacattc
     3061 aacaactaga ctagccggtt gaaatcacat tttcagtcct ctgtaattgt gaaatttttt
     3121 ctaatgcctt gcaaaaacta cagataactg attaagttca tgtaggttcc ttattgaaga
     3181 taaattgtgg tataaattct atactcaagt tactgaacat gagagttagg tttttccaag
     3241 tgatctaact tttccctcta taatctataa accccaaaat aacaatttct gtcagagaga
     3301 atctgtaaca gaagtgttct tgtgtgctga acaaaaaact tctaaattgt ttacaattca
     3361 cttactattt aacccaaaca agtttaacaa gaataagttt atactgttag cccccaatgg
     3421 tcatatatga ttaataaaca ttttttgtaa actcaactat attcacacat caagagttga
     3481 gccagtgagc tcaatcttta aaaaactaca cttgtctaaa gaaagtcttt tagtgctcac
     3541 ttcggcagca catatactaa aattagaaca atacagggaa aattagcatg gcccctgtgc
     3601 aaggatgaca caaattcatg aagcgtttcc atgtttaaaa taatttgaaa agaaagtatt
     3661 ttaaacaaat ccaagtaaaa ataaaatatc tacaagtgtt ttcaaatcta agaaatgaaa
     3721 catgtaaaga ttaagaattt actgaatctt aacagagtat ttccctttgt gatattgaca
     3781 gaagtttctc ataaaatgta taaaacagca taaatgtttg gtagattcac taatagtagt
     3841 catacttttt tttttttact tagtattagc atttgttgaa aaaataaatg gccaaagtgc
     3901 tttaattttc atttagaatg aaataatctg gcttaccttt gactaattaa agaaaatata
     3961 gggtaataca attgttcaaa atctaacaca aataggagcg tttactattt ttgtctgctt
     4021 taagatttta acttgatcga aaataccaac atccccaaac aaaatttact gacctgacat
     4081 cagcttacta tagactgaat acactttcaa catcagtcct tagctacctc aaataatgac
     4141 acaaagtctt agtttctttt gcataaggat caagatcaag ctatttttaa aacaatttaa
     4201 atggtctcaa aacattctcc aacttaagtg caaatttgag tacacataat atttccaaag
     4261 agtagaactg tttttagatt atctttggat tctaataacc attttgtcca tttttaaata
     4321 aattacaaaa aataaca
//
