LOCUS       NM_001330195           12048 bp    mRNA    linear   PRI 24-MAR-2025
DEFINITION  Homo sapiens neurexin 3 (NRXN3), transcript variant 7, mRNA.
ACCESSION   NM_001330195 XM_006720323
VERSION     NM_001330195.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12048)
  AUTHORS   Liu,L., Zhang,P., Dong,X., Li,H., Li,S., Cheng,S., Yuan,J.,
            Yang,X., Qian,Z. and Dong,J.
  TITLE     Circ_0001367 inhibits glioma proliferation, migration and invasion
            by sponging miR-431 and thus regulating NRXN3
  JOURNAL   Cell Death Dis 12 (6), 536 (2021)
   PUBMED   34035217
  REMARK    GeneRIF: Circ_0001367 inhibits glioma proliferation, migration and
            invasion by sponging miR-431 and thus regulating NRXN3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12048)
  AUTHORS   Gulec,G., Cosan,D.T., Sahin,F.M., Calis,I.U., Sonkurt,M.D.,
            Kosger,F. and Essizoglu,A.
  TITLE     Association of Nicotine Use Disorder with Neurexin 3 Gene
            Polymorphisms
  JOURNAL   Turk Psikiyatri Derg 32 (3), 160-166 (2021)
   PUBMED   34647286
  REMARK    GeneRIF: Association of Nicotine Use Disorder with Neurexin 3 Gene
            Polymorphisms.', trans 'Nikotin Kullanim Bozuklugunun Neurexin 3
            Gen Polimorfizmi ile Iliskisi.
REFERENCE   3  (bases 1 to 12048)
  AUTHORS   Hishimoto,A., Liu,Q.R., Drgon,T., Pletnikova,O., Walther,D.,
            Zhu,X.G., Troncoso,J.C. and Uhl,G.R.
  TITLE     Neurexin 3 polymorphisms are associated with alcohol dependence and
            altered expression of specific isoforms
  JOURNAL   Hum Mol Genet 16 (23), 2880-2891 (2007)
   PUBMED   17804423
  REMARK    GeneRIF: details of NRXN3's gene structure and variants, and
            association of NRXN3 SNPs with alcohol dependence
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 12048)
  AUTHORS   Occhi,G., Rampazzo,A., Beffagna,G. and Antonio Danieli,G.
  TITLE     Identification and characterization of heart-specific splicing of
            human neurexin 3 mRNA (NRXN3)
  JOURNAL   Biochem Biophys Res Commun 298 (1), 151-155 (2002)
   PUBMED   12379233
  REMARK    GeneRIF: Identification and characterization of heart-specific
            splicing of neurexin 3 mRNA
REFERENCE   5  (bases 1 to 12048)
  AUTHORS   Tabuchi,K. and Sudhof,T.C.
  TITLE     Structure and evolution of neurexin genes: insight into the
            mechanism of alternative splicing
  JOURNAL   Genomics 79 (6), 849-859 (2002)
   PUBMED   12036300
REFERENCE   6  (bases 1 to 12048)
  AUTHORS   Rowen,L., Young,J., Birditt,B., Kaur,A., Madan,A., Philipps,D.L.,
            Qin,S., Minx,P., Wilson,R.K., Hood,L. and Graveley,B.R.
  TITLE     Analysis of the human neurexin genes: alternative splicing and the
            generation of protein diversity
  JOURNAL   Genomics 79 (4), 587-597 (2002)
   PUBMED   11944992
REFERENCE   7  (bases 1 to 12048)
  AUTHORS   Missler,M., Hammer,R.E. and Sudhof,T.C.
  TITLE     Neurexophilin binding to alpha-neurexins. A single LNS domain
            functions as an independently folding ligand-binding unit
  JOURNAL   J Biol Chem 273 (52), 34716-34723 (1998)
   PUBMED   9856994
  REMARK    GeneRIF: N-terminal sequencing of rat neurexin III alpha provides
            evidence for signal peptide
REFERENCE   8  (bases 1 to 12048)
  AUTHORS   Missler,M. and Sudhof,T.C.
  TITLE     Neurexins: three genes and 1001 products
  JOURNAL   Trends Genet 14 (1), 20-26 (1998)
   PUBMED   9448462
  REMARK    Review article
REFERENCE   9  (bases 1 to 12048)
  AUTHORS   Ichtchenko,K., Nguyen,T. and Sudhof,T.C.
  TITLE     Structures, alternative splicing, and neurexin binding of multiple
            neuroligins
  JOURNAL   J Biol Chem 271 (5), 2676-2682 (1996)
   PUBMED   8576240
REFERENCE   10 (bases 1 to 12048)
  AUTHORS   Ushkaryov,Y.A., Hata,Y., Ichtchenko,K., Moomaw,C., Afendis,S.,
            Slaughter,C.A. and Sudhof,T.C.
  TITLE     Conserved domain structure of beta-neurexins. Unusual cleaved
            signal sequences in receptor-like neuronal cell-surface proteins
  JOURNAL   J Biol Chem 269 (16), 11987-11992 (1994)
   PUBMED   8163501
  REMARK    GeneRIF: N-terminal sequencing of cow neurexin III beta provides
            evidence for signal peptide
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007955.4, AF099810.1,
            AC008045.5, AC009396.5, AC026888.6, AC012099.4, AC008056.6 and
            AF123462.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001330195.1.
            
            Summary: This gene encodes a member of a family of proteins that
            function in the nervous system as receptors and cell adhesion
            molecules. Extensive alternative splicing and the use of
            alternative promoters results in multiple transcript variants and
            protein isoforms for this gene, but the full-length nature of many
            of these variants has not been determined. Transcripts that
            initiate from an upstream promoter encode alpha isoforms, which
            contain epidermal growth factor-like (EGF-like) sequences and
            laminin G domains. Transcripts initiating from the downstream
            promoter encode beta isoforms, which lack EGF-like sequences.
            Genetic variation at this locus has been associated with a range of
            behavioral phenotypes, including alcohol dependence and autism
            spectrum disorder. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (7).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.134779.1,
                                           SRR1660809.9306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335750.7/ ENSP00000338349.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC007955.4         150214-150515
            303-1714            AF099810.1         84527-85938
            1715-1732           AF099810.1         120781-120798
            1733-1762           AF099810.1         139967-139996
            1763-2064           AC008045.5         144968-145269
            2065-2226           AC008045.5         151013-151174
            2227-2665           AC009396.5         25426-25864
            2666-3049           AC009396.5         30965-31348
            3050-3253           AC009396.5         119829-120032
            3254-3280           AC009396.5         126527-126553
            3281-3400           AC026888.6         27317-27436
            3401-3782           AC026888.6         36100-36481
            3783-3973           AC026888.6         37283-37473
            3974-4147           AC026888.6         38248-38421
            4148-4267           AC026888.6         58097-58216
            4268-4449           AC012099.4         56646-56827
            4450-4621           AC008056.6         100016-100187
            4622-4711           AC008056.6         128411-128500
            4712-5019           AC008056.6         133868-134175
            5020-5098           AF123462.1         546-624
            5099-12048          AF123462.1         56776-63725
FEATURES             Location/Qualifiers
     source          1..12048
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3-q31.1"
     gene            1..12048
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /note="neurexin 3"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
     exon            1..302
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            303..1714
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     CDS             1006..5721
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /note="isoform 5 is encoded by transcript variant 7;
                     neurexin III; neurexin-3-alpha"
                     /codon_start=1
                     /product="neurexin 3 isoform 5"
                     /protein_id="NP_001317124.1"
                     /db_xref="CCDS:CCDS81831.1"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
                     /translation="MSSTLHSVFFTLKVSILLGSLLGLCLGLEFMGLPNQWARYLRWD
                     ASTRSDLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLSNK
                     QVNDSSWHFLMVSRDRLRTVLMLDGEGQSGELQPQRPYMDVVSDLFLGGVPTDIRPSA
                     LTLDGVQAMPGFKGLILDLKYGNSEPRLLGSRGVQMDAEGPCGERPCENGGICFLLDG
                     HPTCDCSTTGYGGKLCSEDVSQDPGLSHLMMSEQAREENVATFRGSEYLCYDLSQNPI
                     QSSSDEITLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVN
                     GKFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL
                     PGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATLDPIN
                     FETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFF
                     AVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT
                     ASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIR
                     QLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCERE
                     ASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDG
                     GRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAE
                     GTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDY
                     CELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGD
                     GNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD
                     TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPD
                     LINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDP
                     GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQL
                     HIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYP
                     TGNTDNERFQMVKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGKDKGRLFQGQ
                     LSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETT
                     TTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTDKSLSTSIFEGGYK
                     AHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKP
                     QPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSS
                     TTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQ
                     QSSKSGHKKQKNKDREYYV"
     exon            1715..1732
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1762
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..2064
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2226
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2665
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..3049
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3253
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3280
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3400
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3782
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3973
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3974..4147
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            4148..4267
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            4268..4449
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            4450..4621
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..4711
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            4712..5019
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            5020..5098
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            5099..12048
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8156..8161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /note="hexamer: AATAAA"
     polyA_site      8176
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /note="major polyA site"
     regulatory      11923..11928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /note="hexamer: AATAAA"
     polyA_site      11946
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
     regulatory      12020..12025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /note="hexamer: AATAAA"
     polyA_site      12048
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
ORIGIN      
        1 agtctcaggc tcagcgctca gccctacaca tcgcctcttg catgcaactc acagagaggg
       61 agaggcaacc tgtcctcccc tctctcagcc tcggcatctc cagccaccaa ggacctgctt
      121 ttcgcacctc caacaacccc tcccttctac cctgccactc cctcccagag agaaaggaaa
      181 aggagagaga aagattctgg aatttgaacc tacccaaaga ggaaacatac ccagcaaact
      241 cagttgatta aacatcaaac agacatacag acagatccca aatcttctgt tcaactggaa
      301 aggtcttttc tctggagtcc tgggaggcaa gttatgggca gcactgcttc tggccgcacc
      361 atgaagcctg agtctgcttg cgctctgccc agggccctgc tctgtctgag cattgggctt
      421 ctagctgccc ccctccccac agcctgccgc tgctaggagg tagaacttta ggagtggtcc
      481 ttggcctgtt tctacctgtc acctggctca cctcaccact cactcctcct ccatcacagc
      541 accccggccc tccctgtccc tggcctccct ggctggggca tttgggggtc cgctgggagg
      601 agtgcatcgc tgaaggcttc ttcctactct cctgcacctt ctcctccttg agtcaaggcc
      661 tccggatcca catggatagc tgagatcttt tcttggagaa agacgctttc ctctttactc
      721 cagtccctca cttccccacc tgattttcct cctcttctgc tggtcctgtc tttttctact
      781 gcctctttat tcaatttctt gcttgtgtgc ccctctggga ctctcttgta cactttcctc
      841 catctccact atctcaggat ctgtgtgtgt gctgccttcc tcctgtgtgc tttctgtccc
      901 cccatctctg tcttgtcttt cccacttcta ttgccaaagg gagagatcct ctccgggctg
      961 ttccctggcc tgtctgctcc tccgggctct gtcccagcag cgacaatgag ctccacactc
     1021 cactcggttt tcttcaccct gaaggtcagc atcctgctgg ggtccctgct ggggctctgc
     1081 ctgggccttg agttcatggg cctccccaac cagtgggccc gctacctccg ctgggatgcc
     1141 agcacacgca gtgacctgag tttccagttc aagaccaacg tctctacggg gctgctcctc
     1201 tacctggatg atggcggcgt ctgcgacttc ctatgcctct ccctggtgga tggccgcgtt
     1261 cagctccgct tcagcatgga ctgtgccgag actgccgtgc tgtccaacaa gcaggtgaat
     1321 gacagcagct ggcacttcct catggtgagc cgtgaccgcc tgcgcacggt gctgatgctt
     1381 gatggcgagg gccagtctgg ggagctgcag ccccagcggc cctacatgga tgtggtcagt
     1441 gacttgttcc ttggtggagt ccctactgac atacgacctt ctgccctgac ccttgatgga
     1501 gttcaggcca tgcccggctt caaggggtta attctggatc tcaagtatgg aaactcggag
     1561 cctcggcttc tggggagccg gggtgtccag atggatgccg agggaccctg tggtgagcgt
     1621 ccctgtgaaa atggtgggat ctgctttctc ctggacggcc accccacctg tgactgttct
     1681 accactggct atggtggcaa gctctgctca gaagatgtca gtcaagatcc aggcctctcc
     1741 cacctcatga tgagtgaaca agctcgagag gagaatgtgg ccactttccg aggctcagag
     1801 tatctgtgct acgacctgtc tcagaacccg atccagagca gcagtgatga aatcaccctc
     1861 tcctttaaga cctggcagcg taacggcctc atcctgcaca cgggcaagtc ggctgactat
     1921 gtcaacctgg ctctgaagga tggtgcggtc tccttggtca ttaacctggg gtccggggcc
     1981 tttgaggcca ttgtggagcc agtgaatgga aaattcaacg acaacgcctg gcatgatgtc
     2041 aaagtgacac gcaacctccg gcaggtgaca atctctgtgg atggcattct taccacgacg
     2101 ggctacactc aagaggacta taccatgctg ggctcggacg acttcttcta tgtaggagga
     2161 agcccaagta ccgctgactt gcctggctcc cctgtcagca acaacttcat gggctgcctt
     2221 aaagaggttg tttataagaa taatgacatc cgtctggagc tgtctcgcct ggcccggatt
     2281 gcggacacca agatgaaaat ctatggcgaa gttgtgttta agtgtgagaa tgtggccaca
     2341 ctggacccca tcaactttga gaccccagag gcttacatca gcttgcccaa gtggaacact
     2401 aaacgtatgg gctccatctc ctttgacttc cgcaccacag agcccaatgg cctgatcctc
     2461 ttcactcatg gaaagcccca agagaggaag gatgctcgga gccagaagaa tacaaaagta
     2521 gacttctttg ccgtggaact cctcgatggc aacctgtact tgctgcttga catgggctct
     2581 ggcaccatca aagtgaaagc cactcagaag aaagccaatg atggggaatg gtaccatgtg
     2641 gacattcagc gagatggcag atcaggtact atatcagtga acagcaggcg cacgccattc
     2701 accgccagtg gggagagcga gatcctggac ctggaaggag acatgtacct gggagggctg
     2761 ccggagaacc gtgctggcct tattctcccc accgagctgt ggactgccat gctcaactat
     2821 ggctacgtgg gctgcatccg cgacctattc attgatgggc gcagcaagaa cattcgacag
     2881 ctggcagaga tgcagaatgc tgcgggtgtc aagtcctcct gttcacggat gagtgccaag
     2941 cagtgtgaca gctacccctg caagaataat gctgtgtgca aggacggctg gaaccgcttc
     3001 atctgcgact gcaccggcac cggatactgg ggaagaacct gcgaaaggga ggcatccatc
     3061 ctgagctatg atggtagcat gtacatgaag atcatcatgc ccatggtcat gcatactgag
     3121 gcagaggatg tgtccttccg cttcatgtcc cagcgagctt atgggctgct ggtggctacg
     3181 acctccaggg actctgccga caccctgcgt ctggagctgg atggggggcg tgtcaagctc
     3241 atggttaact tagactgtat caggataaac tgtaactcca gcaaaggacc agagaccttg
     3301 tatgcagggc agaagctcaa tgacaacgag tggcacaccg ttcgggtggt gcggagagga
     3361 aaaagcctta agttaaccgt ggatgatgat gtggctgagg gtacaatggt gggagaccat
     3421 acccgtttgg agttccacaa cattgaaacg ggaatcatga ctgagaaacg ctacatctcc
     3481 gttgtcccct ccagctttat tggccatctg cagagcctca tgtttaatgg ccttctctac
     3541 attgacttgt gcaaaaatgg tgacattgat tattgtgagc tgaaggctcg ttttggactg
     3601 aggaacatca tcgctgaccc tgtcaccttt aagaccaaga gcagctacct gagccttgcc
     3661 actcttcagg cttacacctc catgcacctc ttcttccagt tcaagaccac ctcaccagat
     3721 ggcttcattc tcttcaatag tggtgatggc aatgacttca ttgcagtcga gcttgtcaag
     3781 gggtatatac actacgtttt tgacctcgga aacggtccca atgtgatcaa aggcaacagt
     3841 gaccgccccc tgaatgacaa ccagtggcac aatgtcgtca tcactcggga caatagtaac
     3901 actcatagcc tgaaagtgga caccaaagtg gtcactcagg ttatcaatgg tgccaaaaat
     3961 ctggatttga aaggtgatct ctatatggct ggtctggccc aaggcatgta cagcaacctc
     4021 ccaaagctcg tggcctctcg agatggcttt cagggctgtc tagcatcagt ggacttgaat
     4081 ggacgcctgc cagacctcat caatgatgct cttcatcgga gcggacagat cgagcgtggc
     4141 tgtgaaggac ccagtaccac ctgccaggaa gattcatgtg ccaaccaggg ggtctgcatg
     4201 caacaatggg agggcttcac ctgtgattgt tctatgacct cttattctgg aaaccagtgc
     4261 aatgatcctg gcgctacgta catctttggg aaaagtggtg ggcttatcct ctacacctgg
     4321 ccagccaatg acaggcccag cacgcggtct gaccgccttg ccgtgggctt cagcaccact
     4381 gtgaaggatg gcatcttggt ccgcatcgac agtgctccag gacttggtga cttcctccag
     4441 cttcacatag aacaggggaa aattggagtt gtcttcaaca ttggcacagt tgacatctcc
     4501 atcaaagagg agagaacccc tgtaaatgac ggcaaatacc atgtggtacg cttcaccagg
     4561 aacggcggca acgccaccct gcaggtggac aactggccag tgaatgaaca ttatcctaca
     4621 ggcaacactg ataatgaacg cttccaaatg gtaaaacaga aaatcccctt caaatataat
     4681 cggcctgtag aggagtggct gcaggaaaaa ggccggcagt taaccatctt caacactcag
     4741 gcgcaaatag ccattggtgg aaaggacaaa ggacgcctct tccaaggcca actctctggg
     4801 ctctattatg atggtttgaa agtactgaac atggcggctg agaacaaccc caatattaaa
     4861 atcaatggaa gtgttcggct ggttggagaa gtcccatcaa ttttgggaac aacacagacg
     4921 acctccatgc caccagaaat gtctactact gtcatggaaa ccactactac aatggcgact
     4981 accacaaccc gtaagaatcg ctctacagcc agcattcagc caacatcaga tgatcttgtt
     5041 tcatctgctg aatgttcaag tgatgatgaa gactttgttg aatgtgagcc gagtacagat
     5101 aagagtcttt ccacttcaat cttcgaaggt ggctacaaag cacatgcgcc caagtgggaa
     5161 tccaaggact ttagacctaa caaagtctcc gaaactagta ggactactac cacatcttta
     5221 tcccctgagc tgatccgctt cacagcttcc tcctcgtctg ggatggtgcc caaattgcca
     5281 gctggcaaaa tgaataaccg tgatctcaaa ccccagcctg atatagtctt gcttccgttg
     5341 cccactgcct atgagctaga cagcaccaaa ctgaagagcc cactaattac ttcccccatg
     5401 ttccgtaatg tgcccacagc aaaccccacg gagccgggaa tcagacgggt tccgggggcc
     5461 tcagaggtga tccgggagtc gagcagcaca acagggatgg tcgtcggcat tgtggctgct
     5521 gccgccctct gcatcttgat cctcctgtac gccatgtaca agtacaggaa cagggacgag
     5581 gggtcctatc aagtggacga gacgcggaac tacatcagca actccgccca gagcaacggc
     5641 acgctcatga aggagaagca gcagagctcg aagagcggcc acaagaaaca gaaaaacaag
     5701 gacagggagt attacgtgta aacatgcgaa cactgctcac acgcgagttt tcacagttat
     5761 ttctatccac gcctatgaat ctttggacgg tgagatctca cagatgtcag aactgctgga
     5821 actatgaaat ggggtatata accacgactc tggtggggaa aaccgttttt taaaggacac
     5881 acacacacac agcgatgcat ctctctctaa agctcagcca cggctgcggc aaggtcccag
     5941 cggtcgctgg gagacagaag gttttgtgcc ctgctgtatc ataaagcaca cacttagcgc
     6001 tctggagccg gacggtggct ccaccacttc cgcaggcctg gaaacttcct tctccggagg
     6061 accttttact aaaaggtaga agacttcatg gcttacttgt tccataactc caagtgagtc
     6121 tgtaatgttt gtgaagcttg actgtaacca tgttttttct gtttaattat gtaaaaaaca
     6181 aaactacaac aacaaaaaaa gaaaaaagtt aaaaaagaaa aaaacaccaa aaaacaaaaa
     6241 caaacaaaaa aaaaaaccca caacccttat ctggttctga ccagtgtgcg tgtaacttta
     6301 tgatctgagg ggaaaaatgg cttttgggtt tttgtttatt tttttgataa tgactggaca
     6361 tcagaagagg aaaaaaactc aaaacaaaag cgagagagac tattgccata tgaactcaaa
     6421 agctatcatg gtgttcactc tacatatcag gttatggtgt ctctagaatc tgttgtttgt
     6481 ttcctataag atgctttgct gaacacatag caaaattcat gtgacggatg ataaattgat
     6541 tcgaaaagct ggtcccccag gatctaattt cagaatttac cacccaaacc cggaacagat
     6601 gggtttaggg ctggtgttat cagagctatt ggctttacgt aacaatattg ttcctgtcca
     6661 ttcacccagc caaattgtgt taaagaggaa agccccacaa actaaaacag cctttcctag
     6721 ggaagaggaa ggggaggtgg gctggatctg tgactgattg aaatgcatgc aaataaaaaa
     6781 gacaatatta aagtctgtta tcaaaccaga cagtagggga gttcaactcg tgatggaacc
     6841 acaaaaggtc acacaagcca accatgtcat gccagagtac aaaacacata gttctttccc
     6901 cgccccgaat gtgacaatgg ttttcatagt ggtttaattt tgtagcctga catttatgga
     6961 taactctgtc cttccatttg ctcacttctc tcttcaccca tcttttttaa aaacaaataa
     7021 atgaataaag ctgctgtgac acacacacaa aaggaattta atagtataat atatatataa
     7081 ataaatatat atacagatat atttatcatg gtatgtttga tgggatgact gacacaggaa
     7141 atctgttaaa gtcttaaaat ggaatgagaa tgttgtttta aaagaaaata gcaaaacaac
     7201 aaaaaagcaa accttaaaat gtgaagaaag tgtgaatttt agttttgtca cagttaactg
     7261 tgtcaaagag aattaaaaaa aaaaacttca gattttgttt acatatttta ctacattttt
     7321 gctggtataa ttccttagcc acctatgtac atactgcttt aagaaatgtt tttttcctgt
     7381 ttatttctgt ttggtttata ttctggttgt ctttttcttt ttgtaaagag gaaacaatgt
     7441 acagaaaaac aataaactgg ttgtatggcc atagctatcc gaaaagcaag agacaaagca
     7501 agacaaatat tcacacaaaa atgaagtgtg tcctctggag ggtcagatat acaatttctt
     7561 ttgtacagat gaaaatcaat cagctgctta gatttagaaa tctactcttg ctggtctttg
     7621 taagttgcat gaatatttga ctttgaaaaa atatcttaac gacatggggc aaaaagtgca
     7681 atctaaatgg tagcctttac taatgtgtgt ggaaagaggt gttcctcatt atctaatatt
     7741 tcaatgtgtt aagagtttaa tttttttgtt atcattaaaa aagacaggat tataaagaga
     7801 tatcaaagca cgattttaga taacctaaac ggcccagcct atacgaagtt gattatatct
     7861 cgatgtctgt aaaagattgc tgttcttgga gtcttgaggt cttgtgaatt gatttcctgc
     7921 tttctttcat ttttttcaat ttaagtaata atacatttgt tatattcctt tcagtgtaag
     7981 tttctatttg gacaatttta tgggaacatg tgcattctct atgtgagctt ctatcatatt
     8041 cctgttttat tagcagaacc taaaggaatt tatttaatga tgttgtgaca ttactgcttt
     8101 ttcttttttc ttttcttagt tcatatttgc attttcgttc aaggatatgc ttagcaataa
     8161 aatgttcttc ccaaaacctt gtatgctgat gcacttttat tttcttaaca tttgagaaaa
     8221 tctcgcactg aagctaatta tgtcatatct tattaaaagc cgagtaagag ctagaccact
     8281 ttcatgtgat agaagatatt ctaagcagtt actaattatt acattatcaa aatgccatat
     8341 ttatgagata attatctgtt acttgaggca ttatttttta gattgctatg atagaataac
     8401 caggagggag tgcatttttc tggaaagatg atagaaacat tgtattctag aaaagattat
     8461 tggatactat ggttttgttt gtttgttttt gttttttgtt tttcgttttt tgtttgtttt
     8521 ttttttgaga cagagtctcg ctctgtcgcc cgggctggag tgcagtggca cgatctcggc
     8581 tcactgcaag ctccgcctcc cgggttcaca ccattctcct gcctcagccc cccgagtagg
     8641 tgggactaca ggtgcccgcc accacgcccg gctaattttt tgtatttttc gtagagacgg
     8701 ggtttcaccg tgttagccgg gatggtctcg atctcctgac ctcgtaatcc acccgcctcg
     8761 gcctcccaaa gtgctgggat tacaggcgtg agccaccgcg cccggcttgg atactatgtt
     8821 ttttaaaggc atttcgtacc ttttacgtat tttctataag tcaacaagct ttaaacagta
     8881 tttaaaacta tgttcacata gtgccataag cactagaaag tcttagatgt cttctttcca
     8941 agcctcccac catattaaaa tttaaaatta aaaaacagaa tccaaaacca aaatttaaat
     9001 gagttcttca attttaacag cttcttacaa gaatttctga ttacaacttg tttcatacac
     9061 ccattgtagc agtaatgtct catatttctc gttctctcag cacacactta cttggccaat
     9121 tggataatcc atctaccctt tgttcttcac tgtaatctag aaatatagat ttaactgaac
     9181 agctgtcctt tatccatatg ttggttacca gttttcaaag agttagaatt ttaaaaatat
     9241 atatttagtt aagcctgtgc cttcaagata acattagtgg agtggttata ctatcgacta
     9301 tgttaggaat gggggggaga aagtcaggtt cagtgatgtc aaattatgta aagttttttt
     9361 tttgttcctg tcttcaaagt tctgtattag atgttctccc atcatttttt gagatggagt
     9421 cttgcagcct acagtgcagt ggcatgatat tggctcactg caacctctgc ctctcaacct
     9481 caaacgattc tcctgcctca gcctcctgag tagctgcgac tacaggcatg ggccaccaca
     9541 cccagctcat tttttaattt attttttatt tttttagtaa ggaagggttt caccatgttg
     9601 gcaaggctgg tctcgaactc cttacttcaa gtgatccacc caccttggcc ttgcaaaatg
     9661 ctgggattat aggtgtgagc cactcctcct gaaatctttc taaatctcac taatatataa
     9721 ttctaggact actttaagca ttcacttttt ctttaattca agaaacattt attgaacact
     9781 tatgtacaag ctagtctact attggctatt gttactttgt ttcaatgaag gcagaaaatg
     9841 gctagaagga ttttaagcct ttttgtctct tgtataaatc tatacaggtc cagtctctct
     9901 ttgctcatat tcaaattgaa gtttgatctt tctccaaaaa atatccaagc cctgtgtttg
     9961 tcccagttga actaatatct tgattatata gtttaagatc agtttgataa tgtctattga
    10021 atatttacta aatgattatg ggatattaaa ttgagagcct tgggagctta tcatctagta
    10081 aagatgaaca aaaaatggta ctatagtgaa tgcaaataag ctatcaaaaa gtacaaacta
    10141 agttgggagc ttagaagaaa ttatgtaagg gaaggcttca tagaaggggt gacattttgg
    10201 taaaccttgg aaaactgata ggcagaaata agggctgtat atcattctaa gcaaaccctt
    10261 aaagtgggag caagcaggat caaaaccata atttggattg atgacagact gcaaaaagta
    10321 cattggagga agatatgagt aggaaggttt ttgaaatcat gtcaatgaat gggaagagag
    10381 aaatgggaga atagcttgag aagttcaagg tcaagggctg ctttgtcgag tacaaaggac
    10441 tcgagcatat ttgaaatgaa aggtaataac tgatctactc ttatggagca accgagtttc
    10501 ctgatagaga tgtttatctg ggggaaaaag gcataagtca atcttcttgg agagaatggg
    10561 atcagaaact gacatattgc tacagaggtt acaaaagctg tagtcagagg gcttcagtgt
    10621 tctggatata ttaaaggaca aggtcagata cccaagtggg accgtgagtg attaatggca
    10681 gcagtccact gacagcacca gtaggaaggc gctaatgaaa agatctctaa atatcagtaa
    10741 ggggttagct gccattaata atacaacttt atagctttac tattttttct tttattgttg
    10801 aaatagtgag ggcacgtatt tttctaattg tgtttattac aaagaaaaca gacccgaaga
    10861 acttaaatga cttctccaag gtcacacagc taatacatga caatgtcatg acttaaaatc
    10921 cagtcttgtg gttccaaatt tagagctctt tcataaacct gtctctagag aagcaagtca
    10981 ttttctactt tttccagaag catttgaagt ggaagctaag gcaggaaatg agaggatatt
    11041 gtgttagtct actgggatta ccctggcaaa ataccacagg ctgggtagac aactgaaatg
    11101 tatttctcag ttccagaaac aaagttgcag atcaaagttt gttagggctc agtttctggg
    11161 aagggctctc ttcctggctt gtagataata agctaccttc tcactatgta ctcacagggc
    11221 ctttcttctg ttcatgcact gagagatttc tttttcttgc tcttcttata agaccaccag
    11281 tgctattggt taaagccctg ccattatgac tttgtttgac cttaattact tcctaaagac
    11341 actacctccc aatacagtca tgtttggggt tgggacttca acatatgaat gttggagggg
    11401 atatggttct gtttctagca aatgtatagt agtgggaatt gcaaaggttg aagttccaaa
    11461 gtatcaaggg aatcagaatt gggaagcaat tctaaccttt ttgaagtggt tacatggccc
    11521 aagtagaaga gcaaataatt ccaagagaca ccaagccaca gagcaggtag gatcacgtga
    11581 gtagggccca ggatagaaga gcagtgttag ggttgcatga gagtgagggc atataagaca
    11641 acaacagcta aaagcaatgc atgctcagat cttgggagat gtattaaatg agtagagtga
    11701 atttcaagat atctgagttt ttttttttta atgattacat gggttctaga gtcaaaatgc
    11761 catggctcat ctggtactgt aacttaagat aaactgctta gctaaggctc agctttcata
    11821 cctataattt tgttatactt atcttgcagg tttcttgaga aatattggat gaaataattc
    11881 atgtgaaatg cttaacatat gtgtgacaaa taattatcct taaataaatg ttggtcgtta
    11941 ttacaattgg ctttgttact tgattcaggc aggatcaaaa ttagctgcta tatgcatgac
    12001 taaccaggac caaaaagtta ataaaaatac gaaagtttgg cactctta
//
