LOCUS       NM_015080               6632 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens neurexin 2 (NRXN2), transcript variant alpha-1, mRNA.
ACCESSION   NM_015080
VERSION     NM_015080.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6632)
  AUTHORS   Cuttler,K., de Swardt,D., Engelbrecht,L., Kriel,J., Cloete,R. and
            Bardien,S.
  TITLE     Neurexin 2 p.G849D variant, implicated in Parkinson's disease,
            increases reactive oxygen species, and reduces cell viability and
            mitochondrial membrane potential in SH-SY5Y cells
  JOURNAL   J Neural Transm (Vienna) 129 (12), 1435-1446 (2022)
   PUBMED   36242655
  REMARK    GeneRIF: Neurexin 2 p.G849D variant, implicated in Parkinson's
            disease, increases reactive oxygen species, and reduces cell
            viability and mitochondrial membrane potential in SH-SY5Y cells.
REFERENCE   2  (bases 1 to 6632)
  AUTHORS   Ma,C. and Zhang,Y.
  TITLE     NRXN2 Possesses a Tumor Suppressor Potential via Inhibiting the
            Growth of Thyroid Cancer Cells
  JOURNAL   Comput Math Methods Med 2021, 7993622 (2021)
   PUBMED   34777568
  REMARK    GeneRIF: NRXN2 Possesses a Tumor Suppressor Potential via
            Inhibiting the Growth of Thyroid Cancer Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6632)
  AUTHORS   Alves-Ferreira,M., Quintas,M., Sequeiros,J., Sousa,A.,
            Pereira-Monteiro,J., Alonso,I., Neto,J.L. and Lemos,C.
  TITLE     A genetic interaction of NRXN2 with GABRE, SYT1 and CASK in
            migraine patients: a case-control study
  JOURNAL   J Headache Pain 22 (1), 57 (2021)
   PUBMED   34126933
  REMARK    GeneRIF: A genetic interaction of NRXN2 with GABRE, SYT1 and CASK
            in migraine patients: a case-control study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6632)
  AUTHORS   Ding,X., Meng,S., Zhou,J., Yang,J., Li,H. and Zhou,W.
  TITLE     Translational Inhibition of alpha-Neurexin 2
  JOURNAL   Sci Rep 10 (1), 3403 (2020)
   PUBMED   32099033
  REMARK    GeneRIF: Translational Inhibition of alpha-Neurexin 2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6632)
  AUTHORS   Tabuchi,K. and Sudhof,T.C.
  TITLE     Structure and evolution of neurexin genes: insight into the
            mechanism of alternative splicing
  JOURNAL   Genomics 79 (6), 849-859 (2002)
   PUBMED   12036300
REFERENCE   6  (bases 1 to 6632)
  AUTHORS   Rowen,L., Young,J., Birditt,B., Kaur,A., Madan,A., Philipps,D.L.,
            Qin,S., Minx,P., Wilson,R.K., Hood,L. and Graveley,B.R.
  TITLE     Analysis of the human neurexin genes: alternative splicing and the
            generation of protein diversity
  JOURNAL   Genomics 79 (4), 587-597 (2002)
   PUBMED   11944992
REFERENCE   7  (bases 1 to 6632)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   8  (bases 1 to 6632)
  AUTHORS   Hata,Y., Butz,S. and Sudhof,T.C.
  TITLE     CASK: a novel dlg/PSD95 homolog with an N-terminal
            calmodulin-dependent protein kinase domain identified by
            interaction with neurexins
  JOURNAL   J Neurosci 16 (8), 2488-2494 (1996)
   PUBMED   8786425
REFERENCE   9  (bases 1 to 6632)
  AUTHORS   Ichtchenko,K., Nguyen,T. and Sudhof,T.C.
  TITLE     Structures, alternative splicing, and neurexin binding of multiple
            neuroligins
  JOURNAL   J Biol Chem 271 (5), 2676-2682 (1996)
   PUBMED   8576240
REFERENCE   10 (bases 1 to 6632)
  AUTHORS   Ushkaryov,Y.A., Petrenko,A.G., Geppert,M. and Sudhof,T.C.
  TITLE     Neurexins: synaptic cell surface proteins related to the
            alpha-latrotoxin receptor and laminin
  JOURNAL   Science 257 (5066), 50-56 (1992)
   PUBMED   1621094
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001462.3 and AP001092.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 2, 2019 this sequence version replaced NM_015080.3.
            
            Summary: This gene encodes a member of the neurexin gene family.
            The products of these genes function as cell adhesion molecules and
            receptors in the vertebrate nervous system. These genes utilize two
            promoters. The majority of transcripts are produced from the
            upstream promoter and encode alpha-neurexin isoforms while a
            smaller number of transcripts are produced from the downstream
            promoter and encode beta-neuresin isoforms. The alpha-neurexins
            contain epidermal growth factor-like (EGF-like) sequences and
            laminin G domains, and have been shown to interact with
            neurexophilins. The beta-neurexins lack EGF-like sequences and
            contain fewer laminin G domains than alpha-neurexins. Alternative
            splicing and the use of alternative promoters may generate
            thousands of transcript variants (PMID: 12036300, PMID:
            11944992).[provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (alpha-1) encodes the longest
            isoform (alpha-1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB035266.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265459.11/ ENSP00000265459.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AP001462.3         7246-7472           c
            228-1201            AP001092.5         155900-156873       c
            1202-1219           AP001092.5         140705-140722       c
            1220-1249           AP001092.5         135777-135806       c
            1250-1321           AP001092.5         133335-133406       c
            1322-1623           AP001092.5         128576-128877       c
            1624-1668           AP001092.5         119923-119967       c
            1669-1830           AP001092.5         111373-111534       c
            1831-2269           AP001092.5         110180-110618       c
            2270-2656           AP001092.5         103683-104069       c
            2657-2860           AP001092.5         103262-103465       c
            2861-2887           AP001092.5         96626-96652         c
            2888-3007           AP001092.5         94965-95084         c
            3008-3389           AP001092.5         94185-94566         c
            3390-3580           AP001092.5         93378-93568         c
            3581-3754           AP001092.5         91664-91837         c
            3755-3874           AP001092.5         91149-91268         c
            3875-4056           AP001092.5         78201-78382         c
            4057-4228           AP001092.5         73332-73503         c
            4229-4318           AP001092.5         69393-69482         c
            4319-4644           AP001092.5         65683-66008         c
            4645-4723           AP001092.5         63224-63302         c
            4724-6632           AP001092.5         49104-51012         c
FEATURES             Location/Qualifiers
     source          1..6632
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..6632
                     /gene="NRXN2"
                     /note="neurexin 2"
                     /db_xref="GeneID:9379"
                     /db_xref="HGNC:HGNC:8009"
                     /db_xref="MIM:600566"
     exon            1..227
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            228..1201
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..5610
                     /gene="NRXN2"
                     /note="isoform alpha-1 precursor is encoded by transcript
                     variant alpha-1; neurexin II"
                     /codon_start=1
                     /product="neurexin-2-beta isoform alpha-1 precursor"
                     /protein_id="NP_055895.1"
                     /db_xref="CCDS:CCDS8077.1"
                     /db_xref="GeneID:9379"
                     /db_xref="HGNC:HGNC:8009"
                     /db_xref="MIM:600566"
                     /translation="MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARW
                     AGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQ
                     LDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVR
                     LSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGL
                     CTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAG
                     DVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSA
                     DYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAM
                     VNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGC
                     LKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPR
                     WSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLL
                     LDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLES
                     ELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGV
                     APFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMY
                     MKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDC
                     LRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLE
                     FHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRA
                     IVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVK
                     GYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA
                     RNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQ
                     VERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGA
                     LITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIF
                     NVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAI
                     ARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV
                     LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTR
                     RGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPV
                     ATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASG
                     FASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFA
                     PSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLP
                     TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY
                     QVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV"
     exon            1202..1219
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1249
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1321
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1623
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1668
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1830
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2269
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2656
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2860
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2887
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3007
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3389
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3580
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3754
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3874
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..4056
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4228
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4318
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4644
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4645..4723
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4724..6632
                     /gene="NRXN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6610..6615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRXN2"
                     /note="hexamer: AACAAA"
     polyA_site      6632
                     /gene="NRXN2"
                     /note="major polyA site"
ORIGIN      
        1 agtcggtgtt gcagggatgc ggcggcggga gcagccgccc tgactcgcgg agcatcctcc
       61 tcggagaggc accgcggcgg ggcgggcggg cgggcgggga cgcggcgggg agggagagag
      121 gcgcgaggcg gcagacaccg ctagccctgg ctctgccacc cgtcggagac ggggcggccc
      181 tgtagctctg ctacccaccc tccagcttct ggcgccccga gaaccaggca tccctccctg
      241 ctcttctgtc ggagcccgcg gcgggggagg ggcgccgccg ccgccgcctg agggaagccg
      301 gcatctgggc ctctgcgcgc ctcgccccgc ggccgggccc atggcactgt gagcctgcaa
      361 gggagccccg ctcagcgcgg ggagcgcccg gccccctccc gccccatgcg cccgcggctc
      421 tgaagcctga gcgggggccg ggggccgggc ggggccgggg ccgccgtagg catggcgtcc
      481 gggagccggt ggcggccgac accgccgccg ctgctgttgc tgctgctgct ggcgctggcg
      541 gcgcgcgcgg acggcctgga gttcggcggc ggccccgggc agtgggctcg ctacgcgcgc
      601 tgggcgggcg cggcgagcag cggcgagctc agcttcagcc tgcgcaccaa cgccacgcgc
      661 gcgctgctgc tctacctgga cgacggcggc gactgcgact tcctggagct gctgctggtg
      721 gacggccgcc tgcggctgcg cttcacgctt tcgtgcgccg agccggccac gctgcagctg
      781 gacacgccgg tggccgacga ccgctggcac atggtgctgc tgacccgcga cgcgcgccgc
      841 acggcgctgg cggtggacgg cgaggcccgc gccgccgagg tgcgctccaa gcggcgcgag
      901 atgcaggtgg ccagcgacct gttcgtgggc ggcatcccgc ccgacgtgcg cctctcggcg
      961 cttacgctga gcaccgtcaa gtacgagccg cccttccgcg gcctcttggc caacctgaag
     1021 ctgggcgagc ggccccccgc gctgctgggc agccagggcc tgcgcggcgc caccgccgac
     1081 ccgctgtgcg cgcccgcgcg caacccctgc gccaacggcg gcctctgcac cgtgctggcc
     1141 cccggcgagg tgggctgcga ctgcagccac acgggcttcg gcggcaagtt ctgcagcgaa
     1201 gaggagcacc ccatggaagg tccggctcac ctgacgttaa acagcgaagt agggtcctta
     1261 ctgttctccg aggggggggc cgggagagga ggagccggcg atgtgcacca gccaacaaaa
     1321 ggcaaggagg agtttgtggc gaccttcaaa ggcaatgagt tcttctgcta cgacctgtca
     1381 cacaacccca tccagagcag cactgatgag atcacactgg ccttccgcac cctgcaacgc
     1441 aacggcctga tgctgcatac aggcaagtcg gccgactacg tcaacctgtc cctcaagtct
     1501 ggggctgtct ggctggtcat caacctaggc tcaggtgcct tcgaggccct tgtggaaccc
     1561 gtcaatggca agttcaacga caacgcctgg cacgacgtcc gggtcacccg aaacctgcgc
     1621 cagcacgcag ggattggaca cgctatggta aacaaactgc attatctggt gaccatctcg
     1681 gtggacggga tcctgaccac cacaggctac acgcaggagg attacaccat gctgggctct
     1741 gatgacttct tctacattgg gggcagcccc aacacagctg acctgccggg ctcgcccgtc
     1801 agcaacaact tcatgggctg cctcaaggac gtggtctata agaacaatga cttcaaattg
     1861 gaactatccc gcctggcaaa ggaaggggac cccaagatga agctgcaggg ggacttgtca
     1921 ttccgctgtg aggatgtggc tgccctggac cctgtgacct ttgagagtcc cgaggccttt
     1981 gtggcgctgc cccgctggag cgctaagcgc actggctcca tctccctaga cttccgcacc
     2041 accgagccca atgggctgct gctcttcagc cagggccggc gggctggggg tggagctggc
     2101 agccacagct ctgctcagcg ggccgactac tttgccatgg agctattgga cggccacctc
     2161 tatcttctgc tggacatggg atctgggggc atcaagctgc gggcatccag ccgcaaggtc
     2221 aatgatggcg agtggtgtca cgtggacttc cagagggatg ggcgaaaagg ctccatctca
     2281 gtgaatagtc gcagcacgcc gttcttggcc actggagaca gcgagattct ggacctggag
     2341 agtgagctgt acctgggcgg tctccctgag gggggccggg tggacctgcc cctgccccca
     2401 gaggtgtgga cagcagcact ccgggcaggc tacgtgggct gtgtgcggga cctcttcata
     2461 gatgggcgta gccgagacct ccggggcctg gctgaggctc agggggctgt gggcgttgcc
     2521 cccttttgct cccgggagac gctgaagcag tgtgcatctg ccccctgtcg caatgggggc
     2581 gtctgtcgag aaggctggaa ccgcttcatc tgtgactgca tcgggaccgg ctttcttggg
     2641 cgggtctgtg agagagaggc cacggtcctg agctacgatg gctccatgta catgaagatc
     2701 atgctgccta acgccatgca cacggaggca gaggatgtgt ccctgcgttt catgtcccag
     2761 cgggcctacg gactcatgat ggccaccact tccagggagt ctgccgacac cctacgcctg
     2821 gagctggatg gggggcagat gaagctcact gtcaacctcg actgcctgcg cgtcggctgc
     2881 gcacccagta aaggccccga aacgctgttt gcggggcaca agctcaatga caatgagtgg
     2941 cacacggtga gggtggtccg gcgtggcaag agcctgcagc tgtctgtgga caacgtgact
     3001 gtggagggac agatggcagg agcccatatg cggctggagt tccacaacat tgagacgggc
     3061 atcatgacgg agcggcggtt tatctccgtg gtgccctcca acttcatcgg gcatctgagt
     3121 gggctcgtgt tcaatggcca gccctacatg gaccagtgca aggatggtga catcacctac
     3181 tgtgagctca atgctcgctt tggcctgcgt gccatcgtgg ccgatcccgt caccttcaag
     3241 agtcgcagca gctacctggc actcgccacg ctccaagcct atgcttccat gcacctcttc
     3301 ttccagttca agaccacggc ccctgatggg cttcttctgt tcaactcggg caacggcaat
     3361 gacttcattg tcatcgagct ggtcaagggg tacatccact acgtgtttga cctggggaat
     3421 ggcccgtcct tgatgaaggg gaactcagac aaaccagtca atgacaacca gtggcacaac
     3481 gtggtggtgt ccagggaccc aggcaacgtg cacacgctca agattgactc ccgcactgtc
     3541 acgcagcact ccaatggcgc ccgaaacctc gatctcaaag gggagttgta cattggcggt
     3601 ctgagcaaga atatgttcag caacctgccc aagctggtgg cctcccggga tggctttcag
     3661 ggctgcctgg cctcagtgga cctcaacgga cgtctcccag acctcatcgc cgacgccctg
     3721 caccgcattg ggcaggtgga gaggggctgt gatggcccca gcaccacctg cactgaagag
     3781 tcctgtgcca accagggcgt ctgcttgcag cagtgggatg gcttcacctg cgactgcacc
     3841 atgacttcct atggaggccc tgtctgcaat gatcccggga ccacatacat ctttgggaag
     3901 gggggagcgc tcatcaccta cacgtggccc cccaatgaca ggcccagcac gaggatggat
     3961 cgcctggccg tgggcttcag cacccaccag cggagcgctg tgctggtgcg ggtggacagc
     4021 gcctccggcc ttggagacta cctgcagctg cacatcgacc agggcaccgt gggggtgatc
     4081 tttaacgtgg gcacggacga cattaccatc gacgagccca acgccatagt aagcgacggc
     4141 aaataccacg tggtgcgctt cactcgaagc ggcggcaacg ccaccctgca ggtggacagc
     4201 tggccggtca acgagcggta cccggcagga aactttgata acgagcgcct ggcgattgct
     4261 agacagagaa tcccctaccg gcttggtcga gtagtagatg agtggctgct cgacaaaggc
     4321 cgccagctga ccatcttcaa cagccaggct gccatcaaga tcgggggccg ggatcagggc
     4381 cgccccttcc agggccaggt gtccggcctc tactacaatg ggctcaaggt gctggcgctg
     4441 gccgccgaga gcgaccccaa tgtgcggact gagggtcacc tgcgcctggt gggggagggg
     4501 ccgtccgtgc tgctcagtgc ggagaccacg gccaccaccc tgctggctga catggccacc
     4561 accatcatgg agactaccac caccatggcc actaccacca cgcgccgggg ccgctccccc
     4621 acactgaggg acagcaccac ccagaacaca gatgacctgc tggtggcctc tgctgagtgt
     4681 ccaagcgatg atgaggacct ggaggagtgt gagcccagta ctggaggaga gttaatattg
     4741 cccattatca cggaggactc cttagacccc cctcccgtgg ccacccgatc ccccttcgtg
     4801 cccccgcccc ctaccttcta ccccttcctc acgggagtgg gcgccaccca agacacgctg
     4861 cccccgcccg ccgcgcgccg cccgccctct gggggcccgt gccaggccga gcgggacgac
     4921 agcgactgcg aggagcccat cgaggcctcg ggcttcgcct ccggggaggt ctttgactcc
     4981 agcctccccc ccacggacga cgaggacttt tacaccacct ttcccctggt cacggaccgc
     5041 accaccctcc tgtcaccccg caaacccgct ccccggccca acctcaggac agatggggcc
     5101 acgggcgccc ctggggtgct gtttgccccc tccgccccgg cccccaacct gccggcgggc
     5161 aaaatgaacc accgagaccc gcttcagccc ttgctggaga acccgccctt ggggcccggg
     5221 gcccccacgt cctttgagcc gcggaggccc cctcccctgc gccccggcgt gacctcagcc
     5281 cccggcttcc cccatctgcc cacagccaac cccacagggc ctggggagcg gggcccgccg
     5341 ggcgcagtgg aggtgatccg ggagtccagc agcaccacgg gcatggtggt gggcattgtg
     5401 gcggcggcgg cgctctgcat cctcatcctc ctctacgcca tgtataagta ccgcaatcgt
     5461 gatgagggct cctaccaggt ggaccagagc cgaaactaca tcagtaactc ggcccagagc
     5521 aatggggcgg tggtgaaaga gaaggccccg gctgccccca agacgcccag caaggccaag
     5581 aagaacaaag acaaggagta ttatgtctga gcccccggca ctgcgcccca ctgccagctg
     5641 cccctcctgg gagggcccgg gaggagggtg ccaccctctc cctgccaggg gcctggggac
     5701 cctctccctg gctgcctcag gcttctctta cgaagaggaa acgcaaaaaa agaaaaggaa
     5761 aaaccccgtg ctcgccccct tcctcctgcc gtccactgcg cggcctcgtc agtcccgggg
     5821 ctgactgtcc ctctcagctc tgcgcctgcc aggcagggca cgtgctcaca gccctgggtt
     5881 gatttatttt tttaaggggg tagttttatt ttggtggggt tgggtgggaa ggaaggctgg
     5941 gggttttgta aagtgtccac tgctcgtcct gttaattttc ctcaattttt cttcttcttc
     6001 cttctgtccc tcctgccttc cttctcttcc caagccctcc aatccccatc ccaggcttgc
     6061 tgtgtctcac tgtccccacc ctccttccct acttcttttt ttgtgtgtct ggtttctccc
     6121 ttcctttcct ccctttgggt ttccagagtc ggtgggagaa gggcgggagg gtgggcccga
     6181 gtggcccagt gggtgggtgg ggtggggtgg ggcaagtgcc ccaactcccc tcaccaggag
     6241 aggcacctgc ttggtgccgc ccagggaagg ggctcaggcc tgacggaagg cctgttctgt
     6301 gtgtgccgcc gggcgacgtg cattgatggg gaagctgctg gaggagcagg ggtggggggt
     6361 gggagggagg ggaaaggcaa atgcagatat atattacaga caaatactct agattccacg
     6421 agcagcagcc tgtggcaccc gctgggcgcg ggcagcaggg aagagggagc aaggcattgt
     6481 ccacagactg ctggggtcac ttctttgccc acgggctccc tgctccccca gttttttttc
     6541 tctctttgtt aacaaatgtg tctgagtctt ggaaaacacc ccaaccccgg aaatgtgtgg
     6601 gaaaaagaaa acaaaaactt tccaaattcc aa
//
