LOCUS       NM_004558               1528 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens neurturin (NRTN), mRNA.
ACCESSION   NM_004558 XM_011528041
VERSION     NM_004558.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1528)
  AUTHORS   Man,J., Zhou,W., Zuo,S., Zhao,X., Wang,Q., Ma,H. and Li,H.Y.
  TITLE     TANGO1 interacts with NRTN to promote hepatocellular carcinoma
            progression by regulating the PI3K/AKT/mTOR signaling pathway
  JOURNAL   Biochem Pharmacol 213, 115615 (2023)
   PUBMED   37211171
  REMARK    GeneRIF: TANGO1 interacts with NRTN to promote hepatocellular
            carcinoma progression by regulating the PI3K/AKT/mTOR signaling
            pathway.
REFERENCE   2  (bases 1 to 1528)
  AUTHORS   Xi,G., Esfandiary,R., Sacramento,C.B., Jouihan,H., Sharma,A.,
            Roth,R. and Linke,T.
  TITLE     Refolding and purification of cGMP-grade recombinant human
            neurturin from Escherichia coli inclusion bodies
  JOURNAL   Protein Expr Purif 168, 105552 (2020)
   PUBMED   31866372
  REMARK    GeneRIF: Refolding and purification of cGMP-grade recombinant human
            neurturin from Escherichia coli inclusion bodies.
REFERENCE   3  (bases 1 to 1528)
  AUTHORS   Li,J., Shang,G., Chen,Y.J., Brautigam,C.A., Liou,J., Zhang,X. and
            Bai,X.C.
  TITLE     Cryo-EM analyses reveal the common mechanism and diversification in
            the activation of RET by different ligands
  JOURNAL   Elife 8, e47650 (2019)
   PUBMED   31535977
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1528)
  AUTHORS   Bigalke,J.M., Aibara,S., Roth,R., Dahl,G., Gordon,E., Dorbeus,S.,
            Amunts,A. and Sandmark,J.
  TITLE     Cryo-EM structure of the activated RET signaling complex reveals
            the importance of its cysteine-rich domain
  JOURNAL   Sci Adv 5 (7), eaau4202 (2019)
   PUBMED   31392261
  REMARK    GeneRIF: We have reconstituted the complete extracellular region of
            the RET signaling complex together with Neurturin (NRTN) and
            GFRalpha2 and determined its structure at 5.7-A resolution by
            cryo-EM. The proteins form an assembly through RET-GFRalpha2 and
            RET-NRTN interfaces.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1528)
  AUTHORS   Sandmark,J., Dahl,G., Oster,L., Xu,B., Johansson,P., Akerud,T.,
            Aagaard,A., Davidsson,P., Bigalke,J.M., Winzell,M.S., Rainey,G.J.
            and Roth,R.G.
  TITLE     Structure and biophysical characterization of the human full-length
            neurturin-GFRa2 complex: A role for heparan sulfate in signaling
  JOURNAL   J Biol Chem 293 (15), 5492-5508 (2018)
   PUBMED   29414779
  REMARK    GeneRIF: biophysical results show that the relative concentration
            of GFRa2 on cell surfaces can affect the functional affinity of
            NRTN through avidity effects.
REFERENCE   6  (bases 1 to 1528)
  AUTHORS   Heuckeroth,R.O., Kotzbauer,P., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Zimonjic,D.B., Popescu,N.C., Johnson,E.M. Jr. and
            Milbrandt,J.
  TITLE     Neurturin, a novel neurotrophic factor, is localized to mouse
            chromosome 17 and human chromosome 19p13.3
  JOURNAL   Genomics 44 (1), 137-140 (1997)
   PUBMED   9286710
REFERENCE   7  (bases 1 to 1528)
  AUTHORS   Buj-Bello,A., Adu,J., Pinon,L.G., Horton,A., Thompson,J.,
            Rosenthal,A., Chinchetru,M., Buchman,V.L. and Davies,A.M.
  TITLE     Neurturin responsiveness requires a GPI-linked receptor and the Ret
            receptor tyrosine kinase
  JOURNAL   Nature 387 (6634), 721-724 (1997)
   PUBMED   9192899
REFERENCE   8  (bases 1 to 1528)
  AUTHORS   Klein,R.D., Sherman,D., Ho,W.H., Stone,D., Bennett,G.L., Moffat,B.,
            Vandlen,R., Simmons,L., Gu,Q., Hongo,J.A., Devaux,B., Poulsen,K.,
            Armanini,M., Nozaki,C., Asai,N., Goddard,A., Phillips,H.,
            Henderson,C.E., Takahashi,M. and Rosenthal,A.
  TITLE     A GPI-linked protein that interacts with Ret to form a candidate
            neurturin receptor
  JOURNAL   Nature 387 (6634), 717-721 (1997)
   PUBMED   9192898
  REMARK    Erratum:[Nature 1998 Mar 12;392(6672):210]
REFERENCE   9  (bases 1 to 1528)
  AUTHORS   Kotzbauer,P.T., Lampe,P.A., Heuckeroth,R.O., Golden,J.P.,
            Creedon,D.J., Johnson,E.M. Jr. and Milbrandt,J.
  TITLE     Neurturin, a relative of glial-cell-line-derived neurotrophic
            factor
  JOURNAL   Nature 384 (6608), 467-470 (1996)
   PUBMED   8945474
REFERENCE   10 (bases 1 to 1528)
  AUTHORS   Parisi,M.A.
  TITLE     Hirschsprung Disease Overview - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301612
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011499.5 and AC024592.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jun 23, 2020 this sequence version replaced
            XM_011528041.2, NM_004558.4.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. The
            encoded preproprotein is proteolytically processed to generate the
            mature protein. This protein signals through the RET receptor
            tyrosine kinase and a GPI-linked coreceptor, and promotes survival
            of neuronal populations. A neurturin mutation has been described in
            a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279874.2884.1,
                                           SRR14327317.444349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303212.3/ ENSP00000302648.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               AC011499.5         178444-178828
            386-952             AC011499.5         197145-197711
            953-1528            AC024592.5         7363-7938
FEATURES             Location/Qualifiers
     source          1..1528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1528
                     /gene="NRTN"
                     /gene_synonym="NTN"
                     /note="neurturin"
                     /db_xref="GeneID:4902"
                     /db_xref="HGNC:HGNC:8007"
                     /db_xref="MIM:602018"
     exon            1..385
                     /gene="NRTN"
                     /gene_synonym="NTN"
                     /inference="alignment:Splign:2.1.0"
     exon            386..952
                     /gene="NRTN"
                     /gene_synonym="NTN"
                     /inference="alignment:Splign:2.1.0"
     CDS             784..1377
                     /gene="NRTN"
                     /gene_synonym="NTN"
                     /note="prepro-neurturin"
                     /codon_start=1
                     /product="neurturin preproprotein"
                     /protein_id="NP_004549.1"
                     /db_xref="CCDS:CCDS12151.1"
                     /db_xref="GeneID:4902"
                     /db_xref="HGNC:HGNC:8007"
                     /db_xref="MIM:602018"
                     /translation="MQRWKAAALASVLCSSVLSIWMCREGLLLSHRLGPALVPLHRLP
                     RTLDARIARLAQYRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP
                     CGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVR
                     AQPCCRPTAYEDEVSFLDAHSRYHTVHELSARECACV"
     exon            953..1528
                     /gene="NRTN"
                     /gene_synonym="NTN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1509..1514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRTN"
                     /gene_synonym="NTN"
                     /note="hexamer: GATAAA"
     polyA_site      1528
                     /gene="NRTN"
                     /gene_synonym="NTN"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcggcg ggagagcgcg ccctgaagcc gctccgagtg cccaggtccc tctcgccgcc
       61 gccccggagc cccgtgctgc gcgccgaggc cgcctgcgcc gtccgtgcgc ccccgcgccc
      121 cgcgccctct gagccgccgg ccgtccaggg cacccacccc cagccccagc ccccgccggc
      181 ccgggatggc cgcagcccgc ggctaagcga gcccgggggg ccccatgggc cggcccgcgc
      241 cgcaccccgc ccgcggccgc cccctccggc ccgggccccc cccgggcacc gcgggcccag
      301 gcggcccgga tggcggtcgc ggcggctggg gcaggggctg gggccgcgcg gccgccactg
      361 acgggtagtc cggcgcccac agcagctgca gccgctccgg cctccttgct gttcctggga
      421 tacgccacac tcagtctggc ctcggggcct ttgcactggc tgtgtcccct gcctgtgatg
      481 ccattctcct ctgcctggcc aactcctacg tttattcaag tctggacctt gtcatcggct
      541 cctcaggaag gcactccggg acccccagat gggggcggtt ccctgtgact cctggcacgg
      601 aggccaaccc cttccttgtt caatggttcc ttgagggacc attcccatgt gattatcgac
      661 cattcggcag gcgttcaaag tcaaaggccc cacactgagt cctggcccag cgccctgtgc
      721 ccgttggctg ctggagggac agacggggcg tgcggctgac catcccgtgc ccgcaggctg
      781 aggatgcagc gctggaaggc ggcggccttg gcctcagtgc tctgcagctc cgtgctgtcc
      841 atctggatgt gtcgagaggg cctgcttctc agccaccgcc tcggacctgc gctggtcccc
      901 ctgcaccgcc tgcctcgaac cctggacgcc cggattgccc gcctggccca gtaccgtgca
      961 ctcctgcagg gggccccgga tgcgatggag ctgcgcgagc tgacgccctg ggctgggcgg
     1021 cccccaggtc cgcgccgtcg ggcggggccc cggcggcggc gcgcgcgtgc gcggttgggg
     1081 gcgcggcctt gcgggctgcg cgagctggag gtgcgcgtga gcgagctggg cctgggctac
     1141 gcgtccgacg agacggtgct gttccgctac tgcgcaggcg cctgcgaggc tgccgcgcgc
     1201 gtctacgacc tcgggctgcg acgactgcgc cagcggcggc gcctgcggcg ggagcgggtg
     1261 cgcgcgcagc cctgctgccg cccgacggcc tacgaggacg aggtgtcctt cctggacgcg
     1321 cacagccgct accacacggt gcacgagctg tcggcgcgcg agtgcgcctg cgtgtgaccc
     1381 tacctcactc ggccggcgcg gcggccactc cccccgcctc gacggcacca ctggccggcc
     1441 ccgcgaaaga ctgcgcgtgc gtagagcacg ccggcgcggc cccgggactc tcgcgataac
     1501 tgtactgaga taaagtgtgg caactcga
//
