LOCUS       NM_001323682            2074 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens neurensin 2 (NRSN2), transcript variant 5, mRNA.
ACCESSION   NM_001323682
VERSION     NM_001323682.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2074)
  AUTHORS   Xue,S.T., Cao,S.Q., Ding,J.C., Li,W.J., Hu,G.S., Zheng,J.C.,
            Lin,X., Chen,C., Liu,W. and Zheng,B.
  TITLE     LncRNA LUESCC promotes esophageal squamous cell carcinoma by
            targeting the miR-6785-5p/NRSN2 axis
  JOURNAL   Cell Mol Life Sci 81 (1), 121 (2024)
   PUBMED   38457049
  REMARK    GeneRIF: LncRNA LUESCC promotes esophageal squamous cell carcinoma
            by targeting the miR-6785-5p/NRSN2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2074)
  AUTHORS   Yun,C., Zhang,J. and Morigele.
  TITLE     miR-488-3p Represses Malignant Behaviors and Facilitates Autophagy
            of Osteosarcoma Cells by Targeting Neurensin-2
  JOURNAL   Curr Pharm Biotechnol 25 (10), 1264-1275 (2024)
   PUBMED   37365792
  REMARK    GeneRIF: miR-488-3p Represses Malignant Behaviors and Facilitates
            Autophagy of Osteosarcoma Cells by Targeting Neurensin-2.
REFERENCE   3  (bases 1 to 2074)
  AUTHORS   Yan,Z., Xu,T., Lu,J., Wu,Z., Li,X., Xu,J., Guo,W. and Dong,Z.
  TITLE     E2F1-activated NRSN2 promotes esophageal squamous cell carcinoma
            progression through AKT/mTOR pathway
  JOURNAL   Pathol Res Pract 236, 153963 (2022)
   PUBMED   35662041
  REMARK    GeneRIF: E2F1-activated NRSN2 promotes esophageal squamous cell
            carcinoma progression through AKT/mTOR pathway.
REFERENCE   4  (bases 1 to 2074)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2074)
  AUTHORS   Tang,W., Ren,A., Xiao,H., Sun,H. and Li,B.
  TITLE     Highly expressed NRSN2 is related to malignant phenotype in ovarian
            cancer
  JOURNAL   Biomed Pharmacother 85, 248-255 (2017)
   PUBMED   27908706
  REMARK    GeneRIF: NRSN2 could promote ovarian cancer cell proliferation,
            invasion and chemoresistance in ovarian adenocarcinoma.
REFERENCE   6  (bases 1 to 2074)
  AUTHORS   An,Y., Amr,S.S., Torres,A., Weissman,L., Raffalli,P., Cox,G.,
            Sheng,X., Lip,V., Bi,W., Patel,A., Stankiewicz,P., Wu,B.L. and
            Shen,Y.
  TITLE     SOX12 and NRSN2 are candidate genes for 20p13 subtelomeric
            deletions associated with developmental delay
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (8), 832-840 (2013)
   PUBMED   24019301
  REMARK    GeneRIF: SOX12 and NRSN2 were identified as candidate genes that
            may be involved in the developmental defects in 20p13
            microdeletion.
REFERENCE   7  (bases 1 to 2074)
  AUTHORS   Ma,H.Q., Liang,X.T., Zhao,J.J., Wang,H., Sun,J.C., Chen,Y.B.,
            Pan,K. and Xia,J.C.
  TITLE     Decreased expression of Neurensin-2 correlates with poor prognosis
            in hepatocellular carcinoma
  JOURNAL   World J Gastroenterol 15 (38), 4844-4848 (2009)
   PUBMED   19824122
  REMARK    GeneRIF: NRSN2 could be a tumor suppressor gene for hepatocellular
            carcinoma and a candidate biomarker for long-term survival in HCC
REFERENCE   8  (bases 1 to 2074)
  AUTHORS   Nakanishi,K., Ida,M., Suzuki,H., Kitano,C., Yamamoto,A., Mori,N.,
            Araki,M. and Taketani,S.
  TITLE     Molecular characterization of a transport vesicle protein
            Neurensin-2, a homologue of Neurensin-1, expressed in neural cells
  JOURNAL   Brain Res 1081 (1), 1-8 (2006)
   PUBMED   16527258
REFERENCE   9  (bases 1 to 2074)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 2074)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP202782.1, AK026982.1 and BC001963.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001323682.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.82386.1,
                                           SRR3476690.448863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382285.7/ ENSP00000371722.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-582               BP202782.1         1-582
            583-886             AK026982.1         502-805
            887-2074            BC001963.1         772-1959
FEATURES             Location/Qualifiers
     source          1..2074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2074
                     /gene="NRSN2"
                     /gene_synonym="C20orf98; dJ1103G7.6"
                     /note="neurensin 2"
                     /db_xref="GeneID:80023"
                     /db_xref="HGNC:HGNC:16229"
                     /db_xref="MIM:610666"
     exon            1..32
                     /gene="NRSN2"
                     /gene_synonym="C20orf98; dJ1103G7.6"
                     /inference="alignment:Splign:2.1.0"
     exon            33..111
                     /gene="NRSN2"
                     /gene_synonym="C20orf98; dJ1103G7.6"
                     /inference="alignment:Splign:2.1.0"
     exon            112..226
                     /gene="NRSN2"
                     /gene_synonym="C20orf98; dJ1103G7.6"
                     /inference="alignment:Splign:2.1.0"
     exon            227..421
                     /gene="NRSN2"
                     /gene_synonym="C20orf98; dJ1103G7.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..847
                     /gene="NRSN2"
                     /gene_synonym="C20orf98; dJ1103G7.6"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="neurensin-2 isoform 1"
                     /protein_id="NP_001310611.1"
                     /db_xref="CCDS:CCDS12996.1"
                     /db_xref="GeneID:80023"
                     /db_xref="HGNC:HGNC:16229"
                     /db_xref="MIM:610666"
                     /translation="MMPSCNRSCSCSRGPSVEDGKWYGVRSYLHLFYEDCAGTALSDD
                     PEGPPVLCPRRPWPSLCWKISLSSGTLLLLLGVAALTTGYAVPPKLEGIGEGEFLVLD
                     QRAADYNQALGTCRLAGTALCVAAGVLLAICLFWAMIGWLSQDTKAEPLDPEADSHVE
                     VFGDEPEQQLSPIFRNASGQSWFSPPASPFGQSSVQTIQPKRDS"
     exon            422..2074
                     /gene="NRSN2"
                     /gene_synonym="C20orf98; dJ1103G7.6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2056..2061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRSN2"
                     /gene_synonym="C20orf98; dJ1103G7.6"
                     /note="hexamer: AATAAA"
     polyA_site      2074
                     /gene="NRSN2"
                     /gene_synonym="C20orf98; dJ1103G7.6"
                     /note="major polyA site"
ORIGIN      
        1 gcctttgctc ggcggagaca gcaggcagag agtttctctc tagggaaaag gacgcagttg
       61 gtgtggagca gggcatcggt ggtcctgtca ggaagagtgg cgcgggtgcc gatgaggaaa
      121 ctgagaccca gaaaggtgga agcacttgtc taaggtcacg cctccaggaa gcagtgtgtc
      181 cacgactcca gtccaagtgg tcaggctcca gagcccacag tcccaggggt ccatgatgcc
      241 gagctgcaat cgttcctgca gctgcagccg cggccccagc gtggaggatg gcaagtggta
      301 tggggtccgc tcctacctgc acctcttcta tgaggactgt gcaggcactg ctctcagcga
      361 cgaccctgag ggacctccgg tcctgtgccc ccgccggccc tggccctcac tgtgttggaa
      421 gatcagcctg tcctcgggga ccctgcttct gctgctgggt gtggcggctc tgaccactgg
      481 ctatgcagtg ccccccaagc tggagggcat cggtgagggt gagttcctgg tgttggatca
      541 gcgggcagcc gactacaacc aggccctggg cacctgtcgc ctggcaggca cagcgctctg
      601 tgtggcagct ggagttctgc tcgccatctg cctcttctgg gccatgatag gctggctgag
      661 ccaggacacc aaggcagagc ccttggaccc cgaagccgac agccacgtgg aggtcttcgg
      721 ggatgagcca gagcagcagt tgtcacccat tttccgcaat gccagtggcc agtcatggtt
      781 ctcgccaccc gccagcccct ttgggcaatc ttctgtgcag actatccagc ccaagaggga
      841 ctcctgagct gcccacatgg cctaagatgt gggtcctgga tccttccccc cttctcacca
      901 taaccccctc tcagtgtttc cccaacttct cccttttagc agggtccctt tagagcccaa
      961 ctccaggtca aatctggagc tcaaatccca gtgctccctc cccaggagtg gggccccaac
     1021 tcttccaaga taccagcatt cctcaagtcc tcccaaaact tcctacccac accctcttcc
     1081 caaggccctc aggggcagaa aacatctcct tcaacccgtc cccactcctt cctctgcatg
     1141 accttgggca aacccttgcc ctttcaagcc atcagctcct gcctctctgc catgagggct
     1201 ttggatcaga ttcctcttct cgccaggatg aggacacgca ctgccctcca tagacacaga
     1261 tgaaggggtg ggggtcattc agctcgaatg ggtcccagat gctcacttgg cctttccctg
     1321 caggatgagt gaagacgttt gcctctcaca gtgtgtcttc tacctgcatt ttggcatcag
     1381 agccccccag cccacccacc acaggcaatt actagcccta gttgataggt gaggtgggtg
     1441 aagaaggctg gaggtgacat gtccgaggtc acacaacaaa gcagcatgca ggaactagaa
     1501 acacatcttc agcctcctcc tgggccagct cttgtgctac aggtggggcg gagccagccc
     1561 ctcaccttcc tggttccctg agggtcctca gggtggagga caggtttggc ccagaaagac
     1621 tagccagagg cctgatggtc ccaggtggct ctggatatac tttggatatg gatttaaatg
     1681 gtctctaaga gccgggggta gggggcagga aaagtgggtt gtctttgccc ctcaaagtcc
     1741 acctacctag aaaccaagcc cacggtcttg gccgtgaccc tgataataaa tgggctctct
     1801 cagaggcgcc agcccctccc tccccagccg gaggcgtcat ctctcttctg taccactaga
     1861 gggagctctg atgcagctgg agagcagcgc tcaaggctct cgcccctccc ctccctaacc
     1921 cttaccttca gtctccacca gcctgaaggg cctcctaggg gatcctcagg cggcccccac
     1981 cagggcacac cctactgtcc ttgtgcctca cgccccctcc tcatcctgca ccccttccat
     2041 cccaccttcc ctttcaataa acagctggga tgga
//
