LOCUS       NM_080723               2380 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens neurensin 1 (NRSN1), mRNA.
ACCESSION   NM_080723
VERSION     NM_080723.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2380)
  AUTHORS   Rinne,N., Wikman,P., Sahari,E., Salmi,J., Einarsdottir,E., Kere,J.
            and Alho,K.
  TITLE     Developmental dyslexia susceptibility genes DNAAF4, DCDC2, and
            NRSN1 are associated with brain function in fluently reading
            adolescents and young adults
  JOURNAL   Cereb Cortex 34 (4) (2024)
   PUBMED   38610086
  REMARK    GeneRIF: Developmental dyslexia susceptibility genes DNAAF4, DCDC2,
            and NRSN1 are associated with brain function in fluently reading
            adolescents and young adults.
REFERENCE   2  (bases 1 to 2380)
  AUTHORS   Zhang,X.X., Wu,X.S., Mi,S.H., Fang,S.J., Liu,S., Xin,Y. and
            Zhao,Q.M.
  TITLE     Neuregulin-1 promotes mitochondrial biogenesis, attenuates
            mitochondrial dysfunction, and prevents hypoxia/reoxygenation
            injury in neonatal cardiomyocytes
  JOURNAL   Cell Biochem Funct 38 (5), 549-557 (2020)
   PUBMED   32037595
  REMARK    GeneRIF: Neuregulin-1 promotes mitochondrial biogenesis, attenuates
            mitochondrial dysfunction, and prevents hypoxia/reoxygenation
            injury in neonatal cardiomyocytes.
REFERENCE   3  (bases 1 to 2380)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2380)
  AUTHORS   Wang,Y., Yan,W., Wang,J., Zhou,Y., Chen,J., Gu,B. and Cai,W.
  TITLE     Common genetic variants in GAL, GAP43 and NRSN1 and interaction
            networks confer susceptibility to Hirschsprung disease
  JOURNAL   J Cell Mol Med 22 (7), 3377-3387 (2018)
   PUBMED   29654647
  REMARK    GeneRIF: GAL, GAP43 and NRSN1 single nucleotide polymorphisms and
            related gene-gene interaction networks might be involved in the
            altered susceptibility to Hirschsprung disease in the Han Chinese
            population.
REFERENCE   5  (bases 1 to 2380)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   6  (bases 1 to 2380)
  AUTHORS   Luciano,M., Hansell,N.K., Lahti,J., Davies,G., Medland,S.E.,
            Raikkonen,K., Tenesa,A., Widen,E., McGhee,K.A., Palotie,A.,
            Liewald,D., Porteous,D.J., Starr,J.M., Montgomery,G.W.,
            Martin,N.G., Eriksson,J.G., Wright,M.J. and Deary,I.J.
  TITLE     Whole genome association scan for genetic polymorphisms influencing
            information processing speed
  JOURNAL   Biol Psychol 86 (3), 193-202 (2011)
   PUBMED   21130836
REFERENCE   7  (bases 1 to 2380)
  AUTHORS   Hasegawa,H., Liu,L. and Nishimura,M.
  TITLE     Dilysine retrieval signal-containing p24 proteins collaborate in
            inhibiting gamma-cleavage of amyloid precursor protein
  JOURNAL   J Neurochem 115 (3), 771-781 (2010)
   PUBMED   20807314
  REMARK    GeneRIF: dilysine retrieval signal-containing p24 proteins,
            p24alpha(2) and p24delta(1), bind with gamma-secretase complexes
            and collaborate in attenuating gamma-cleavage of beta-amyloid
            precursor protein
REFERENCE   8  (bases 1 to 2380)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 2380)
  AUTHORS   Cheng,C., Xu,J., Ye,X., Dai,J., Wu,Q., Zeng,L., Wang,L., Zhao,W.,
            Ji,C., Gu,S., Xie,Y. and Mao,Y.
  TITLE     Cloning, expression and characterization of a novel human VMP gene
  JOURNAL   Mol Biol Rep 29 (3), 281-286 (2002)
   PUBMED   12463420
  REMARK    GeneRIF: Cloning, expression and characterization of VMP gene.
REFERENCE   10 (bases 1 to 2380)
  AUTHORS   Hecht,H.J., Szardenings,M., Collins,J. and Schomburg,D.
  TITLE     Three-dimensional structure of the complexes between bovine
            chymotrypsinogen A and two recombinant variants of human pancreatic
            secretory trypsin inhibitor (Kazal-type)
  JOURNAL   J Mol Biol 220 (3), 711-722 (1991)
   PUBMED   1870127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096290.1, BC023514.2, AF418980.1, DB553646.1, DB552652.1 and
            FO393410.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080723.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.199100.1,
                                           SRR1803615.186248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378491.9/ ENSP00000367752.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AK096290.1         107-150
            45-1839             BC023514.2         1-1795
            1840-2104           AF418980.1         1798-2062
            2105-2205           DB553646.1         158-258
            2206-2255           BC023514.2         2162-2211
            2256-2379           DB552652.1         355-478
            2380-2380           FO393410.1         17085-17085
FEATURES             Location/Qualifiers
     source          1..2380
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..2380
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
                     /note="neurensin 1"
                     /db_xref="GeneID:140767"
                     /db_xref="HGNC:HGNC:17881"
                     /db_xref="MIM:616630"
     exon            1..126
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
                     /inference="alignment:Splign:2.1.0"
     exon            127..199
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
                     /inference="alignment:Splign:2.1.0"
     exon            200..397
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..796
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
                     /note="vesicular membrane protein p24; vesicular membrain
                     protein p24; neuro-p24; vesicular membrane protein of 24
                     kDa"
                     /codon_start=1
                     /product="neurensin-1"
                     /protein_id="NP_542454.3"
                     /db_xref="CCDS:CCDS4549.1"
                     /db_xref="GeneID:140767"
                     /db_xref="HGNC:HGNC:17881"
                     /db_xref="MIM:616630"
                     /translation="MSSCSNVCGSRQAQAAAEGGYQRYGVRSYLHQFYEDCTASIWEY
                     EDDFQIQRSPNRWSSVFWKVGLISGTVFVILGLTVLAVGFLVPPKIEAFGEADFVVVD
                     THAVQFNSALDMYKLAGAVLFCIGGTSMAGCLLMSVFVKSYSKEEKFLQQKFKERIAD
                     IKAHTQPVTKAPGPGETKIPVTLSRVQNVQPLLAT"
     exon            398..2380
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
                     /note="hexamer: AATAAA"
     regulatory      2245..2250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
                     /note="hexamer: AACAAG"
     polyA_site      2255
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
                     /note="major polyA site"
     polyA_site      2261
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
     regulatory      2361..2366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
                     /note="hexamer: AATAAA"
     polyA_site      2380
                     /gene="NRSN1"
                     /gene_synonym="p24; VMP"
ORIGIN      
        1 gtcaatcagg cgcgggctga gctctacgag gcggagcggc ggcggtggcg acggcgatgg
       61 gaccccagcg agagatctgc agctaggctg gctgcacttg ctccacgggt caggggatcg
      121 gagggggatt gaagaatgcg ccattaaaag gaaagatcaa ggagtaaacc agaagaagaa
      181 gaaaaagagg acttcaaagc tgggaaggat gagttcttgc agcaacgtct gtgggtccag
      241 gcaggcacag gctgcagctg agggtggtta ccagcgctat ggagtccggt cctacctgca
      301 ccagttttat gaggactgta cagcctcaat ttgggagtat gaggatgatt tccagatcca
      361 aagatcacct aacaggtgga gctcagtatt ctggaaggtt ggactcatct caggtacagt
      421 ttttgtgatc ctcggattga ctgttctggc agtgggcttt cttgtgcccc ccaaaatcga
      481 agcatttggc gaagccgatt ttgtggtggt cgacacacat gctgtccagt ttaacagtgc
      541 tctggacatg tacaagctgg caggagctgt tctcttctgc attggaggca cgtccatggc
      601 agggtgcctg ctgatgtcgg tgtttgtaaa gagctactcc aaagaagaaa aattcctcca
      661 gcagaagttt aaagaacgaa tcgcagacat caaagcccac acccagccgg ttacaaaagc
      721 tccagggcca ggggaaacaa agattccagt cactttgtcc agggttcaaa atgtccagcc
      781 tctactggca acctgaaacc tttcccaccc cagttcttct tgtctgattt atgcccgtgg
      841 ttaaaaagag caggccagtt ttcgagataa agaagatttg gcgttgactg ccctagggct
      901 gtgttcagct gtgggcaata taatgggtgg actcacactt gctcagttca ggcagctctg
      961 ctggagggcg gtgccatgcc taagcctgtg cacatgcatc cagctgctta agatgggtgc
     1021 ttccttgtac ccggccacca gaaaacccct ggaactcctc tttcatagat cgtgactttg
     1081 tgttattttc cgtgttgttt gaaagtgccg aacagtttag accagctcac caatggctaa
     1141 tgtggtccat tttattttct aatattggtt tatctaatgt tttctgcgtg gtgctgtctt
     1201 ccattcctgt ctcactatgt gtaagatttt gtcatatgtg ttcatagaaa catggaattc
     1261 tctgattttg agccgaacat gagtttttag actgtatctt gacatgaggt tcctgacatt
     1321 ggatacaaag ttatcagcat tcacaaatct ttttgttttc tccatttttt ttccctttga
     1381 gatgaagtgc tgttcttttg cctaggttgg agtacagcgg tgaaatcata gcgcactgca
     1441 gccttgaact cctgggctca agcgatcctc ccacctcagc ctcccaagta gctgggacta
     1501 caggcacctg ccaccacccc cagttaatat tttttttaat tttttttaga ggcaggatct
     1561 tgctgtccaa ttttttttaa aaagctaaaa ttgccaactt tagaatcttg accaaaaaaa
     1621 attaatttta ggagcatcta tttatgcagt gttcaaaagt actgaattag aaaccaggaa
     1681 gttttagttc cttctactac ctgtgtgatc ttggggaaat tatttaacct ctcagtccta
     1741 attttcccct tctgtataat gggagttctg gatcacaata tgtctgggct ctcattaccc
     1801 aaacatctga gattccattt ttgccatgtg tcatcgagtc gctccccaac agatgtttgt
     1861 gatgtttttg tggctgtcac catggtggga ttctttcaga atgagactcc tggaaattca
     1921 ctgagtcagc agccttcaca ccatctaccc ttaaatatcc aaccccagca atttatacaa
     1981 cgctgtcata tttttaaaaa aacaaaagta agccatcctc aaataaggaa ccccttggta
     2041 gatattaacc ttaaaaaggg ttttcattct caaacaagat gctttgttct ccaacaagat
     2101 gttcatctca tcacttgcac ttttgtttta atgtatggat tcagattaga ctgagaaaaa
     2161 tggatggtat tttcttaaaa ttgtgccacc ttagagcccc cccccttttt tttttcttcc
     2221 ttcactggat aaataaaata tgtgaacaag tggaacctga attgcattgt cattccttca
     2281 gtgtggttat tttctctcca acatgtaatt ttccattctg agactgaata agctctgatg
     2341 tttccccggc taaatggaag aataaatgaa gcaattagta
//
