LOCUS       NM_198565               2556 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens negative regulator of reactive oxygen species (NRROS),
            mRNA.
ACCESSION   NM_198565 XM_351575
VERSION     NM_198565.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Duan,Z., Lin,X., Wang,L., Zhen,Q., Jiang,Y., Chen,C., Yang,J.,
            Lee,C.H., Qin,Y., Li,Y., Zhao,B., Wang,J. and Zhang,Z.
  TITLE     Specificity of TGF-beta1 signal designated by LRRC33 and integrin
            alphaVbeta8
  JOURNAL   Nat Commun 13 (1), 4988 (2022)
   PUBMED   36008481
  REMARK    GeneRIF: Specificity of TGF-beta1 signal designated by LRRC33 and
            integrin alphaVbeta8.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2556)
  AUTHORS   Smith,C., McColl,B.W., Patir,A., Barrington,J., Armishaw,J.,
            Clarke,A., Eaton,J., Hobbs,V., Mansour,S., Nolan,M., Rice,G.I.,
            Rodero,M.P., Seabra,L., Uggenti,C., Livingston,J.H., Bridges,L.R.,
            Jeffrey,I.J.M. and Crow,Y.J.
  TITLE     Biallelic mutations in NRROS cause an early onset lethal
            microgliopathy
  JOURNAL   Acta Neuropathol 139 (5), 947-951 (2020)
   PUBMED   32100099
  REMARK    GeneRIF: Biallelic mutations in NRROS cause an early onset lethal
            microgliopathy.
REFERENCE   3  (bases 1 to 2556)
  AUTHORS   Dong,X., Tan,N.B., Howell,K.B., Barresi,S., Freeman,J.L.,
            Vecchio,D., Piccione,M., Radio,F.C., Calame,D., Zong,S., Eggers,S.,
            Scheffer,I.E., Tan,T.Y., Van Bergen,N.J., Tartaglia,M.,
            Christodoulou,J. and White,S.M.
  TITLE     Bi-allelic LoF NRROS Variants Impairing Active TGF-beta1 Delivery
            Cause a Severe Infantile-Onset Neurodegenerative Condition with
            Intracranial Calcification
  JOURNAL   Am J Hum Genet 106 (4), 559-569 (2020)
   PUBMED   32197075
  REMARK    GeneRIF: Wild-type and mutant NRROS proteins co-localize with
            latent TGF-beta1 intracellularly.
REFERENCE   4  (bases 1 to 2556)
  AUTHORS   Tang,X., Fang,F., Yang,J., Zheng,X., Fan,M., Wang,L. and Zhang,A.
  TITLE     Association Study Reveals One Susceptibility Locus with Vitiligo in
            the Chinese Han Population
  JOURNAL   Genet Test Mol Biomarkers 23 (11), 791-796 (2019)
   PUBMED   31644309
  REMARK    GeneRIF: A SNP at the rs6583331 locus 3q29 is associated with the
            susceptibility of vitiligo in the Chinese Han population. The T
            allele of the locus within the FBXO45-NRROS gene (3q29) was
            significantly associated with vitiligo (odds ratio = 1.22, 95%
            confidence interval: 1.10-1.36, p = 0.0001). Association at the
            genotype level was strong (p = 0.0007).
REFERENCE   5  (bases 1 to 2556)
  AUTHORS   Ma,W., Qin,Y., Chapuy,B. and Lu,C.
  TITLE     LRRC33 is a novel binding and potential regulating protein of
            TGF-beta1 function in human acute myeloid leukemia cells
  JOURNAL   PLoS One 14 (10), e0213482 (2019)
   PUBMED   31600200
  REMARK    GeneRIF: LRRC33 co-localizes and forms complex with latent
            TGF-beta1 protein on the cell surface and intracellularly in these
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2556)
  AUTHORS   Qin,Y., Garrison,B.S., Ma,W., Wang,R., Jiang,A., Li,J., Mistry,M.,
            Bronson,R.T., Santoro,D., Franco,C., Robinton,D.A., Stevens,B.,
            Rossi,D.J., Lu,C. and Springer,T.A.
  TITLE     A Milieu Molecule for TGF-beta Required for Microglia Function in
            the Nervous System
  JOURNAL   Cell 174 (1), 156-171 (2018)
   PUBMED   29909984
REFERENCE   7  (bases 1 to 2556)
  AUTHORS   Su,X., Mei,S., Liang,X., Wang,S., Liu,J., Zhang,Y., Bao,Y.,
            Chen,Y., Che,Y., Chunhua Zhao,R., Zhang,Z. and Yang,R.
  TITLE     Epigenetically modulated LRRC33 acts as a negative physiological
            regulator for multiple Toll-like receptors
  JOURNAL   J Leukoc Biol 96 (1), 17-26 (2014)
   PUBMED   24550525
  REMARK    GeneRIF: results suggest that LRRC33 and TLRs may form a
            negative-feedback loop, which is important for the maintenance of
            immune homeostasis.
REFERENCE   8  (bases 1 to 2556)
  AUTHORS   Noubade,R., Wong,K., Ota,N., Rutz,S., Eidenschenk,C., Valdez,P.A.,
            Ding,J., Peng,I., Sebrell,A., Caplazi,P., DeVoss,J., Soriano,R.H.,
            Sai,T., Lu,R., Modrusan,Z., Hackney,J. and Ouyang,W.
  TITLE     NRROS negatively regulates reactive oxygen species during host
            defence and autoimmunity
  JOURNAL   Nature 509 (7499), 235-239 (2014)
   PUBMED   24739962
REFERENCE   9  (bases 1 to 2556)
  AUTHORS   Liu,J., Zhang,Z., Chai,L., Che,Y., Min,S. and Yang,R.
  TITLE     Identification and characterization of a unique leucine-rich repeat
            protein (LRRC33) that inhibits Toll-like receptor-mediated
            NF-kappaB activation
  JOURNAL   Biochem Biophys Res Commun 434 (1), 28-34 (2013)
   PUBMED   23545260
  REMARK    GeneRIF: LRRC33 represents the first identified LRR-containing
            protein that plays a critical role in desensitizing Toll-like
            receptor (TLR)-mediated innate immune responses.
REFERENCE   10 (bases 1 to 2556)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055725.22, HY084054.1, BC044233.1, BQ070837.1 and AA534416.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198565.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034704.1, AY358322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328557.5/ ENSP00000328625.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC055725.22        6760-6761
            3-91                HY084054.1         4-92
            92-527              BC044233.1         1-436
            528-645             BQ070837.1         514-631
            646-2475            BC044233.1         555-2384
            2476-2556           AA534416.1         15-95               c
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..2556
                     /gene="NRROS"
                     /gene_synonym="ELLP3030; GARPL1; LRRC33; SENEBAC; UNQ3030"
                     /note="negative regulator of reactive oxygen species"
                     /db_xref="GeneID:375387"
                     /db_xref="HGNC:HGNC:24613"
                     /db_xref="MIM:615322"
     exon            1..182
                     /gene="NRROS"
                     /gene_synonym="ELLP3030; GARPL1; LRRC33; SENEBAC; UNQ3030"
                     /inference="alignment:Splign:2.1.0"
     exon            183..303
                     /gene="NRROS"
                     /gene_synonym="ELLP3030; GARPL1; LRRC33; SENEBAC; UNQ3030"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2274
                     /gene="NRROS"
                     /gene_synonym="ELLP3030; GARPL1; LRRC33; SENEBAC; UNQ3030"
                     /note="leucine-rich repeat-containing protein 33;
                     transforming growth factor beta activator LRRC33;
                     glycoprotein A repetitions predominant like 1"
                     /codon_start=1
                     /product="transforming growth factor beta activator LRRC33
                     precursor"
                     /protein_id="NP_940967.1"
                     /db_xref="CCDS:CCDS3319.1"
                     /db_xref="GeneID:375387"
                     /db_xref="HGNC:HGNC:24613"
                     /db_xref="MIM:615322"
                     /translation="MELLPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCR
                     GQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQ
                     EQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLR
                     SVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLP
                     CIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRT
                     LLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLD
                     MSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELH
                     LAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRV
                     GPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQD
                     VAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLR
                     RNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQHGQTVADWAMVTCNLS
                     SKIIRVTELPGGVPRDCKWERLDLGLLYLVLILPSCLTLLVACTVIVLTFKKPLLQVI
                     KSRCHWSSVY"
     exon            304..2556
                     /gene="NRROS"
                     /gene_synonym="ELLP3030; GARPL1; LRRC33; SENEBAC; UNQ3030"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2535..2540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRROS"
                     /gene_synonym="ELLP3030; GARPL1; LRRC33; SENEBAC; UNQ3030"
                     /note="hexamer: CATAAA"
     polyA_site      2556
                     /gene="NRROS"
                     /gene_synonym="ELLP3030; GARPL1; LRRC33; SENEBAC; UNQ3030"
                     /note="major polyA site"
ORIGIN      
        1 gagtcgccga gcagcccgct ctccatgtga cttcagtttc cgtccgttcc ttccgctggt
       61 gctaaaataa tctgatgccc cacagcaagg aggtagccca gccccgcgtt cggctgctct
      121 cgaggaggcc ggagcccccg gagacgatgc gccccgcgca gccgcctgcg cctgcgggag
      181 ccggctgccc ttgagatgga gttgctgcct ctttggctct gcctgggttt tcacttcctg
      241 accgtgggct ggaggaacag aagcggaaca gccacagcag cctcccaagg agtctgcaag
      301 ttggtgggtg gagccgctga ctgccgaggg cagagcctcg cttcggtgcc cagcagcctc
      361 ccgccccacg cccggatgct caccctggat gccaaccctc tcaagaccct gtggaatcac
      421 tccctccagc cttaccctct cctggagagc ctcagcctgc acagctgcca cctggagcgc
      481 atcagccgcg gcgccttcca ggagcaaggt cacctgcgca gcctggtcct gggggacaac
      541 tgcctctcag agaactacga agagacggca gccgccctcc acgccctgcc gggcctgcgg
      601 aggctggact tgtcaggaaa cgccctgacg gaggacatgg cagccctcat gctccagaac
      661 ctctcctcgc tgcggtccgt gtccctggcg gggaacacca tcatgcggct ggacgactcc
      721 gtcttcgagg gcctggagcg tctccgggag ctggatctgc agaggaacta catcttcgag
      781 atcgagggcg gcgctttcga cggcctggct gagctgaggc acctcaacct ggccttcaac
      841 aacctcccct gcatcgtgga cttcgggctc acgcggctgc gggtcctcaa cgtcagctac
      901 aacgtcctgg agtggttcct cgcgaccggg ggagaggctg ccttcgagct ggagacgctg
      961 gacctgtctc acaaccagct gctgttcttc ccgctgctgc cccagtacag caagttgcgg
     1021 accctcctgc tgcgcgacaa caacatgggc ttctaccggg acctgtacaa cacctcgtcg
     1081 ccgagggaga tggtggccca gttcctcctc gtggacggca acgtgaccaa catcaccacc
     1141 gtcagcctct gggaagaatt ctcctccagc gacctcgcag atctccgctt cctggacatg
     1201 agccagaacc agttccagta cctgccagac ggcttcctga ggaaaatgcc ttccctctcc
     1261 cacctgaacc tccaccagaa ttgcctgatg acgcttcaca ttcgggagca cgagcccccc
     1321 ggagcgctca ccgagctgga cctgagccac aaccagctgt cggagctgca cctggctccg
     1381 gggctggcca gctgcctggg cagcctgcgc ttgttcaacc tgagctccaa ccagctcctg
     1441 ggcgtccccc ctggcctctt cgccaatgct aggaacatca ctacacttga catgagccac
     1501 aatcagatct cactttgtcc cctgccagct gcctcggacc gggtgggccc ccctagctgt
     1561 gtggatttca ggaatatggc atctttaagg agcctgtctc tggagggctg tggcctgggg
     1621 gcattgccag actgcccatt ccaagggacc tccctgacct acttagacct ctcaagcaac
     1681 tggggggttc tgaatgggag cctcgcccca ctccaggatg ttgcccccat gttacaggtc
     1741 ctgtctctca ggaacatggg cctccactcc agctttatgg cgttggactt ctctgggttt
     1801 gggaatctca gggacttaga tctgtcgggg aattgcttga ccaccttccc aaggtttggg
     1861 ggcagcctgg ccctggagac cctggatctc cgtagaaact cgctcacagc ccttccccag
     1921 aaggctgtgt ctgagcagct ctcgagaggt ctgcggacca tctacctcag tcagaatcca
     1981 tatgactgct gtggggtgga tggctggggg gccctgcagc atgggcagac ggtggccgac
     2041 tgggccatgg tcacctgcaa cctctcctcc aagatcatcc gcgtgacgga gctgcccgga
     2101 ggtgtgcctc gggactgcaa gtgggagcgg ctggacctgg gcctgctcta cctcgtgctc
     2161 atcctcccca gctgcctcac cctgctggtg gcctgcactg tcatcgtcct cacttttaag
     2221 aagcctctgc ttcaggtcat caagagccgc tgccactggt cctccgttta ctgacctggc
     2281 tgtgtgccaa gactcgaaat tcggtccgca cacaacagga cactttctct gccagctttc
     2341 aagatgtgat gcagaggcca agtctgacga attgaagttt caattaaaat ttaatatgtt
     2401 tccattcctc atcgcccacc ccacccccgc ccccaccacc gcccaagttc tttttccatc
     2461 attataattc atcctcatta tcttggtaaa atatttatta agtgactttt tcagaaataa
     2521 aaggcaacgt gtctcataaa tattttttaa attaaa
//
