LOCUS       NM_003872               6644 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens neuropilin 2 (NRP2), transcript variant 2, mRNA.
ACCESSION   NM_003872
VERSION     NM_003872.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6644)
  AUTHORS   Moragas,N., Fernandez-Nogueira,P., Recalde-Percaz,L., Inman,J.L.,
            Lopez-Plana,A., Bergholtz,H., Noguera-Castells,A., Del Burgo,P.J.,
            Chen,X., Sorlie,T., Gascon,P., Bragado,P., Bissell,M., Carbo,N. and
            Fuster,G.
  TITLE     The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of
            invasive traits in in situ breast ductal carcinoma
  JOURNAL   Breast Cancer Res 26 (1), 122 (2024)
   PUBMED   39138514
  REMARK    GeneRIF: The SEMA3F-NRP1/NRP2 axis is a key factor in the
            acquisition of invasive traits in in situ breast ductal carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6644)
  AUTHORS   Ahn,M.H., Kim,J.H., Choi,S.J., Kim,H.J., Park,D.G., Oh,K.Y.,
            Yoon,H.J., Hong,S.D., Lee,J.I., Shin,J.A. and Cho,S.D.
  TITLE     Neuropilin-2 acts a critical determinant for
            epithelial-to-mesenchymal transition and aggressive behaviors of
            human head and neck cancer
  JOURNAL   Cell Oncol (Dordr) 47 (2), 497-511 (2024)
   PUBMED   37787967
  REMARK    GeneRIF: Neuropilin-2 acts a critical determinant for
            epithelial-to-mesenchymal transition and aggressive behaviors of
            human head and neck cancer.
REFERENCE   3  (bases 1 to 6644)
  AUTHORS   Gundogan,A.O., Oltulu,R., Belviranli,S. and Oltulu,P.
  TITLE     Expression of placental growth factor, neuropilin-1, and
            neuropilin-2 in primary pterygium tissue
  JOURNAL   Graefes Arch Clin Exp Ophthalmol 262 (3), 957-965 (2024)
   PUBMED   37878035
  REMARK    GeneRIF: Expression of placental growth factor, neuropilin-1, and
            neuropilin-2 in primary pterygium tissue.
REFERENCE   4  (bases 1 to 6644)
  AUTHORS   Mullen,S.A., Das,D., Ziamiavaghi,N., High,R., Datta,K. and
            Teply,B.A.
  TITLE     Association of plasma NRP2 and VEGF-C levels with prostate cancer
            disease severity
  JOURNAL   Prostate 84 (3), 277-284 (2024)
   PUBMED   37942701
  REMARK    GeneRIF: Association of plasma NRP2 and VEGF-C levels with prostate
            cancer disease severity.
REFERENCE   5  (bases 1 to 6644)
  AUTHORS   Sun,H., Xu,F. and You,D.
  TITLE     CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis
            Metabolism in Papillary Thyroid Carcinoma by Causing the
            miR-1287-5p-Mediated NRP2 Expression Elevation
  JOURNAL   Horm Metab Res 55 (10), 701-710 (2023)
   PUBMED   37813099
  REMARK    GeneRIF: CircPI4KA Overexpression Enhances Carcinogenesis and
            Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the
            miR-1287-5p-Mediated NRP2 Expression Elevation.
REFERENCE   6  (bases 1 to 6644)
  AUTHORS   Neufeld,G., Cohen,T., Gengrinovitch,S. and Poltorak,Z.
  TITLE     Vascular endothelial growth factor (VEGF) and its receptors
  JOURNAL   FASEB J 13 (1), 9-22 (1999)
   PUBMED   9872925
  REMARK    Review article
REFERENCE   7  (bases 1 to 6644)
  AUTHORS   Chen,H., He,Z., Bagri,A. and Tessier-Lavigne,M.
  TITLE     Semaphorin-neuropilin interactions underlying sympathetic axon
            responses to class III semaphorins
  JOURNAL   Neuron 21 (6), 1283-1290 (1998)
   PUBMED   9883722
REFERENCE   8  (bases 1 to 6644)
  AUTHORS   Giger,R.J., Urquhart,E.R., Gillespie,S.K., Levengood,D.V.,
            Ginty,D.D. and Kolodkin,A.L.
  TITLE     Neuropilin-2 is a receptor for semaphorin IV: insight into the
            structural basis of receptor function and specificity
  JOURNAL   Neuron 21 (5), 1079-1092 (1998)
   PUBMED   9856463
REFERENCE   9  (bases 1 to 6644)
  AUTHORS   Takahashi,T., Nakamura,F., Jin,Z., Kalb,R.G. and Strittmatter,S.M.
  TITLE     Semaphorins A and E act as antagonists of neuropilin-1 and agonists
            of neuropilin-2 receptors
  JOURNAL   Nat Neurosci 1 (6), 487-493 (1998)
   PUBMED   10196546
REFERENCE   10 (bases 1 to 6644)
  AUTHORS   Chen,H., Chedotal,A., He,Z., Goodman,C.S. and Tessier-Lavigne,M.
  TITLE     Neuropilin-2, a novel member of the neuropilin family, is a high
            affinity receptor for the semaphorins Sema E and Sema IV but not
            Sema III
  JOURNAL   Neuron 19 (3), 547-559 (1997)
   PUBMED   9331348
  REMARK    Erratum:[Neuron 1997 Sep;19(3):559]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007362.4, KF459587.1 and
            AC007561.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_003872.2.
            
            Summary: This gene encodes a member of the neuropilin family of
            receptor proteins. The encoded transmembrane protein binds to
            SEMA3C protein {sema domain, immunoglobulin domain (Ig), short
            basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema
            domain, immunoglobulin domain (Ig), short basic domain, secreted,
            (semaphorin) 3F}, and interacts with vascular endothelial growth
            factor (VEGF). This protein may play a role in cardiovascular
            development, axon guidance, and tumorigenesis. This protein has
            also been determined to act as a co-receptor for SARS-CoV-2 (which
            causes COVID-19) to infect host cells. [provided by RefSeq, Jul
            2021].
            
            Transcript Variant: This variant (2), also known as NRP2a(17),
            lacks an alternate in-frame segment, compared to variant 1. This
            results in a shorter isoform (2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2963318.1,
                                           SRR11853561.17392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000357785.10/ ENSP00000350432.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-863               AC007362.4         13251-14113
            864-1041            AC007362.4         28294-28471
            1042-1223           KF459587.1         64-245              c
            1224-1454           AC007362.4         53228-53458
            1455-1610           AC007362.4         54535-54690
            1611-1780           AC007362.4         56663-56832
            1781-1936           AC007362.4         58641-58796
            1937-2081           AC007362.4         71269-71413
            2082-2431           AC007362.4         73953-74302
            2432-2576           AC007362.4         76496-76640
            2577-2693           AC007362.4         80475-80591
            2694-2834           AC007362.4         83585-83725
            2835-3097           AC007362.4         94424-94686
            3098-3194           AC007362.4         96224-96320
            3195-3215           AC007362.4         97533-97553
            3216-3266           AC007561.4         7146-7196
            3267-6644           AC007561.4         9665-13042
FEATURES             Location/Qualifiers
     source          1..6644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..6644
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /note="neuropilin 2"
                     /db_xref="GeneID:8828"
                     /db_xref="HGNC:HGNC:8005"
                     /db_xref="MIM:602070"
     exon            1..863
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             791..3571
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; neuropilin-2b(0); receptor for VEGF165 and
                     semaphorins class3; neuropilin-2a(17); neuropilin-2a(22);
                     vascular endothelial cell growth factor 165 receptor 2"
                     /codon_start=1
                     /product="neuropilin-2 isoform 2 precursor"
                     /protein_id="NP_003863.2"
                     /db_xref="CCDS:CCDS46496.1"
                     /db_xref="GeneID:8828"
                     /db_xref="HGNC:HGNC:8005"
                     /db_xref="MIM:602070"
                     /translation="MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPG
                     YPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLG
                     KHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTI
                     ESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDG
                     IPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQ
                     CNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLR
                     FLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQANNDATE
                     VVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADSQI
                     SASSTQEYLWSPSAARLVSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGARG
                     GDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI
                     PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEAT
                     ECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYDHAKWLRTTWASSSSPNDRTFPD
                     DRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQYQATGGRGVALQVVREASQES
                     KLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIRISTDVPLE
                     NCMEPISAFAVDIPEIHEREGYEDEIDDEYEVDWSNSSSATSGSGAPSTDKEKSWLYT
                     LDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHK
                     VKMNHQKCCSEA"
     exon            864..1041
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1223
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1454
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1610
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1780
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1936
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2081
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2431
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2576
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2693
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2834
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3097
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3194
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3215
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3266
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..6644
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4059..4064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /note="hexamer: AATAAA"
     polyA_site      4087
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
     regulatory      6625..6630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /note="hexamer: AATAAA"
     polyA_site      6644
                     /gene="NRP2"
                     /gene_synonym="NP2; NPN2; PRO2714; VEGF165R2"
                     /note="major polyA site"
ORIGIN      
        1 agagatcgcg agcgaggcac cagcctgcag ccggccccca gcacatcctc agccgcacag
       61 acactcggcg aggtggaggt gagggcgggc gccagcgaac tcggagaggg gctcgctcac
      121 tcccaggcga tcccagccgc caccgccgcc gcaccagcag cagcaacagc agcagcagct
      181 tccttcctca gactcccctc gagaggctgg ccaagcgggt gtagccgttg ggggaggctc
      241 ccgccggggg aacccggcga ggacaagagc agggcggccg ccttccactc gggctgtccg
      301 gcggcggctg cctccgcccg tgtgtccgtc aagggtgccg cgggatgtgt gtcagtttac
      361 gcctctgaga tcacacagct gcctgggggc cgtgtgatgc ccaaggcaag tcttggtttt
      421 aattattatt attatcatta ttgttacgct tggctttcgg gaaatactcg tgatatttgt
      481 aggataaagg aaatgacact ttgaggaact ggagagaaca tatatgcgtt ttgtttttaa
      541 gaggaaaacc gtgttctctt cccggcttgt tccctctttg ctgatttcag gagctactct
      601 cctcctggtg aggtggaaat tccagcaaga atagaggtga agacaagcca ccaggactca
      661 ggagggaaac gctgaccatt agaaacctct gcataagacg ttgtaaggag gaaaataaaa
      721 gagagaaaaa cacaaagatt taaacaagaa acctacgaac ccagctctgg aaagagccac
      781 cttctccaaa atggatatgt ttcctctcac ctgggttttc ttagccctct acttttcaag
      841 acaccaagtg agaggccaac cagacccacc gtgcggaggt cgtttgaatt ccaaagatgc
      901 tggctatatc acctctcccg gttaccccca ggactacccc tcccaccaga actgcgagtg
      961 gattgtttac gcccccgaac ccaaccagaa gattgtcctc aacttcaacc ctcactttga
     1021 aatcgagaag cacgactgca agtatgactt tatcgagatt cgggatgggg acagtgaatc
     1081 cgcagacctc ctgggcaaac actgtgggaa catcgccccg cccaccatca tctcctcggg
     1141 ctccatgctc tacatcaagt tcacctccga ctacgcccgg cagggggcag gcttctctct
     1201 gcgctacgag atcttcaaga caggctctga agattgctca aaaaacttca caagccccaa
     1261 cgggaccatc gaatctcctg ggtttcctga gaagtatcca cacaacttgg actgcacctt
     1321 taccatcctg gccaaaccca agatggagat catcctgcag ttcctgatct ttgacctgga
     1381 gcatgaccct ttgcaggtgg gagaggggga ctgcaagtac gattggctgg acatctggga
     1441 tggcattcca catgttggcc ccctgattgg caagtactgt gggaccaaaa caccctctga
     1501 acttcgttca tcgacgggga tcctctccct gacctttcac acggacatgg cggtggccaa
     1561 ggatggcttc tctgcgcgtt actacctggt ccaccaagag ccactagaga actttcagtg
     1621 caatgttcct ctgggcatgg agtctggccg gattgctaat gaacagatca gtgcctcatc
     1681 tacctactct gatgggaggt ggacccctca acaaagccgg ctccatggtg atgacaatgg
     1741 ctggaccccc aacttggatt ccaacaagga gtatctccag gtggacctgc gctttttaac
     1801 catgctcacg gccatcgcaa cacagggagc gatttccagg gaaacacaga atggctacta
     1861 tgtcaaatcc tacaagctgg aagtcagcac taatggagag gactggatgg tgtaccggca
     1921 tggcaaaaac cacaaggtat ttcaagccaa caacgatgca actgaggtgg ttctgaacaa
     1981 gctccacgct ccactgctga caaggtttgt tagaatccgc cctcagacct ggcactcagg
     2041 tatcgccctc cggctggagc tcttcggctg ccgggtcaca gatgctccct gctccaacat
     2101 gctggggatg ctctcaggcc tcattgcaga ctcccagatc tccgcctctt ccacccagga
     2161 atacctctgg agccccagtg cagcccgcct ggttagcagc cgctcgggct ggttccctcg
     2221 aatccctcag gcccagcccg gtgaggagtg gcttcaggta gatctgggaa cacccaagac
     2281 agtgaaaggt gtcatcatcc agggagcccg cggaggagac agtatcactg ctgtggaagc
     2341 cagagcattt gtgcgcaagt tcaaagtctc ctacagccta aacggcaagg actgggaata
     2401 cattcaggac cccaggaccc agcagccaaa gctgttcgaa gggaacatgc actatgacac
     2461 ccctgacatc cgaaggtttg accccattcc ggcacagtat gtgcgggtat acccggagag
     2521 gtggtcgccg gcggggattg ggatgcggct ggaggtgctg ggctgtgact ggacagactc
     2581 caagcccacg gtagagacgc tgggacccac tgtgaagagc gaagagacaa ccacccccta
     2641 ccccaccgaa gaggaggcca cagagtgtgg ggagaactgc agctttgagg atgacaaaga
     2701 tttgcagctc ccttcgggat tcaattgcaa cttcgatttc ctcgaggagc cctgtggttg
     2761 gatgtatgac catgccaagt ggctccggac cacctgggcc agcagctcca gcccaaacga
     2821 ccggacgttt ccagatgaca ggaatttctt gcggctgcag agtgacagcc agagagaggg
     2881 ccagtatgcc cggctcatca gcccccctgt ccacctgccc cgaagcccgg tgtgcatgga
     2941 gttccagtac caggccacgg gcggccgcgg ggtggcgctg caggtggtgc gggaagccag
     3001 ccaggagagc aagttgctgt gggtcatccg tgaggaccag ggcggcgagt ggaagcacgg
     3061 gcggatcatc ctgcccagct acgacatgga gtaccagatt gtgttcgagg gagtgatagg
     3121 gaaaggacgt tccggagaga ttgccattga tgacattcgg ataagcactg atgtcccact
     3181 ggagaactgc atggaaccca tctcggcttt tgcagtggac atcccagaaa tacatgagag
     3241 agaaggatat gaagatgaaa ttgatgatga atacgaggtg gactggagca attcttcttc
     3301 tgcaacctca gggtctggcg ccccctcgac cgacaaagaa aagagctggc tgtacaccct
     3361 ggatcccatc ctcatcacca tcatcgccat gagctcactg ggcgtcctcc tgggggccac
     3421 ctgtgcaggc ctcctgctct actgcacctg ttcctactcg ggcctgagct cccgaagctg
     3481 caccacactg gagaactaca acttcgagct ctacgatggc cttaagcaca aggtcaagat
     3541 gaaccaccaa aagtgctgct ccgaggcatg acggattgca cctgaatcct atctgacgtt
     3601 tcattccagc aagaggggct ggggaagatt acattttttt ttcctttgga aactgaatgc
     3661 cataatctcg atcaaaccga tccagaatac cgaaggtatg gacaggacag aaaagcgagt
     3721 cgcaggagga agggagatgc agccgcacag gggatgatta ccctcctagg accgcggtgg
     3781 ctaagtcatt gcaggaacgg ggctgtgttc tctgctggga caaaacagga gctcatctct
     3841 ttggggtcac agttctattt tgtttgtgag tttgtattat tattattatt attattatta
     3901 ttatatttta tttctttggt ctgtgagcaa ctcaaagagg cagaagagga gaatgacttt
     3961 tccagaatag aagtggagca gtgatcatta ttctccgctt tctctttcta atcaacactt
     4021 gaaaagcaaa gtgtcttttc agcctttcca tctttacaaa taaaactcaa aaaagccgtc
     4081 cagcttatcc catcctctga ttgtcttctg acttaaggga tttactgtgg tgtaggttct
     4141 gccagccaac cctacaagct gccatttcca gtcctagcat ttaagtagga tgttgttgcc
     4201 tttaactttt cttatccagg ggaaaattgc cattttaggg tcagcatgaa cagctctttc
     4261 ttgtatgcga tttaaaacaa actggaaagg aaacttcaca cgtcaaaatc catagaagcg
     4321 cctggacgag gcttaaagtg ctttgtgagt gaataggagc cattcgctaa ttctagaccc
     4381 acagtgtctg gtggtggggc ttcccttgtg gggcttctgg tggtggtttt gccttttctt
     4441 ttccctcctc catgttcttc taaaacatat acatatatac atacacacat acacatattc
     4501 ttcaggtctc taagcccctg gaagcagcat tgtgtgatat tctcagaggc aggggaaaat
     4561 agagggaaaa atagagacta ttggtatgtt ctccccatca gcgagttatt gtaactggtc
     4621 accactggac gggaaggaga acagaggaga gggaaagaga agcccaacct ctgtgatcat
     4681 atgagggcca aggctgagca gtgtagacag agaccctttg aaatgcattt gtctctcaaa
     4741 tagactagta aacaccgact tctcctttgg gttacaaaca ccatttcaac ctttcgggag
     4801 agtcagagct aggatgtaca agaactgatt ctaaccagaa gtccgcaagt actgtggaca
     4861 agaatgctta accatgctgc ttcagccttg agagacctag gttcttacac atatgcacac
     4921 acgcatacac acatgcacgc acacacacat acacacatgc acgcacgcac gcatgcacac
     4981 caatttatgt ttttattaag tgccttgaaa aaatgaagaa aaatgtattt tccctttatg
     5041 taaaaattag tgaatatctt atgaattaag gcattcctct ttccctaacc ccgatggctc
     5101 cattcccaag taccccaact cactgctgat cctattaaag gaatgagtcc tgctacccga
     5161 gtggtagtca tagccctaga tgactctcaa ctactcttca aagggaggca tcaggaatag
     5221 aatgaaactg tgtgaaggat aagattgttc gcatcaagat ccaaatcttg atttcatatt
     5281 aacgcctaag gattgcctgt gtgctggaaa tatatttgaa actcaaccag tatgcccagc
     5341 ctattgcata tcattgtcag accatttttg ctgctgtggt cacccacgat ttcatttgtc
     5401 ttatacccag gtgaaagggg aagggtgaat gggactggct ggttccttta aatgttaact
     5461 tatggaaatg ctagttcaaa tggtaatgtc acagtgtttt gtatgcagag agcaagagtt
     5521 caaccaacag ctgtttattc atgtgtgtgt gtctttgctg ctttgagttc tctgtatcta
     5581 ctgtgtatgt gaatggtcat gtgggactca gtggtggtgt tgtgactttg acctagggtc
     5641 cgagtgtcac agctgatctt ggcactcggc actcattggc acagtggtag ttagaggtga
     5701 aaagtagagc tgtcaagccc aagggcttag ctttagggct cctcctgagt tcggcccaca
     5761 gtagaagcaa gattttaact agcccctttt cctcttcacc ctcccatgat gcgcagtgtt
     5821 cagaaagctg gtaagtccta gggatttcca gaagtagcct gcagaagaag gtaagtttga
     5881 aagccactcc aggggtcctg atgctgtcat gctcagtgag ccattttaca gttctccaaa
     5941 gtctagccct gtttcggacc tgcacttcac ctctaagtta tgtacaactc aacctgcatc
     6001 cctctaaaag tcctatatcc atattcacca ttggctaatt tgaggccctg agtgggcctt
     6061 gaatgctaaa aagaagcagg gtacgcaggg ctacatgtag ataccacacc aaggctggag
     6121 gctggtctgt cataagacag aaagaaagac gctgggccca attttgactt ggccagggga
     6181 caccttggtg tgtttgttat ctttatctgt gggtaggcta gctgacccat ctccttgagt
     6241 cattcccttt gggaaacccc actgccagta ttgatctcct ttttgccttg tactgaatga
     6301 cacattacct ccacactctc ccggactagg tggtcaacag ggccacaggg ttgctttctg
     6361 tctttggtgg ggcaggggag ttgacaggga tgagggtcca aggaataagc atgaatgaca
     6421 agaaaacaag ggaaagagtt aacctgtcac atagcaggtt aactttttca gggtttgcag
     6481 ttagaggtat tcgaccattc actggctgag ccagatcacg ggaacttgag agcttttact
     6541 gtgattcttc aatgtaaaaa ataaacaaca atgtcaaact gtgtttatat gatttgtata
     6601 aagccttttt aagattacta tttaaataaa cattatacca gaga
//
