LOCUS       NM_003873               5640 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neuropilin 1 (NRP1), transcript variant 1, mRNA.
ACCESSION   NM_003873
VERSION     NM_003873.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5640)
  AUTHORS   Moragas,N., Fernandez-Nogueira,P., Recalde-Percaz,L., Inman,J.L.,
            Lopez-Plana,A., Bergholtz,H., Noguera-Castells,A., Del Burgo,P.J.,
            Chen,X., Sorlie,T., Gascon,P., Bragado,P., Bissell,M., Carbo,N. and
            Fuster,G.
  TITLE     The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of
            invasive traits in in situ breast ductal carcinoma
  JOURNAL   Breast Cancer Res 26 (1), 122 (2024)
   PUBMED   39138514
  REMARK    GeneRIF: The SEMA3F-NRP1/NRP2 axis is a key factor in the
            acquisition of invasive traits in in situ breast ductal carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5640)
  AUTHORS   Nguyen,H.L., Hieu,H.K., Nguyen,T.Q., Nhung,N.T.A. and Li,M.S.
  TITLE     Neuropilin-1 Protein May Serve as a Receptor for SARS-CoV-2
            Infection: Evidence from Molecular Dynamics Simulations
  JOURNAL   J Phys Chem B 128 (29), 7141-7147 (2024)
   PUBMED   39010661
  REMARK    GeneRIF: Neuropilin-1 Protein May Serve as a Receptor for
            SARS-CoV-2 Infection: Evidence from Molecular Dynamics Simulations.
REFERENCE   3  (bases 1 to 5640)
  AUTHORS   Gong,P., Zhang,R., Xiao,K., Shu,H., Li,X., Fan,H. and Sun,X.
  TITLE     DNA G-Quadruplex in NRP1 Promoter Facilitates SARS-CoV-2 Infection
  JOURNAL   Int J Mol Sci 25 (8), 4422 (2024)
   PUBMED   38674009
  REMARK    GeneRIF: DNA G-Quadruplex in NRP1 Promoter Facilitates SARS-CoV-2
            Infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5640)
  AUTHORS   Sarabipour,S., Kinghorn,K., Quigley,K.M., Kovacs-Kasa,A.,
            Annex,B.H., Bautch,V.L. and Mac Gabhann,F.
  TITLE     Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human
            endothelial cells
  JOURNAL   PLoS Comput Biol 20 (2), e1011798 (2024)
   PUBMED   38324585
  REMARK    GeneRIF: Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human
            endothelial cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5640)
  AUTHORS   Daly,J.L., Simonetti,B., Klein,K., Chen,K.E., Williamson,M.K.,
            Anton-Plagaro,C., Shoemark,D.K., Simon-Gracia,L., Bauer,M.,
            Hollandi,R., Greber,U.F., Horvath,P., Sessions,R.B., Helenius,A.,
            Hiscox,J.A., Teesalu,T., Matthews,D.A., Davidson,A.D.,
            Collins,B.M., Cullen,P.J. and Yamauchi,Y.
  TITLE     Neuropilin-1 is a host factor for SARS-CoV-2 infection
  JOURNAL   Science 370 (6518), 861-865 (2020)
   PUBMED   33082294
  REMARK    GeneRIF: Neuropilin-1 is a host factor for SARS-CoV-2 infection.
REFERENCE   6  (bases 1 to 5640)
  AUTHORS   Rossignol,M., Gagnon,M.L. and Klagsbrun,M.
  TITLE     Genomic organization of human neuropilin-1 and neuropilin-2 genes:
            identification and distribution of splice variants and soluble
            isoforms
  JOURNAL   Genomics 70 (2), 211-222 (2000)
   PUBMED   11112349
REFERENCE   7  (bases 1 to 5640)
  AUTHORS   Rossignol,M., Beggs,A.H., Pierce,E.A. and Klagsbrun,M.
  TITLE     Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34,
            respectively
  JOURNAL   Genomics 57 (3), 459-460 (1999)
   PUBMED   10329017
REFERENCE   8  (bases 1 to 5640)
  AUTHORS   Soker,S., Takashima,S., Miao,H.Q., Neufeld,G. and Klagsbrun,M.
  TITLE     Neuropilin-1 is expressed by endothelial and tumor cells as an
            isoform-specific receptor for vascular endothelial growth factor
  JOURNAL   Cell 92 (6), 735-745 (1998)
   PUBMED   9529250
REFERENCE   9  (bases 1 to 5640)
  AUTHORS   Chen,H., Chedotal,A., He,Z., Goodman,C.S. and Tessier-Lavigne,M.
  TITLE     Neuropilin-2, a novel member of the neuropilin family, is a high
            affinity receptor for the semaphorins Sema E and Sema IV but not
            Sema III
  JOURNAL   Neuron 19 (3), 547-559 (1997)
   PUBMED   9331348
  REMARK    Erratum:[Neuron 1997 Sep;19(3):559]
REFERENCE   10 (bases 1 to 5640)
  AUTHORS   He,Z. and Tessier-Lavigne,M.
  TITLE     Neuropilin is a receptor for the axonal chemorepellent Semaphorin
            III
  JOURNAL   Cell 90 (4), 739-751 (1997)
   PUBMED   9288753
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353600.10 and AL121748.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_003873.6.
            
            Summary: This gene encodes one of two neuropilins, which contain
            specific protein domains which allow them to participate in several
            different types of signaling pathways that control cell migration.
            Neuropilins contain a large N-terminal extracellular domain, made
            up of complement-binding, coagulation factor V/VIII, and meprin
            domains. These proteins also contains a short membrane-spanning
            domain and a small cytoplasmic domain. Neuropilins bind many
            ligands and various types of co-receptors; they affect cell
            survival, migration, and attraction. Some of the ligands and
            co-receptors bound by neuropilins are vascular endothelial growth
            factor (VEGF) and semaphorin family members. This protein has also
            been determined to act as a co-receptor for SARS-CoV-2 (which
            causes COVID-19) to infect host cells. [provided by RefSeq, Nov
            2020].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX510902.1, AB209641.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000374867.7/ ENSP00000364001.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AL353600.10        70654-71011         c
            359-533             AL353600.10        67052-67226         c
            534-715             AL353600.10        7019-7200           c
            716-943             AL121748.7         176173-176400       c
            944-1099            AL121748.7         168843-168998       c
            1100-1266           AL121748.7         166555-166721       c
            1267-1422           AL121748.7         138661-138816       c
            1423-1567           AL121748.7         134246-134390       c
            1568-1899           AL121748.7         125913-126244       c
            1900-2044           AL121748.7         120099-120243       c
            2045-2149           AL121748.7         115418-115522       c
            2150-2209           AL121748.7         110177-110236       c
            2210-2347           AL121748.7         104808-104945       c
            2348-2619           AL121748.7         98744-99015         c
            2620-2716           AL121748.7         98155-98251         c
            2717-2767           AL121748.7         95225-95275         c
            2768-5640           AL121748.7         90020-92892         c
FEATURES             Location/Qualifiers
     source          1..5640
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.22"
     gene            1..5640
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="neuropilin 1"
                     /db_xref="GeneID:8829"
                     /db_xref="HGNC:HGNC:8004"
                     /db_xref="MIM:602069"
     exon            1..358
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..3057
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; transmembrane receptor; vascular endothelial
                     cell growth factor 165 receptor"
                     /codon_start=1
                     /product="neuropilin-1 isoform a precursor"
                     /protein_id="NP_003864.5"
                     /db_xref="CCDS:CCDS7177.1"
                     /db_xref="GeneID:8829"
                     /db_xref="HGNC:HGNC:8004"
                     /db_xref="MIM:602069"
                     /translation="MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGY
                     PHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGK
                     FCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKS
                     PGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFP
                     DVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCM
                     EALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLR
                     FVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVV
                     AVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSS
                     NQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHREN
                     KVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYP
                     ERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGT
                     TVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGP
                     IQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKL
                     RYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDI
                     SINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDP
                     ILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKL
                     NTQSTYSEA"
     exon            359..533
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            534..715
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            716..943
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1099
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1266
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1422
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1567
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1899
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2044
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2149
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2209
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2347
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2619
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2716
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2767
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..5640
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5354..5359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="hexamer: AGTAAA"
     polyA_site      5379
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
     regulatory      5615..5620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="hexamer: ATTAAA"
     polyA_site      5640
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="major polyA site"
ORIGIN      
        1 agacatggcc cgggcagtgg ctcctggaag aggaacaagt gtgggaaaag ggagaggaag
       61 ccggagctaa atgacaggat gcaggcgact tgagacacaa aaagagaagc gttcctctcg
      121 gatccaggca ttgcctcgct gctttctttt ctccaagacg ggctgaggat tgtacagctc
      181 taggcggagt tggggctctt cggatcgctt agattctcct ctttgctgca tttcccccca
      241 cgtcctcgtt ctcccgcgtc tgcctgcgga cccggagaag ggagaatgga gagggggctg
      301 ccgctcctct gcgccgtgct cgccctcgtc ctcgccccgg ccggcgcttt tcgcaacgat
      361 aaatgtggcg atactataaa aattgaaagc cccgggtacc ttacatctcc tggttatcct
      421 cattcttatc acccaagtga aaaatgcgaa tggctgattc aggctccgga cccataccag
      481 agaattatga tcaacttcaa ccctcacttc gatttggagg acagagactg caagtatgac
      541 tacgtggaag tcttcgatgg agaaaatgaa aatggacatt ttaggggaaa gttctgtgga
      601 aagatagccc ctcctcctgt tgtgtcttca gggccatttc tttttatcaa atttgtctct
      661 gactacgaaa cacatggtgc aggattttcc atacgttatg aaattttcaa gagaggtcct
      721 gaatgttccc agaactacac aacacctagt ggagtgataa agtcccccgg attccctgaa
      781 aaatatccca acagccttga atgcacttat attgtctttg tgccaaagat gtcagagatt
      841 atcctggaat ttgaaagctt tgacctggag cctgactcaa atcctccagg ggggatgttc
      901 tgtcgctacg accggctaga aatctgggat ggattccctg atgttggccc tcacattggg
      961 cgttactgtg gacagaaaac accaggtcga atccgatcct catcgggcat tctctccatg
     1021 gttttttaca ccgacagcgc gatagcaaaa gaaggtttct cagcaaacta cagtgtcttg
     1081 cagagcagtg tctcagaaga tttcaaatgt atggaagctc tgggcatgga atcaggagaa
     1141 attcattctg accagatcac agcttcttcc cagtatagca ccaactggtc tgcagagcgc
     1201 tcccgcctga actaccctga gaatgggtgg actcccggag aggattccta ccgagagtgg
     1261 atacaggtag acttgggcct tctgcgcttt gtcacggctg tcgggacaca gggcgccatt
     1321 tcaaaagaaa ccaagaagaa atattatgtc aagacttaca agatcgacgt tagctccaac
     1381 ggggaagact ggatcaccat aaaagaagga aacaaacctg ttctctttca gggaaacacc
     1441 aaccccacag atgttgtggt tgcagtattc cccaaaccac tgataactcg atttgtccga
     1501 atcaagcctg caacttggga aactggcata tctatgagat ttgaagtata cggttgcaag
     1561 ataacagatt atccttgctc tggaatgttg ggtatggtgt ctggacttat ttctgactcc
     1621 cagatcacat catccaacca aggggacaga aactggatgc ctgaaaacat ccgcctggta
     1681 accagtcgct ctggctgggc acttccaccc gcacctcatt cctacatcaa tgagtggctc
     1741 caaatagacc tgggggagga gaagatcgtg aggggcatca tcattcaggg tgggaagcac
     1801 cgagagaaca aggtgttcat gaggaagttc aagatcgggt acagcaacaa cggctcggac
     1861 tggaagatga tcatggatga cagcaaacgc aaggcgaagt cttttgaggg caacaacaac
     1921 tatgatacac ctgagctgcg gacttttcca gctctctcca cgcgattcat caggatctac
     1981 cccgagagag ccactcatgg cggactgggg ctcagaatgg agctgctggg ctgtgaagtg
     2041 gaagccccta cagctggacc gaccactccc aacgggaact tggtggatga atgtgatgac
     2101 gaccaggcca actgccacag tggaacaggt gatgacttcc agctcacagg tggcaccact
     2161 gtgctggcca cagaaaagcc cacggtcata gacagcacca tacaatcaga gtttccaaca
     2221 tatggtttta actgtgaatt tggctggggc tctcacaaga ccttctgcca ctgggaacat
     2281 gacaatcacg tgcagctcaa gtggagtgtg ttgaccagca agacgggacc cattcaggat
     2341 cacacaggag atggcaactt catctattcc caagctgacg aaaatcagaa gggcaaagtg
     2401 gctcgcctgg tgagccctgt ggtttattcc cagaactctg cccactgcat gaccttctgg
     2461 tatcacatgt ctgggtccca cgtcggcaca ctcagggtca aactgcgcta ccagaagcca
     2521 gaggagtacg atcagctggt ctggatggcc attggacacc aaggtgacca ctggaaggaa
     2581 gggcgtgtct tgctccacaa gtctctgaaa ctttatcagg tgattttcga gggcgaaatc
     2641 ggaaaaggaa accttggtgg gattgctgtg gatgacatta gtattaataa ccacatttca
     2701 caagaagatt gtgcaaaacc agcagacctg gataaaaaga acccagaaat taaaattgat
     2761 gaaacaggga gcacgccagg atacgaaggt gaaggagaag gtgacaagaa catctccagg
     2821 aagccaggca atgtgttgaa gaccttagac cccatcctca tcaccatcat agccatgagt
     2881 gccctggggg tcctcctggg ggctgtctgt ggggtcgtgc tgtactgtgc ctgttggcat
     2941 aatgggatgt cagaaagaaa cttgtctgcc ctggagaact ataactttga acttgtggat
     3001 ggtgtgaagt tgaaaaaaga caaactgaat acacagagta cttattcgga ggcatgaagg
     3061 cagacagaga tgaaaagaca gtcaaaggac ggaagtggaa ggacgggagt gagctgggga
     3121 gctgttgatc tttcactata caggctggga agtgtgttga tgaccactga gccaggcttt
     3181 tctcaggagc ttcaatgagt atggccgaca gacatggaca aggagctgtg ttcaccatcg
     3241 gactcatgtg cagtcagctt ttttcctgtt ggtttcattt gaataatcag atgctggtgt
     3301 tgagaccaag tatgattgac ataatcattc atttcgaccc ctcctgcccc tctctctctc
     3361 tctcctctcc cctttgtgga ttctttttgg aaactgagcg aaatccaaga tgctggcacc
     3421 aagcgtattc cgtgtggccc tttggatgga catgctacct gaaacccagt gcccagaata
     3481 tactagaatc accgcatttc agtggactcc tgaagttgta cttgtgtata attgcccgcg
     3541 tcgtgcatag gcaaagaagg attaggctgt tttcttttta aagtactgta gcctcagtac
     3601 tggtgtagtg tgtcagctct gtttacgaag caatactgtc cagttttctt gctgtttttc
     3661 cggtgttgta ctaaacctcg tgcttgtgaa ctccatacag aaaacggtgc catccctgaa
     3721 cacggctggc cactgggtat actgctgaca accgcaacaa caaaaacaca aatccttggc
     3781 actggctagt ctatgtcctc tcaagtgcct ttttgtttgt actggttcat tgtgttacat
     3841 taacgaccca ctctgcttct tgctggtgaa agccctgctc tttaatcaaa ctctggtggc
     3901 ccactgacta agaagaaagt ttattttcgt gtgagatgcc agcccctccg ggcaggcaag
     3961 ggctctgaag atttggcaac gtggcttaat tgttctgctt tttctgtagt tcaatttcat
     4021 gtttcttgac ccttttgtat aaagctacaa tattctctct tattgttctt tcatatggaa
     4081 tgtattttca aatgtaaact ctcttctctt tctctctcct atctctctgt cttttttctc
     4141 tcttagaatt ggaggatttg ccattgtcca ggaaagaaac ttgcagcttt aacctgctgg
     4201 gaatggcaaa cgattttact agactttatg tttaaaaata aataaataag ggaaattcct
     4261 aactttgccc tccaaagtct aactttggtt ttcttgttaa ctggttaaag tgacagtatc
     4321 ttttttcctt atctattcta ttcaaaatga cctttgatag aaatgttggc atttagtaga
     4381 aatagtgata agttgaggaa agaaataata caaattggct ttcaagtgag acccaaagga
     4441 agaactggat aaaatcttcc aaatccaaaa gcatgagatt tttctatcca aatatgcaaa
     4501 aatgacccaa gagaactttc ttattttgct actgagtcac acaagggaag tggaaggaag
     4561 aacagttaat ttaagaatga aactataaat cctgatgcct gggggtcaag tattttaaga
     4621 taagaggggg aaaaacacat aaagtcaaac aaatgtttta aaaattcata acagcaacct
     4681 tgaaaaaata gacttaaatg aatgcttcta gaaacttcca gcggctcaca aagaataagc
     4741 ctgccttagg gctggcaaca tctaagcctc taacagcaca gggaagcaaa tatcttacca
     4801 ggcagcctat gaattaaccc aaagaagctt tggttggttt tggtggattt ttatcatgcc
     4861 atgttggaca tgagattttt tagatcttcc ttcccacatt gctagacgtc tcactcaaag
     4921 acatttgttg ggagtcacat ttgcatcata gacgagacag tccattcatc ttagttaaat
     4981 tggattgaga atgccttttg tttccaggaa aatattgatc accatgaaag aagaatagtt
     5041 ttttgtcccc agagacattc atttagttga tataatccta ccagaaggaa agcactaaga
     5101 aacactcgtt tgttgttttt aaaggcaaca gacttaaagt tgtcctcagc caaggaaaaa
     5161 tgatactgca actttaaaat ttaaagtatc ttgcactgat aaatatattt aaaaattata
     5221 tgtttataaa gttattaatt tgtaaaggca gtgttacaaa atgttcagtt tatattgttt
     5281 tagattgttt tgtaattttt aaaggtgtaa aataacatat tttttcttta tggaaatcta
     5341 taaaactttc tgtagtaaaa tgttttcatt ttactggtat attattgctt catgttttgt
     5401 accatcataa gattttgtgc agattttttt tacagaaatt attattttct atgacaatat
     5461 gacacttgta aattgttgtt tcaaaatgaa cagcgaagcc ttaactttaa atgacatttg
     5521 tattctcaga cactgagtag cataaaaacc acatagaact gaactgtaac ttaaattcca
     5581 aactatgact actacattcc aaagaaacag ttgaattaaa cattttcata aaatatccca
//
