LOCUS       NM_001330068            5589 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neuropilin 1 (NRP1), transcript variant 7, mRNA.
ACCESSION   NM_001330068 XM_006717523
VERSION     NM_001330068.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5589)
  AUTHORS   Moragas,N., Fernandez-Nogueira,P., Recalde-Percaz,L., Inman,J.L.,
            Lopez-Plana,A., Bergholtz,H., Noguera-Castells,A., Del Burgo,P.J.,
            Chen,X., Sorlie,T., Gascon,P., Bragado,P., Bissell,M., Carbo,N. and
            Fuster,G.
  TITLE     The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of
            invasive traits in in situ breast ductal carcinoma
  JOURNAL   Breast Cancer Res 26 (1), 122 (2024)
   PUBMED   39138514
  REMARK    GeneRIF: The SEMA3F-NRP1/NRP2 axis is a key factor in the
            acquisition of invasive traits in in situ breast ductal carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5589)
  AUTHORS   Nguyen,H.L., Hieu,H.K., Nguyen,T.Q., Nhung,N.T.A. and Li,M.S.
  TITLE     Neuropilin-1 Protein May Serve as a Receptor for SARS-CoV-2
            Infection: Evidence from Molecular Dynamics Simulations
  JOURNAL   J Phys Chem B 128 (29), 7141-7147 (2024)
   PUBMED   39010661
  REMARK    GeneRIF: Neuropilin-1 Protein May Serve as a Receptor for
            SARS-CoV-2 Infection: Evidence from Molecular Dynamics Simulations.
REFERENCE   3  (bases 1 to 5589)
  AUTHORS   Gong,P., Zhang,R., Xiao,K., Shu,H., Li,X., Fan,H. and Sun,X.
  TITLE     DNA G-Quadruplex in NRP1 Promoter Facilitates SARS-CoV-2 Infection
  JOURNAL   Int J Mol Sci 25 (8), 4422 (2024)
   PUBMED   38674009
  REMARK    GeneRIF: DNA G-Quadruplex in NRP1 Promoter Facilitates SARS-CoV-2
            Infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5589)
  AUTHORS   Sarabipour,S., Kinghorn,K., Quigley,K.M., Kovacs-Kasa,A.,
            Annex,B.H., Bautch,V.L. and Mac Gabhann,F.
  TITLE     Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human
            endothelial cells
  JOURNAL   PLoS Comput Biol 20 (2), e1011798 (2024)
   PUBMED   38324585
  REMARK    GeneRIF: Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human
            endothelial cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5589)
  AUTHORS   Daly,J.L., Simonetti,B., Klein,K., Chen,K.E., Williamson,M.K.,
            Anton-Plagaro,C., Shoemark,D.K., Simon-Gracia,L., Bauer,M.,
            Hollandi,R., Greber,U.F., Horvath,P., Sessions,R.B., Helenius,A.,
            Hiscox,J.A., Teesalu,T., Matthews,D.A., Davidson,A.D.,
            Collins,B.M., Cullen,P.J. and Yamauchi,Y.
  TITLE     Neuropilin-1 is a host factor for SARS-CoV-2 infection
  JOURNAL   Science 370 (6518), 861-865 (2020)
   PUBMED   33082294
  REMARK    GeneRIF: Neuropilin-1 is a host factor for SARS-CoV-2 infection.
REFERENCE   6  (bases 1 to 5589)
  AUTHORS   Rossignol,M., Gagnon,M.L. and Klagsbrun,M.
  TITLE     Genomic organization of human neuropilin-1 and neuropilin-2 genes:
            identification and distribution of splice variants and soluble
            isoforms
  JOURNAL   Genomics 70 (2), 211-222 (2000)
   PUBMED   11112349
REFERENCE   7  (bases 1 to 5589)
  AUTHORS   Rossignol,M., Beggs,A.H., Pierce,E.A. and Klagsbrun,M.
  TITLE     Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34,
            respectively
  JOURNAL   Genomics 57 (3), 459-460 (1999)
   PUBMED   10329017
REFERENCE   8  (bases 1 to 5589)
  AUTHORS   Soker,S., Takashima,S., Miao,H.Q., Neufeld,G. and Klagsbrun,M.
  TITLE     Neuropilin-1 is expressed by endothelial and tumor cells as an
            isoform-specific receptor for vascular endothelial growth factor
  JOURNAL   Cell 92 (6), 735-745 (1998)
   PUBMED   9529250
REFERENCE   9  (bases 1 to 5589)
  AUTHORS   Chen,H., Chedotal,A., He,Z., Goodman,C.S. and Tessier-Lavigne,M.
  TITLE     Neuropilin-2, a novel member of the neuropilin family, is a high
            affinity receptor for the semaphorins Sema E and Sema IV but not
            Sema III
  JOURNAL   Neuron 19 (3), 547-559 (1997)
   PUBMED   9331348
  REMARK    Erratum:[Neuron 1997 Sep;19(3):559]
REFERENCE   10 (bases 1 to 5589)
  AUTHORS   He,Z. and Tessier-Lavigne,M.
  TITLE     Neuropilin is a receptor for the axonal chemorepellent Semaphorin
            III
  JOURNAL   Cell 90 (4), 739-751 (1997)
   PUBMED   9288753
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353600.10 and AL121748.7.
            
            On May 21, 2020 this sequence version replaced NM_001330068.1.
            
            Summary: This gene encodes one of two neuropilins, which contain
            specific protein domains which allow them to participate in several
            different types of signaling pathways that control cell migration.
            Neuropilins contain a large N-terminal extracellular domain, made
            up of complement-binding, coagulation factor V/VIII, and meprin
            domains. These proteins also contains a short membrane-spanning
            domain and a small cytoplasmic domain. Neuropilins bind many
            ligands and various types of co-receptors; they affect cell
            survival, migration, and attraction. Some of the ligands and
            co-receptors bound by neuropilins are vascular endothelial growth
            factor (VEGF) and semaphorin family members. This protein has also
            been determined to act as a co-receptor for SARS-CoV-2 (which
            causes COVID-19) to infect host cells. [provided by RefSeq, Nov
            2020].
            
            Transcript Variant: This variant (7) lacks an alternate in-frame
            exon in the 3' coding region compared to variant 1. It encodes
            isoform f, which is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3327464.1, AY249243.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: involved in SARS-CoV-2 infection
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AL353600.10        70654-71011         c
            359-533             AL353600.10        67052-67226         c
            534-715             AL353600.10        7019-7200           c
            716-943             AL121748.7         176173-176400       c
            944-1099            AL121748.7         168843-168998       c
            1100-1266           AL121748.7         166555-166721       c
            1267-1422           AL121748.7         138661-138816       c
            1423-1567           AL121748.7         134246-134390       c
            1568-1899           AL121748.7         125913-126244       c
            1900-2044           AL121748.7         120099-120243       c
            2045-2149           AL121748.7         115418-115522       c
            2150-2209           AL121748.7         110177-110236       c
            2210-2347           AL121748.7         104808-104945       c
            2348-2619           AL121748.7         98744-99015         c
            2620-2716           AL121748.7         98155-98251         c
            2717-5589           AL121748.7         90020-92892         c
FEATURES             Location/Qualifiers
     source          1..5589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.22"
     gene            1..5589
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="neuropilin 1"
                     /db_xref="GeneID:8829"
                     /db_xref="HGNC:HGNC:8004"
                     /db_xref="MIM:602069"
     exon            1..358
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..3006
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="isoform f precursor is encoded by transcript
                     variant 7; transmembrane receptor; vascular endothelial
                     cell growth factor 165 receptor"
                     /codon_start=1
                     /product="neuropilin-1 isoform f precursor"
                     /protein_id="NP_001316997.2"
                     /db_xref="CCDS:CCDS81448.1"
                     /db_xref="GeneID:8829"
                     /db_xref="HGNC:HGNC:8004"
                     /db_xref="MIM:602069"
                     /translation="MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGY
                     PHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGK
                     FCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKS
                     PGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFP
                     DVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCM
                     EALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLR
                     FVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVV
                     AVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSS
                     NQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHREN
                     KVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYP
                     ERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGT
                     TVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGP
                     IQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKL
                     RYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDI
                     SINNHISQEDCARSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGA
                     VCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA"
     exon            359..533
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            534..715
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            716..943
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1099
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1266
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1422
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1567
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1899
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2044
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2149
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2209
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2347
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2619
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2716
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..5589
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5303..5308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="hexamer: AGTAAA"
     polyA_site      5328
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
     regulatory      5564..5569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="hexamer: ATTAAA"
     polyA_site      5589
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="major polyA site"
ORIGIN      
        1 agacatggcc cgggcagtgg ctcctggaag aggaacaagt gtgggaaaag ggagaggaag
       61 ccggagctaa atgacaggat gcaggcgact tgagacacaa aaagagaagc gttcctctcg
      121 gatccaggca ttgcctcgct gctttctttt ctccaagacg ggctgaggat tgtacagctc
      181 taggcggagt tggggctctt cggatcgctt agattctcct ctttgctgca tttcccccca
      241 cgtcctcgtt ctcccgcgtc tgcctgcgga cccggagaag ggagaatgga gagggggctg
      301 ccgctcctct gcgccgtgct cgccctcgtc ctcgccccgg ccggcgcttt tcgcaacgat
      361 aaatgtggcg atactataaa aattgaaagc cccgggtacc ttacatctcc tggttatcct
      421 cattcttatc acccaagtga aaaatgcgaa tggctgattc aggctccgga cccataccag
      481 agaattatga tcaacttcaa ccctcacttc gatttggagg acagagactg caagtatgac
      541 tacgtggaag tcttcgatgg agaaaatgaa aatggacatt ttaggggaaa gttctgtgga
      601 aagatagccc ctcctcctgt tgtgtcttca gggccatttc tttttatcaa atttgtctct
      661 gactacgaaa cacatggtgc aggattttcc atacgttatg aaattttcaa gagaggtcct
      721 gaatgttccc agaactacac aacacctagt ggagtgataa agtcccccgg attccctgaa
      781 aaatatccca acagccttga atgcacttat attgtctttg tgccaaagat gtcagagatt
      841 atcctggaat ttgaaagctt tgacctggag cctgactcaa atcctccagg ggggatgttc
      901 tgtcgctacg accggctaga aatctgggat ggattccctg atgttggccc tcacattggg
      961 cgttactgtg gacagaaaac accaggtcga atccgatcct catcgggcat tctctccatg
     1021 gttttttaca ccgacagcgc gatagcaaaa gaaggtttct cagcaaacta cagtgtcttg
     1081 cagagcagtg tctcagaaga tttcaaatgt atggaagctc tgggcatgga atcaggagaa
     1141 attcattctg accagatcac agcttcttcc cagtatagca ccaactggtc tgcagagcgc
     1201 tcccgcctga actaccctga gaatgggtgg actcccggag aggattccta ccgagagtgg
     1261 atacaggtag acttgggcct tctgcgcttt gtcacggctg tcgggacaca gggcgccatt
     1321 tcaaaagaaa ccaagaagaa atattatgtc aagacttaca agatcgacgt tagctccaac
     1381 ggggaagact ggatcaccat aaaagaagga aacaaacctg ttctctttca gggaaacacc
     1441 aaccccacag atgttgtggt tgcagtattc cccaaaccac tgataactcg atttgtccga
     1501 atcaagcctg caacttggga aactggcata tctatgagat ttgaagtata cggttgcaag
     1561 ataacagatt atccttgctc tggaatgttg ggtatggtgt ctggacttat ttctgactcc
     1621 cagatcacat catccaacca aggggacaga aactggatgc ctgaaaacat ccgcctggta
     1681 accagtcgct ctggctgggc acttccaccc gcacctcatt cctacatcaa tgagtggctc
     1741 caaatagacc tgggggagga gaagatcgtg aggggcatca tcattcaggg tgggaagcac
     1801 cgagagaaca aggtgttcat gaggaagttc aagatcgggt acagcaacaa cggctcggac
     1861 tggaagatga tcatggatga cagcaaacgc aaggcgaagt cttttgaggg caacaacaac
     1921 tatgatacac ctgagctgcg gacttttcca gctctctcca cgcgattcat caggatctac
     1981 cccgagagag ccactcatgg cggactgggg ctcagaatgg agctgctggg ctgtgaagtg
     2041 gaagccccta cagctggacc gaccactccc aacgggaact tggtggatga atgtgatgac
     2101 gaccaggcca actgccacag tggaacaggt gatgacttcc agctcacagg tggcaccact
     2161 gtgctggcca cagaaaagcc cacggtcata gacagcacca tacaatcaga gtttccaaca
     2221 tatggtttta actgtgaatt tggctggggc tctcacaaga ccttctgcca ctgggaacat
     2281 gacaatcacg tgcagctcaa gtggagtgtg ttgaccagca agacgggacc cattcaggat
     2341 cacacaggag atggcaactt catctattcc caagctgacg aaaatcagaa gggcaaagtg
     2401 gctcgcctgg tgagccctgt ggtttattcc cagaactctg cccactgcat gaccttctgg
     2461 tatcacatgt ctgggtccca cgtcggcaca ctcagggtca aactgcgcta ccagaagcca
     2521 gaggagtacg atcagctggt ctggatggcc attggacacc aaggtgacca ctggaaggaa
     2581 gggcgtgtct tgctccacaa gtctctgaaa ctttatcagg tgattttcga gggcgaaatc
     2641 ggaaaaggaa accttggtgg gattgctgtg gatgacatta gtattaataa ccacatttca
     2701 caagaagatt gtgcaaggag cacgccagga tacgaaggtg aaggagaagg tgacaagaac
     2761 atctccagga agccaggcaa tgtgttgaag accttagacc ccatcctcat caccatcata
     2821 gccatgagtg ccctgggggt cctcctgggg gctgtctgtg gggtcgtgct gtactgtgcc
     2881 tgttggcata atgggatgtc agaaagaaac ttgtctgccc tggagaacta taactttgaa
     2941 cttgtggatg gtgtgaagtt gaaaaaagac aaactgaata cacagagtac ttattcggag
     3001 gcatgaaggc agacagagat gaaaagacag tcaaaggacg gaagtggaag gacgggagtg
     3061 agctggggag ctgttgatct ttcactatac aggctgggaa gtgtgttgat gaccactgag
     3121 ccaggctttt ctcaggagct tcaatgagta tggccgacag acatggacaa ggagctgtgt
     3181 tcaccatcgg actcatgtgc agtcagcttt tttcctgttg gtttcatttg aataatcaga
     3241 tgctggtgtt gagaccaagt atgattgaca taatcattca tttcgacccc tcctgcccct
     3301 ctctctctct ctcctctccc ctttgtggat tctttttgga aactgagcga aatccaagat
     3361 gctggcacca agcgtattcc gtgtggccct ttggatggac atgctacctg aaacccagtg
     3421 cccagaatat actagaatca ccgcatttca gtggactcct gaagttgtac ttgtgtataa
     3481 ttgcccgcgt cgtgcatagg caaagaagga ttaggctgtt ttctttttaa agtactgtag
     3541 cctcagtact ggtgtagtgt gtcagctctg tttacgaagc aatactgtcc agttttcttg
     3601 ctgtttttcc ggtgttgtac taaacctcgt gcttgtgaac tccatacaga aaacggtgcc
     3661 atccctgaac acggctggcc actgggtata ctgctgacaa ccgcaacaac aaaaacacaa
     3721 atccttggca ctggctagtc tatgtcctct caagtgcctt tttgtttgta ctggttcatt
     3781 gtgttacatt aacgacccac tctgcttctt gctggtgaaa gccctgctct ttaatcaaac
     3841 tctggtggcc cactgactaa gaagaaagtt tattttcgtg tgagatgcca gcccctccgg
     3901 gcaggcaagg gctctgaaga tttggcaacg tggcttaatt gttctgcttt ttctgtagtt
     3961 caatttcatg tttcttgacc cttttgtata aagctacaat attctctctt attgttcttt
     4021 catatggaat gtattttcaa atgtaaactc tcttctcttt ctctctccta tctctctgtc
     4081 ttttttctct cttagaattg gaggatttgc cattgtccag gaaagaaact tgcagcttta
     4141 acctgctggg aatggcaaac gattttacta gactttatgt ttaaaaataa ataaataagg
     4201 gaaattccta actttgccct ccaaagtcta actttggttt tcttgttaac tggttaaagt
     4261 gacagtatct tttttcctta tctattctat tcaaaatgac ctttgataga aatgttggca
     4321 tttagtagaa atagtgataa gttgaggaaa gaaataatac aaattggctt tcaagtgaga
     4381 cccaaaggaa gaactggata aaatcttcca aatccaaaag catgagattt ttctatccaa
     4441 atatgcaaaa atgacccaag agaactttct tattttgcta ctgagtcaca caagggaagt
     4501 ggaaggaaga acagttaatt taagaatgaa actataaatc ctgatgcctg ggggtcaagt
     4561 attttaagat aagaggggga aaaacacata aagtcaaaca aatgttttaa aaattcataa
     4621 cagcaacctt gaaaaaatag acttaaatga atgcttctag aaacttccag cggctcacaa
     4681 agaataagcc tgccttaggg ctggcaacat ctaagcctct aacagcacag ggaagcaaat
     4741 atcttaccag gcagcctatg aattaaccca aagaagcttt ggttggtttt ggtggatttt
     4801 tatcatgcca tgttggacat gagatttttt agatcttcct tcccacattg ctagacgtct
     4861 cactcaaaga catttgttgg gagtcacatt tgcatcatag acgagacagt ccattcatct
     4921 tagttaaatt ggattgagaa tgccttttgt ttccaggaaa atattgatca ccatgaaaga
     4981 agaatagttt tttgtcccca gagacattca tttagttgat ataatcctac cagaaggaaa
     5041 gcactaagaa acactcgttt gttgttttta aaggcaacag acttaaagtt gtcctcagcc
     5101 aaggaaaaat gatactgcaa ctttaaaatt taaagtatct tgcactgata aatatattta
     5161 aaaattatat gtttataaag ttattaattt gtaaaggcag tgttacaaaa tgttcagttt
     5221 atattgtttt agattgtttt gtaattttta aaggtgtaaa ataacatatt ttttctttat
     5281 ggaaatctat aaaactttct gtagtaaaat gttttcattt tactggtata ttattgcttc
     5341 atgttttgta ccatcataag attttgtgca gatttttttt acagaaatta ttattttcta
     5401 tgacaatatg acacttgtaa attgttgttt caaaatgaac agcgaagcct taactttaaa
     5461 tgacatttgt attctcagac actgagtagc ataaaaacca catagaactg aactgtaact
     5521 taaattccaa actatgacta ctacattcca aagaaacagt tgaattaaac attttcataa
     5581 aatatccca
//
