LOCUS       NM_001024629            2133 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neuropilin 1 (NRP1), transcript variant 3, mRNA.
ACCESSION   NM_001024629
VERSION     NM_001024629.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2133)
  AUTHORS   Moragas,N., Fernandez-Nogueira,P., Recalde-Percaz,L., Inman,J.L.,
            Lopez-Plana,A., Bergholtz,H., Noguera-Castells,A., Del Burgo,P.J.,
            Chen,X., Sorlie,T., Gascon,P., Bragado,P., Bissell,M., Carbo,N. and
            Fuster,G.
  TITLE     The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of
            invasive traits in in situ breast ductal carcinoma
  JOURNAL   Breast Cancer Res 26 (1), 122 (2024)
   PUBMED   39138514
  REMARK    GeneRIF: The SEMA3F-NRP1/NRP2 axis is a key factor in the
            acquisition of invasive traits in in situ breast ductal carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2133)
  AUTHORS   Nguyen,H.L., Hieu,H.K., Nguyen,T.Q., Nhung,N.T.A. and Li,M.S.
  TITLE     Neuropilin-1 Protein May Serve as a Receptor for SARS-CoV-2
            Infection: Evidence from Molecular Dynamics Simulations
  JOURNAL   J Phys Chem B 128 (29), 7141-7147 (2024)
   PUBMED   39010661
  REMARK    GeneRIF: Neuropilin-1 Protein May Serve as a Receptor for
            SARS-CoV-2 Infection: Evidence from Molecular Dynamics Simulations.
REFERENCE   3  (bases 1 to 2133)
  AUTHORS   Gong,P., Zhang,R., Xiao,K., Shu,H., Li,X., Fan,H. and Sun,X.
  TITLE     DNA G-Quadruplex in NRP1 Promoter Facilitates SARS-CoV-2 Infection
  JOURNAL   Int J Mol Sci 25 (8), 4422 (2024)
   PUBMED   38674009
  REMARK    GeneRIF: DNA G-Quadruplex in NRP1 Promoter Facilitates SARS-CoV-2
            Infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2133)
  AUTHORS   Sarabipour,S., Kinghorn,K., Quigley,K.M., Kovacs-Kasa,A.,
            Annex,B.H., Bautch,V.L. and Mac Gabhann,F.
  TITLE     Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human
            endothelial cells
  JOURNAL   PLoS Comput Biol 20 (2), e1011798 (2024)
   PUBMED   38324585
  REMARK    GeneRIF: Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human
            endothelial cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2133)
  AUTHORS   Daly,J.L., Simonetti,B., Klein,K., Chen,K.E., Williamson,M.K.,
            Anton-Plagaro,C., Shoemark,D.K., Simon-Gracia,L., Bauer,M.,
            Hollandi,R., Greber,U.F., Horvath,P., Sessions,R.B., Helenius,A.,
            Hiscox,J.A., Teesalu,T., Matthews,D.A., Davidson,A.D.,
            Collins,B.M., Cullen,P.J. and Yamauchi,Y.
  TITLE     Neuropilin-1 is a host factor for SARS-CoV-2 infection
  JOURNAL   Science 370 (6518), 861-865 (2020)
   PUBMED   33082294
  REMARK    GeneRIF: Neuropilin-1 is a host factor for SARS-CoV-2 infection.
REFERENCE   6  (bases 1 to 2133)
  AUTHORS   Rossignol,M., Gagnon,M.L. and Klagsbrun,M.
  TITLE     Genomic organization of human neuropilin-1 and neuropilin-2 genes:
            identification and distribution of splice variants and soluble
            isoforms
  JOURNAL   Genomics 70 (2), 211-222 (2000)
   PUBMED   11112349
REFERENCE   7  (bases 1 to 2133)
  AUTHORS   Rossignol,M., Beggs,A.H., Pierce,E.A. and Klagsbrun,M.
  TITLE     Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34,
            respectively
  JOURNAL   Genomics 57 (3), 459-460 (1999)
   PUBMED   10329017
REFERENCE   8  (bases 1 to 2133)
  AUTHORS   Soker,S., Takashima,S., Miao,H.Q., Neufeld,G. and Klagsbrun,M.
  TITLE     Neuropilin-1 is expressed by endothelial and tumor cells as an
            isoform-specific receptor for vascular endothelial growth factor
  JOURNAL   Cell 92 (6), 735-745 (1998)
   PUBMED   9529250
REFERENCE   9  (bases 1 to 2133)
  AUTHORS   Chen,H., Chedotal,A., He,Z., Goodman,C.S. and Tessier-Lavigne,M.
  TITLE     Neuropilin-2, a novel member of the neuropilin family, is a high
            affinity receptor for the semaphorins Sema E and Sema IV but not
            Sema III
  JOURNAL   Neuron 19 (3), 547-559 (1997)
   PUBMED   9331348
  REMARK    Erratum:[Neuron 1997 Sep;19(3):559]
REFERENCE   10 (bases 1 to 2133)
  AUTHORS   He,Z. and Tessier-Lavigne,M.
  TITLE     Neuropilin is a receptor for the axonal chemorepellent Semaphorin
            III
  JOURNAL   Cell 90 (4), 739-751 (1997)
   PUBMED   9288753
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353600.10 and AL121748.7.
            
            On May 21, 2020 this sequence version replaced NM_001024629.2.
            
            Summary: This gene encodes one of two neuropilins, which contain
            specific protein domains which allow them to participate in several
            different types of signaling pathways that control cell migration.
            Neuropilins contain a large N-terminal extracellular domain, made
            up of complement-binding, coagulation factor V/VIII, and meprin
            domains. These proteins also contains a short membrane-spanning
            domain and a small cytoplasmic domain. Neuropilins bind many
            ligands and various types of co-receptors; they affect cell
            survival, migration, and attraction. Some of the ligands and
            co-receptors bound by neuropilins are vascular endothelial growth
            factor (VEGF) and semaphorin family members. This protein has also
            been determined to act as a co-receptor for SARS-CoV-2 (which
            causes COVID-19) to infect host cells. [provided by RefSeq, Nov
            2020].
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            coding region segment, uses a different splice site in the 3' end
            and contains a different segment for the 3' end of the coding
            region and the 3' UTR, compared to variant 1. The resulting protein
            (isoform c) has a shorter C-terminus when compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007737.2, SRR14038192.3268469.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: involved in SARS-CoV-2 infection
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AL353600.10        70654-71011         c
            359-533             AL353600.10        67052-67226         c
            534-715             AL353600.10        7019-7200           c
            716-943             AL121748.7         176173-176400       c
            944-1099            AL121748.7         168843-168998       c
            1100-1266           AL121748.7         166555-166721       c
            1267-1422           AL121748.7         138661-138816       c
            1423-1567           AL121748.7         134246-134390       c
            1568-1899           AL121748.7         125913-126244       c
            1900-2044           AL121748.7         120099-120243       c
            2045-2133           AL121748.7         110148-110236       c
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.22"
     gene            1..2133
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="neuropilin 1"
                     /db_xref="GeneID:8829"
                     /db_xref="HGNC:HGNC:8004"
                     /db_xref="MIM:602069"
     exon            1..358
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2115
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; transmembrane receptor; vascular endothelial
                     cell growth factor 165 receptor"
                     /codon_start=1
                     /product="neuropilin-1 isoform c precursor"
                     /protein_id="NP_001019800.2"
                     /db_xref="CCDS:CCDS31179.1"
                     /db_xref="GeneID:8829"
                     /db_xref="HGNC:HGNC:8004"
                     /db_xref="MIM:602069"
                     /translation="MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGY
                     PHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGK
                     FCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKS
                     PGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFP
                     DVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCM
                     EALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLR
                     FVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVV
                     AVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSS
                     NQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHREN
                     KVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYP
                     ERATHGGLGLRMELLGCEVEGGTTVLATEKPTVIDSTIQSGIK"
     exon            359..533
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            534..715
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            716..943
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1099
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1266
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1422
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1567
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1899
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2044
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2133
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2111..2116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="hexamer: AATAAA"
     polyA_site      2133
                     /gene="NRP1"
                     /gene_synonym="BDCA4; CD304; NP1; NRP; VEGF165R"
                     /note="major polyA site"
ORIGIN      
        1 agacatggcc cgggcagtgg ctcctggaag aggaacaagt gtgggaaaag ggagaggaag
       61 ccggagctaa atgacaggat gcaggcgact tgagacacaa aaagagaagc gttcctctcg
      121 gatccaggca ttgcctcgct gctttctttt ctccaagacg ggctgaggat tgtacagctc
      181 taggcggagt tggggctctt cggatcgctt agattctcct ctttgctgca tttcccccca
      241 cgtcctcgtt ctcccgcgtc tgcctgcgga cccggagaag ggagaatgga gagggggctg
      301 ccgctcctct gcgccgtgct cgccctcgtc ctcgccccgg ccggcgcttt tcgcaacgat
      361 aaatgtggcg atactataaa aattgaaagc cccgggtacc ttacatctcc tggttatcct
      421 cattcttatc acccaagtga aaaatgcgaa tggctgattc aggctccgga cccataccag
      481 agaattatga tcaacttcaa ccctcacttc gatttggagg acagagactg caagtatgac
      541 tacgtggaag tcttcgatgg agaaaatgaa aatggacatt ttaggggaaa gttctgtgga
      601 aagatagccc ctcctcctgt tgtgtcttca gggccatttc tttttatcaa atttgtctct
      661 gactacgaaa cacatggtgc aggattttcc atacgttatg aaattttcaa gagaggtcct
      721 gaatgttccc agaactacac aacacctagt ggagtgataa agtcccccgg attccctgaa
      781 aaatatccca acagccttga atgcacttat attgtctttg tgccaaagat gtcagagatt
      841 atcctggaat ttgaaagctt tgacctggag cctgactcaa atcctccagg ggggatgttc
      901 tgtcgctacg accggctaga aatctgggat ggattccctg atgttggccc tcacattggg
      961 cgttactgtg gacagaaaac accaggtcga atccgatcct catcgggcat tctctccatg
     1021 gttttttaca ccgacagcgc gatagcaaaa gaaggtttct cagcaaacta cagtgtcttg
     1081 cagagcagtg tctcagaaga tttcaaatgt atggaagctc tgggcatgga atcaggagaa
     1141 attcattctg accagatcac agcttcttcc cagtatagca ccaactggtc tgcagagcgc
     1201 tcccgcctga actaccctga gaatgggtgg actcccggag aggattccta ccgagagtgg
     1261 atacaggtag acttgggcct tctgcgcttt gtcacggctg tcgggacaca gggcgccatt
     1321 tcaaaagaaa ccaagaagaa atattatgtc aagacttaca agatcgacgt tagctccaac
     1381 ggggaagact ggatcaccat aaaagaagga aacaaacctg ttctctttca gggaaacacc
     1441 aaccccacag atgttgtggt tgcagtattc cccaaaccac tgataactcg atttgtccga
     1501 atcaagcctg caacttggga aactggcata tctatgagat ttgaagtata cggttgcaag
     1561 ataacagatt atccttgctc tggaatgttg ggtatggtgt ctggacttat ttctgactcc
     1621 cagatcacat catccaacca aggggacaga aactggatgc ctgaaaacat ccgcctggta
     1681 accagtcgct ctggctgggc acttccaccc gcacctcatt cctacatcaa tgagtggctc
     1741 caaatagacc tgggggagga gaagatcgtg aggggcatca tcattcaggg tgggaagcac
     1801 cgagagaaca aggtgttcat gaggaagttc aagatcgggt acagcaacaa cggctcggac
     1861 tggaagatga tcatggatga cagcaaacgc aaggcgaagt cttttgaggg caacaacaac
     1921 tatgatacac ctgagctgcg gacttttcca gctctctcca cgcgattcat caggatctac
     1981 cccgagagag ccactcatgg cggactgggg ctcagaatgg agctgctggg ctgtgaagtg
     2041 gaaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa
     2101 tcaggtatca aataaaatac gaaatgtgac aga
//
