LOCUS       NM_198443                626 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens neuritin 1 like (NRN1L), transcript variant 1, mRNA.
ACCESSION   NM_198443 XM_058747
VERSION     NM_198443.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 626)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 626)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   3  (bases 1 to 626)
  AUTHORS   Fujino,T., Wu,Z., Lin,W.C., Phillips,M.A. and Nedivi,E.
  TITLE     cpg15 and cpg15-2 constitute a family of activity-regulated ligands
            expressed differentially in the nervous system to promote neurite
            growth and neuronal survival
  JOURNAL   J Comp Neurol 507 (5), 1831-1845 (2008)
   PUBMED   18265009
  REMARK    GeneRIF: CPG15 and CPG15-2 perform similar cellular functions but
            may play distinct roles in vivo through their cell-type- and
            tissue-specific transcriptional regulation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358782.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198443.1.
            
            Summary: The protein encoded by this gene is extracellular and
            enhances both neurite growth and neuronal survival. The encoded
            protein is found both as a GPI anchored membrane-bound form and as
            a secreted form. This activity-related ligand functions as a
            homodimer or heterodimer. [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358782.1, BM676935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339176.8/ ENSP00000342411.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-626               AY358782.1         8-633
FEATURES             Location/Qualifiers
     source          1..626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..626
                     /gene="NRN1L"
                     /gene_synonym="cpg15-2; MRCC2446; UNQ2446"
                     /note="neuritin 1 like"
                     /db_xref="GeneID:123904"
                     /db_xref="HGNC:HGNC:29811"
     exon            1..98
                     /gene="NRN1L"
                     /gene_synonym="cpg15-2; MRCC2446; UNQ2446"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..517
                     /gene="NRN1L"
                     /gene_synonym="cpg15-2; MRCC2446; UNQ2446"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; neuritin-like protein"
                     /codon_start=1
                     /product="neuritin-like protein isoform 1 precursor"
                     /protein_id="NP_940845.1"
                     /db_xref="CCDS:CCDS10850.1"
                     /db_xref="GeneID:123904"
                     /db_xref="HGNC:HGNC:29811"
                     /translation="MMRCCRRRCCCRQPPHALRPLLLLPLVLLPPLAAAAAGPNRCDT
                     IYQGFAECLIRLGDSMGRGGELETICRSWNDFHACASQVLSGCPEEAAAVWESLQQEA
                     RQAPRPNNLHTLCGAPVHVRERGTGSETNQETLRATAPALPMAPAPPLLAAALALAYL
                     LRPLA"
     exon            99..231
                     /gene="NRN1L"
                     /gene_synonym="cpg15-2; MRCC2446; UNQ2446"
                     /inference="alignment:Splign:2.1.0"
     exon            232..626
                     /gene="NRN1L"
                     /gene_synonym="cpg15-2; MRCC2446; UNQ2446"
                     /inference="alignment:Splign:2.1.0"
     regulatory      605..610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRN1L"
                     /gene_synonym="cpg15-2; MRCC2446; UNQ2446"
                     /note="hexamer: ATTAAA"
     polyA_site      626
                     /gene="NRN1L"
                     /gene_synonym="cpg15-2; MRCC2446; UNQ2446"
                     /note="major polyA site"
ORIGIN      
        1 actaggctct cagccaggga tgatgcgctg ctgccgccgc cgctgctgct gccggcaacc
       61 accccatgcc ctgaggccgt tgctgttgct gcccctcgtc cttttacctc ccctggcagc
      121 agctgcagcg ggcccaaacc gatgtgacac catataccag ggcttcgccg agtgtctcat
      181 ccgcttgggg gacagcatgg gccgcggagg cgagctggag accatctgca ggtcttggaa
      241 tgacttccat gcctgtgcct ctcaggtcct gtcaggctgt ccggaggagg cagctgcagt
      301 gtgggaatca ctacagcaag aagctcgcca ggccccccgt ccgaataact tgcacactct
      361 gtgcggtgcc ccggtgcatg ttcgggagcg cggcacaggc tccgaaacca accaggagac
      421 gctgcgggct acagcgcctg cactccccat ggcccctgcg cccccactgc tggcggctgc
      481 tctggctctg gcctacctcc tgaggcctct ggcctagctt gttgggttgg gtagcagcgc
      541 ccgtacctcc agccctgctc tggcggtggt tgtccaggct ctgcagagcg cagcagggct
      601 tttcattaaa ggtatttata tttgta
//
