LOCUS       NM_016588               1582 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens neuritin 1 (NRN1), transcript variant 1, mRNA.
ACCESSION   NM_016588
VERSION     NM_016588.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1582)
  AUTHORS   Almodovar-Paya,C., Guardiola-Ripoll,M., Giralt-Lopez,M.,
            Oscoz-Irurozqui,M., Canales-Rodriguez,E.J., Madre,M.,
            Soler-Vidal,J., Ramiro,N., Callado,L.F., Arias,B., Gallego,C.,
            Pomarol-Clotet,E. and Fatjo-Vilas,M.
  TITLE     NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom
            severity through neuroanatomical changes in schizophrenia
  JOURNAL   Brain Struct Funct 229 (5), 1299-1315 (2024)
   PUBMED   38720004
  REMARK    GeneRIF: NRN1 epistasis with BDNF and CACNA1C: mediation effects on
            symptom severity through neuroanatomical changes in schizophrenia.
REFERENCE   2  (bases 1 to 1582)
  AUTHORS   Devitt,L., Westphal,D., Pieger,K., Schneider,N., Bosserhoff,A.K.
            and Kuphal,S.
  TITLE     NRN1 interacts with Notch to increase oncogenic STAT3 signaling in
            melanoma
  JOURNAL   Cell Commun Signal 22 (1), 256 (2024)
   PUBMED   38705997
  REMARK    GeneRIF: NRN1 interacts with Notch to increase oncogenic STAT3
            signaling in melanoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1582)
  AUTHORS   Zhu,J., Li,Y., Zhong,C., Zhu,M., Zheng,Y., Xiong,A., Meng,P.,
            Shan,L., Li,Y. and Huang,J.
  TITLE     Neuritin affects the activity of neuralized-like 1 by promoting
            degradation and weakening its affinity for substrate
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1650-1658 (2023)
   PUBMED   37249336
  REMARK    GeneRIF: Neuritin affects the activity of neuralized-like 1 by
            promoting degradation and weakening its affinity for substrate.
REFERENCE   4  (bases 1 to 1582)
  AUTHORS   Hurst,C., Pugh,D.A., Abreha,M.H., Duong,D.M., Dammer,E.B.,
            Bennett,D.A., Herskowitz,J.H. and Seyfried,N.T.
  TITLE     Integrated Proteomics to Understand the Role of Neuritin (NRN1) as
            a Mediator of Cognitive Resilience to Alzheimer's Disease
  JOURNAL   Mol Cell Proteomics 22 (5), 100542 (2023)
   PUBMED   37024090
  REMARK    GeneRIF: Integrated Proteomics to Understand the Role of Neuritin
            (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's
            Disease.
REFERENCE   5  (bases 1 to 1582)
  AUTHORS   Almodovar-Paya,C., Guardiola-Ripoll,M., Giralt-Lopez,M.,
            Gallego,C., Salgado-Pineda,P., Miret,S., Salvador,R., Munoz,M.J.,
            Lazaro,L., Guerrero-Pedraza,A., Parellada,M., Carrion,M.I.,
            Cuesta,M.J., Maristany,T., Sarro,S., Fananas,L., Callado,L.F.,
            Arias,B., Pomarol-Clotet,E. and Fatjo-Vilas,M.
  TITLE     NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia:
            Evidence from Genetic and Neuroimaging Approaches
  JOURNAL   Int J Mol Sci 23 (13), 7456 (2022)
   PUBMED   35806464
  REMARK    GeneRIF: NRN1 Gene as a Potential Marker of Early-Onset
            Schizophrenia: Evidence from Genetic and Neuroimaging Approaches.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1582)
  AUTHORS   Zhang,L., Zhao,Y., Wang,C.G., Fei,Z., Wang,Y., Li,L., Li,L. and
            Zhen,H.N.
  TITLE     Neuritin expression and its relation with proliferation, apoptosis,
            and angiogenesis in human astrocytoma
  JOURNAL   Med Oncol 28 (3), 907-912 (2011)
   PUBMED   20405246
  REMARK    GeneRIF: we found neuritin is overexpressed in astrocytoma, which
            may be an important factor in tumorigenesis and progression of
            astrocytoma
REFERENCE   7  (bases 1 to 1582)
  AUTHORS   Chandler,D., Dragovic,M., Cooper,M., Badcock,J.C., Mullin,B.H.,
            Faulkner,D., Wilson,S.G., Hallmayer,J., Howell,S., Rock,D.,
            Palmer,L.J., Kalaydjieva,L. and Jablensky,A.
  TITLE     Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in
            schizophrenia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (2), 428-437 (2010)
   PUBMED   19569075
  REMARK    GeneRIF: NRN1 polymorphisms have roles in fluid intelligence in
            schizophrenia
REFERENCE   8  (bases 1 to 1582)
  AUTHORS   Fujino,T., Wu,Z., Lin,W.C., Phillips,M.A. and Nedivi,E.
  TITLE     cpg15 and cpg15-2 constitute a family of activity-regulated ligands
            expressed differentially in the nervous system to promote neurite
            growth and neuronal survival
  JOURNAL   J Comp Neurol 507 (5), 1831-1845 (2008)
   PUBMED   18265009
  REMARK    GeneRIF: CPG15 and CPG15-2 perform similar cellular functions but
            may play distinct roles in vivo through their cell-type- and
            tissue-specific transcriptional regulation
REFERENCE   9  (bases 1 to 1582)
  AUTHORS   Le Jan,S., Le Meur,N., Cazes,A., Philippe,J., Le Cunff,M.,
            Leger,J., Corvol,P. and Germain,S.
  TITLE     Characterization of the expression of the hypoxia-induced genes
            neuritin, TXNIP and IGFBP3 in cancer
  JOURNAL   FEBS Lett 580 (14), 3395-3400 (2006)
   PUBMED   16723126
  REMARK    GeneRIF: By Northern blot, we confirm hypoxia-induced expression of
            insulin-like growth factor binding protein 3 (igfbp3),
            thioredoxin-interacting protein (txnip), neuritin (nrn1).
REFERENCE   10 (bases 1 to 1582)
  AUTHORS   Naeve,G.S., Ramakrishnan,M., Kramer,R., Hevroni,D., Citri,Y. and
            Theill,L.E.
  TITLE     Neuritin: a gene induced by neural activity and neurotrophins that
            promotes neuritogenesis
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2648-2653 (1997)
   PUBMED   9122250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136307.12 and BC002683.2.
            
            On Nov 22, 2018 this sequence version replaced NM_016588.2.
            
            Summary: This gene encodes a member of the neuritin family, and is
            expressed in postmitotic-differentiating neurons of the
            developmental nervous system and neuronal structures associated
            with plasticity in the adult. The expression of this gene can be
            induced by neural activity and neurotrophins. The encoded protein
            contains a consensus cleavage signal found in
            glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded
            protein promotes neurite outgrowth and arborization, suggesting its
            role in promoting neuritogenesis. Overexpression of the encoded
            protein may be associated with astrocytoma progression. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) encodes isoform 1. Both
            variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.254938.1,
                                           SRR3476690.361482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244766.7/ ENSP00000244766.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL136307.12        151490-151536       c
            48-1582             BC002683.2         1-1535
FEATURES             Location/Qualifiers
     source          1..1582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.1"
     gene            1..1582
                     /gene="NRN1"
                     /gene_synonym="dJ380B8.2; NRN"
                     /note="neuritin 1"
                     /db_xref="GeneID:51299"
                     /db_xref="HGNC:HGNC:17972"
                     /db_xref="MIM:607409"
     exon            1..231
                     /gene="NRN1"
                     /gene_synonym="dJ380B8.2; NRN"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..605
                     /gene="NRN1"
                     /gene_synonym="dJ380B8.2; NRN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="neuritin isoform 1 precursor"
                     /protein_id="NP_057672.1"
                     /db_xref="CCDS:CCDS4495.1"
                     /db_xref="GeneID:51299"
                     /db_xref="HGNC:HGNC:17972"
                     /db_xref="MIM:607409"
                     /translation="MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLK
                     LGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLN
                     IQGSLFELCGSGNGAAGSLLPAFPVLLVSLSAALATWLSF"
     exon            232..376
                     /gene="NRN1"
                     /gene_synonym="dJ380B8.2; NRN"
                     /inference="alignment:Splign:2.1.0"
     exon            377..1582
                     /gene="NRN1"
                     /gene_synonym="dJ380B8.2; NRN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRN1"
                     /gene_synonym="dJ380B8.2; NRN"
                     /note="hexamer: AATAAA"
     polyA_site      1582
                     /gene="NRN1"
                     /gene_synonym="dJ380B8.2; NRN"
                     /note="major polyA site"
ORIGIN      
        1 ctctttctgt ctcttcctcg ctccctctct ttctctcctc cctctgcctt cccagtgcat
       61 aaagtctctg tcgctcccgg aacttgttgg caatgcctat tttttggctt tcccccgcgt
      121 tctctaaact aactatttaa aggtctgcgg tcgcaaatgg tttgactaaa cgtaggatgg
      181 gacttaagtt gaacggcaga tatatttcac tgatcctcgc ggtgcaaata gcgtatctgg
      241 tgcaggccgt gagagcagcg ggcaagtgcg atgcggtctt caagggcttt tcggactgtt
      301 tgctcaagct gggcgacagc atggccaact acccgcaggg cctggacgac aagacgaaca
      361 tcaagaccgt gtgcacatac tgggaggatt tccacagctg cacggtcaca gcccttacgg
      421 attgccagga aggggcgaaa gatatgtggg ataaactgag aaaagaatcc aaaaacctca
      481 acatccaagg cagcttattc gaactctgcg gcagcggcaa cggggcggcg gggtccctgc
      541 tcccggcgtt cccggtgctc ctggtgtctc tctcggcagc tttagcgacc tggctttcct
      601 tctgagcgtg gggccagctc cccccgcgcg cccacccaca ctcactccat gctcccggaa
      661 atcgagagga agatccatta gttctttggg gacgttgtga ttctctgtga tgctgaaaac
      721 actcatatag gattgtggga aatcctgatt ctctttttta tttcgtttga tttcttgtgt
      781 tttatttgcc aaatgttacc aatcagtgag caagcaagca cagccaaaat cggacctcag
      841 ctttagtccg tcttcacaca caaataagaa aacggcaaac ccaccccatt ttttaatttt
      901 attattatta attttttttg ttggcaaaag aatctcagga acggccctgg gccacctact
      961 atattaatca tgctagtaac atgaaaaatg atgggctcct cctaatagga aggcgaggag
     1021 aggagaaggc caggggaatg aattcaagag agatgtccac ggacgaaaca tacggtgaat
     1081 aattcacgct cacgtcgttc ttccacagta tcttgttttg atcatttcca ctgcacattt
     1141 ctcctcaaga aaagcgaaag gacagactgt tggctttgtg tttggaggat aggagggaga
     1201 gagggaaggg gctgaggaaa tctctggggt aagagtaaag gcttccagaa gacatgctgc
     1261 tatggtcact gaggggttag ctttatctgc tgttgttgat gcatccgtcc aagttcactg
     1321 cctttatttt ccctcctccc tcttgtttta gctgttacac acacagtaat acctgaatat
     1381 ccaacggtat agatcacaag ggggggatgt taaatgttaa tctaaaatat agctaaaaaa
     1441 agattttgac ataaaagagc cttgatttta aaaaaaaaag agagagagat gtaatttaaa
     1501 aagtttatta taaattaaat tcagcaaaaa aagatttgct acaaagtata gagaagtata
     1561 aaataaaagt tattgtttga aa
//
