LOCUS       NM_001384369            1411 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens nurim (NRM), transcript variant 9, mRNA.
ACCESSION   NM_001384369
VERSION     NM_001384369.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1411)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1411)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1411)
  AUTHORS   Chen,H., Chen,K., Chen,J., Cheng,H. and Zhou,R.
  TITLE     The integral nuclear membrane protein nurim plays a role in the
            suppression of apoptosis
  JOURNAL   Curr Mol Med 12 (10), 1372-1382 (2012)
   PUBMED   23092226
  REMARK    GeneRIF: these findings implicate that the inner nuclear membrane
            protein Nurim plays an important role in the suppression of
            apoptosis
REFERENCE   4  (bases 1 to 1411)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1411)
  AUTHORS   Braunagel,S.C., Williamson,S.T., Ding,Q., Wu,X. and Summers,M.D.
  TITLE     Early sorting of inner nuclear membrane proteins is conserved
  JOURNAL   Proc Natl Acad Sci U S A 104 (22), 9307-9312 (2007)
   PUBMED   17517639
REFERENCE   6  (bases 1 to 1411)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 1411)
  AUTHORS   Hofemeister,H. and O'Hare,P.
  TITLE     Analysis of the localization and topology of nurim, a polytopic
            protein tightly associated with the inner nuclear membrane
  JOURNAL   J Biol Chem 280 (4), 2512-2521 (2005)
   PUBMED   15542857
  REMARK    GeneRIF: nurim is a polytopic protein tightly associated with the
            inner nuclear membrane
REFERENCE   8  (bases 1 to 1411)
  AUTHORS   Holmer,L. and Worman,H.J.
  TITLE     Inner nuclear membrane proteins: functions and targeting
  JOURNAL   Cell Mol Life Sci 58 (12-13), 1741-1747 (2001)
   PUBMED   11766875
  REMARK    Review article
REFERENCE   9  (bases 1 to 1411)
  AUTHORS   Rolls,M.M., Stein,P.A., Taylor,S.S., Ha,E., McKeon,F. and
            Rapoport,T.A.
  TITLE     A visual screen of a GFP-fusion library identifies a new type of
            nuclear envelope membrane protein
  JOURNAL   J Cell Biol 146 (1), 29-44 (1999)
   PUBMED   10402458
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662797.7.
            
            Summary: The protein encoded by this gene contains transmembrane
            domains and resides within the inner nuclear membrane, where it is
            tightly associated with the nucleus. This protein shares homology
            with isoprenylcysteine carboxymethyltransferase enzymes.
            Alternative splicing results in multiple transcript variants that
            encode different protein isoforms. [provided by RefSeq, Jul 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039865.1, AF143676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376421.7/ ENSP00000365603.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AL662797.7         13927-14069         c
            144-340             AL662797.7         13132-13328         c
            341-517             AL662797.7         12361-12537         c
            518-1411            AL662797.7         11134-12027         c
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1411
                     /gene="NRM"
                     /gene_synonym="NRM29"
                     /note="nurim"
                     /db_xref="GeneID:11270"
                     /db_xref="HGNC:HGNC:8003"
                     /db_xref="MIM:620017"
     exon            1..143
                     /gene="NRM"
                     /gene_synonym="NRM29"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..799
                     /gene="NRM"
                     /gene_synonym="NRM29"
                     /note="isoform 1 is encoded by transcript variant 9;
                     nuclear rim protein; nurim (nuclear envelope membrane
                     protein)"
                     /codon_start=1
                     /product="nurim isoform 1"
                     /protein_id="NP_001371298.1"
                     /db_xref="CCDS:CCDS4686.1"
                     /db_xref="GeneID:11270"
                     /db_xref="HGNC:HGNC:8003"
                     /db_xref="MIM:620017"
                     /translation="MAPALLLIPAALASFILAFGTGVEFVRFTSLRPLLGGIPESGGP
                     DARQGWLAALQDRSILAPLAWDLGLLLLFVGQHSLMAAERVKAWTSRYFGVLQRSLYV
                     ACTALALQLVMRYWEPIPKGPVLWEARAEPWATWVPLLCFVLHVISWLLIFSILLVFD
                     YAELMGLKQVYYHVLGLGEPLALKSPRALRLFSHLRHPVCVELLTVLWVVPTLGTDRL
                     LLAFLLTLYLGLAHGLDQQDLRYLRAQLQRKLHLLSRPQDGEAE"
     exon            144..340
                     /gene="NRM"
                     /gene_synonym="NRM29"
                     /inference="alignment:Splign:2.1.0"
     exon            341..517
                     /gene="NRM"
                     /gene_synonym="NRM29"
                     /inference="alignment:Splign:2.1.0"
     exon            518..1411
                     /gene="NRM"
                     /gene_synonym="NRM29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1388..1393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRM"
                     /gene_synonym="NRM29"
                     /note="hexamer: AATAAA"
     polyA_site      1411
                     /gene="NRM"
                     /gene_synonym="NRM29"
                     /note="major polyA site"
ORIGIN      
        1 atttctcgcc atggcccctg cactgctcct gatccctgct gccctcgcct ctttcatcct
       61 ggcctttggc accggagtgg agttcgtgcg ctttacctcc cttcggccac ttcttggagg
      121 gatcccggag tctggtggtc cggatgcccg ccagggatgg ctggctgccc tgcaggaccg
      181 cagcatcctt gcccccctgg catgggatct ggggctcctg cttctatttg ttgggcagca
      241 cagcctcatg gcagctgaaa gagtgaaggc atggacatcc cggtactttg gggtccttca
      301 gaggtcactg tatgtggcct gcactgccct ggccttgcag ctggtgatgc ggtactggga
      361 gcccataccc aaaggccctg tgttgtggga ggctcgggct gagccatggg ccacctgggt
      421 gccgctcctc tgctttgtgc tccatgtcat ctcctggctc ctcatcttta gcatccttct
      481 cgtctttgac tatgctgagc tcatgggcct caaacaggta tactaccatg tgctggggct
      541 gggcgagcct ctggccctga agtctccccg ggctctcaga ctcttctccc acctgcgcca
      601 cccagtgtgt gtggagctgc tgacagtgct gtgggtggtg cctaccctgg gcacggaccg
      661 tctcctcctt gctttcctcc ttaccctcta cctgggcctg gctcacgggc ttgatcagca
      721 agacctccgc tacctccggg cccagctaca aagaaaactc cacctgctct ctcggcccca
      781 ggatggggag gcagagtgag gagctcactc tggttacaag ccctgttctt cctctcccac
      841 tgaattctaa atccttaaca tccaggccct ggctgcttca tgccagaggc ccaaatccat
      901 ggactgaagg agatgcccct tctactactt gagactttat tctctgggtc cagctccata
      961 ccctaaattc tgagtttcag ccactgaact ccaaggtcca cttctcacca gcaaggaaga
     1021 gtggggtatg gaagtcatct gtcccttcac tgtttagagc atgacactct ccccctcaac
     1081 agcctcctga gaaggaaagg atctgccctg accactcccc tggcactgtt acttgcctct
     1141 gcgcctcagg ggtccccttc tgcaccgctg gcttccactc caagaaggtg gaccagggtc
     1201 tgcaagttca acggtcatag ctgtccctcc aggccccaac cttgcctcac cactcccggc
     1261 cctagtctct gcacctcctt aggccctgcc tctgggctca gaccccaacc tagtcaaggg
     1321 gattctcctg ctcttaactc gatgacttgg ggctccctgc tctcccgagg aagatgctct
     1381 gcaggaaaat aaaagtcagc ctttttctac a
//
