LOCUS       NM_031474               2757 bp    mRNA    linear   PRI 23-DEC-2024
DEFINITION  Homo sapiens nuclear receptor interacting protein 2 (NRIP2), mRNA.
ACCESSION   NM_031474
VERSION     NM_031474.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2757)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2757)
  AUTHORS   Wen,Z., Pan,T., Yang,S., Liu,J., Tao,H., Zhao,Y., Xu,D., Shao,W.,
            Wu,J., Liu,X., Wang,Y., Mao,J. and Zhu,Y.
  TITLE     Up-regulated NRIP2 in colorectal cancer initiating cells modulates
            the Wnt pathway by targeting RORbeta
  JOURNAL   Mol Cancer 16 (1), 20 (2017)
   PUBMED   28137278
  REMARK    GeneRIF: Results show that NRIP2 was significantly up-regulated in
            Colorectal cancer initiating cells (CCICs) from both cell lines and
            primary colorectal cancer tissues, and identified it as a novel
            molecule acting in Wnt pathway. The interaction between NRIP2 and
            RORbeta activates downstream target HBP1 and is probably involved
            in CCIC self-renewal.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2757)
  AUTHORS   Nakashima,K., Hirota,T., Suzuki,Y., Akahoshi,M., Shimizu,M.,
            Jodo,A., Doi,S., Fujita,K., Ebisawa,M., Yoshihara,S., Enomoto,T.,
            Shirakawa,T., Kishi,F., Nakamura,Y. and Tamari,M.
  TITLE     Association of the RIP2 gene with childhood atopic asthma
  JOURNAL   Allergol Int 55 (1), 77-83 (2006)
   PUBMED   17075290
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2757)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   5  (bases 1 to 2757)
  AUTHORS   Greiner,E.F., Kirfel,J., Greschik,H., Huang,D., Becker,P.,
            Kapfhammer,J.P. and Schule,R.
  TITLE     Differential ligand-dependent protein-protein interactions between
            nuclear receptors and a neuronal-specific cofactor
  JOURNAL   Proc Natl Acad Sci U S A 97 (13), 7160-7165 (2000)
   PUBMED   10860982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA391605.1, AL136557.1 and BC036063.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031474.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136557.1, BC036063.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337508.9/ ENSP00000337501.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA391605.1         21-32
            13-2044             AL136557.1         1-2032
            2045-2502           BC036063.1         2038-2495
            2503-2704           AL136557.1         2490-2691
            2705-2705           BC036063.1         2698-2698
            2706-2757           AL136557.1         2693-2744
FEATURES             Location/Qualifiers
     source          1..2757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..2757
                     /gene="NRIP2"
                     /gene_synonym="NIX1"
                     /note="nuclear receptor interacting protein 2"
                     /db_xref="GeneID:83714"
                     /db_xref="HGNC:HGNC:23078"
                     /db_xref="MIM:621054"
     exon            1..394
                     /gene="NRIP2"
                     /gene_synonym="NIX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..898
                     /gene="NRIP2"
                     /gene_synonym="NIX1"
                     /codon_start=1
                     /product="nuclear receptor-interacting protein 2"
                     /protein_id="NP_113662.1"
                     /db_xref="CCDS:CCDS8514.1"
                     /db_xref="GeneID:83714"
                     /db_xref="HGNC:HGNC:23078"
                     /db_xref="MIM:621054"
                     /translation="MLFIFPLSLPWRPSCWKESCSTGQRQAGRSREDSVTPPPSSPWP
                     TPPAGAMSTKQEARRDEGEARTRGQEAQLRDRAHLSQQRRLKQATQFLHKDSADLLPL
                     DSLKRLGTSKDLQPRSVIQRRLVEGNPNWLQGEPPRMQDLIHGQESRRKTSRTEIPAL
                     LVNCKCQDQLLRVAVDTGTQYNRISAGCLSRLGLEKRVLKASAGDLAPGPPTQVEQLE
                     LQLGQETVVCSAQVVDAESPEFCLGLQTLLSLKCCIDLEHGVLRLKAPFSELPFLPLY
                     QEPGQ"
     exon            395..547
                     /gene="NRIP2"
                     /gene_synonym="NIX1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..630
                     /gene="NRIP2"
                     /gene_synonym="NIX1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..752
                     /gene="NRIP2"
                     /gene_synonym="NIX1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..805
                     /gene="NRIP2"
                     /gene_synonym="NIX1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..2757
                     /gene="NRIP2"
                     /gene_synonym="NIX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2738..2743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRIP2"
                     /gene_synonym="NIX1"
                     /note="hexamer: AATAAA"
     polyA_site      2757
                     /gene="NRIP2"
                     /gene_synonym="NIX1"
                     /note="major polyA site"
ORIGIN      
        1 actccctcta cagcaatctc gggaaattgg agactgacgc ggctgctcct gcatgttatt
       61 tatttttcct ctttccctcc cgtggagacc ctcctgttgg aaagagagct gcagcacggg
      121 acagagacag gcaggaagaa gcagagagga ctcggtgacg cccccaccga gcagcccctg
      181 gcccactcct ccagcagggg ccatgagcac caagcaggag gccaggagag atgagggaga
      241 agccaggacg agggggcagg aggcacagct tcgagaccga gcccacctga gccagcagcg
      301 ccggctcaaa caggccaccc agttcctgca caaggactcg gccgacctgc tcccgctgga
      361 cagcctcaag aggctcggca cctccaagga cttgcagccg cgcagtgtga tccaaagacg
      421 cctggtggag ggaaacccga attggcttca gggggagcct ccccggatgc aggacctgat
      481 tcatggccag gagagcagga ggaagaccag caggacagag attccagctc ttctggtcaa
      541 ctgcaagtgc caggaccagc tgcttagagt ggccgttgac acaggcaccc aatacaatcg
      601 gatctctgct ggatgtctca gccgcctggg gttagagaaa agggtcctaa aagcctcagc
      661 tggggacctg gcccctgggc ccccaaccca ggtggagcag ttggagctac agctggggca
      721 ggagactgtg gtgtgctcgg cacaggtggt ggatgctgag agtcctgaat tctgcctggg
      781 cctgcagact ctgctttctc tcaagtgctg catcgacctg gagcacggag tgctgcggct
      841 gaaagccccg ttctcagagc tacccttcct gcctttgtac caagagcctg gccagtgact
      901 gctgtctcag tcagtcccca gagggaaaga ccttgcctta gaagaagagg cgtgtgggga
      961 acgggggctc ttgaagccag gtagctgggg actatggtgt ctgcccttcc aatcacctcc
     1021 ctgacccctg ctgtcccatt ttccccagct ggccgcattc ctctctgctt ctcagcagct
     1081 gtcctactcc ccaggacgag ttttcactag agggcccacg atgccaggat tctgattcat
     1141 cttcctccca agaaaagcaa agccaaatca agaccacaga taggaaccta agcacaatgg
     1201 ggtgcctgct tgggctgggt cgaaggctct gctgactgct gtccttgtcc atcacccaat
     1261 accaccccaa acacaactca acttcccaca ccaccatgtc tctcaccaca ccttctgggc
     1321 ctcattatct cccacaacta gaccgccatg cctcaccaac ctatgtccct ggacctcctg
     1381 gtgtctgcct ctcggagtct gtgcacatct gctcacagtt gagtggggga agaaacagcc
     1441 agaattcaat acaacaaaga gcgggagtta gtataggaat gtccatctca taaggctgag
     1501 agctattttt tcctgtggct gcaaatgtct gaagccagtt agtttgatta ccctgtgcaa
     1561 aaccttggac atacttctgc tattaacgct ataggtattt atccgtttcc actggctttt
     1621 tgtacccacc gagcccctga gccttgcgtg tgtgtgtgtg gaagagcctt gtagagaact
     1681 gctcctgtga ggcagacagg acagtgaggt tgtcaccact cagacttcac ctattcagca
     1741 ttctttctga tttctagaac tatccacctc attaggcctt cttcctatcc ccatctctgg
     1801 cctcttgagc ttaagcttgt attgtcctgg aatcagtggc tttctaaccc cctgccaggc
     1861 tttgccaaag caaaaagaca gaggcttttt tttttttttt aaagtttggg gtctgtcagg
     1921 agacagaggc ttttttgaat tcactgtgaa gagaagaacc cgaaccttaa gacgccagat
     1981 ccctgagagt ctttctggct ggtttgagtc tctcaaatca tggattagga gtaaagaaag
     2041 aggccaggcg caatggctca tgcctgtaat cccagcactt tgggaggctg aggtgggtgg
     2101 atcacttgag gtcaggagtt tgagaccagc ctgggtaata tggcaaaacc ccatctctac
     2161 taaaaaatac aaaaattagc caggtatggt ggtgaacacc tgtaatccca gctacttgga
     2221 aggctgaggc ataggagttg cttgaacctg ggagatgggg gttgtagtga gccaagttcg
     2281 tgccatcgga ctccagcctg ggtgaaggag tgagaccctg tctccaaaaa caaacaaaaa
     2341 aggagcagag aaagacagtg gtacagctaa cctgaacaag ggaactggga ccgttgggct
     2401 gaaacagtct tgagcctggg gttgactggg ttagagaaga accgggatgc aaggagctgc
     2461 ctgtgacacc tggcctgccc tttctcagct gcctcccctg ccctttctca gctgcctccc
     2521 ctgccctcag aaggaaagga gagggctcac ttatcacttg tgccatagca cctggtctca
     2581 aaatcctaaa agctttcctc gccctcactg ccttgctcca caaggtccac tttcctgggt
     2641 cttgtgctgt gcctttcctt gtctgcctcc tgctgcttct gtaactgcag accccaggcc
     2701 caatggcaag ccctcggctc agctgcttct ccattggaat aaactcttgt ttctcta
//
