LOCUS       NM_003489               7751 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens nuclear receptor interacting protein 1 (NRIP1), mRNA.
ACCESSION   NM_003489
VERSION     NM_003489.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7751)
  AUTHORS   Cao,X., Fang,H. and Zhou,L.
  TITLE     CircNRIP1 promotes proliferation, migration and phenotypic switch
            of Ang II-induced HA-VSMCs by increasing CXCL5 mRNA stability via
            recruiting IGF2BP1
  JOURNAL   Autoimmunity 57 (1), 2304820 (2024)
   PUBMED   38269483
  REMARK    GeneRIF: CircNRIP1 promotes proliferation, migration and phenotypic
            switch of Ang II-induced HA-VSMCs by increasing CXCL5 mRNA
            stability via recruiting IGF2BP1.
REFERENCE   2  (bases 1 to 7751)
  AUTHORS   Sfeir,N., Kajdan,M., Jalaguier,S., Bonnet,S., Teyssier,C.,
            Pyrdziak,S., Yuan,R., Bousquet,E., Maraver,A., Bernex,F., Pirot,N.,
            Boissiere-Michot,F., Castet-Nicolas,A., Lapierre,M. and
            Cavailles,V.
  TITLE     RIP140 regulates transcription factor HES1 oscillatory expression
            and mitogenic activity in colon cancer cells
  JOURNAL   Mol Oncol 18 (6), 1510-1530 (2024)
   PUBMED   38459621
  REMARK    GeneRIF: RIP140 regulates transcription factor HES1 oscillatory
            expression and mitogenic activity in colon cancer cells.
REFERENCE   3  (bases 1 to 7751)
  AUTHORS   Watanabe,F., Sato,S., Hirose,T., Endo,M., Endo,A., Ito,H., Ohba,K.,
            Mori,T. and Takahashi,K.
  TITLE     NRIP1 regulates cell proliferation in lung adenocarcinoma cells
  JOURNAL   J Biochem 175 (3), 323-333 (2024)
   PUBMED   38102728
  REMARK    GeneRIF: NRIP1 regulates cell proliferation in lung adenocarcinoma
            cells.
REFERENCE   4  (bases 1 to 7751)
  AUTHORS   Gao,X., Yu,S., Liu,S., Zhang,S., Sha,X., Sun,D. and Jiang,X.
  TITLE     Circular RNA nuclear receptor interacting protein 1 promoted
            biliary tract cancer epithelial-mesenchymal transition and stemness
            by regulating the miR-515-5p/AKT2 axis and PI3K/AKT/mTOR signaling
            pathway
  JOURNAL   Environ Toxicol 38 (11), 2632-2644 (2023)
   PUBMED   37466171
  REMARK    GeneRIF: Circular RNA nuclear receptor interacting protein 1
            promoted biliary tract cancer epithelial-mesenchymal transition and
            stemness by regulating the miR-515-5p/AKT2 axis and PI3K/AKT/mTOR
            signaling pathway.
REFERENCE   5  (bases 1 to 7751)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7751)
  AUTHORS   Treuter,E., Albrektsen,T., Johansson,L., Leers,J. and
            Gustafsson,J.A.
  TITLE     A regulatory role for RIP140 in nuclear receptor activation
  JOURNAL   Mol Endocrinol 12 (6), 864-881 (1998)
   PUBMED   9626662
REFERENCE   7  (bases 1 to 7751)
  AUTHORS   Yan,Z.H., Karam,W.G., Staudinger,J.L., Medvedev,A., Ghanayem,B.I.
            and Jetten,A.M.
  TITLE     Regulation of peroxisome proliferator-activated receptor
            alpha-induced transactivation by the nuclear orphan receptor
            TAK1/TR4
  JOURNAL   J Biol Chem 273 (18), 10948-10957 (1998)
   PUBMED   9556573
REFERENCE   8  (bases 1 to 7751)
  AUTHORS   Katsanis,N., Ives,J.H., Groet,J., Nizetic,D. and Fisher,E.M.
  TITLE     Localisation of receptor interacting protein 140 (RIP140) within
            100 kb of D21S13 on 21q11, a gene-poor region of the human genome
  JOURNAL   Hum Genet 102 (2), 221-223 (1998)
   PUBMED   9521594
REFERENCE   9  (bases 1 to 7751)
  AUTHORS   L'Horset,F., Dauvois,S., Heery,D.M., Cavailles,V. and Parker,M.G.
  TITLE     RIP-140 interacts with multiple nuclear receptors by means of two
            distinct sites
  JOURNAL   Mol Cell Biol 16 (11), 6029-6036 (1996)
   PUBMED   8887632
REFERENCE   10 (bases 1 to 7751)
  AUTHORS   Cavailles,V., Dauvois,S., L'Horset,F., Lopez,G., Hoare,S.,
            Kushner,P.J. and Parker,M.G.
  TITLE     Nuclear factor RIP140 modulates transcriptional activation by the
            estrogen receptor
  JOURNAL   EMBO J 14 (15), 3741-3751 (1995)
   PUBMED   7641693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF127577.2, AK289786.1 and
            BC040361.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003489.3.
            
            Summary: Nuclear receptor interacting protein 1 (NRIP1) is a
            nuclear protein that specifically interacts with the
            hormone-dependent activation domain AF2 of nuclear receptors. Also
            known as RIP140, this protein modulates transcriptional activity of
            the estrogen receptor. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289786.1, SRR11853558.16244.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318948.7/ ENSP00000327213.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AF127577.2         147474-147668       c
            196-986             AK289786.1         1-791
            987-3653            BC040361.1         486-3152
            3654-4195           AK289786.1         3459-4000
            4196-4502           BC040361.1         3695-4001
            4503-7751           AF127577.2         43903-47151         c
FEATURES             Location/Qualifiers
     source          1..7751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q11.2-q21.1"
     gene            1..7751
                     /gene="NRIP1"
                     /gene_synonym="CAKUT3; RIP140"
                     /note="nuclear receptor interacting protein 1"
                     /db_xref="GeneID:8204"
                     /db_xref="HGNC:HGNC:8001"
                     /db_xref="MIM:602490"
     exon            1..256
                     /gene="NRIP1"
                     /gene_synonym="CAKUT3; RIP140"
                     /inference="alignment:Splign:2.1.0"
     exon            257..336
                     /gene="NRIP1"
                     /gene_synonym="CAKUT3; RIP140"
                     /inference="alignment:Splign:2.1.0"
     exon            337..459
                     /gene="NRIP1"
                     /gene_synonym="CAKUT3; RIP140"
                     /inference="alignment:Splign:2.1.0"
     exon            460..7751
                     /gene="NRIP1"
                     /gene_synonym="CAKUT3; RIP140"
                     /inference="alignment:Splign:2.1.0"
     CDS             794..4270
                     /gene="NRIP1"
                     /gene_synonym="CAKUT3; RIP140"
                     /note="nuclear factor RIP140; receptor-interacting protein
                     140"
                     /codon_start=1
                     /product="nuclear receptor-interacting protein 1"
                     /protein_id="NP_003480.2"
                     /db_xref="CCDS:CCDS13568.1"
                     /db_xref="GeneID:8204"
                     /db_xref="HGNC:HGNC:8001"
                     /db_xref="MIM:602490"
                     /translation="MTHGEELGSDVHQDSIVLTYLEGLLMHQAAGGSGTAVDKKSAGH
                     NEEDQNFNISGSAFPTCQSNGPVLNTHTYQGSGMLHLKKARLLQSSEDWNAAKRKRLS
                     DSIMNLNVKKEALLAGMVDSVPKGKQDSTLLASLLQSFSSRLQTVALSQQIRQSLKEQ
                     GYALSHDSLKVEKDLRCYGVASSHLKTLLKKSKVKDQKPDTNLPDVTKNLIRDRFAES
                     PHHVGQSGTKVMSEPLSCAARLQAVASMVEKRASPATSPKPSVACSQLALLLSSEAHL
                     QQYSREHALKTQNANQAASERLAAMARLQENGQKDVGSYQLPKGMSSHLNGQARTSSS
                     KLMASKSSATVFQNPMGIIPSSPKNAGYKNSLERNNIKQAANNSLLLHLLKSQTIPKP
                     MNGHSHSERGSIFEESSTPTTIDEYSDNNPSFTDDSSGDESSYSNCVPIDLSCKHRTE
                     KSESDQPVSLDNFTQSLLNTWDPKVPDVDIKEDQDTSKNSKLNSHQKVTLLQLLLGHK
                     NEENVEKNTSPQGVHNDVSKFNTQNYARTSVIESPSTNRTTPVSTPPLLTSSKAGSPI
                     NLSQHSLVIKWNSPPYVCSTQSEKLTNTASNHSMDLTKSKDPPGEKPAQNEGAQNSAT
                     FSASKLLQNLAQCGMQSSMSVEEQRPSKQLLTGNTDKPIGMIDRLNSPLLSNKTNAVE
                     ENKAFSSQPTGPEPGLSGSEIENLLERRTVLQLLLGNPNKGKSEKKEKTPLRDESTQE
                     HSERALSEQILMVKIKSEPCDDLQIPNTNVHLSHDAKSAPFLGMAPAVQRSAPALPVS
                     EDFKSEPVSPQDFSFSKNGLLSRLLRQNQDSYLADDSDRSHRNNEMALLESKNLCMVP
                     KKRKLYTEPLENPFKKMKNNIVDAANNHSAPEVLYGSLLNQEELKFSRNDLEFKYPAG
                     HGSASESEHRSWARESKSFNVLKQLLLSENCVRDLSPHRSNSVADSKKKGHKNNVTNS
                     KPEFSISSLNGLMYSSTQPSSCMDNRTFSYPGVVKTPVSPTFPEHLGCAGSRPESGLL
                     NGCSMPSEKGPIKWVITDAEKNEYEKDSPRLTKTNPILYYMLQKGGNSVTSRETQDKD
                     IWREASSAESVSQVTAKEELLPTAETKASFFNLRSPYNSHMGNNASRPHSANGEVYGL
                     LGSVLTIKKESE"
     regulatory      7727..7732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRIP1"
                     /gene_synonym="CAKUT3; RIP140"
                     /note="hexamer: AATAAA"
     polyA_site      7751
                     /gene="NRIP1"
                     /gene_synonym="CAKUT3; RIP140"
                     /note="major polyA site"
ORIGIN      
        1 agacattgca gcagagcccc gaactcggga ggcggcggcg gaggaggcgg cggcgaggcg
       61 cagggacgac ccggccccac gcccgcccgc cacccgcgcg cgcccgtccg cccgtggcct
      121 cgcgtccgcc gctgcgccgt gagcgccgct ggtcggaggg aagagctcgc cggggcgccg
      181 ggccaggacg gggcggcagg cgccttcgcg gaccgagcct gacggagccg gaggctggga
      241 gccgcggcgg cctggggaag tgtttggatt gtgagctatt tcagaactgt tctcaggact
      301 cattatttta acatttggga gaaacacagc cagaagatgc acacttgact gaaggaggac
      361 agggaatctg aagactccgg atgacatcag agctactttt caacagcctt ctcaattttc
      421 tttctcagaa agcagaggct cagagcttgg agacagacga acactgatat ttgcatttaa
      481 tggggaacaa aagatgaaga aggaaaagga atatattcac taaggattct atctgcttac
      541 tgctacagac ctatgtgtta aggaattctt ctcctcctcc ttgcgtagaa gttgatcagc
      601 actgtggtca gactgcattt atcttgtcat tgccagaaga aatcttggac agaatgtaac
      661 agtacgtctc tctctgattg cgatggaagg tgataaactg atactccttt attaaagtta
      721 catcgcactc accacagaaa accattcttt aaagtgaata gaaaccaagc ccttgtgaac
      781 acttctattg aacatgactc atggagaaga gcttggctct gatgtgcacc aggattctat
      841 tgttttaact tacctagaag gattactaat gcatcaggca gcagggggat caggtactgc
      901 cgttgacaaa aagtctgctg ggcataatga agaggatcag aactttaaca tttctggcag
      961 tgcatttccc acctgtcaaa gtaatggtcc agttctcaat acacatacat atcaggggtc
     1021 tggcatgctg cacctcaaaa aagccagact gttgcagtct tctgaggact ggaatgcagc
     1081 aaagcggaag aggctgtctg attctatcat gaatttaaac gtaaagaagg aagctttgct
     1141 agctggcatg gttgacagtg tgcctaaagg caaacaggat agcacattac tggcctcttt
     1201 gcttcagtca ttcagctcta ggctgcagac tgttgctctg tcacaacaaa tcaggcagag
     1261 cctcaaggag caaggatatg ccctcagtca tgattcttta aaagtggaga aggatttaag
     1321 gtgctatggt gttgcatcaa gtcacttaaa aactttgttg aagaaaagta aagttaaaga
     1381 tcaaaagcct gatacgaatc ttcctgatgt gactaaaaac ctcatcagag ataggtttgc
     1441 agagtctcct catcatgttg gacaaagtgg aacaaaggtc atgagtgaac cgttgtcatg
     1501 tgctgcaaga ttacaggctg ttgcaagcat ggtggaaaaa agggctagtc ctgccacctc
     1561 acctaaacct agtgttgctt gtagccagtt agcattactt ctgtcaagcg aagcccattt
     1621 gcagcagtat tctcgagaac acgctttaaa aacgcaaaat gcaaatcaag cagcaagtga
     1681 aagacttgct gctatggcca gattgcaaga aaatggccag aaggatgttg gcagttacca
     1741 gctcccaaaa ggaatgtcaa gccatcttaa tggtcaggca agaacatcat caagcaaact
     1801 gatggctagc aaaagtagtg ctacagtgtt tcaaaatcca atgggtatca ttccttcttc
     1861 ccctaaaaat gcaggttata agaactcact ggaaagaaac aatataaaac aagctgctaa
     1921 caatagtttg cttttacatc ttcttaaaag ccagactata cctaagccaa tgaatggaca
     1981 cagtcacagt gagagaggaa gcatttttga ggaaagtagt acacctacaa ctattgatga
     2041 atattcagat aacaatccta gttttacaga tgacagcagt ggtgatgaaa gttcttattc
     2101 caactgtgtt cccatagact tgtcttgcaa acaccgaact gaaaaatcag aatctgacca
     2161 acctgtttcc ctggataact tcactcaatc cttgctaaac acttgggatc caaaagtccc
     2221 agatgtagat atcaaagaag atcaagatac ctcaaagaat tctaagctaa actcacacca
     2281 gaaagtaaca cttcttcaat tgctacttgg ccataagaat gaagaaaatg tagaaaaaaa
     2341 caccagccct cagggagtac acaatgatgt gagcaagttc aatacacaaa attatgcaag
     2401 gacttctgtg atagaaagcc ccagtacaaa tcggactact ccagtgagca ctccaccttt
     2461 acttacatca agcaaagcag ggtctcccat caatctctct caacactctc tggtcatcaa
     2521 atggaattcc ccaccatatg tctgcagtac tcagtctgaa aagctaacaa atactgcatc
     2581 taaccactca atggacctta caaaaagcaa agacccacca ggagagaaac cagcccaaaa
     2641 tgaaggtgca cagaactctg caacgtttag tgccagtaag ctgttacaaa atttagcaca
     2701 atgtggaatg cagtcatcca tgtcagtgga agagcagaga cccagcaaac agctgttaac
     2761 tggaaacaca gataaaccga taggtatgat tgatagatta aatagccctt tgctctcaaa
     2821 taaaacaaat gcagttgaag aaaataaagc atttagtagt caaccaacag gtcctgaacc
     2881 agggctttct ggttctgaaa tagaaaatct gcttgaaaga cgtactgtcc tccagttgct
     2941 cctggggaac cccaacaaag ggaagagtga aaaaaaagag aaaactccct taagagatga
     3001 aagtactcag gaacactcag agagagcttt aagtgaacaa atactgatgg tgaaaataaa
     3061 atctgagcct tgtgatgact tacaaattcc taacacaaat gtgcacttga gccatgatgc
     3121 taagagtgcc ccattcttgg gtatggctcc tgctgtgcag agaagcgcac ctgccttacc
     3181 agtgtccgaa gactttaaat cggagcctgt ttcacctcag gatttttctt tctccaagaa
     3241 tggtctgcta agtcgattgc taagacaaaa tcaagatagt tacctggcag atgattcaga
     3301 caggagtcac agaaataatg aaatggcact tctagaatca aagaatcttt gcatggtccc
     3361 taagaaaagg aagctttata ctgagccatt agaaaatcca tttaaaaaga tgaaaaacaa
     3421 cattgttgat gctgcaaaca atcacagtgc cccagaagta ctgtatgggt ccttgcttaa
     3481 ccaggaagag ctgaaattta gcagaaatga tcttgaattt aaatatcctg ctggtcatgg
     3541 ctcagccagc gaaagtgaac acaggagttg ggccagagag agcaaaagct ttaatgttct
     3601 gaaacagctg cttctctcag aaaactgtgt gcgagatttg tccccgcaca gaagtaactc
     3661 tgtggctgac agtaaaaaga aaggacacaa aaataatgtg accaacagca aacctgaatt
     3721 tagcatttct tctttaaatg gactgatgta cagttccact cagcccagca gttgcatgga
     3781 taacaggaca ttttcatacc caggtgtagt aaaaactcct gtgagtccta ctttccctga
     3841 gcacttgggc tgtgcagggt ctagaccaga atctgggctt ttgaatgggt gttccatgcc
     3901 cagtgagaaa ggacccatta agtgggttat cactgatgcg gagaagaatg agtatgaaaa
     3961 agactctcca agattgacca aaaccaaccc aatactatat tacatgcttc aaaaaggagg
     4021 caattctgtt accagtcgag aaacacaaga caaggacatt tggagggagg cttcatctgc
     4081 tgaaagtgtc tcacaggtca cagccaaaga agagttactt cctactgcag aaacgaaagc
     4141 ttctttcttt aatttaagaa gcccttacaa tagccatatg ggaaataatg cttctcgccc
     4201 acacagcgca aatggagaag tttatggact tctgggaagc gtgctaacga taaagaaaga
     4261 atcagaataa aatgtacctg ccatccagtt ttggatcttt ttaaaactaa tgagtatgaa
     4321 cttgagatct gtataaataa gagcatgatt tgaaaaaaag catggtataa ttgaaacttt
     4381 tttcattttg aaaagtattg gttactggtg atgttgaaat atgcatacta atttttgctt
     4441 aacattagat gtcatgagga aactactgaa ctagcaattg gttgtttaac acttctgtat
     4501 gcatcagata acaactgtga gtagcctatg aatgaaattc ttttataaat attaggcata
     4561 aattaaaatg taaaactcca ttcatagtgg attaatgcat tttgctgcct ttattagggt
     4621 actttatttt gcttttcaga agtcagccta cataacacat ttttaaagtc taaactgtta
     4681 aacaactctt taaaggataa ttatccaata aaaaaaaacc tagtgctgat tcacagctta
     4741 ttatccaatt caaaaataaa ttagaaaaat atatgcttac atttttcact tttgctaaaa
     4801 agaaaaaaaa aaggtgttta tttttaactc ttggaagagg ttttgtggtt cccaatgtgt
     4861 ctgtcccacc ctgatccttt tcaatatata tttctttaaa ccttgtgcta cttagtaaaa
     4921 attgattaca attgagggaa gtttgataga tcctttaaaa aaaaggcaga tttccatttt
     4981 ttgtatttta actactttac taaattaata ctcctccttt tacagaatta gaaaagttaa
     5041 catttatctt taggtggttt cctgaaaagt tgaatattta agaaattgtt tttaacagaa
     5101 gcaaaatggc ttttctttgg acagttttca ccatctcttg taaaagttaa ttctcaccat
     5161 tcctgtggta cctgcgagtg ttatgaccag gattccttaa acctgaactc agaccacttg
     5221 cattagaacc atctggagca cttgttttaa aatgcagatt cataggcagc atctcagatc
     5281 tacagaacaa gaatctctgc taagtggacc tggaatcttc catctgcatc ttaacatgct
     5341 ctctaggtgt ttcttgtgtt tgagaaccat gacttatgac tttcctcaga acatgagact
     5401 gtaaaacaaa aacaaaaaac tatgtgatgc ctctattttc cccaatacag tcacacatca
     5461 gctcaaaatt tgcaatattg tagttcatat attaccgtta tgtctttgga aatcgggttc
     5521 agaacacttt ttatgacaaa aattgggtgg aggggataac tttcatatct ggctcaacat
     5581 ctcaggaaaa tctgtgatta tttgtgtgtt ctaatgagta acatctactt agttagcctt
     5641 agggatggaa aaacagggcc acttaccaaa ctcaggtgat tccaggatgg tttggaaact
     5701 tctcctgaat gcatccttaa cctttattaa aaccattgtc ctaagaacaa tgccaacaaa
     5761 gcttacaaca tttagtttaa acccaagaag ggcactaaac tcagattgac taaataaaaa
     5821 gtacaaaggg cacatatacg tgacagaatt gtacacaatc actccattgg atcttttact
     5881 ttaaagtagt gatgaaaagt acatgttgat actgtcttag aagaaattaa tatattagtg
     5941 aagccacatg gggtttcagt tgcgaaacag gtctgttttt atgttcagtt tgtacaatcc
     6001 acaattcatt caccagatat tttgttctta attgtgaacc aggttagcaa atgacctatc
     6061 aaaaattatt ctataatcac tactagttag gatattgatt taaaattgtt ctacttgaag
     6121 tggtttctaa gatttttata ttaaaaatag gtgtgatttc ctaatatgat ctaaaaccct
     6181 aaatggttat ttttcctcag aatgatttgt aaatagctac tggaaatatt atacagtaat
     6241 aggagtgggt attatgcaac atcatggaga agtgaaggca taggcttatt ctgacataaa
     6301 attccactgg ccagttgaat atattctatt ccatgtccat actatgacaa tcttattgtc
     6361 aacactatat aaataagctt ttaaacaagt catttttctt gatcgttgtg gaaggtttgg
     6421 agccttagag gtatgtcaga aaaaatatgt tggtattctc ccttgggtag ggggaaatga
     6481 cctttttaca agagagtgaa atttaggtca gggaaaagac caagggccag cattgctact
     6541 tttgtgtgtg tgtgtgtggg ttttgttttg tttttttggt tggctggttg ttttcgttgt
     6601 tgttaacaaa ggaatgagaa tatgtaatac ttaaataaac atgaccacga agaatgctgt
     6661 tctgatttac tagagaatgt tcccaatttg aatttagggt gattttaaag aacagtgaga
     6721 aagggcatac atccacagat tcactttgtt tatgcatatg tagatacaag gatgcacata
     6781 tacacatttt caaggactat tttagatatc tagacaattt cttctaataa agtcatttgt
     6841 gaaagggtac tacagcttat tgacatcagt aaggtagcat tcattacctg tttattctct
     6901 gctgcatctt acagaagagt aaactggtga gagtatatat tttatatata tatatatata
     6961 tatatatata atatgtatat atatatatat tgacttgtta catgaagatg ttaaaatcgg
     7021 tttttaaagg tgatgtaaat agtgatttcc ttaatgaaaa atacatattt tgtattgttc
     7081 taatgcaaca gaaaagcctt ttaatctctt tggttcctgt atattccatg tataagtgta
     7141 aatataatca gacaggttta aaagttgtgc atgtatgtat acagttgcaa gtctggacaa
     7201 atgtatagaa taaacctttt atttaagttg tgattacctg ctgcatgaaa agtgcatggg
     7261 ggaccctgtg catctgtgca tttggcaaaa tgtcttaaca aatcagatca gatgttcatc
     7321 ctaacatgac agtattccat ttctggacat gacgtctgtg gtttaagctt tgtgaaagaa
     7381 tgtgctttga ttcgaagggt cttaaagaat ttttttaatc gtcaaccact tttaaacata
     7441 aagaattcac acaactactt tcatgaattt tttaatccca ttgcaaacat tattccaaga
     7501 gtatcccagt attagcaata ctggaatata ggcacattac cattcatagt aagaattctg
     7561 gtgtttacac aaccaaattt gatgcgatct gctcagtaat ataatttgcc atttttatta
     7621 gaaatttaat ttcttcatgt gatgtcatga aactgtacat actgcagtgt gaattttttt
     7681 gttttgtttt ttaatctttt agtgtttact tcctgcagtg aatttgaata aatgagaaaa
     7741 aatgcattgt c
//
