LOCUS       NM_006176               1210 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens neurogranin (NRGN), transcript variant 1, mRNA.
ACCESSION   NM_006176
VERSION     NM_006176.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1210)
  AUTHORS   Jurasova,V., Andel,R., Katonova,A., Veverova,K., Zuntychova,T.,
            Horakova,H., Vyhnalek,M., Kolarova,T., Matoska,V., Blennow,K. and
            Hort,J.
  TITLE     CSF neurogranin levels as a biomarker in Alzheimer's disease and
            frontotemporal lobar degeneration: a cross-sectional analysis
  JOURNAL   Alzheimers Res Ther 16 (1), 199 (2024)
   PUBMED   39242539
  REMARK    GeneRIF: CSF neurogranin levels as a biomarker in Alzheimer's
            disease and frontotemporal lobar degeneration: a cross-sectional
            analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1210)
  AUTHORS   Jorgensen,A.N., Rashdan,N.A., Rao,K.N.S., Delgadillo,L.F.,
            Kolluru,G.K., Krzywanski,D.M., Pattillo,C.B., Kevil,C.G. and
            Nam,H.W.
  TITLE     Neurogranin expression regulates mitochondrial function and redox
            balance in endothelial cells
  JOURNAL   Redox Biol 70, 103085 (2024)
   PUBMED   38359746
  REMARK    GeneRIF: Neurogranin expression regulates mitochondrial function
            and redox balance in endothelial cells.
REFERENCE   3  (bases 1 to 1210)
  AUTHORS   Kusdogan,M., Vural,S., Albayrak,L., Caltekin,I. and Gokcen,E.
  TITLE     The diagnostic and prognostic value of serum neurogranin in acute
            ischemic stroke
  JOURNAL   J Stroke Cerebrovasc Dis 32 (2), 106889 (2023)
   PUBMED   36481578
  REMARK    GeneRIF: The diagnostic and prognostic value of serum neurogranin
            in acute ischemic stroke.
REFERENCE   4  (bases 1 to 1210)
  AUTHORS   Kivisakk,P., Carlyle,B.C., Sweeney,T., Quinn,J.P., Ramirez,C.E.,
            Trombetta,B.A., Mendes,M., Brock,M., Rubel,C., Czerkowicz,J.,
            Graham,D. and Arnold,S.E.
  TITLE     Increased levels of the synaptic proteins PSD-95, SNAP-25, and
            neurogranin in the cerebrospinal fluid of patients with Alzheimer's
            disease
  JOURNAL   Alzheimers Res Ther 14 (1), 58 (2022)
   PUBMED   35461266
  REMARK    GeneRIF: Increased levels of the synaptic proteins PSD-95, SNAP-25,
            and neurogranin in the cerebrospinal fluid of patients with
            Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1210)
  AUTHORS   Martinez de Arrieta,C., Morte,B., Coloma,A. and Bernal,J.
  TITLE     The human RC3 gene homolog, NRGN contains a thyroid
            hormone-responsive element located in the first intron
  JOURNAL   Endocrinology 140 (1), 335-343 (1999)
   PUBMED   9886843
REFERENCE   6  (bases 1 to 1210)
  AUTHORS   Mertsalov,I.B., Stumm,M., Wieacker,P., tom Dieck,S.,
            Gundelfinger,E. and Tsetlin,V.I.
  TITLE     [Structure and chromosomal localization of human neurogranin gene]
  JOURNAL   Bioorg Khim 23 (12), 961-968 (1997)
   PUBMED   9499372
REFERENCE   7  (bases 1 to 1210)
  AUTHORS   Martinez de Arrieta,C., Perez Jurado,L., Bernal,J. and Coloma,A.
  TITLE     Structure, organization, and chromosomal mapping of the human
            neurogranin gene (NRGN)
  JOURNAL   Genomics 41 (2), 243-249 (1997)
   PUBMED   9143500
REFERENCE   8  (bases 1 to 1210)
  AUTHORS   Mertsalov,I.B., Gundelfinger,E. and Tsetlin,V.I.
  TITLE     [Cloning cDNA for human neurogranin]
  JOURNAL   Bioorg Khim 22 (5), 366-369 (1996)
   PUBMED   8929222
REFERENCE   9  (bases 1 to 1210)
  AUTHORS   Watson,J.B., Szijan,I. and Coulter,P.M. 2nd.
  TITLE     Localization of RC3 (neurogranin) in rat brain subcellular
            fractions
  JOURNAL   Brain Res Mol Brain Res 27 (2), 323-328 (1994)
   PUBMED   7898318
REFERENCE   10 (bases 1 to 1210)
  AUTHORS   Huang,K.P., Huang,F.L. and Chen,H.C.
  TITLE     Characterization of a 7.5-kDa protein kinase C substrate (RC3
            protein, neurogranin) from rat brain
  JOURNAL   Arch Biochem Biophys 305 (2), 570-580 (1993)
   PUBMED   8080473
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB474181.1, Y09689.1,
            BC002835.2 and AP000866.4.
            
            On Nov 22, 2018 this sequence version replaced NM_006176.2.
            
            Summary: Neurogranin (NRGN) is the human homolog of the
            neuron-specific rat RC3/neurogranin gene. This gene encodes a
            postsynaptic protein kinase substrate that binds calmodulin in the
            absence of calcium. The NRGN gene contains four exons and three
            introns. The exons 1 and 2 encode the protein and exons 3 and 4
            contain untranslated sequences. It is suggested that the NRGN is a
            direct target for thyroid hormone in human brain, and that control
            of expression of this gene could underlay many of the consequences
            of hypothyroidism on mental states during development as well as in
            adult subjects. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) uses an alternate splice
            acceptor site in a 3'UTR exon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DN989633.1, Y09689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284292.11/ ENSP00000284292.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DB474181.1         10-23
            15-1200             Y09689.1           1-1186
            1201-1206           BC002835.2         1101-1106
            1207-1210           AP000866.4         65824-65827
FEATURES             Location/Qualifiers
     source          1..1210
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..1210
                     /gene="NRGN"
                     /gene_synonym="hng; RC3"
                     /note="neurogranin"
                     /db_xref="GeneID:4900"
                     /db_xref="HGNC:HGNC:8000"
                     /db_xref="MIM:602350"
     exon            1..158
                     /gene="NRGN"
                     /gene_synonym="hng; RC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..380
                     /gene="NRGN"
                     /gene_synonym="hng; RC3"
                     /note="calmodulin-binding protein; protein kinase C
                     substrate; neurogranin (protein kinase C substrate, RC3)"
                     /codon_start=1
                     /product="neurogranin"
                     /protein_id="NP_006167.1"
                     /db_xref="CCDS:CCDS8451.1"
                     /db_xref="GeneID:4900"
                     /db_xref="HGNC:HGNC:8000"
                     /db_xref="MIM:602350"
                     /translation="MDCCTENACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARK
                     KIKSGERGRKGPGPGGPGGAGVARGGAGGGPSGD"
     exon            159..385
                     /gene="NRGN"
                     /gene_synonym="hng; RC3"
                     /inference="alignment:Splign:2.1.0"
     exon            386..403
                     /gene="NRGN"
                     /gene_synonym="hng; RC3"
                     /inference="alignment:Splign:2.1.0"
     exon            404..1210
                     /gene="NRGN"
                     /gene_synonym="hng; RC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1185..1190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRGN"
                     /gene_synonym="hng; RC3"
                     /note="hexamer: AATAAA"
     polyA_site      1210
                     /gene="NRGN"
                     /gene_synonym="hng; RC3"
                     /note="major polyA site"
ORIGIN      
        1 agaccggacc cgagagcaga gctgctgttt cggcgcgggt cggctggcgg ccgactgccc
       61 cagagccccc acccggcacc acacagaccc cacccccgcc ctgcgccagc cttcgtcccc
      121 gcagaggacc ccccgacacc agcatggact gctgcaccga gaacgcctgc tccaagccgg
      181 acgacgacat tctagacatc ccgctggacg atcccggcgc caacgcggcc gccgccaaaa
      241 tccaggcgag ttttcggggc cacatggcgc ggaagaagat aaagagcgga gagcgcggcc
      301 ggaagggccc gggccctggg gggcctggcg gagctggggt ggcccgggga ggcgcgggcg
      361 gcggccccag cggagactag gccagaactg agcattttca aagttcccga ggagagatgg
      421 atgccgcgtc cccttcgcag cgacgagact tccctgccgt gtttgtgacc ccctcctgcc
      481 cagcaacctg ccagctacag gagccccctg cgtcccagag actccctcac ccaggcaggc
      541 tccgtcgcgg agtcgctgag tccgtgccct tttagttagt tctgcagtct agtatggtcc
      601 ccatttgccc ttccactcca ccccacccta aaccatgcgc tcccaatctt ccttcttttg
      661 cttctcgccc acctcttccc gcacccagca tgcagctctg cctccgcagc ctcagtgcgc
      721 tttcctgcgc gcactgcgga gggcgcccta agcgtcaccc aagcacactc acttaaagaa
      781 aaaacgagtt ctttcgttct gtgcgcagct aaaaggggcg ccctacatct ccgtgccact
      841 cccgccccag cctagcccca agactttgga tccggggcga gatgaaggga agagggttgt
      901 tttggtttcg gacgaccctt gctctgaccg gaagagaagt ccctatccca cacctgcctg
      961 tcacgttccc tcccctttcc ccagcgcact gttgagggca gcctctccag ctctcttgtt
     1021 tatgcaaacg ccgagcgcct gggaggctcg gtaggaggag tcttccacgg ccccgccccg
     1081 cccctgtcgg tcccgccctc ccccccgccg ggctcctggg gctgtggccg aaaggtttct
     1141 gatctccgtg tgtgcatgtg actgtgctgg gttggaatgt gaacaataaa gaggaatgtc
     1201 caagtgttca
//
