LOCUS       NM_001010848            3811 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens neuregulin 3 (NRG3), transcript variant 1, mRNA.
ACCESSION   NM_001010848 XM_166086
VERSION     NM_001010848.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3811)
  AUTHORS   Ahmad,T., Vullhorst,D., Chaudhuri,R., Guardia,C.M., Chaudhary,N.,
            Karavanova,I., Bonifacino,J.S. and Buonanno,A.
  TITLE     Transcytosis and trans-synaptic retention by postsynaptic ErbB4
            underlie axonal accumulation of NRG3
  JOURNAL   J Cell Biol 221 (7) (2022)
   PUBMED   35579602
  REMARK    GeneRIF: Transcytosis and trans-synaptic retention by postsynaptic
            ErbB4 underlie axonal accumulation of NRG3.
REFERENCE   2  (bases 1 to 3811)
  AUTHORS   Kara,H.G., Erdal,M.E., Yilmaz,S.G., Sengul,C., Sengul,C.B. and
            Karakulah,K.
  TITLE     Association of NRG3 and ERBB4 gene polymorphism with nicotine
            dependence in Turkish population
  JOURNAL   Mol Biol Rep 48 (6), 5319-5326 (2021)
   PUBMED   34247340
  REMARK    GeneRIF: Association of NRG3 and ERBB4 gene polymorphism with
            nicotine dependence in Turkish population.
REFERENCE   3  (bases 1 to 3811)
  AUTHORS   Zhou,Y., Li,Y., Meng,Y., Wang,J., Wu,F., Ning,Y., Li,Y.,
            Cassidy,R.M., Li,Z. and Zhang,X.Y.
  TITLE     Neuregulin 3 rs10748842 polymorphism contributes to the effect of
            body mass index on cognitive impairment in patients with
            schizophrenia
  JOURNAL   Transl Psychiatry 10 (1), 62 (2020)
   PUBMED   32066712
  REMARK    GeneRIF: Neuregulin 3 rs10748842 polymorphism contributes to the
            effect of body mass index on cognitive impairment in patients with
            schizophrenia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3811)
  AUTHORS   Li,Z., Liu,L., Lin,W., Zhou,Y., Zhang,G., Du,X., Li,Y., Tang,W. and
            Zhang,X.
  TITLE     NRG3 contributes to cognitive deficits in chronic patients with
            schizophrenia
  JOURNAL   Schizophr Res 215, 134-139 (2020)
   PUBMED   31753594
  REMARK    GeneRIF: NRG3 contributes to cognitive deficits in chronic patients
            with schizophrenia.
REFERENCE   5  (bases 1 to 3811)
  AUTHORS   Pinto,R., Assis,J., Nogueira,A., Pereira,C., Coelho,S., Brandao,M.,
            Dias,J., Alves,S., Pereira,D. and Medeiros,R.
  TITLE     Pharmacogenomics in epithelial ovarian cancer first-line treatment
            outcome: validation of GWAS-associated NRG3 rs1649942 and BRE
            rs7572644 variants in an independent cohort
  JOURNAL   Pharmacogenomics J 19 (1), 25-32 (2019)
   PUBMED   30287910
  REMARK    GeneRIF: The BRE rs7572644 and NRG3 rs1649942 genetic variants were
            validated in an independent cohort of EOC Portuguese patients.
REFERENCE   6  (bases 1 to 3811)
  AUTHORS   Benzel,I., Bansal,A., Browning,B.L., Galwey,N.W., Maycox,P.R.,
            McGinnis,R., Smart,D., St Clair,D., Yates,P. and Purvis,I.
  TITLE     Interactions among genes in the ErbB-Neuregulin signalling network
            are associated with increased susceptibility to schizophrenia
  JOURNAL   Behav Brain Funct 3, 31 (2007)
   PUBMED   17598910
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3811)
  AUTHORS   Carteron,C., Ferrer-Montiel,A. and Cabedo,H.
  TITLE     Characterization of a neural-specific splicing form of the human
            neuregulin 3 gene involved in oligodendrocyte survival
  JOURNAL   J Cell Sci 119 (Pt 5), 898-909 (2006)
   PUBMED   16478787
  REMARK    GeneRIF: The NRG3 protein is a new post-translationally regulated
            isoform of neuregulin 3 expressed in the developing human central
            nervous system with a role in oligodendrocyte survival.
REFERENCE   8  (bases 1 to 3811)
  AUTHORS   Hobbs,S.S., Coffing,S.L., Le,A.T., Cameron,E.M., Williams,E.E.,
            Andrew,M., Blommel,E.N., Hammer,R.P., Chang,H. and Riese,D.J. 2nd.
  TITLE     Neuregulin isoforms exhibit distinct patterns of ErbB family
            receptor activation
  JOURNAL   Oncogene 21 (55), 8442-8452 (2002)
   PUBMED   12466964
REFERENCE   9  (bases 1 to 3811)
  AUTHORS   Gizatullin,R.Z., Muravenko,O.V., Al-Amin,A.N., Wang,F.,
            Protopopov,A.I., Kashuba,V.I., Zelenin,A.V. and Zabarovsky,E.R.
  TITLE     Human NRG3 gene Map position 10q22-q23
  JOURNAL   Chromosome Res 8 (6), 560 (2000)
   PUBMED   11032326
REFERENCE   10 (bases 1 to 3811)
  AUTHORS   Zhang,D., Sliwkowski,M.X., Mark,M., Frantz,G., Akita,R., Sun,Y.,
            Hillan,K., Crowley,C., Brush,J. and Godowski,P.J.
  TITLE     Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that
            binds and activates ErbB4
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9562-9567 (1997)
   PUBMED   9275162
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL096706.10, BC136811.1,
            DQ001411.1 and AL589782.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001010848.3.
            
            Summary: This gene is a member of the neuregulin gene family. This
            gene family encodes ligands for the transmembrane tyrosine kinase
            receptors ERBB3 and ERBB4 - members of the epidermal growth factor
            receptor family. Ligand binding activates intracellular signaling
            cascades and the induction of cellular responses including
            proliferation, migration, differentiation, and survival or
            apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been
            shown to activate the tyrosine phosphorylation of its cognate
            receptor, ERBB4, and is thought to influence neuroblast
            proliferation, migration and differentiation by signalling through
            ERBB4. NRG3 also promotes mammary differentiation during
            embryogenesis. Linkage studies have implicated this gene as a
            susceptibility locus for schizophrenia and schizoaffective
            disorder. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. Additional transcript variants
            have been described but their biological validity has not been
            verified.[provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.171656.1, DQ001411.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372141.7/ ENSP00000361214.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AL096706.10        104967-105086
            121-165             BC136811.1         1-45
            166-2238            DQ001411.1         19-2091
            2239-3811           AL589782.7         7368-8940
FEATURES             Location/Qualifiers
     source          1..3811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..3811
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /note="neuregulin 3"
                     /db_xref="GeneID:10718"
                     /db_xref="HGNC:HGNC:7999"
                     /db_xref="MIM:605533"
     exon            1..970
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2238
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuregulin-3-like polypeptide"
                     /codon_start=1
                     /product="pro-neuregulin-3, membrane-bound isoform isoform
                     1"
                     /protein_id="NP_001010848.2"
                     /db_xref="CCDS:CCDS31233.1"
                     /db_xref="GeneID:10718"
                     /db_xref="HGNC:HGNC:7999"
                     /db_xref="MIM:605533"
                     /translation="MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEG
                     AAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDL
                     VDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTT
                     ITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPST
                     QAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHT
                     TTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPK
                     TDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQI
                     QEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVG
                     PQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGP
                     AYQQLEESRIPDQDTIPCQGYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGY
                     SSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQ
                     QEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQF
                     VLRNEIQRDSALTK"
     exon            971..1100
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1174
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1201
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1304
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1431
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1559
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1730
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..3811
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3618..3623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /note="hexamer: AATAAA"
     polyA_site      3657
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /note="major polyA site"
     regulatory      3785..3790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /note="hexamer: AATAAA"
     polyA_site      3811
                     /gene="NRG3"
                     /gene_synonym="HRG3; pro-NRG3"
                     /note="major polyA site"
ORIGIN      
        1 ggatttgcat gcggccgccg cggccgctgc ctgcgcccga gcccgccgcc gccgccggag
       61 cccgcgcccg cgcccgcgcc cggcccgcgc ggccccatgc ctctgccgcg gccctcgggg
      121 gggcgaaggt gaagaccggc tcctaggatg agtgaagggg cggccgctgc ctcgccacct
      181 ggtgccgctt cggcagccgc cgcctcggcc gaggagggca ccgcggcggc tgcggcggcg
      241 gcagcggcgg gcgggggccc ggacggcggc ggcgaagggg cggccgagcc cccccgggag
      301 ttacgctgta gcgactgcat cgtgtggaac cggcagcaga cgtggctgtg cgtggtacct
      361 ctgttcatcg gcttcatcgg cctggggctc agcctcatgc ttctcaaatg gatcgtggtg
      421 ggctccgtca aggagtacgt gcccaccgac ctagtggact ccaaggggat gggccaggac
      481 cccttcttcc tctccaagcc cagctctttc cccaaggcca tggagaccac caccactacc
      541 acttccacca cgtcccccgc caccccctcc gccgggggtg ccgcctcctc caggacgccc
      601 aaccggatta gcactcgcct gaccaccatc acgcgggcgc ccactcgctt ccccgggcac
      661 cgggtgccca tccgggccag cccgcgctcc accacagcac ggaacactgc ggcccctgcg
      721 acggtcccgt ccaccacggc cccgttcttc agtagcagca cgctgggctc ccgacccccg
      781 gtgccaggaa ctccaagtac ccaggcaatg ccctcctggc ctactgcggc atacgctacc
      841 tcctcctacc ttcacgattc tactccctcc tggaccctgt ctccctttca ggatgctgcc
      901 tcctcttctt cctcttcttc ctcctccgct accaccacca caccagaaac tagcaccagc
      961 cccaaatttc atacgacgac atattccaca gagcgatccg agcacttcaa accctgccga
     1021 gacaaggacc ttgcatactg tctcaatgat ggcgagtgct ttgtgatcga aaccctgacc
     1081 ggatcccata aacactgtcg gtgcaaagaa ggctaccaag gagtccgttg tgatcaattt
     1141 ctgccgaaaa ctgattccat cttatcggat ccaacagacc acttggggat tgaattcatg
     1201 gagagtgaag aagtttatca aaggcaggtg ctgtcaattt catgtatcat ctttggaatt
     1261 gtcatcgtgg gcatgttctg tgcagcattc tacttcaaaa gcaagaaaca agctaaacaa
     1321 atccaagagc agctgaaagt gccacaaaat ggtaaaagct acagtctcaa agcatccagc
     1381 acaatggcaa agtcagagaa cttggtgaag agccatgtcc agctgcaaaa ttattcaaag
     1441 gtggaaaggc atcctgtgac tgcattggag aaaatgatgg agtcaagttt tgtcggcccc
     1501 cagtcattcc ctgaggtccc ttctcctgac agaggaagcc agtctgtcaa acaccacagg
     1561 agtctatcct cttgctgcag cccagggcaa agaagtggca tgctccatag gaatgccttc
     1621 agaaggacac ccccgtcacc ccgaagtagg ctaggtggaa ttgtgggacc agcatatcag
     1681 caactcgaag aatcaaggat cccagaccag gatacgatac cttgccaagg gtattcatcc
     1741 agtggtttaa aaacccaacg aaatacatca ataaatatgc aactgccttc aagagagaca
     1801 aacccctatt ttaatagctt ggagcaaaag gacctggtgg gctattcatc cacaagggcc
     1861 agttctgtgc ccatcatccc ttcagtgggt ttagaggaaa cctgcctgca aatgccaggg
     1921 atttctgaag tcaaaagcat caaatggtgc aaaaactcct attcagctga cgttgtcaat
     1981 gtgagtattc cagtcagcga ttgtcttata gcagaacaac aagaagtgaa aatattgcta
     2041 gaaactgtcc aggagcagat ccgaattctg actgatgcca gacggtcaga agactacgaa
     2101 ctggccagcg tagaaaccga ggacagtgca agcgaaaaca cagcctttct ccccctgagt
     2161 cccacagcca aatcagaacg agaggcgcaa tttgtcttaa gaaatgaaat acaaagagac
     2221 tctgcattga ccaagtgact tgagatgtag gaatctgtgc attctatgct ttgctcaaca
     2281 ggaaagagag gaaatcaaat acaaattatt tatatgcatt aatttaagag catctactta
     2341 gaagaaacca aatagtctat cgccctcata tcatagtgtt ttttaacaaa atattttttt
     2401 aagggaaaga aatgtttcag gagggataaa gcttaccatt aaagcttttg ggtagaattc
     2461 tgaatccaat ttcgtttagt cccaacactg tcctctttgg ctcttagaag atgtgggcaa
     2521 ttcagaccct tggccccaca gtgccagtgt ctcattaaaa aacactggca gttacctggt
     2581 ttcaaaaaga ggagagctgc atcccgcagg tggatgcacc agtgagcagg tggctcttgc
     2641 catttggctt gccagtccca agccctaaat ttctattcac ccaatagcct catcacaggt
     2701 tatgtcatgt cgacacatgt agtgttttct atttgatttt tggagaatgc cacaaaagac
     2761 tctgcaatgg gaaggaggac aggagataga aggagaaacc gggggcaatc ttaactactc
     2821 ttgtgtgcca ccttcctctg agatttgaat gcacagatct cagctggagg tatgaaatta
     2881 ttacagaaaa agagacaaaa aaatccttat atcgtgtcac taaaatcatg ctaatagaaa
     2941 tgtttttcct tgagattgtt tagaggctct ggaggagcgt ttctcagttt ttgtgtgcct
     3001 gtgtgcacat gtgtgtgcga gcgtgtgtgt gtgtggactt gctcacgcgg gcacatatgc
     3061 tgtaagcaca tgtgttcatt gtgcgtatgt gtgtgcatgt gtgcgcgtat tacgcttgct
     3121 aaaatttgtt ctgaaacatc agggaatcta ctattcagaa aaattatttc cctcttagat
     3181 cttttcactt taaatttttc cattaagtat aaagttcagt tagttcttaa atcaaggtca
     3241 cttgcatggt ggggtcgtat aaaactcttg acactgtcta gaccattttc tgatgtgaat
     3301 acttttgaga ggatcaacta ttggctcatt aatgatatca gtatcataag gtgagttcat
     3361 caaggatgtg tgtttatttt gaatcatgcc tacttaaatt attaatacaa gacaattaac
     3421 aaattgacag ttaccatttg ctttctcatc atcctcatta ccatttattt tatagcaagt
     3481 ctgctatgtg tggaccaagg cttcggcttc tgtggttagt atgggaagaa taaattgttg
     3541 aaataaaaat acccagacta ttcagttcac aagaagcccc ccaaaagaac agtaaattgt
     3601 gttgtatgtt catttggaat aaagcaatat ttttaccact gctaaggtga actgaaacct
     3661 ctcctgaaga tttgtctgtt tatttaccct cactttcatg ggacatatga ggaaattagt
     3721 gttcacatat ccagtctttt tccaattatt ggtggtgttg agttgttatg tttacactgt
     3781 tttaaataaa aaggcaccgt atttgaaagc a
//
