LOCUS       NM_004883               3919 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens neuregulin 2 (NRG2), transcript variant 1, mRNA.
ACCESSION   NM_004883
VERSION     NM_004883.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3919)
  AUTHORS   Chien,W.H., Chen,C.H., Cheng,M.C., Wu,Y.Y. and Gau,S.S.
  TITLE     Neuregulin 2 Is a Candidate Gene for Autism Spectrum Disorder
  JOURNAL   Int J Mol Sci 25 (10), 5547 (2024)
   PUBMED   38791584
  REMARK    GeneRIF: Neuregulin 2 Is a Candidate Gene for Autism Spectrum
            Disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3919)
  AUTHORS   Latorre,J., Martinez,C., Ortega,F., Oliveras-Canellas,N.,
            Diaz-Saez,F., Aragones,J., Camps,M., Guma,A., Ricart,W.,
            Fernandez-Real,J.M. and Moreno-Navarrete,J.M.
  TITLE     The relevance of EGFR, ErbB receptors and neuregulins in human
            adipocytes and adipose tissue in obesity
  JOURNAL   Biomed Pharmacother 156, 113972 (2022)
   PUBMED   36411648
  REMARK    GeneRIF: The relevance of EGFR, ErbB receptors and neuregulins in
            human adipocytes and adipose tissue in obesity.
REFERENCE   3  (bases 1 to 3919)
  AUTHORS   Nagasaka,M. and Ou,S.I.
  TITLE     NRG1 and NRG2 fusion positive solid tumor malignancies: a paradigm
            of ligand-fusion oncogenesis
  JOURNAL   Trends Cancer 8 (3), 242-258 (2022)
   PUBMED   34996744
  REMARK    GeneRIF: NRG1 and NRG2 fusion positive solid tumor malignancies: a
            paradigm of ligand-fusion oncogenesis.
            Review article
REFERENCE   4  (bases 1 to 3919)
  AUTHORS   Ponomareva,O.N., Ma,H., Dakour,R., Raabe,T.D., Lai,C. and Rimer,M.
  TITLE     Stimulation of acetylcholine receptor transcription by neuregulin-2
            requires an N-box response element and is regulated by alternative
            splicing
  JOURNAL   Neuroscience 134 (2), 495-503 (2005)
   PUBMED   15961242
  REMARK    GeneRIF: Nrg-2-induced Acetylcholine Receptor transcription
            requires an N-box motif and is regulated by alternative splicing.
REFERENCE   5  (bases 1 to 3919)
  AUTHORS   Yamada,K., Ichino,N., Nishii,K., Sawada,H., Higashiyama,S.,
            Ishiguro,H. and Nagatsu,T.
  TITLE     Characterization of the human NTAK gene structure and distribution
            of the isoforms for rat NTAK mRNA
  JOURNAL   Gene 255 (1), 15-24 (2000)
   PUBMED   10974560
REFERENCE   6  (bases 1 to 3919)
  AUTHORS   Ring,H.Z., Chang,H., Guilbot,A., Brice,A., LeGuern,E. and
            Francke,U.
  TITLE     The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation
            as a candidate for the autosomal recessive form of
            Charcot-Marie-Tooth disease linked to 5q
  JOURNAL   Hum Genet 104 (4), 326-332 (1999)
   PUBMED   10369162
REFERENCE   7  (bases 1 to 3919)
  AUTHORS   Reddy,P.H., Stockburger,E., Gillevet,P. and Tagle,D.A.
  TITLE     Mapping and characterization of novel (CAG)n repeat cDNAs from
            adult human brain derived by the oligo capture method
  JOURNAL   Genomics 46 (2), 174-182 (1997)
   PUBMED   9417904
REFERENCE   8  (bases 1 to 3919)
  AUTHORS   Higashiyama,S., Horikawa,M., Yamada,K., Ichino,N., Nakano,N.,
            Nakagawa,T., Miyagawa,J., Matsushita,N., Nagatsu,T., Taniguchi,N.
            and Ishiguro,H.
  TITLE     A novel brain-derived member of the epidermal growth factor family
            that interacts with ErbB3 and ErbB4
  JOURNAL   J Biochem 122 (3), 675-680 (1997)
   PUBMED   9348101
REFERENCE   9  (bases 1 to 3919)
  AUTHORS   Busfield,S.J., Michnick,D.A., Chickering,T.W., Revett,T.L., Ma,J.,
            Woolf,E.A., Comrack,C.A., Dussault,B.J., Woolf,J., Goodearl,A.D.
            and Gearing,D.P.
  TITLE     Characterization of a neuregulin-related gene, Don-1, that is
            highly expressed in restricted regions of the cerebellum and
            hippocampus
  JOURNAL   Mol Cell Biol 17 (7), 4007-4014 (1997)
   PUBMED   9199335
REFERENCE   10 (bases 1 to 3919)
  AUTHORS   Carraway,K.L. 3rd, Weber,J.L., Unger,M.J., Ledesma,J., Yu,N.,
            Gassmann,M. and Lai,C.
  TITLE     Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases
  JOURNAL   Nature 387 (6632), 512-516 (1997)
   PUBMED   9168115
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA090538.1, AB005060.1,
            AC008667.10 and AI271427.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004883.2.
            
            Summary: This gene encodes a novel member of the neuregulin family
            of growth and differentiation factors. Through interaction with the
            ERBB family of receptors, this protein induces the growth and
            differentiation of epithelial, neuronal, glial, and other types of
            cells. The gene consists of 12 exons and the genomic structure is
            similar to that of neuregulin 1, another member of the neuregulin
            family of ligands. The products of these genes mediate distinct
            biological processes by acting at different sites in tissues and
            eliciting different biological responses in cells. This gene is
            located close to the region for demyelinating Charcot-Marie-Tooth
            disease locus, but is not responsible for this disease. Alternative
            transcript variants encoding distinct isoforms have been described.
            [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) encodes isoform 1, which is
            also known as isoform alpha or alpha2. This variant is supported by
            data in PMID:10369162.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB005060.1, ERR4368409.206198.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361474.6/ ENSP00000354910.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DA090538.1         1-5
            6-3025              AB005060.1         1-3020
            3026-3815           AC008667.10        140852-141641       c
            3816-3919           AI271427.1         21-124              c
FEATURES             Location/Qualifiers
     source          1..3919
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..3919
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /note="neuregulin 2"
                     /db_xref="GeneID:9542"
                     /db_xref="HGNC:HGNC:7998"
                     /db_xref="MIM:603818"
     exon            1..930
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1102
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1221
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1342
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1419
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1522
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1646
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1774
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..2002
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..3919
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2873..2878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /note="hexamer: AATAAA"
     polyA_site      2908
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
     regulatory      3897..3902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /note="hexamer: AATAAA"
     polyA_site      3919
                     /gene="NRG2"
                     /gene_synonym="DON1; HRG2; NTAK"
                     /note="major polyA site"
ORIGIN      
        1 atcctcctcc aggtcctggc gcacagggtg ggagcgctgc gctgcgccgc gctgcgcatc
       61 gcggcccgct tgccgcctgc cccctgccct agctgggcca cctccccggg ctgccggtgg
      121 agggctaaga ggcgctaacg ttacgctgtt tccggttttc cagcgggctc tgtttcccct
      181 cccaaggcgg cggcggctga gcggcggagc cccccaaatg gcctggccag atgcggcagg
      241 tttgctgctc agcgctgccg ccgccgccac tggagaaggg tcggtgcagc agctacagcg
      301 acagcagcag cagcagcagc gagaggagca gcagcagcag cagcagcagc agcgagagcg
      361 gcagcagcag caggagcagc agcaacaaca gcagcatctc tcgtcccgct gcgcccccag
      421 agccgcggcc gcagcaacag ccgcagcccc gcagccccgc agcccggaga gccgccgccc
      481 gttcgcgagc cgcagccgcc ggcggcatga ggcgcgaccc ggcccccggc ttctccatgc
      541 tgctcttcgg tgtgtcgctc gcctgctact cgcccagcct caagtcagtg caggaccagg
      601 cgtacaaggc acccgtggtg gtggagggca aggtacaggg gctggtccca gccggcggct
      661 ccagctccaa cagcacccga gagccgcccg cctcgggtcg ggtggcgttg gtaaaggtgc
      721 tggacaagtg gccgctccgg agcggggggc tgcagcgcga gcaggtgatc agcgtgggct
      781 cctgtgtgcc gctcgaaagg aaccagcgct acatcttttt cctggagccc acggaacagc
      841 ccttagtctt taagacggcc tttgcccccc tcgataccaa cggcaaaaat ctcaagaaag
      901 aggtgggcaa gatcctgtgc actgactgcg ccacccggcc caagttgaag aagatgaaga
      961 gccagacggg acaggtgggt gagaagcaat cgctgaagtg tgaggcagca gccggtaatc
     1021 cccagccttc ctaccgttgg ttcaaggatg gcaaggagct caaccgcagc cgagacattc
     1081 gcatcaaata tggcaacggc agaaagaact cacgactaca gttcaacaag gtgaaggtgg
     1141 aggacgctgg ggagtatgtc tgcgaggccg agaacatcct ggggaaggac accgtccggg
     1201 gccggcttta cgtcaacagc gtgagcacca ccctgtcatc ctggtcgggg cacgcccgga
     1261 agtgcaacga gacagccaag tcctattgcg tcaatggagg cgtctgctac tacatcgagg
     1321 gcatcaacca gctctcctgc aaatgtccaa atggattctt cggacagaga tgtttggaga
     1381 aactgccttt gcgattgtac atgccagatc ctaagcaaaa agccgaggag ctgtaccaga
     1441 agagggtcct gaccatcacg ggcatctgcg tggctctgct ggtcgtgggc atcgtctgtg
     1501 tggtggccta ctgcaagacc aaaaaacagc ggaagcagat gcacaaccac ctccggcaga
     1561 acatgtgccc ggcccatcag aaccggagct tggccaatgg gcccagccac ccccggctgg
     1621 acccagagga gatccagatg gcagattata tttccaagaa cgtgccagcc acagaccatg
     1681 tcatcaggag agaaactgag accaccttct ctgggagcca ctcctgttct ccttctcacc
     1741 actgctccac agccacaccc acctccagcc acagacacga gagccacacg tggagcctgg
     1801 aacgttctga gagcctgact tctgactccc agtcggggat catgctatca tcagtgggta
     1861 ccagcaaatg caacagccca gcatgtgtgg aggcccgggc aaggcgggca gcagcctaca
     1921 acctggagga gcggcgcagg gccaccgcgc caccctatca cgattccgtg gactcccttc
     1981 gcgactcccc acacagcgag aggtacgtgt cggccctgac cacgcccgcg cgcctctcgc
     2041 ccgtggactt ccactactcg ctggccacgc aggtgccaac tttcgagatc acgtccccca
     2101 actcggcgca cgccgtgtcg ctgccgccgg cggcgcccat cagttaccgc ctggccgagc
     2161 agcagccgtt actgcggcac ccggcgcccc ccggcccggg acccggaccc gggcccgggc
     2221 ccgggcccgg cgcagacatg cagcgcagct atgacagcta ctattacccc gcggcggggc
     2281 ccggaccgcg gcgcgggacc tgcgcgctcg gcggcagcct gggcagcctg cctgccagcc
     2341 ccttccgcat ccccgaggac gacgagtacg agaccacgca ggagtgcgcg cccccgccgc
     2401 cgccgcggcc gcgcgcgcgc ggtgcgtccc gcaggacgtc ggcggggccc cggcgctggc
     2461 gccgctcgcg cctcaacggg ctggcggcgc agcgcgcacg ggcggcgagg gactcgctgt
     2521 cgctgagcag cggctcgggc ggcggctcag cctcggcgtc ggacgacgac gcggacgacg
     2581 cggacggggc gctggcggcc gagagcacac ctttcctggg cctgcgtggg gcgcacgacg
     2641 cgctgcgctc ggactcgccg ccactgtgcc cggcggccga cagcaggact tactactcac
     2701 tggacagcca cagcacgcgg gccagcagca gacacagccg cgggccgccc ccgcgggcca
     2761 agcaggactc ggcgccactc tagggccccg ccgcgcgccc ctccgccccg cccgccccac
     2821 tatctttaag gagaccagag accgcctact ggagagaaag gaggaaaaaa gaaataaaaa
     2881 tatttttatt ttctataaaa ggaaaaaagt ataacaaaat gttttatttt cattttagca
     2941 aaaattgtct tataatacta gctaacggca aaggcgtttt tatagggaaa ctatttatat
     3001 gtaacatcct gatttacagc ttcggaaaaa aaaaagaaac aacaaaaaaa aaagagagat
     3061 gggccaattt tttgactctt taatagaaac ctattttgtg gtgccttttg ctgtatgctc
     3121 atctggggct ccgggggaca ggtctgggtt gtggggtgct gagagtgaca gctgggagag
     3181 aagaggtgcg ggttctgttg ggggcgaggg tggggggcgg tggggggttg gccctaagga
     3241 agaactgagg acggaagtag ctttgctccc aggcaagagc tgaagttccc gacccctggg
     3301 aggagagggc caggacccta ggcttggagc tggagctggg gtaacttcca gggggagata
     3361 aagacacagc tacccgaatg gggaagccct ggctactcac agctgttaaa ggaggggggg
     3421 cagagaaacg tttccccaag agcctgagcc cagggaggtg gcagctctgc caggggccca
     3481 atgttggcgg ctcctgtccc ccacagcctc caggacgccc ctccgtcctc tgcagcacct
     3541 tcgtttacag gtcgtctttt ctattttaca cctgcatgtc ctttgcattt cagattcttt
     3601 agattggatg catggtcacg ctgggaccga gaagagccac tcgacagtgt attccccttt
     3661 tagcaataaa gtaacaccat ttccttctca caggctgcct cctagccccc aacccaccta
     3721 tgacatccac tcgtctccag tcctgccctc ccacccccaa aaactgggtc cactgctaat
     3781 ttgtcaaaaa ggtaattgtt taaaaaaaaa aaaaatccca aacagaaaca gatgggaatc
     3841 ctgtcctgaa atgtctgaac acctgactgt tgacacttga acatttttat attataaata
     3901 aaatcagaaa taactcctg
//
